Your browser does not fully support modern features. Please upgrade for a smoother experience.
Subject:
All Disciplines Arts & Humanities Biology & Life Sciences Business & Economics Chemistry & Materials Science Computer Science & Mathematics Engineering Environmental & Earth Sciences Medicine & Pharmacology Physical Sciences Public Health & Healthcare Social Sciences
Sort by:
Most Viewed Latest Alphabetical (A-Z) Alphabetical (Z-A)
Filter:
All Topic Review Biography Peer Reviewed Entry Video Entry
Topic Review
Molecular Glues for Cancer Treatment
Molecular glue (MG) compounds are a type of unique small molecule that can change the protein–protein interactions (PPIs) and interactomes by degrading, stabilizing, or activating the target protein after their binging. These small-molecule MGs are gradually being recognized for their potential application in treating human diseases, including cancer. Evidence suggests that small-molecule MG compounds could essentially target any proteins, which play critical roles in human disease etiology, where many of these protein targets were previously considered undruggable. Intriguingly, most MG compounds with high efficacy for cancer treatment can glue on and control multiple key protein targets. On the other hand, a single key protein target can also be glued by multiple MG compounds with distinct chemical structures. The high flexibility of MG–protein interaction profiles provides rich soil for the growth and development of small-molecule MG compounds that can be used as molecular tools to assist in unraveling disease mechanisms, and they can also facilitate drug development for the treatment of human disease, especially human cancer. 
  • 3.0K
  • 23 Jun 2022
Topic Review
School Recess: Safety Situations and Assumable Risk
Recess at school takes place during the school day to provide the children with a change from academic activities. In the field of education, rest times within the academic activities at school are necessary for the healthy development of children and as tools to promote learning, bringing health, social, cognitive, and developmental benefits.
  • 3.0K
  • 21 Apr 2022
Topic Review
Optical Accelerometers
Optical accelerometers are high-precision inertial sensors that use optical measurement technology to achieve high-precision and electromagnetic interference-resistant acceleration measurements. With the intensive research and development of optical accelerometers in recent years, their applications in inertial navigation, structural health monitoring, precision vibration isolation systems, wind turbine fault monitoring, earthquake monitoring, and other low-frequency vibration detection have flourished. Optical accelerometers have various schemes; however, their characteristics vary considerably due to different optical modulation schemes. This study aims to address the lack of systematic evaluation of currently available low-frequency optical accelerometers. Optical accelerometers can be classified into four categories in accordance with their optical modulation schemes: optical path-, optical intensity-, optical phase-, and optical wave-length-modulated accelerometers. 
  • 3.0K
  • 16 Jun 2022
Topic Review
Taupo Volcano
Lake Taupo, in the centre of New Zealand’s North Island, is the caldera of a large rhyolitic supervolcano called the Taupo Volcano. This huge volcano has produced two of the world’s most violent eruptions in geologically recent times. The Taupo Volcano forms part of the Taupo Volcanic Zone, a region of volcanic activity that extends from Ruapehu in the South, through the Taupo and Rotorua districts, to White Island, in the Bay of Plenty region. Taupo began erupting about 300,000 years ago, but the main eruptions that still affect the surrounding landscape are the Oruanui eruption, about 26,500 years ago, which is responsible for the shape of the modern caldera, and the Hatepe eruption, dated 232 ± 5 CE. However, there have been many more eruptions, with major ones every thousand years or so (see timeline of last 10,000 years of eruptions). Considering recent history alone, the volcano has been inactive for an unusually long period of time, but considering its long-term activity, it was inactive for much longer between 8100 and 5100 BCE (3,000 year inactivity, compared to the current 1,800 years). Some volcanoes within the Taupo Volcanic Zone have erupted far more recently, however, notably a violent VEI-5 eruption of Mount Tarawera in 1886, and frequent activity of Whakaari/White Island, which erupted most recently in December 2019.
  • 3.0K
  • 18 Oct 2022
Topic Review
Plug-In Electric Vehicles in the United Kingdom
The adoption of plug-in electric vehicles in the United Kingdom is actively supported by the British government through the plug-in car and van grants schemes and other incentives. Around 455,000 light-duty plug-in electric vehicles had been registered in the UK up until February 2021, consisting of about 215,000 all-electric vehicles and 240,000 plug-in hybrids. Until 2019, the UK had the second largest European stock of light-duty plug-in vehicles in use after Norway.
  • 3.0K
  • 11 Nov 2022
Topic Review
Ganapati Atharvashirsa
The Ganapati Atharvashirsa (Sanskrit: गणपत्यथर्वशीर्ष, Gaṇapatyatharvaśīrṣa) is a Sanskrit text and a minor Upanishad of Hinduism. It is a late Upanishadic text dedicated to Ganesha, the deity representing intellect and learning. It asserts that Ganesha is same as the eternal underlying reality, Brahman. The text is attached to the Atharvaveda, and is also referred to as the Sri Ganapati Atharva Sirsha, the Ganapati Atharvashirsha, the Ganapati Atharvasirsa, or the Ganapati Upanishad. The text exists in several variants, but with the same message. Ganesha is described to be same as other Hindu gods, as ultimate truth and reality (Brahman), as satcitananda, as the soul in oneself (Atman) and in every living being, as Om.
  • 3.0K
  • 17 Nov 2022
Topic Review
(1,3;1,4)-β-D-Glucans
(1,3;1,4)-β-D-Glucans, also named as mixed-linkage glucans, are unbranched non-cellulosic polysaccharides containing both (1,3)- and (1,4)-β-linkages. The linkage ratio varies depending upon species origin and has a significant impact on the physicochemical properties of the (1,3;1,4)-β-D-glucans.
  • 3.0K
  • 24 Sep 2021
Topic Review
Drone Architecture for Crowd Monitoring and Analysis
Crowd monitoring and analysis is an important evolving applications of unmanned aerial vehicle or drones. From preventing stampede in high concentration crowds to estimating crowd density and to surveilling crowd movements, crowd monitoring and analysis have long been employed in the past by authorities and regulatory bodies to tackle challenges posed by large crowds.
  • 3.0K
  • 03 Mar 2022
Topic Review
Brick (Electronics)
The word "brick", when used in reference to consumer electronics, describes an electronic device such as a mobile device, game console, or router that, due to corrupted firmware, a hardware problem, or other damage, can no longer function, and thus is "bricked". The device becomes as technologically useful as a brick, hence the name.
  • 3.0K
  • 19 Oct 2022
Topic Review
Mode (Computer Interface)
In user interface design, a mode is a distinct setting within a computer program or any physical machine interface, in which the same user input will produce perceived results different to those that it would in other settings. The best-known modal interface components are probably the Caps lock and Insert keys on the standard computer keyboard, both of which put the user's typing into a different mode after being pressed, then return it to the regular mode after being re-pressed. An interface that uses no modes is known as a modeless interface. Modeless interfaces avoid mode errors by making it impossible for the user to commit them.
  • 3.0K
  • 16 Nov 2022
Biography
Claire Wineland
Claire Lucia Wineland (April 10, 1997 – September 2, 2018) was an American activist and author. Through her non-profit organization "Claire's Place Foundation," she supported people with terminal and chronic illnesses, as well as their families.[1][2] She died from a stroke one week after a lung transplant, at the age of 21. Wineland wrote the book Every Breath I Take, Surviving and Thriving
  • 3.0K
  • 22 Nov 2022
Topic Review
COVID-19 Pandemic Impact Tourism Stakeholder
The impact of the COVID-19 pandemic on the tourism industry is still sustained, and the response of the tourism industry is an indispensable element that is increasingly recognized. This response has led to the emergence of literature about the impact of COVID-19 on the stakeholders of the tourism industry, thereby contributing to the industry. Nonetheless, criterion factors and investigated practices on the implementation of decision-making by stakeholders in the tourism industry have not been fully explored. Practically, the irresistible risk industry is already synonymous with tourism. Indeed, it is an unstable industry. 2003, 2 million tourists reduce of SARS. 2009, Global Economic Crisis tourist 37 million reduce. 2020, the COVID-19 pandemic, the world's borders are blocked, all international travel is stopped, and the mobility of tourists is prohibited. However, effective decision-making is lacking, and few studies have determined the solutions in the tourism industry of stakeholder. How the tourism industry survives under the crisis context is an urgent issue.
  • 3.0K
  • 11 Aug 2021
Topic Review
Diagnosis of Postural Tachycardia Syndrome and vasovagal Syncope
In children, vasovagal syncope and postural tachycardia syndrome constitute the major types of orthostatic intolerance. The clinical characteristics of postural tachycardia syndrome and vasovagal syncope are similar but their treatments differ. Therefore, their differential diagnosis is important to guide the correct treatment. Children suffering from vasovagal syncope or postural tachycardia syndrome might be treated using water, β-blockers, salt, or midodrine. However, the effificacy of the drugs varies. Biomarkers or certain hemodynamic parameters that can predict the treatment effects of individualized treatment for POTS or VVS have been used.
  • 3.0K
  • 08 Jul 2022
Topic Review
History of Biotechnology
Biotechnology is the application of scientific and engineering principles to the processing of materials by biological agents to provide goods and services. From its inception, biotechnology has maintained a close relationship with society. Although now most often associated with the development of drugs, historically biotechnology has been principally associated with food, addressing such issues as malnutrition and famine. The history of biotechnology begins with zymotechnology, which commenced with a focus on brewing techniques for beer. By World War I, however, zymotechnology would expand to tackle larger industrial issues, and the potential of industrial fermentation gave rise to biotechnology. However, both the single-cell protein and gasohol projects failed to progress due to varying issues including public resistance, a changing economic scene, and shifts in political power. Yet the formation of a new field, genetic engineering, would soon bring biotechnology to the forefront of science in society, and the intimate relationship between the scientific community, the public, and the government would ensue. These debates gained exposure in 1975 at the Asilomar Conference, where Joshua Lederberg was the most outspoken supporter for this emerging field in biotechnology. By as early as 1978, with the development of synthetic human insulin, Lederberg's claims would prove valid, and the biotechnology industry grew rapidly. Each new scientific advance became a media event designed to capture public support, and by the 1980s, biotechnology grew into a promising real industry. In 1988, only five proteins from genetically engineered cells had been approved as drugs by the United States Food and Drug Administration (FDA), but this number would skyrocket to over 125 by the end of the 1990s. The field of genetic engineering remains a heated topic of discussion in today's society with the advent of gene therapy, stem cell research, cloning, and genetically modified food. While it seems only natural nowadays to link pharmaceutical drugs as solutions to health and societal problems, this relationship of biotechnology serving social needs began centuries ago.
  • 3.0K
  • 21 Apr 2023
Topic Review
E-Cigarette Impact on Reproductive Health
Electronic cigarettes (e-cigarettes) are often considered a “safe substitute” for conventional cigarette cessation. The composition of the fluid is not always clearly defined and shows a large variation within brands and manufacturers. More than 80 compounds were detected in liquids and aerosols. E-cigarettes contain nicotine, and the addition of flavorings increases the toxicity of e-cigarette vapour in a significant manner. The heat generated by the e-cigarette leads to the oxidation and decomposition of its components, eventually forming harmful constituents in the inhaled vapour. The effects of these toxicants on male and female reproduction are well established in conventional cigarette smokers. 
  • 3.0K
  • 27 Mar 2023
Topic Review
Seafood Spoilage
The term “seafood” includes (i) free-swimming, pelagic and freshwater fish, (ii) crustaceans, (iii) mollusks and (iv) the respective aquacultured species.
  • 3.0K
  • 19 Feb 2021
Topic Review
Convolutional Neural Network + Recurrent Neural Network
A convolutional neural network and recurrent neural network (CNN + RNN) combination is an effective approach for many modern image recognition tasks that need to identify the behaviour of objects through a sequence of frames. For example, in a security CCTV camera footage, want to identify what abnormal actions a character is doing in the scene (e.g. fighting with someone, breaking into a store, etc.). A deep convolutional neural network (e.g. ResNet50) has many layers of abstraction and is good for extracting essential features in each frame of the input stream. These extracted features, which may represent low-level image features or even high-level objects, can be monitored over a sequence of frames by a recurrent neural network (e.g. ConvLSTM) so as to detect whether a certain action or event has happened.
  • 3.0K
  • 23 Feb 2022
Topic Review
Kidney Failure after Liver Transplantation
One-third of patients with cirrhosis present kidney failure (AKI and CKD). It has multifactorial causes and a harmful effect on morbidity and mortality before and after liver transplantation. Kidney function does not improve in all patients after liver transplantation, and liver transplant recipients are at a high risk of developing chronic kidney disease. The causes of renal dysfunction can be divided into three groups: pre-operative, perioperative and post-operative factors.
  • 3.0K
  • 22 Sep 2021
Topic Review
Compressed Air Energy Storage
The recent increase in the use of carbonless energy systems have resulted in the need for reliable energy storage due to the intermittent nature of renewables. Among the existing energy storage technologies, compressed-air energy storage (CAES) has significant potential to meet techno-economic requirements in different storage domains due to its long lifespan, reasonable cost, and near-zero self-decay. 
  • 3.0K
  • 25 Sep 2023
Topic Review
Glutathione-Mediated Conjugation of Anticancer Drugs
The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar and water-soluble glutathione S-conjugates, readily excreted outside the body. In this regard, glutathione plays a role in detoxification, decreasing the likelihood that a xenobiotic will react with cellular targets.
  • 3.0K
  • 26 Aug 2022
  • Page
  • of
  • 2859
Featured Entry Collections
>>

Featured Reprints

>>
Encyclopedia of Digital Society, Industry 5.0 and Smart City
Encyclopedia of Engineering
Encyclopedia of Social Sciences
Encyclopedia of Medieval Royal Iconography
Academic Video Service
Feedback