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Topic Review
CAR-T Cells Immunotherapies for Acute Myeloid Leukemia Therapy
The CAR is composed of four regions, namely: the extracellular antigen-binding domain usually made of a single-chain variable fragment (scFv), the hinge (the spacer region), which increases flexibility and allows the CAR to be properly matched to the target antigen, the transmembrane domain, and the intracellular signaling domain. The CAR construct was modified so as to increase the efficiency and expansion of CAR-T cells in the immunosuppressive tumor microenvironment (TME). AML is a malignancy of the hematopoietic system of a heterogeneous nature. The disease is caused by mutations resulting in the proliferation of cancer cells derived from progenitor cells of the myeloid lineage.
  • 2.9K
  • 01 Jun 2023
Topic Review
Handfasting
Handfasting is a traditional practice that, depending on the term's usage, may correspond to an unofficiated wedding (in which a couple marries without an officiant, usually with the intent of later undergoing a second wedding with an officiant), a betrothal (an engagement in which a couple has formally promised to wed, and which can be broken only through divorce), or a temporary wedding (in which a couple makes an intentionally temporary marriage commitment). The phrase refers to the making fast of a pledge by the shaking or joining of hands. The terminology and practice is especially associated with Germanic peoples, including the English and Norse, as well as the Gaelic Scots. As a form of betrothal or unofficiated wedding, it was common up through Tudor England; as a form of temporary marriage, it was practiced in 17th-century Scotland and has been revived in Neopaganism. Sometimes the term is also used synonymously with "wedding" or "marriage" among Neopagans to avoid perceived non-Pagan religious connotations associated with those terms. It is also used, apparently ahistorically, to refer to an alleged pre-Christian practice of symbolically fastening or wrapping the hands of a couple together during the wedding ceremony.
  • 2.9K
  • 17 Oct 2022
Topic Review
Nanophotocatalysts
Biomedical waste management is getting significant consideration among treatment technologies, since insufficient management can cause danger to medicinal service specialists, patients, and their environmental conditions. The improvement of waste administration protocols, plans, and policies are surveyed, despite setting up training programs on legitimate waste administration for all healthcare service staff. Most biomedical waste substances do not degrade in the environment, and may also not be thoroughly removed through treatment processes. Therefore, the long-lasting persistence of biomedical waste can effectively have adverse impact on wildlife and human beings, as well. Hence, photocatalysis is gaining increasing attention for eradication of pollutants and for improving the safety and clearness of the environment due to its great potential as a green and eco-friendly process. In this regard, nanostructured photocatalysts, in contrast to their regular counterparts, exhibit significant attributes such as non-toxicity, low cost and higher absorption efficiency in a wider range of the solar spectrum, making them the best candidate to employ for photodegradation. Due to these unique properties of nanophotocatalysts for biomedical waste management, we aim to critically evaluate various aspects of these materials in the present review and highlight their importance in healthcare service settings.
  • 2.9K
  • 18 Aug 2020
Topic Review
Non-Cannabinoid Compounds
Cannabinoid and non-cannabinoid phytochemicals possess bioactive and protective properties that are beneficial to human health. In addition to cannabinoids, the cannabis plant also produces hundreds of non-cannabinoid secondary metabolites including approximately 120 terpenoids (61 monoterpenes, 52 sesquiterpenoids, and 5 triterpenoids, essential oils, over 26 flavonoids lignans, stilbenoid derivatives, alkaloids, amino acids, spiroindans, polyphenols, 20 steroids ), dihydrophenanthrenes, glycoproteins (such as galactose, glucose, mannose and xylose), and dibenzyls. This list also includes a-cannabispiranol, chrysoeriol, 6-prenylapigenin, cannflavin A and b-acetyl cannabispiranol.
  • 2.9K
  • 01 Apr 2021
Topic Review
Rice Bran Arabinoxylan Compound
Rice bran arabinoxylan compound (RBAC) is derived from defatted rice bran hydrolyzed with Lentinus edodes mycelial enzyme. It has been marketed as a functional food and a nutraceutical with health-promoting properties. Some research has demonstrated this rice bran derivative to be a potent immunomodulator, which also possesses anti-inflammatory, antioxidant, and anti-angiogenic properties. To date, research on RBAC has predominantly focused on its immunomodulatory action and application as a complementary therapy for cancer. Nonetheless, the clinical applications of RBAC can extend beyond cancer therapy.
  • 2.9K
  • 18 May 2021
Topic Review
A2 Milk
Although milk consumption is increasing worldwide, in some geographical regions, its consumption has persistently declined. This fact, together with the increase in milk production prices, has caused both milk producers and the dairy industry to be immersed in a major crisis. Some possible solutions to this problem are to get people who do not currently consume milk to start drinking it again, or to market milk and dairy products with a higher added value. In this context, a type of milk called A2 has recently received attention from the industry. This type of milk, characterized by a difference in an amino acid at position 67 of the β-casein polypeptide chain, releases much smaller amounts of bioactive opioid peptide β-casomorphin 7 upon digestion, which has been linked to harmful effects on human health. Additionally, A2 milk has been attributed worse technological properties in the production of some dairy products. Thus, doubts exist about the convenience for the dairy industry to bet on this product. 
  • 2.9K
  • 30 Aug 2022
Topic Review
Rainfall Threshold
Sediment-related disaster is one of the most significant natural disasters, from the perspective of magnitude, damage and loss to human life and infrastructure, and disruption to socio-economic activities. The rainfall threshold is the condition or amount of rainfall that is likely to initiate sediment-related disasters, it is agreed that the rainfall threshold is the most significant tool to predict impending occurrences.
  • 2.9K
  • 26 Oct 2022
Topic Review
Microsoft Azure
Microsoft Azure, often referred to as Azure (/ˈæʒər, ˈeɪʒər/ AZH-ər, AY-zhər, UK also /ˈæzjʊər, ˈeɪzjʊər/ AZ-ure, AY-zure), is a cloud computing service operated by Microsoft for application management via Microsoft-managed data centers. It provides software as a service (SaaS), platform as a service (PaaS) and infrastructure as a service (IaaS) and supports many different programming languages, tools, and frameworks, including both Microsoft-specific and third-party software and systems. Azure, announced at Microsoft's Professional Developers Conference (PDC) in October 2008, went by the internal project codename "Project Red Dog", and was formally released in February 2010 as Windows Azure, before being renamed Microsoft Azure on March 25, 2014.
  • 2.9K
  • 01 Dec 2022
Topic Review
Brake-by-Wire System
With the rapid development of electric vehicles (EVs) in the direction of advanced driving assistance systems and autonomous vehicles, the demands for X-by-wire systems are huge. For example, the brake-by-wire (BBW) system must have a fast enough step response, the adjustable ability of higher accuracy and fault tolerance to ensure the safety of vehicles. The BBW system of “safety, comfort, and low carbon” has become a troublesome issue in the development of the industry. In EVs, the moving parts that can achieve automatic control are more than 200. As an important assurance system for the safe driving of vehicles, the BBW system has the advantages of accurately and independently controlling the pressure of each wheel cylinder and a fast response. 
  • 2.9K
  • 26 Apr 2022
Topic Review
Resveratrol Production in Yeast Hosts
Resveratrol is a plant secondary metabolite known for its therapeutic applications as an antioxidant, anti-cancer, anti-inflammatory, anti-aging, cardio-protective, and neuroprotective agent. Topical formulas of resveratrol are also used for skin disease management and in cosmetic industries. Due to its importance, high resveratrol production is urgently required. Yeasts were proven to be excellent host candidates for resveratrol production.
  • 2.9K
  • 30 Jul 2021
Topic Review
One-Carbon Metabolism Modulates Ageing and Neurodegeneration
One-carbon metabolism (OCM) is a network of biochemical reactions delivering one-carbon units to various biosynthetic pathways. The folate cycle and methionine cycle are the two key modules of this network that regulate purine and thymidine synthesis, amino acid homeostasis, and epigenetic mechanisms. Intersection with the transsulfuration pathway supports glutathione production and regulation of the cellular redox state. Dietary intake of micronutrients, such as folates and amino acids, directly contributes to OCM, thereby adapting the cellular metabolic state to environmental inputs. The contribution of OCM to cellular proliferation during development and in adult proliferative tissues is well established. Nevertheless, accumulating evidence reveals the pivotal role of OCM in cellular homeostasis of non-proliferative tissues and in coordination of signaling cascades that regulate energy homeostasis and longevity. 
  • 2.9K
  • 12 Jan 2022
Topic Review
Technology Tree
In strategy games, a technology, tech, or research tree is a hierarchical visual representation of the possible sequences of upgrades a player can take (most often through the act of research). Because these trees are technically directed and acyclic, they can more accurately be described as a technology directed acyclic graph. The diagram is tree-shaped in the sense that it branches between each 'level', allowing the player to choose one sequence or another. Each level is called a tier and is often used to describe the technological strength of a player. Typically, at the beginning of a session of a strategy game, a player will start at tier 1, and will only have a few options for technologies to research. Each technology that a player researches will open up one or more new options, but may or may not, depending on the computer game, close off the paths to other options. The tech tree is the representation of all possible paths of research a player can take, up to the culmination of said sequence. A player who is engaged in research activities is said to be "teching up", "going up the tech tree", or "moving up the tech tree". Analysis of a tech tree can lead players to memorize and use specific build orders.
  • 2.9K
  • 26 Oct 2022
Topic Review
Fault Detection for Belt Conveyor Idlers
Bulk materials are transported worldwide using belt conveyors as an essential transport system. The majority of conveyor components are monitored continuously to ensure their reliability, but idlers remain a challenge to monitor due to the large number of idlers (rollers) distributed throughout the working environment. These idlers are prone to external noises or disturbances that cause a failure in the underlying system operations.
  • 2.9K
  • 22 Feb 2023
Topic Review
Geoheritage
“Geoheritage” is a new term that assumes complete perception of Man for nature and the environment. As stated by McBriar “Geological-geomorphological heritage is the collection of geotopes, deposits, forms, and processes that comprise the geological history of each region, and the concept of preserving geological-geomorphological heritage is a cultural concept”.
  • 2.9K
  • 23 Sep 2021
Topic Review
Germanium Ion Implantation and Annealing
Germanium (Ge) ion implantation into silicon waveguides will induce lattice defects in the silicon, which can eventually change the crystal silicon into amorphous silicon and increase the refractive index from 3.48 to 3.96. A subsequent annealing process, either by using an external laser or integrated thermal heaters can partially or completely remove those lattice defects and gradually change the amorphous silicon back into the crystalline form and, therefore, reduce the material’s refractive index.  In addition, Ge ion implantation and annealing are also demonstrated to enable post-fabrication trimming of ring resonators and Mach–Zehnder interferometers and to implement nonvolatile programmable photonic circuits. 
  • 2.9K
  • 01 Mar 2022
Topic Review
Remote Sensing Methods for Flood Prediction
Floods are a major cause of loss of lives, destruction of infrastructure, and massive damage to a country’s economy. Floods, being natural disasters, cannot be prevented completely; therefore, precautionary measures must be taken by the government, concerned organizations such as the United Nations Office for Disaster Risk Reduction and Office for the coordination of Human Affairs, and the community to control its disastrous effects. Floods are uncertain depending on several climatic and environmental factors, and therefore are difficult to predict. A classification framework is presented which classifies the remote sensing technologies being used for flood prediction into three types, which are: multispectral, radar, and light detection and ranging (LIDAR). 
  • 2.9K
  • 21 Mar 2022
Topic Review
Apple By-Product Valorisation
About 30% of the total production of apples is processed, being juice and cider the main resulting products. Regarding this procedure, a large quantity of apple by-product is generated, which tends to be undervalued, and commonly remains underutilised, landfilled, or incinerated. However, apple by-product is a proven source of bioactive compounds, namely dietary fibre, fatty acids, triterpenes, or polyphenols. Therefore, the application of green technologies should be considered in order to improve the functionality of apple by-product while promoting its use as the raw material of a novel product line. 
  • 2.9K
  • 03 Nov 2022
Topic Review
Burmese Amber
Burmese amber, also known as Burmite or Kachin amber, is amber from the Hukawng Valley in northern Myanmar. The amber is dated to around 99 million years old, during the earliest part of the Cenomanian age of the Late Cretaceous. The amber is of significant palaeontological interest due to the diversity of flora and fauna contained as inclusions, particularly arthropods including insects and arachnids but also birds, lizards, snakes, frogs and fragmentary dinosaur remains. The amber has been known and commercially exploited since the first century AD, and has been known to science since the mid-nineteenth century. Research on the deposit has attracted controversy due to its role in funding internal conflict in Myanmar and hazardous working conditions in the mines where it is collected.
  • 2.9K
  • 24 Nov 2022
Topic Review
Contaminants in Tattoo Inks
Tattooing has been an enduring form of body art since ancient times, but it carries inherent health risks, primarily due to the complex composition of tattoo inks. These inks consist of complex mixtures of various ingredients, including pigments, solvents, impurities and contaminants. 
  • 2.9K
  • 19 Oct 2023
Topic Review
General Performance of Pressure Wave Supercharger
One main direction in improving the efficiency of an internal combustion engine, together with lowering the emissions, is supercharging, i.e., creating a considerable amount of boost for the inlet combustion air. Turbochargers are the most commonly used for this task, but another advantageous alternative exploiting the energy within exhaust gases is the pressure wave supercharger (PWS).
  • 2.9K
  • 21 Apr 2022
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