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Topic Review
Gamma-Aminobutyric Acid
Gamma-Aminobutyric acid, or γ-aminobutyric acid /ˈɡæmə əˈmiːnoʊbjuːˈtɪrɪk ˈæsɪd/, or GABA /ˈɡæbə/, is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. Its principal role is reducing neuronal excitability throughout the nervous system. GABA is sold as a dietary supplement in many countries. It has been traditionally thought that exogenous GABA (i.e. taken as a supplement) doesn't cross the blood-brain barrier, however data obtained from more current research indicates that it may be possible.
  • 2.5K
  • 01 Dec 2022
Topic Review
Kodkod
The Kodkod, scientifically known as Leopardus guigna, is a small wild cat species native to the temperate forests of South America. It is one of the smallest wild cats in the Americas, with adults typically weighing between 2 to 3 kilograms. Despite its diminutive size, the Kodkod is a skilled predator, preying on small mammals, birds, and insects, and plays a crucial role in maintaining ecosystem balance within its habitat.
  • 2.5K
  • 15 Mar 2024
Topic Review
Functional Aspects of Epidermal Barrier
The epidermis is a living, multilayered barrier with five functional levels, including a physical, a chemical, a microbial, a neuronal, and an immune level. 
  • 2.5K
  • 03 Nov 2021
Topic Review
{001} Faceted Anatase TiO2-Based Composites
For anatase TiO2, the {001} crystal facets are the most reactive because they exhibit unique surface characteristics such as visible light responsiveness, dissociative adsorption, efficient charge separation capabilities and photocatalytic selectivity. In this review, a concise survey of the literature in the field of {001} dominated anatase TiO2 crystals and their composites is presented. Even though the design and morphologically controlled synthesis of TiO2-001 is considered to be a hot spot in scientific research, it still has some drawbacks like its wide band gap and high recombination rate. These drawbacks can easily be overcome by coupling them with other materials to form TiO2-001-based composites. This review focusses on the synthesis, properties and applications of TiO2-001-based composites. 
  • 2.5K
  • 12 Nov 2021
Topic Review
Antioxidant Activity of Natural Products
Natural products identified with potential antioxidant activity need to be further evaluated in the cellular model. Antioxidant activity of a large number of natural products will not extrapolate its performance in the biological system, either in vitro as cellular assays or in vivo as animal model studies. Thus, it is necessary to examine the bioavailability, metabolism and mechanism of action in a living system to prove potential antioxidant activities of new natural products.
  • 2.5K
  • 09 Dec 2021
Topic Review
Emmer
Emmer wheat or hulled wheat is a type of awned wheat. Emmer is a tetraploid (2n = 4x = 28 chromosomes). The domesticated types are Triticum turgidum subsp. dicoccum and Triticum turgidum conv. durum. The wild plant is called Triticum turgidum subsp. dicoccoides. The principal difference between the wild and the domestic is that the ripened seed head of the wild plant shatters and scatters the seed onto the ground, while in the domesticated emmer the seed head remains intact, thus making it easier for humans to harvest the grain. Along with einkorn wheat, emmer was one of the first crops domesticated in the Near East. It was widely cultivated in the ancient world, but is now a relict crop in mountainous regions of Europe and Asia. Emmer is considered a type of farro food especially in Italy.
  • 2.5K
  • 01 Dec 2022
Topic Review
Black-footed Cat
The Black-footed Cat (Felis nigripes) is a small and elusive wild cat species native to southern Africa. Renowned for its diminutive size and distinctive black markings on its legs and feet, this nocturnal predator is considered one of the smallest wild cats in Africa. Despite its small stature, the Black-footed Cat is a formidable hunter, preying on a variety of small mammals, birds, and insects in its arid savanna and scrubland habitats.
  • 2.5K
  • 08 Mar 2024
Topic Review
Apple Bandai Pippin
The Apple Bandai Pippin, stylized PiP P!N, is a multimedia technology console, designed by Apple Computer. The console is based on the Apple Pippin platform – a derivative of the Apple Macintosh platform. Bandai produced the ATMARK and @WORLD consoles between 1996 and 1997. It was sold at $599. The goal of the Bandai Pippin was to create an inexpensive computer system aimed mostly at playing CD-based multimedia software, especially games, but also functioning as a thin client. The operating system is a version of System 7.5.2, and is based on a 66 MHz PowerPC 603 processor and a 14.4 kb/s modem. It features a 4×-speed CD-ROM drive and a video output that can connect to a standard television display.
  • 2.5K
  • 27 Oct 2022
Topic Review
Vortex86
The Vortex86 is a computing system-on-a-chip (SoC) based on a core compatible with the x86 microprocessor family. It is produced by DM&P Electronics, but originated with Rise Technology.
  • 2.5K
  • 04 Nov 2022
Topic Review
Insulation System and Aging Phenomenon
The insulating system of the windings of electrical machines is multi-layer and consists of coil and main (slot) insulation. The thickness of the insulation is selected with a margin so that its durability to breakdown is greater than the existing voltage. 
  • 2.5K
  • 23 Nov 2022
Topic Review
Eye Movement Desensitization and Reprocessing
Eye movement desensitization and reprocessing (EMDR) is a form of psychotherapy in which the person being treated is asked to recall distressing images; the therapist then directs the patient in one type of bilateral stimulation, such as side-to-side eye rapid movement or hand tapping. EMDR was developed by Francine Shapiro starting in 1988. According to the 2013 World Health Organization (WHO) practice guideline: "This therapy [EMDR] is based on the idea that negative thoughts, feelings and behaviours are the result of unprocessed memories. The treatment involves standardized procedures that include focusing simultaneously on (a) spontaneous associations of traumatic images, thoughts, emotions and bodily sensations and (b) bilateral stimulation that is most commonly in the form of repeated eye movements." EMDR is included in several evidence-based guidelines for the treatment of post-traumatic stress disorder (PTSD), with varying levels of recommendation and evidence (very low to moderate per WHO stress guidelines). As of 2020, the American Psychological Association lists EMDR as an evidence-based treatment for PTSD but stresses that "the available evidence can be interpreted in several ways" and notes there is debate about the precise mechanism by which EMDR appears to relieve PTSD symptoms with some evidence EMDR may simply be a variety of exposure therapy. Even though EMDR is effective, critics call it a pseudoscience because only the desensitization component has scientific support.
  • 2.5K
  • 22 Nov 2022
Topic Review
CYP2D6 and Tamoxifen Metabolism
Tamoxifen is an important adjuvant endocrine therapy in estrogen receptor (ER)-positive breast cancer patients. It is metabolized into its most active antiestrogenic metabolite endoxifen, predominantly by cytochrome P450 2D6 (CYP2D6). Many factors, including genetic variation in CYP2D6, influence tamoxifen metabolism and pharmacokinetics.
  • 2.5K
  • 09 Mar 2021
Topic Review
InP based HEMTs
High Electron Mobility Transistors (HEMT), also known as HFETs or modulation doped Field Effect Transistors (MODFETs), is a form of field effect transistor, which is capable of providing high levels of performances at microwave frequencies.
  • 2.5K
  • 26 May 2021
Topic Review
Digital Twins and Key Performance Indications
A dashboard application is proposed and developed to act as a Digital Twin that would indicate the Measured Value to be held accountable for any future failures. The dashboard is implemented in the Java programming language, while information is stored into a Database that is aggregated by an Online Analytical Processing (OLAP) server. This achieves easy Key Performance Indicators (KPIs) visualization through the dashboard.
  • 2.5K
  • 09 Sep 2022
Topic Review
Hemorheology
Hemorheology, the study of cell deformation and blood flow, has been more focused on red blood cells (RBCs) rheology, relating the deformation and aggregation of RBCs, since erythrocytes comprise the major components in blood. Blood rheology can be used as an important clinical assay, correlating various aspects of blood rheology and associated changes in cell behavior and morphology to a wide range of diseases and health conditions.
  • 2.5K
  • 05 Jan 2021
Topic Review
Technologies for Biogas Upgradation
Biogas is a mixture of CO2, CH4, H2S, is an eco-friendly and inexpensive renewable biofuel. This mixture of gases restricts biogas utilization in vehicular fuel, CHPs, therefore, biogas upgradation becomes a necessary step.
  • 2.5K
  • 13 Jan 2023
Topic Review
Silphium
The chemical composition of three Silphium species in the aspect of the possibility of their use for various purposes has been evaluated. The plant material of three Silphium species (S. perfoliatum, S. trifoliatum and S. integrifolium) was acquired from cultivation located in eastern Poland. The vegetative propagating material consisted of seeds and rhizomes. Content of protein (up to 22.9% in leaves of S. perfoliatum), amino acids (aspartic acid—up to 12.0%, glutamic acid—up to 9.5%, and leucine—up to 9.4%), fat (up to 4.2% in inflorescences of S. perfoliatum), cellulose (up to 42.9% in stems of S. trifoliatum), water-soluble sugars (up to 26.7% in rhizomes of S. perfoliatum) and mineral substances (ash up to 20.9% in stems of S. integrifolium, with significant levels of elements such as K, Ca, Mg, Fe, Mn) in the tested Silphium species can be an important criterion determining a positive evaluation of these plants as sources of alternative raw materials. The conducted research is meant to draw attention to the possibility of use of the biomass of three Silphium species as a potential source of ecological and renewable raw material for food, pharmaceuticals, feed and possibly also for energy generation purposes.
  • 2.5K
  • 02 Nov 2020
Topic Review
Endocannabinoid Signaling in Parkinson’s Disease
This review focuses on what endocannabinoid means related to its possible action in the treatment of Parkinson's disease symptoms, also presenting the role of cannabinoid receptors in these symptoms, but also in terms of the cause and treatment of this pathology. Current pharmacotherapy of Parkinson’s disease (PD) is symptomatic and palliative, with levodopa/carbidopa therapy remaining the prime treatment, and nevertheless, being unable to modulate the progression of the neurodegeneration. No available treatment for PD can enhance the patient’s life-quality by regressing this diseased state. Various studies have encouraged the enrichment of treatment possibilities by discovering the association of the effects of the endocannabinoid system (ECS) in PD. These reviews delineate the reported evidence from the literature on the neuromodulatory role of the endocannabinoid system and expression of cannabinoid receptors in symptomatology, cause, and treatment of PD progression, wherein cannabinoid (CB) signalling experiences alterations of biphasic pattern during PD progression. Published papers to date were searched via MEDLINE, PubMed, etc., using specific key words in the topic of our manuscript. Endocannabinoids regulate the basal ganglia neuronal circuit pathways, synaptic plasticity, and motor functions via communication with dopaminergic, glutamatergic, and GABAergic signalling systems bidirectionally in PD. Further, gripping preclinical and clinical studies demonstrate the context regarding the cannabinoid compounds, which is supported by various evidence (neuroprotection, suppression of excitotoxicity, oxidative stress, glial activation, and additional benefits) provided by cannabinoid-like compounds (much research addresses the direct regulation of cannabinoids with dopamine transmission and other signalling pathways in PD). More data related to endocannabinoids efficacy, safety, and pharmacokinetic profiles need to be explored, providing better insights into their potential to ameliorate or even regress PD.
  • 2.5K
  • 01 Sep 2020
Topic Review
Date Palm Fruits (Phoenix dactylifera L.)
The date palm (Phoenix dactylifera L.) is traditionally cultivated in arid regions of the world, including the Arabian Peninsula. It is one of the oldest fruit trees, a key component of the food system, and is recognized as a symbol of prosperity in the Arab world.
  • 2.5K
  • 16 Dec 2021
Topic Review
Pincer Transition Metal Catalysts for Sustainability
Sustainable solutions are needed to avoid global warming and climate change. Homogeneous catalysis might play a fundamental role for this. Pincer-type complexes are promising in terms of stability, selectivity, efficiency and the use of mild reaction conditions. Pincer complexes have been used in many sustainable chemical reactions, for example hydrogen release and upconversion of CO2, N2, and biomass.
  • 2.5K
  • 08 Apr 2022
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