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Topic Review
Windows 2.0
Windows 2.0 is an obsoleted 16-bit Microsoft Windows GUI-based operating environment that was released on December 9, 1987, and the successor to Windows 1.0. This product's family includes Windows 2.0, a base edition for 8086 real mode, and Windows/386 2.0, an enhanced edition for i386 protected mode.
  • 2.7K
  • 08 Oct 2022
Topic Review
Understanding HII Framework and Related Technologies
The Unified Extensible Firmware Interface (UEFI) is currently the most popular industry standard, defining the software interface between an operating system and its underlying platform firmware. HII (Human Interface Infrastructure) is a part of the UEFI specification, which provides a standard framework for managing user interfaces based on UEFI systems. 
  • 2.7K
  • 17 Nov 2023
Topic Review
LINC Complex in Sperm Development
The LINC (LInker of Nucleoskeleton and Cytoskeleton) complex is localized within the nuclear envelope and consists of SUN (Sad1/UNc84 homology domain-containing) proteins located in the inner nuclear membrane and KASH (Klarsicht/Anc1/Syne1 homology domain-containing) proteins located in the outer nuclear membrane, hence linking nuclear with cytoplasmic structures. While the nucleoplasm-facing side acts as a key player for correct pairing of homolog chromosomes and rapid chromosome movements during meiosis, the cytoplasm-facing side plays a pivotal role for sperm head development and proper acrosome formation during spermiogenesis. A further complex present in spermatozoa is involved in head-to-tail coupling. An intact LINC complex is crucial for the production of fertile sperm, as mutations in genes encoding for complex proteins are known to be associated with male subfertility in both mice and men.
  • 2.7K
  • 04 Dec 2020
Topic Review
Serious Gaming for Behaviour Change
Serious games (SG) are defined as “interactive computer applications, with or without a significant hardware component, that have challenging goals, are fun to play and engaging, incorporate some scoring mechanism, and supply the user with skills, knowledge or attitudes useful in reality".
  • 2.7K
  • 28 Mar 2022
Topic Review
A Systematic Approach to Healthcare Knowledge Management Systems
Big data in healthcare contain a huge amount of tacit knowledge that brings great value to healthcare activities such as diagnosis, decision support, and treatment. However, effectively exploring and exploiting knowledge on such big data sources exposes many challenges for both managers and technologists. A healthcare knowledge management system that ensures the systematic knowledge development process on various data in hospitals was proposed. It leverages big data technologies to capture, organize, transfer, and manage large volumes of medical knowledge, which cannot be handled with traditional data-processing technologies. In addition, machine-learning algorithms are used to derive knowledge at a higher level in supporting diagnosis and treatment.
  • 2.7K
  • 13 May 2022
Topic Review
Metal Nanoclusters
Metal nanoclusters (NCs), comprising only a few to roughly hundreds of metal atoms, have a metal core-protective agent shell structure. Owing to the size of metal NCs approaching the Fermi wavelength of electrons, the spatial confinement of free electrons in metal NCs generates discrete electronic transitions, thereby exhibiting intriguing molecular-like properties. Therefore, metal NCs are deemed to bridge the gap between molecules and nanoparticles.
  • 2.7K
  • 01 Dec 2020
Topic Review
Oxidative Stress in DiGeorge Syndrome
DiGeorge syndrome (DGS) is a rare genetic disease caused by microdeletions of the 22q11.2 region (DGS1). A haploinsufficiency at 10p level has been proposed also as a DGS cause (DGS2). Clinical manifestations are variable. The most frequent features are thymic hypoplasia or aplasia with consequent immune deficiency, cardiac malformations, hypoparathyroidism, facial and palatine abnormalities, variable degrees of cognitive impairment and psychiatric disorders. The specific aim of this descriptive report is to discuss the correlation between oxidative stress and neuroinflammation in DGS patients with microdeletions of the 22q11.2 region. The deleted chromosomic region maps various genes involved in mitochondrial metabolisms, such as DGCR8 and TXNRD2, that could lead to reactive oxygen species (ROS) increased production and antioxidant depletion.
  • 2.7K
  • 08 Mar 2023
Topic Review
Titanium Nitriding Methods: Drawbacks and Benefits
The application of titanium alloys in aircraft construction is expanding due to their high corrosion resistance and excellent strength-to-weight ratio. However, if not specially treated, they are characterized by relatively low wear resistance [1,2], a significant limiting factor for their application. The surface treatment may improve this characteristic, and diffusion-saturation by nitrogen is the gold standard, and this section discusses the features, benefits, and shortcomings of the most common titanium nitriding methods.
  • 2.7K
  • 20 Jan 2022
Topic Review
Naturally alkaloids as Antimicrobial agents
Antibiotic resistance is a serious threat to public health and new antimicrobial compounds are urgently needed. One of the most promising classes for the development of new antimicrobials are plant-derived alkaloids.
  • 2.7K
  • 25 Aug 2020
Topic Review
Eye Involvement in Wilson’s Disease
Wilson’s disease (WD) is an autosomal recessive genetic disorder due to a mutation of the ATP7B gene, resulting in impaired hepatic copper excretion and accumulation in various tissues. Ocular findings are one of the hallmarks of the disease. Many ophthalmological manifestations have been described and new techniques are currently available to improve their diagnosis and to follow their evolution. The most common ocular findings seen in WD patients are Kayser–Fleischer ring (KFR) and sunflower cataracts. Other ocular manifestations may involve retinal tissue, visual systems and eye mobility. Diagnosis and follow-up under decoppering treatment of these ocular findings are generally easily performed with slit-lamp examination (SLE). However, new techniques are available for the precocious detection of ocular findings due to WD and may be of great value for non-experimented ophthalmologists and non-ophthalmologists practitioners. 
  • 2.7K
  • 18 Aug 2022
Topic Review Video
New Drip Irrigation Technologies in Upper Egypt
Saving fresh water is a big challenge for the next generation due to enhanced living standards and population growth. In addition, the expansion of agricultural and industrial activities is causing unmatched demands for fresh water supplies across Egypt. The Nile River is Egypt’s main water resource, representing 69.4% of the total water resources, while rainwater, torrential water and groundwater, as well as recycled agricultural and sanitary drainage water and desalinated seawater, are estimated at about 30.6%. Smart drip irrigation systems are in great demand, especially in Upper Egypt. SDG’s of the circular economy and the WEF nexus lead to full implementation of drip irrigation systems, achieving ~6.6 BM3/year of direct saving from fresh water and/or doubling the cultivated area. In addition to PV tubes and other utilities, renewable energy, e.g, photovoltaic panels, will posses an important role in low-energy driven drip irrigation systems, reducing fossil-uses, CO2 emissions and devolving more sustainable processes that are less dependent on conventional energy sources.
  • 2.7K
  • 01 Nov 2022
Topic Review
Sjögren’s Syndrome Pathogenic Molecular Pathways
Sjögren’s syndrome (SS) is a systemic autoimmune rheumatic disorder characterized by the lymphocytic infiltration of exocrine glands and the production of autoantibodies to self-antigens. The involvement of the exocrine glands drives the pathognomonic manifestations of dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia) that define sicca syndrome.
  • 2.7K
  • 01 Nov 2022
Topic Review
Telework, Remote Work and Hybrid Work
Employees’ work environment has drastically shifted from offices to homes. Telework is often a desired employee benefit, but employers consider it a temporary setting. The lasting COVID-19 pandemic has changed the concept of telework. Home office has gained importance and will likely become an essential part of the working environment even after the pandemic.
  • 2.7K
  • 25 Jun 2023
Topic Review
Carbon-11 Production and Transformation
The short-lived positron-emitter carbon-11 (t1/2 = 20.4 min; β+, 99.8%) is prominent for labeling tracers for use in biomedical research with positron emission tomography (PET). Carbon-11 is produced for this purpose with a cyclotron, by the 14N(p,α)11C nuclear reaction, either on nitrogen containing a low concentration of oxygen (0.1–0.5%) or hydrogen (~5%) to produce [11C]carbon dioxide or [11C]methane, respectively. These primary radioactive products can be produced in high yields and with high molar activities. However, only [11C]carbon dioxide has some utility for directly labeling PET tracers. Primary products are required to be converted rapidly and efficiently into secondary labeling synthons to provide versatile radiochemistry for labeling diverse tracer chemotypes at molecular positions of choice. Because of their simplicity, reliability, re-usability, and amenability for automation, gas phase transformations play a major part in carbon-11 chemistry and in PET tracer development.
  • 2.7K
  • 31 Jan 2024
Topic Review
Tiva-C LaunchPad
The Tiva-C (a.k.a. TM4C) LaunchPads are inexpensive self-contained, single-board microcontrollers, about the size of a credit card, featuring an ARM Cortex-M4F 32-bit CPU operating at 80 to 120 MHz, manufactured by Texas Instruments. The TM4C Series TM4C123G LaunchPad is an upgrade from TI's Stellaris LaunchPad adding support options for motion control PWMs and USB Host functionality. The more recently released TM4C1294 Connected LaunchPad is the first cloud-connected offering in TI's LaunchPad ecosystem and provides a solid foundation for beginning and evaluating embedded IoT designs. There are many I/O pins (40 to 80 depending upon version) that have multi-personality. This means that they can be easily configured as digital inputs or outputs, analog inputs and outputs or other functions, allowing a great variety of applications, are just the multiple serial ports have the ability to interface with more items such as test cards or other communication modules, etc. Among those pins there are included the GND and POWER (3.3 V) pins. The clock is 80 or 120 MHz (vers based), which makes them 5 to over 7 times faster than the Arduino Uno's 16 MHz ATmega328P microcontroller. As with any Cortex M4, the CPU has some DSP (digital signal processor) instructions, with some limitations. One can do signal processing, for example, sampling a human voice with a good quality, able to be processed in MATLAB. The CPU contains the optional floating-point unit with single-precision floating point operations supported. They have an additional USB port which can act as USB host, allowing the connection of multiple devices and the "Connected" one has an integrated 10/100 Ethernet MAC+PHY for Internet connectivity. They also have a temperature sensor and on-board LED(s) and RGB LED(s), which allows you to generate various colors by combining the three basic colors (red, blue and green) of the additive color synthesis. The Tiva/TM4C LaunchPads come preloaded with software to demonstrate many of the capabilities of the ARM microcontroller and with a quickstart application to get up and running within minutes.
  • 2.7K
  • 01 Dec 2022
Topic Review
SLMed Magnesium Alloys
The selective laser melting（SLM） technology has the characteristics of rapid solidification.Therefore, refined microstructures and high-performance products can be obtained.The microstructure of magnesium alloy varies with the cooling rate(processing).And the higher the cooling rate, the finer the microstructure of the magnesium alloy.Different cooling rates also affect the phase composition of magnesium alloys. The SLM process inhibits the formation of the second phase in the magnesium alloy due to the characteristics of rapid solidification.Post-treatment processes, such as heat treatment and hot isostatic pressing（HIP）, can be applied to SLMed magnesium alloys. These processes help to close the pores , dissolve the second phase and reduce the source of cracks caused by the mismatch between the second phase and the α-Mg matrix, thereby improving the  mechanical properties of the magnesium alloy, especially the elongation.However, SLMed magnesium alloys need further research in the application of post-processing, alloy design, base material purification, and thermodynamic and kinetic theoretical calculations of intermetallic compounds.
  • 2.7K
  • 19 Aug 2020
Topic Review
Beetroot, A Remarkable Vegetable
The cardioprotective effects of dietary nitrate from beetroot in healthy and hypertensive individuals are undeniable and irrefutable. Nitrate and nitrate-derived nitrite are precursors for nitric oxide synthesis, which promotes positive effects on cardiomyocytes and myocardial ischemia/reperfusion, improving endothelial function, reducing arterial stiffness and stimulating smooth muscle relaxation, consequently decreasing systolic and diastolic blood pressures.
  • 2.7K
  • 24 Oct 2020
Topic Review
Green Synthesis of Zinc Oxide Nanoparticles
Zinc oxide nanoparticles (ZnO NPs) can be used effectively and efficiently for water treatment, along with other nanotechnologies. Owing to rising concerns regarding the environmental unfriendliness and toxicity of nanomaterials, ZnO NPs have been synthesized through biologically available and replenishable sources using a green chemistry or green synthesis protocol. The green-synthesized ZnO NPs are less toxic, more eco-friendly, and more biocompatible than other chemically and physically synthesized materials.
  • 2.7K
  • 13 Dec 2022
Topic Review
Functions of Lysosomes
Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substances across the membrane and are integral to lysosomal function. Mutations or aberrant expression of these proteins trigger a variety of disorders, making them attractive targets for drug development for lysosomal disorder-related diseases. 
  • 2.7K
  • 08 May 2023
Topic Review
Responsive Traffic Signaling System Using Graph Theory/VDM-SL
The Responsive Traffic Signaling System Using Graph Theory and Vienna Development Method Specification Language (VDM-SL) is a robust traffic monitoring and signaling system that improves signal efficiency by providing a responsive scheme; appropriate routes; a mechanism for emergency vehicles and pedestrians in real-time using VDM-SL formal method and graph theory. A formal model is constructed by considering objects, such as wireless sensors and cameras that are used for collecting information. Graph theory is used to represent the network and find appropriate routes. Unified Modeling Language is used to design the system requirements. The graph-based framework is converted into a formal model by using VDM-SL. The model has been validated and analyzed using many facilities available in the VDM-SL toolbox. 
  • 2.7K
  • 01 Nov 2021
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