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Topic Review
Testosterone and DHEA and Immune Response
Androgens are steroids that modulate various processes in the body, ranging from reproduction, metabolism, and even immune response. The main androgens are testosterone, dihydrotestosterone (DHT) and dehydroepiandrosterone (DHEA). These steroids modulate the development and function of immune response cells. Androgens are generally attributed to immunosuppressive effects; however, this is not always the case. Variations in the concentrations of these hormones induce differences in the innate, humoral, and cell-mediated immune response, which is concentration dependent. The androgens at the highest concentration in the organism that bind to the androgen receptor (AR) are DHEA and testosterone. 
  • 2.4K
  • 15 Dec 2022
Topic Review
The Role of Cytochromes P450 in Plants
Cytochromes P450 are ancient enzymes diffused in organisms belonging to all kingdoms of life, including viruses, with the largest number of P450 genes found in plants. The functional characterization of cytochromes P450 has been extensively investigated in mammals, where these enzymes are involved in the metabolism of drugs and in the detoxification of pollutants and toxic chemicals.
  • 2.4K
  • 29 Mar 2023
Topic Review
Adaptation to EUTR Requirements: Slovenia, Croatia and Serbia
Eight years after the European Union Timber Regulation (EUTR) came into force, its effectiveness is still unsatisfactory due to deficient and uneven implementation among member states.  In addition, some Western Balkan countries have poor legality monitoring systems, increasing the risk of trade in illegally harvested timber. Regardless of this, no recent work has analyzed the adaptation of national forest policies to the EUTR obligations. Author study aims to contribute to the understanding of EUTR implementation by analyzing the adaptation of policies of the Western Balkan countries (Slovenia, Croatia, and Serbia) to the EUTR. Qualitative content analysis was conducted on 22 policy documents from Slovenia, Croatia, and Serbia. Documents were coded using coding categories derived from EUTR. Our results point out that none of the analyzed countries have a policy to directly address illegal logging or prevention of illegal activities. As EU members, Slovenia and Croatia has implemented EUTR through laws. The Slovenian Forest Act addresses all EUTR obligations, while Croatian Law on EUTR Implementation does not directly address the obligation of legality. This obligation is addressed by the Law on Forests. As Serbia is not an EU member, it did not implement EUTR. Nevertheless, Serbian Law on Forests addresses all EUTR obligations, but has some discrepancies regarding Traceability obligation. With ongoing discourses on Green Deal policies and the increasing focus on “deforestation-free” commodities, stricter implementation might be expected of EUTR at EU level. Most countries would probably have to build capacities for EUTR implementation and become more transparent and responsible concerning information availability. To successfully implement EUTR, an increased number of checks as well as stricter fines will be needed.
  • 2.4K
  • 22 Dec 2021
Topic Review
Halophyte Common Ice Plants
The problems associated with the salinization of soils and water bodies and the increasing competition for scarce freshwater resources are increasing. Current attempts to adapt to these conditions through sustainable agriculture involves searching for new highly salt-tolerant crops, and wild species that have potential as saline crops are particularly suitable. The common ice plant (Mesembryanthemum crystallinum L.) is an edible halophyte member of the Aizoaceae family, which switches from C3 photosynthesis to crassulacean acid metabolism (CAM) when exposed to salinity or water stress. The aim of this review was to examine the potential of using the ice plant in both the wild and as a crop, and to describe its ecology and morphology, environmental and agronomic requirements, and physiology. The antioxidant properties and mineral composition of the ice plant are also beneficial to human health and have been extensively examined.
  • 2.4K
  • 13 Oct 2021
Topic Review
Biological Nitrogen Fixation in Agriculture
Biological nitrogen fixation (BNF) is a natural process of changing atmospheric nitrogen (N2) into a simple soluble nontoxic form (NH4+ primarily) which is used by plant cell for synthesis of various biomolecules. Nitrogen fixation is one of the major sources of nitrogen for plants and a key step distributing this nutrient in the ecosystem. Optimization of BNF is critical to sustain both food production and environmental health. 
  • 2.4K
  • 17 Oct 2022
Topic Review
Gamma Squeeze
In the stock market, a gamma squeeze occurs when the underlying price of a stock increases within a very short timeframe. A higher amount of money moving into call options results in greater buying activity and can push the stock price up as a result.
  • 2.4K
  • 07 Nov 2022
Topic Review
Deep Foundation
A deep foundation is a type of foundation that transfers building loads to the earth farther down from the surface than a shallow foundation does to a subsurface layer or a range of depths. A pile or piling is a vertical structural element of a deep foundation, driven or drilled deep into the ground at the building site. There are many reasons that a geotechnical engineer would recommend a deep foundation over a shallow foundation, such as for a skyscraper. Some of the common reasons are very large design loads, a poor soil at shallow depth, or site constraints like property lines. There are different terms used to describe different types of deep foundations including the pile (which is analogous to a pole), the pier (which is analogous to a column), drilled shafts, and caissons. Piles are generally driven into the ground in situ; other deep foundations are typically put in place using excavation and drilling. The naming conventions may vary between engineering disciplines and firms. Deep foundations can be made out of timber, steel, reinforced concrete or prestressed concrete.
  • 2.4K
  • 23 Nov 2022
Topic Review
Joint Configuration and Geometry
The use of carbon fibre-reinforced polymer (CFRP) materials is increasing in many different industries, such as those operating in the aviation, marine, and automotive sectors. In these applications, composite parts are often joined with other composite or metallic parts, where adhesive bonding plays a key role. 
  • 2.4K
  • 17 Jan 2023
Topic Review
Atherogenic Dyslipidemia Associated with Metabolic Syndrome
Atherogenic dyslipidemia plays a critical role in the development of metabolic syndrome (MetS), being one of its major components, along with central obesity, insulin resistance, and hypertension.
  • 2.4K
  • 19 Jul 2023
Topic Review
Smart Electro-Clothing Systems
This entry presents an overview of the smart electro-clothing systems (SeCSs) targeted at health monitoring, sports benefits, fitness tracking, and social activities. Technical features of the available SeCSs, covering both textile and electronic components, are thoroughly discussed and their applications in the industry and research purposes are highlighted. In addition, it also presents the developments in the associated areas of wearable sensor systems and textile-based dry sensors. As became evident during the literature research, such a review on SeCSs covering all relevant issues has not been presented before. This entry will be particularly helpful for new generation researchers who are and will be investigating the design, development, function, and comforts of the sensor integrated clothing materials.
  • 2.4K
  • 01 Nov 2020
Topic Review
Mismatch Negativity
Mismatch negativity (MMN) is a component of the difference waveform derived from passive auditory oddball stimulation.
  • 2.4K
  • 19 May 2021
Topic Review
Oxidative Strong Metal–Support Interactions
Oxidative Strong Metal–Support Interactions (OMSI) can be defined as a phenomenon occurring in a supported metal catalyst that is triggered by oxidative (or non-reductive) conditions with the typical features resembling that of SMSI, including 1) small-molecule of CO or H2 adsorption on metal will be significantly suppressed, 2) the support would encapsulate metal particles, 3) electron transfer from metal to the support, and 4) a reversal of the above phenomena following reduction treatment.
  • 2.4K
  • 27 Aug 2021
Topic Review
Chitosan-Based Applications
Chitin is a nitrogen-enriched polymer abundantly present in the exoskeletons of arthropods, cell walls of fungi, green algae, and microorganisms, radulae and beaks of molluscs and cephalopods, etc. Chitosan is a promising candidate for a wide variety of applications due to its macromolecular structure and its unique biological and physiological properties, including solubility, biocompatibility, biodegradability, and reactivity. Chitosan and its derivatives have been known to be applicable in medicine, pharmaceuticals, food, cosmetics, agriculture, the textile and paper industries, the energy industry, and industrial sustainability. More specifically, their use in drug delivery, dentistry, ophthalmology, wound dressing, cell encapsulation, bioimaging, tissue engineering, food packaging, gelling and coating, food additives and preservatives, active biopolymeric nanofilms, nutraceuticals, skin and hair care, preventing abiotic stress in flora, increasing water availability in plants, controlled release fertilizers, dye-sensitised solar cells, wastewater and sludge treatment, and metal extraction. 
  • 2.4K
  • 21 Mar 2023
Topic Review
Antioxidant Assays
Antioxidant assay methods are essential tools for evaluating the ability of substances to combat oxidative stress, a process linked to aging and various diseases. These methods assess different aspects of antioxidant activity, helping researchers quantify and compare the antioxidant potential of compounds. They contribute to our understanding of how antioxidants protect cells and guide the development of health-promoting products. These assays are integral to advancing research on oxidative stress and antioxidants' roles in maintaining cellular health and reducing disease risk.
  • 2.4K
  • 11 Sep 2023
Topic Review
Bone Morphogenetic Protein-2
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Specifically, within the BMP family, Bone Morphogenetic Protein-2 (BMP-2) was the first BMP to be characterized and has been well-studied. BMP-2 has important roles during embryonic development, as well as bone remodeling and homeostasis in adulthood. Some of its specific functions include digit formation and activating osteogenic genes, such as Runt-Related Transcription Factor 2 (RUNX2). Because of its diverse functions and osteogenic potential, the Food and Drug Administration (FDA) approved usage of recombinant human BMP-2 (rhBMP-2) during spinal fusion surgery, tibial shaft repair, and maxillary sinus reconstructive surgery. However, shortly after initial injections of rhBMP-2, several adverse complications were reported, and alternative therapeutics have been developed to limit these side-effects.
  • 2.4K
  • 26 Oct 2020
Topic Review
Dolomite Phenomenon
The so-called dolomite phenomenon, also known as dolomite edaphism or dolomitophily, occurs globally and is evidenced through the appearance of an endemic flora on nutrient-poor soils with high levels of magnesium. It occurs when dolomitic rocks emerge, especially with high Mg content, and when tectonic or weathering processes generate skeletal soils, predominantly sandy or gravelly in texture. These types of habitats are associated with a specific flora, also accompanied by other tolerant species.
  • 2.4K
  • 02 Feb 2021
Topic Review
Ferroelastic Twinning in Minerals
Ferroelastic twinning in minerals is a very common phenomenon. The twin laws follow simple symmetry rules and they are observed in minerals, like feldspar, palmierite, leucite, perovskite, and so forth. The major discovery over the last two decades was that the thin areas between the twins yield characteristic physical and chemical properties, but not the twins themselves. Research greatly focusses on these twin walls (or ‘twin boundaries’); therefore, because they possess different crystal structures and generate a large variety of ‘emerging’ properties. Research on wall properties has largely overshadowed research on twin domains. 
  • 2.4K
  • 15 Jun 2021
Topic Review
Applications of Ellagic Acid and Its Derivatives
Ellagitannins (ETs), characterized by their diversity and chemical complexity, belong to the class of hydrolysable tannins that, via hydrolysis under acidic or alkaline conditions, can yield ellagic acid (EA). They are mostly found as a part of extractives in angiosperms. As known antioxidants and chelators, EA and EA derivatives are drawing an increasing interest towards extensive technical and biomedical applications. 
  • 2.4K
  • 29 Mar 2022
Topic Review
Analytical Assessment of Biosimilars
The analytical assessment includes testing physicochemical and functional attributes to establish a claim of biosimilarity. How closely a biosimilar candidate should match the reference product will remain questionable since a reference product is approved based on whatever quality attributes it presents; a biosimilar candidate, on the other hand, must match these quality attributes, even if the reference product’s attributes are not the most desirable.
  • 2.4K
  • 27 Apr 2022
Topic Review
Façade Defects and Inspection Practices
The increasing number of accidents arising from falling objects from the façade of tall buildings has attracted much attention globally. To regulators, a preventive approach based on a mandatory periodic façade inspection has been deemed as a necessary measure to maintain the functionality and integrity of the façade of tall buildings.
  • 2.4K
  • 30 Aug 2022
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