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Topic Review
Chromodomain-Helicase-DNA Binding Family
The CHD (chromodomain-helicase-DNA binding) family consists of nine members (CHD1–CHD9). Their structure is characterised by two consecutive chromodomains in the N-terminal region and an SNF2-like (sucrose-non-fermenting (SNF)) ATP-dependent helicase domain positioned in the central region. They recognise and bind nucleosomes to contribute, in many cases, to the formation of heterochromatin typically marked by the presence of methylated histones and other repressive chromatin markers. CHD proteins can bind to methylated histones through their chromodomains and use their helicase activity to remodel the chromatin and contribute to the formation of heterochromatin, a fundamental feature of chromosomes that ensures genomic stability.
  • 2.6K
  • 17 Feb 2023
Topic Review
Carbon-Isotope Signature of Diagenetic Carbonates
Diagenetic carbonates often show large variations in their carbon isotope compositions. Variations are mainly the result of isotope fractionation effects during microbial metabolic processes, and these processes themselves may induce carbonate formation. Inorganic carbon from dissimilatory microbial activity shows negative carbon isotope values (d13C), in particular if methane is used as a carbon source. In turn, inorganic carbon produced during methanogenesis shows positive d13C values. The range of isotope values preserved in the carbonate phase ultimately depends on the reservoir sizes, diffusive mixing of different carbon sources, and episodic formation of carbonate. The carbon-isotope signature of diagenetic carbonates therefore represents an archive of past biogeochemical activity in the subsurface.
  • 2.6K
  • 30 Oct 2020
Topic Review
Personal Protective Equipment for Dentists
Severe Acute Respiratory-Syndrome-CoronaVirus-2 ( SARS-CoV-2) and all infectious agents can determine serious risk for systemic diseases. In literature there are some models of safety protocols in dentistry. All the personal protective equipment (PPE) actually on the market and their indications are reported and compared before and after COVID-19 onset, focusing on the correct safety procedures for each dental practice. 
  • 2.6K
  • 06 Nov 2020
Topic Review
Andrographolide
Traditionally, Andrographis paniculata has been used as an herbal remedy for lung infection treatments. Its leaves contain a diterpenoid labdane called andrographolide responsible for a wide range of biological activities such as antioxidant, anti-inflammatory, and anti-cancer properties. This entry is a brief review of the antioxidant mechanisms and the regulation of the Nrf2 (nuclear factor (erythroid-derived 2)-like 2) signaling pathway by andrographolide.
  • 2.6K
  • 30 Jul 2021
Topic Review
Conceptualization of the Migration Phenomenon
The migration process has become particularly important for Romania in the last 20 years, and its socio-economic, political and cultural effects affect the Romanian state. That is why flexible policies are needed in order to be coherent, to have as main purpose keeping specialists in the country in certain basic economic fields, as well to implement measures to determine the return of specialists and students who have left to study abroad.
  • 2.6K
  • 14 Apr 2022
Topic Review
Modesto Manifesto
The Modesto Manifesto, was a set of standards for religious leaders that became notable as the signature practice among men in which they avoid spending time alone with people of the opposite sex to whom they are not married. It has additionally taken a more modern meaning as a display of integrity, a means of avoiding sexual temptation, to avoid any appearance of doing something considered morally objectionable, and to avoid being accused of sexual harassment or assault. Created for male evangelical Protestant leaders by Billy Graham, it has been popularly known as the "Billy Graham rule." Its adoption by U.S. Vice President Mike Pence has had it additionally nicknamed the "Mike Pence rule". The Modesto Manifesto has found a prominent foothold on Wall Street and more generally in American finance for its ability to limit the "risk" of perceived sexual impropriety.
  • 2.6K
  • 14 Oct 2022
Topic Review
Split-Single
The split-single (Doppelkolbenmotor to its German and Austrian manufacturers), is a variant on the two-stroke engine with two cylinders sharing a single combustion chamber.
  • 2.6K
  • 02 Dec 2022
Topic Review
Technologies in Detection of Mycotoxins
Mycotoxins are secondary metabolites produced by filamentous fungi that cause harmful effects on human and animal health as well as significant economic losses. As mycotoxins are responsible for food contamination and certain permissible limits have already been established, developing sensitive and reliable methods to detect them is a top priority. Proteomic and genomic methods, molecular techniques, electronic nose, aggregation-induced emission dye, quantitative NMR, and hyperspectral imaging are some innovative techniques which are applied in the analysis and determination of important mycotoxins in foods and are used alternatively in chromatographic techniques. Some of them have proven to be particularly effective in not only the detection of mycotoxins, but also in detecting mycotoxin-producing fungi. As mycotoxin-contaminated foods can appear anywhere in the world through international trade, their detection and identification are considered essential to the protection of human health by providing safe foods free of major food contaminants such as mycotoxins.
  • 2.6K
  • 29 Oct 2020
Topic Review
Treatment Methods of SC
Sulfur compounds(SC) are removed from petroleum by the addition of sodium hydroxide at a very high concentration. As a result, a residue called spent soda or spent caustic is generated, being extremely aggressive to the environment. In this work, the chemical properties of this residue are described in detail. The sodium hydroxide remains that have not reacted, sulfur compounds, and organic matter are the primary pollutants reported. Additionally, the main characteristics of the methods of treatment used to reduce them are described.
  • 2.6K
  • 14 Jan 2021
Topic Review
Green Seaweeds and Ulvan
This entry analyzed the recent trend towards, progresses towards the preparation of chemicals of, and value-added biomaterials from marine macroalgae resources, especially green seaweeds and their derived ulvan polysaccharides for various applications. In recent years, ulvan both in pristine and modified forms has gained a large amount of attention for its effective utilization in various areas due to its unique physiochemical properties, lack of exploration, and higher green seaweed production. The pristine form of ulvan (sulfated polysaccharides) is used as a bio-component; food ingredient; or a raw material for the production of numerous chemicals such as fuels, cosmetics, and pharmaceuticals, whereas its modified form is used in the sector of composites, membranes, and scaffolds, among others, because of its physicochemical properties.
  • 2.6K
  • 15 Jun 2021
Topic Review
Tumor Temperature
The temperature of a solid tumor is often dissimilar to baseline body temperature and, compared to healthy tissues, may be elevated, reduced, or a mix of both. The temperature of a tumor is dependent on metabolic activity and vascularization and can change due to tumor progression, treatment, or cancer type.
  • 2.6K
  • 13 Sep 2022
Topic Review
Timeline of DOS Operating Systems
This article presents a timeline of events in the history of 16-bit x86 DOS-family disk operating systems from 1980 to present. Non-x86 operating systems named "DOS" are not part of the scope of this timeline. Also presented is a timeline of events in the history of the 8-bit 8080-based and 16-bit x86-based CP/M operating systems from 1974 to 2014, as well as the hardware and software developments from 1973 to 1995 which formed the foundation for the initial version and subsequent enhanced versions of these operating systems.
  • 2.6K
  • 26 Oct 2022
Topic Review Peer Reviewed
COVID-19 and Participatory Music-Making
Participatory music-making is any music-making activity in which individuals engage for the sake of the activity itself. It can be contrasted with presentational music-making, which takes the production of a performance or recording for consumption by an audience as a principal objective. During the COVID-19 pandemic, participatory musicians adopted a variety of technological means by which to make music together online. While virtual activities allowed these individuals to sustain their communities and grow as musicians, they did not satisfy all the needs met by in-person music-making. Additionally, online music-making increased access for some but posed barriers to access for others. Virtual participatory music-making remains relevant following the relaxation of pandemic restrictions, and it will likely grow in significance as communications technologies and internet access improve.
  • 2.6K
  • 07 May 2024
Topic Review
B-cell non-Hodgkin lymphoma
The term B-cell non-Hodgkin lymphoma (B-NHL) encompasses different neoplasms characterized by an abnormal proliferation of lymphoid B cells.
  • 2.6K
  • 13 Jan 2022
Topic Review
Theranostic Radiopharmaceuticals
Theranostic Radiopharmaceuticals (Radiotheranostics) is a term in the medical field to define the combination of therapeutic and diagnostic techniques by a suitable radiopharmaceutical agent. Radionuclides are isotopes that emit radiation or have excess nuclear energy, making them chemically unstable and tend to change into another atom. Various types of radiation can be emitted by radionuclides e.g. alpha particles, beta particles, and gamma energy. In radiotheranostics, a pharmaceutical agent (drug) is needed to be a carrier molecule that introduces the radionuclide to its target. Radionuclides are then used as a source of radiation in radiotheranostics that are responsible for diagnosing or treating various diseases.
  • 2.6K
  • 24 May 2022
Topic Review
Nanotechnological Approaches for Removal of Persistent Organic Pollutants
Persistent organic pollutants (POPs) are a group of hazardous chemical compounds that originate from anthropogenic activities during production, utilization, and disposal. They can impact living beings and the environment adversely because of their ease of transportation by wind and water. The level of hazardous persistent organic pollutants is increasing every day in the environment.
  • 2.6K
  • 02 Aug 2022
Topic Review
H2S Removal from Gas Mixtures Using Zeolites
Natural gas, biogas, and refinery gas all include H2S, which has adverse effects not only on the environment and human health but also on the equipment and catalysts that are employed in the relevant processes. H2S is removed from the aforementioned gases using a variety of techniques in order to fulfill the necessary sales criteria and for reasons of safety. The adsorption method stands out among various other approaches due to its straightforward operation, high level of efficiency, and low overall cost. This technique makes use of a variety of adsorbents, such as metal-organic frameworks (MOFs), activated carbon, and zeolites. The use of zeolite-based adsorbents is by far the most common of these various types.
  • 2.6K
  • 12 Aug 2022
Topic Review
Preparation and Purification of In Vitro-Transcribed-mRNA-Based Molecules
The Corona Virus Disease 2019 (COVID-19) pandemic poses a disruptive impact on public health and the global economy. Fortunately, the development of COVID-19 vaccines based on in vitro transcribed messenger RNA (IVT mRNA) has been a breakthrough in medical history, benefiting billions of people with its high effectiveness, safety profile, and ease of large-scale production. This success is the result of decades of continuous RNA research, which has led to significant improvements in the stability and expression level of IVT mRNA through various approaches such as sequence optimization and improved preparation processes. IVT mRNA sequence optimization has been shown to have a positive effect on enhancing mRNA expression level. The innovation of IVT mRNA purification technology is also indispensable, as the purity of IVT mRNA directly affects success of downstream vaccine preparation processes and the potential for inducing unwanted side effects in therapeutic applications. Despite the progress made, challenges related to IVT mRNA sequence design and purification still require further attention to enhance the quality of IVT mRNA in the future.
  • 2.6K
  • 06 Sep 2023
Topic Review
Perseus
Perseus, a prominent constellation in the northern celestial hemisphere, is named after the legendary Greek hero known for slaying the monstrous Gorgon Medusa. Located near the celestial equator, Perseus is recognizable for its distinctive "W" shape formed by its brightest stars and is rich in fascinating deep-sky objects.
  • 2.6K
  • 15 Mar 2024
Topic Review
Impact of COVID-19 on Social/Health/Economy
The COVID-19 pandemic is the most large-scale pandemic on earth this century, and the impact in all life sectors is devasting and directly affected human activity in the first wave. The impact on the economy, social care systems, and human relationships is causing an unprecedented global crisis. SARS-CoV-2 has a strong direct acute impact on population health, not only at the physiological level but also at the psychological level for those who suffer it, those close to them, and the general population, who suffer from the social consequences of the pandemic. In this line, the economic recession increased, even more, the social imbalance and inequity, hitting the most vulnerable families, and creating a difficult context for public institutions to address. 
  • 2.6K
  • 15 Jun 2021
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