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Topic Review
WHO Critical Priority Pathogens
The rise of multidrug-resistant (MDR) pathogens has become a global health threat and an economic burden in providing adequate and effective treatment for many infections. This large-scale concern has emerged mainly due to mishandling of antibiotics (ABs) and has resulted in the rapid expansion of antimicrobial resistance (AMR). Nowadays, there is an urgent need for more potent, non-toxic and effective antimicrobial agents against MDR strains. In this regard, clinicians, pharmacists, microbiologists and the entire scientific community are encouraged to find alternative solutions in treating infectious diseases cause by these strains. In its “10 global issues to track in 2021”, the World Health Organization (WHO) has made fighting drug resistance a priority. 
  • 2.9K
  • 21 Jul 2022
Topic Review
Clathrate Gun Hypothesis
The clathrate gun hypothesis refers to a proposed explanation for the periods of rapid warming during the Quaternary. The idea is that changes in fluxes in upper intermediate waters in the ocean caused temperature fluctuations that alternately accumulated and occasionally released methane clathrate on upper continental slopes, these events would have caused the Bond Cycles and individual interstadial events, such as the Dansgaard–Oeschger interstadials. The hypothesis was supported for the Bølling-Allerød and Preboreal period, but not for Dansgaard–Oeschger interstadials, although there are still debates on the topic.
  • 2.9K
  • 18 Oct 2022
Topic Review
Power Generation Using Dielectric Elastomers
Power generation using dielectric elastomer (DE) artificial muscle is attracting attention because of its light weight, low cost, and high-efficiency. Since this method is a system that produces electricity without emitting carbon dioxide nor using rare earths, it would contribute to the goal of environmental sustainability. 
  • 2.9K
  • 30 Jun 2021
Topic Review
Aflatoxins in Feed
Feeding farm animals with aflatoxin-contaminated feed can cause various severe toxic effects, leading to increased susceptibility to infectious diseases and increased mortality, weight loss, poor performance and reduced reproductive capability. Following ingestion of contaminated foodstuffs, aflatoxins are metabolized and biotransformed differently in animals. 
  • 2.9K
  • 16 Dec 2022
Topic Review
3D Point Cloud Classification
Three-dimensional (3D) point cloud classification methods based on deep learning have good classification performance. The 3D point cloud is mainly collected by light detection and ranging (LiDAR) scanner, red, green, blue, and depth (RGB-D) camera, and other sensor equipment or obtained by model conversion using computer software.
  • 2.9K
  • 10 Jun 2022
Topic Review
Technologies for Soft Robotics Grippers
Robotics grippers are one of the most important components in the industry because of their capability to manipulate objects. They not only realize transportation tasks but also perform quality control to optimize robotic work cells. Thanks to the advance in soft material and soft actuators, soft grippers have gained relief in the field of soft robotics in the last years. Soft grippers have considerable flexibility that allows them to grasp a variety of objects, in contrast to hard grippers, which are designed for a specific item. Using the principles of soft robotics, gripping tools with a greater robustness can be developed. This implies that they do not require changes in their programming or construction to manipulate different objects, and the precision needed to make the grips is reduced.
  • 2.9K
  • 21 May 2021
Topic Review
Role of Environmental Accounting
Environmental accounting (EA) can be a way toward solving the issue of environmental degradation and shifting toward sustainable solutions. One of the significant reasons for EA is the role of industrial and commercial activities in environmental contamination.
  • 2.9K
  • 15 Jun 2022
Topic Review
Stingless Bee-Collected Pollen
Stingless Bee-collected pollen is a mixture of bee pollen, bee salivary enzymes, and regurgitated honey, fermented by indigenous microbes during storage in the cerumen pot. This review provides knowledge on stingless bee collected pollen, its nutrient and microbes for application in the food and pharmaceutical industries 
  • 2.9K
  • 12 Apr 2021
Topic Review
SOS Family and Ras-GEFs
The SOS family of Ras-GEFs encompasses two highly homologous and widely expressed members, SOS1 and SOS2. Despite their similar structures and expression patterns, early studies of constitutive KO mice showing that SOS1-KO mutants were embryonic lethal while SOS2-KO mice were viable led to initially viewing SOS1 as the main Ras-GEF linking external stimuli to downstream RAS signaling, while obviating the functional significance of SOS2. Subsequently, different genetic and/or pharmacological ablation tools defined more precisely the functional specificity/redundancy of the SOS1/2 GEFs.
  • 2.9K
  • 05 Jul 2021
Topic Review
Chemistry and Biosynthesis of Apigenin
Apigenin, a natural bioactive flavonoid widely present in medicinal plants, functional foods, vegetables and fruits, exerts protective effects in models of neurological disorders and cardiovascular diseases and most of these effects are attributed to its antioxidant action.
  • 2.9K
  • 05 Nov 2021
Topic Review
HP Operations Manager
HP Operations Manager is a System monitoring package manufactured by Hewlett-Packard (HP). HP Operations Manager is part of HP Operations Center that includes too: On May 20, 2015 HP started the migration for HP OM users to Operations Manager i, very similar names for very different softwares architectures. On September 1, 2016 HP Enterprise announced the End of Sale of HP Operations Manager for Windows (OMW) 9.0x and HP Operations Manager for Windows Basic Suite (OMW BS) 9.0x and all customerswas migrate to HPE Operations Bridge Suite, a hybrid IT monitoring solution.
  • 2.9K
  • 14 Oct 2022
Topic Review
Job Satisfaction and Service Quality in Hotel Industry
The quality of service is one of the key assumptions of a sustainable and profitable business in the hotel industry. On the other hand, employees as direct providers of hotel services have a direct impact on the perceived quality of service. Establishing a relationship between job satisfaction and perceived intangible service quality is of great importance for customer relationship management and sustainable competitive advantage.
  • 2.9K
  • 08 Oct 2023
Topic Review
Natural Cyclopeptides
Cyclopeptides, also known as cyclic peptides, are polypeptides formed from amino acids arranged in a cyclic ring structure.
  • 2.9K
  • 07 May 2021
Topic Review
Humanitarian Logistics
Although logistics has been mostly utilized in commercial supply chains, it is also an important tool in disaster relief operations. Humanitarian logistics is a branch of logistics which specializes in organizing the delivery and warehousing of supplies during natural disasters or complex emergencies to the affected area and people. However, this definition focuses only on the physical flow of goods to final destinations, and in reality, humanitarian logistics is far more complicated and includes forecasting and optimizing resources, managing inventory, and exchanging information. Thus, a good broader definition of humanitarian logistics is the process of planning, implementing and controlling the efficient, cost-effective flow and storage of goods and materials, as well as related information, from the point of origin to the point of consumption for the purpose of alleviating the suffering of vulnerable people. This figure presents numerous important aspects in humanitarian logistics, including transport, inventory management, infrastructure, and communications.
  • 2.9K
  • 04 Nov 2022
Topic Review
Non-Invasive Electrode Materials for Brain–Computer Interface
The brain–computer interface (BCI) has emerged in recent years and has attracted great attention. As an indispensable part of the BCI signal acquisition system, brain electrodes have a great influence on the quality of the signal, which determines the final effect. Due to the special usage scenario of brain electrodes, some specific properties are required for them.
  • 2.9K
  • 22 Dec 2021
Topic Review
Prion
Prions are misfolded proteins that have the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It is not known what causes a normal protein to misfold, but the resulting abnormal three-dimensional structure confers infectious properties by collapsing nearby protein molecules into the same shape. The word prion is derived from the term, "proteinaceous infectious particle". In comparison to all other known infectious agents such as viroids, viruses, bacteria, fungi, and parasites, all of which contain nucleic acids (DNA, RNA, or both), the hypothesized role of a protein as an infectious agent stands in contrast. Prion isoforms of the prion protein (PrP), whose specific function is uncertain, are hypothesized as the cause of transmissible spongiform encephalopathies (TSEs), including scrapie in sheep, chronic wasting disease (CWD) in deer, bovine spongiform encephalopathy (BSE) in cattle (commonly known as "mad cow disease") and Creutzfeldt–Jakob disease (CJD) in humans. All known prion diseases in mammals affect the structure of the brain or other neural tissue; all are progressive, have no known effective treatment, and are always fatal. Until 2015, all known mammalian prion diseases were caused by the prion protein (PrP); however, in 2015 it was hypothesized that multiple system atrophy (MSA) was caused by a prion form of alpha-synuclein. Prions are a type of intrinsically disordered protein, which change their conformation unless they are bound to a specific partner such as another protein. With a prion, two protein chains are stabilized if one binds to another in the same conformation. The probability of this happening is low, but once it does the combination of the two is very stable. Then more units can get added, making a sort of "fibril". Prions form abnormal aggregates of proteins called amyloids, which accumulate in infected tissue and are associated with tissue damage and cell death. Amyloids are also responsible for several other neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. A prion disease is a type of proteopathy, or disease of structurally abnormal proteins. In humans, prions are believed to be the cause of Creutzfeldt–Jakob disease (CJD), its variant (vCJD), Gerstmann–Sträussler–Scheinker syndrome (GSS), fatal familial insomnia (FFI), and kuru. There is also evidence suggesting prions may play a part in the process of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS); these have been termed prion-like diseases. Several yeast proteins have also been identified as having prionogenic properties, as well as a protein involved in modification of synapses during the formation of memories (see Eric Kandel § Molecular changes during learning). Prion replication is subject to epimutation and natural selection just as for other forms of replication, and their structure varies slightly between species. Prion aggregates are stable, and this structural stability means that prions are resistant to denaturation by chemical and physical agents: they cannot be destroyed by ordinary disinfection or cooking. This makes disposal and containment of these particles difficult.
  • 2.9K
  • 14 Nov 2022
Topic Review
Ursa Minor
Ursa Minor, Latin for "Lesser Bear," is a constellation in the northern celestial hemisphere. It is best known for containing the North Star, Polaris, which marks the position of the north celestial pole and aids in navigation. Despite its small size and dim stars, Ursa Minor holds significant cultural and navigational importance throughout human history.
  • 2.9K
  • 15 Mar 2024
Topic Review
Scorpion Venom
Scorpion venom may cause severe medical complications and untimely death if injected into the human body. A wide range of bioactive molecules can be found in scorpion venoms. Advances in separation, characterization, and biotechnological approaches have enabled not only the development of more effective treatments against scorpion envenomings, but have also led to the discovery of several scorpion venom peptides with interesting therapeutic properties. Thus, scorpion venom may not only be a medical threat to human health, but could prove to be a valuable source of bioactive molecules that may serve as leads for the development of new therapies against current and emerging diseases. 
  • 2.9K
  • 25 Jun 2021
Topic Review
Metal Additive Manufacturing
Additive Manufacturing (AM), also called 3D printing, has been expanding into several industrial sectors due to the technology providing opportunities in terms of improved functionality, productivity, and competitiveness.
  • 2.9K
  • 10 Mar 2021
Topic Review
Procaviidae
Hyraxes (from grc ὕραξ (Script error: No such module "Ancient Greek".) 'shrewmouse'), also called dassies, are small, thickset, herbivorous mammals in the order Hyracoidea. Hyraxes are well-furred, rotund animals with short tails. Typically, they measure between 30 and 70 cm (12 and 28 in) long and weigh between 2 and 5 kg (4 and 11 lb). They are superficially similar to pikas and marmots, but are more closely related to elephants and sea cows. Hyraxes have a life span from 9 to 14 years. Five extant species are recognised: the rock hyrax (Procavia capensis) and the yellow-spotted rock hyrax (Heterohyrax brucei), which both live on rock outcrops, including cliffs in Ethiopia and isolated granite outcrops called koppies in southern Africa; the western tree hyrax (Dendrohyrax dorsalis), southern tree hyrax (D. arboreus), and eastern tree hyrax (D. validus). Their distribution is limited to Africa, except for P. capensis, which is also found in the Middle East.
  • 2.9K
  • 20 Oct 2022
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