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Topic Review
P62
P62 is a versatile protein involved in the delicate balance between cell death and survival, which is fundamental for cell fate decision in the context of both cancer and neurodegenerative diseases. As an autophagy adaptor, p62 recognizes polyubiquitin chains and interacts with LC3, thereby targeting the selected cargo to the autophagosome with consequent autophagic degradation. Beside this function, p62 behaves as an interactive hub in multiple signalling including those mediated by Nrf2, NF-κB, caspase-8, and mTORC1. The protein is thus crucial for the control of oxidative stress, inflammation and cell survival, apoptosis, and metabolic reprogramming, respectively. As a multifunctional protein, p62 falls into the category of those factors that can exert opposite roles in the cells. Chronic p62 accumulation was found in many types of tumors as well as in stress granules present in different forms of neurodegenerative diseases. However, the protein seems to have a Janus behaviour since it may also serve protective functions against tumorigenesis or neurodegeneration. 
  • 3.0K
  • 04 Aug 2020
Topic Review
Gravitational Influence
Gravity constituted the only constant environmental parameter, during the evolutionary period of living matter on Earth. However, whether gravity has affected the evolution of species, and its impact is still ongoing.
  • 3.0K
  • 14 Jul 2021
Topic Review
Non-Enzymatic Electrochemical Sensing
Simultaneous detection of analytes that together exist in biological organisms necessitates the development of effective and efficient non enzymatic electrodes in sensing. In this regard, development of sensing elements for detecting glucose and hydrogen peroxide (H2O2) is significant. The non-enzymatic sensing is more economical and has longer lifetime than enzymatic electrochemical sensing, but it has several drawbacks such as high working potential, slow electrode kinetics, poisoning from intermediate species and weak sensing parameters. Here is a comprehensive overview of the recent developments in non-enzymatic glucose and H2O2 (NEGH) sensing, by focusing mainly on sensing performance, electro catalytic mechanism, morphology and design of electrode materials. A comparison of glucose and H2O2 sensing parameters using same electrode materials is outlined to predict the efficient sensing performances of advanced nanomaterials with metal/metal oxides and hybrid metallic nanocomposites.
  • 3.0K
  • 24 Nov 2020
Topic Review Peer Reviewed
Residential Segregation
Residential segregation refers to the disproportionate distribution of population groups across a geographical area. Groups can be segregated on the basis of any characteristic (such as occupation, income, religion, age or ethnicity) and at any geographical scale. In most cases, segregation is, however, measured with regard to residential areas of a city. The extent of the unequal distribution of selected characteristics can be expressed by different statistical measures. Sociologists, economists and demographers have long studied how social groups tend to be differentiated in residential space and developed a broad range of explanations. As a consequence, segregation has been explained by a variety of theories, which are discussed in this paper. The topics examined by empirical research include temporal dynamics, geographical patterns, societal causes and effects on life chances. This entry focuses on major conceptual facts regarding residential segregation and only marginally discusses the methodological issues connected with its measurement.
  • 3.0K
  • 02 Nov 2023
Topic Review
Citizenship
Citizenship is a relationship between an individual and a state to which the individual owes allegiance and in turn is entitled to its protection.(quoted) Each state determines the conditions under which it will recognize persons as its citizens, and the conditions under which that status will be withdrawn. Recognition by a state as a citizen generally carries with it recognition of civil, political, and social rights which are not afforded to non-citizens. In general, the basic rights normally regarded as arising from citizenship are the right to a passport, the right to leave and return to the country/ies of citizenship, the right to live in that country and to work there. Some countries permit their citizens to have multiple citizenships, while others insist on exclusive allegiance. A person who does not have citizenship of any state is said to be stateless, while one who lives on state borders whose territorial status is uncertain is a border-lander.
  • 3.0K
  • 18 Nov 2022
Topic Review
Protein S-Glutathionylation
S-glutathionylation, the post-translational modification forming mixed disulfides between protein reactive thiols and glutathione, regulates redox-based signaling events in the cell and serves as a protective mechanism against oxidative damage. S-glutathionylation alters protein function, interactions, and localization across physiological processes, and its aberrant function is implicated in various human diseases.
  • 3.0K
  • 10 Nov 2020
Topic Review
Microalgae
Recently, microalgal biotechnology has received increasing interests in producing valuable, sustainable and environmentally friendly bioproducts. The development of economically viable production processes entails resolving certain limitations of microalgal biotechnology, and fast evolving genetic engineering technologies have emerged as new tools to overcome these limitations. 
  • 3.0K
  • 05 May 2022
Topic Review Peer Reviewed
COVID-19 and Peace in Conflict-Affected Areas
The relationship between COVID-19 and peace has been considered from a variety of perspectives. In addition, different empirical studies on the link between the pandemic and peace in conflict-affected areas exist. However, little work has been performed on examining these studies to highlight key findings on the theme of COVID-19 and peace in conflict-affected areas. A conflict-affected area is a country, or part of a country, where widespread violence or armed conflict was present when COVID-19 emerged in December 2019, or that was transitioning from recent armed conflict to peace by the time the disease arose. What do we know, so far, about how peace has been affected by the COVID-19 pandemic in conflict-affected areas? To address this question, this paper begins by recognizing the multidimensionality of peace and clarifying that the main aspects of peace in conflict-affected areas being considered in the article are relations between conflict parties, peace efforts, and peace processes. Afterwards, the paper discusses existing evidence regarding the impact of COVID-19 and state responses to it on these components of peace in conflict-affected areas. The conflict-affected areas considered include Afghanistan, Colombia, Iraq, Israel-Palestine, Libya, Myanmar, Nigeria, South Sudan, Syria, the Philippines, Yemen, and other zones. The central finding of the article is that the existing studies on COVID-19 and peace in conflict-affected areas present mixed findings. On the one hand, the virus generated opportunities for cooperation between conflict parties in some cases, such as in the West Bank and Gaza Strip of Israel-Palestine. However, on the other hand, it created conditions that enabled conflict and impeded peace efforts and processes in many or most conflict-affected areas. The paper explains that two factors that determined how the disease affected peace in conflict-affected and non-conflict-affected areas are the pre-COVID-19 political and socio-economic conditions in an area, and how state and non-state actors responded to the pandemic. The article closes with a summary of the discussion and identification of its major limitations. 
  • 3.0K
  • 28 Sep 2022
Topic Review
Convolutional Neural Network + Recurrent Neural Network
A convolutional neural network and recurrent neural network (CNN + RNN) combination is an effective approach for many modern image recognition tasks that need to identify the behaviour of objects through a sequence of frames. For example, in a security CCTV camera footage, want to identify what abnormal actions a character is doing in the scene (e.g. fighting with someone, breaking into a store, etc.). A deep convolutional neural network (e.g. ResNet50) has many layers of abstraction and is good for extracting essential features in each frame of the input stream. These extracted features, which may represent low-level image features or even high-level objects, can be monitored over a sequence of frames by a recurrent neural network (e.g. ConvLSTM) so as to detect whether a certain action or event has happened.
  • 3.0K
  • 23 Feb 2022
Topic Review
Solid Lipid Nanoparticle Preparation Techniques
Solid lipid nanoparticles (SLNs) are an alternate carrier system to liposomes, polymeric nanoparticles, and inorganic carriers. SLNs have attracted increasing attention for delivering drugs, nucleic acids, proteins, peptides, nutraceuticals, and cosmetics. These nanocarriers have attracted industrial attention due to their ease of preparation, physicochemical stability, and scalability. These characteristics make SLNs attractive for manufacture on a large scale. 
  • 3.0K
  • 23 Sep 2022
Topic Review
DNS Tunnelling Detection
The Domain Name System (DNS) protocol is fundamental to the operation of the Internet with the primary purpose of translating domain names to IP addresses. This important service facilitates access to the Internet by using website names or any arbitrary domain names. The DNS protocol communicates internal requests to external remote servers and creates a landscape for attackers to perform malicious activities such as stealing credentials and sensitive data. One of the most effective DNS attack types is DNS tunnelling, where the attacker creates a tunnel between the client’s network and the attacker’s machine, utilising command and control channels to obscure data and bypass the firewall and intrusion detection systems.
  • 3.0K
  • 01 Mar 2024
Topic Review
Lipid Metabolism in COVID-19
The current Coronavirus disease 2019 or COVID-19 pandemic has infected over two million people and resulted in the death of over one hundred thousand people at the time of writing this review. The disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). Even though multiple vaccines and treatments are under development so far, the disease is only slowing down under extreme social distancing measures that are difficult to maintain. SARS-COV2 is an enveloped virus that is surrounded by a lipid bilayer. Lipids are fundamental cell components that play various biological roles ranging from being a structural building block to a signaling molecule as well as a central energy store. The role lipids play in viral infection involves the fusion of the viral membrane to the host cell, viral replication, and viral endocytosis and exocytosis. Since lipids play a crucial function in the viral life cycle, we asked whether drugs targeting lipid metabolism, such as statins, can be utilized against SARS-CoV-2 and other viruses. In this review, we discuss the role of lipid metabolism in viral infection as well as the possibility of targeting lipid metabolism to interfere with the viral life cycle.
  • 3.0K
  • 28 Oct 2020
Topic Review
MEMS Actuators for Fiber-Optic Endoscopes
Endoscopes are used routinely in modern medicine for in-vivo imaging of luminal organs. Technical advances in the micro-electro-mechanical system (MEMS) and optical fields have enabled the further miniaturization of endoscopes, resulting in the ability to image previously inaccessible small-caliber luminal organs, enabling the early detection of lesions and other abnormalities in these tissues. A large number of optical devices have been researched and developed for imaging purposes. Among these, optical coherence tomography (OCT), confocal microscopy (CM), and photoacoustic (PA) imaging are the predominant ones. The size of an endoscope is highly dependent on the actuation and scanning method used to illuminate the target image area. Different actuation methods used in the design of small-sized cantilever-based endoscopes are reviewed in here along with their working principles, advantages and disadvantages, generated scanning patterns, and applications.
  • 3.0K
  • 13 Jan 2021
Topic Review
Endothelial Cell Dysfunction
Endothelial Cell (EC) dysfunction is one of the first triggers initiating the process of Pulmonary Arterial Hypertension (PAH). EC dysfunction leads to the activation of several cellular signalling pathways in the endothelium, resulting in the uncontrolled proliferation of ECs, pulmonary artery smooth muscle cells, and fibroblasts, and eventually leads to vascular remodelling and the occlusion of the pulmonary blood vessels. Other factors that are related to EC dysfunction in PAH are an increase in endothelial to mesenchymal transition, inflammation, apoptosis, and thrombus formation.
  • 3.0K
  • 18 Jan 2021
Topic Review
Advantages and Disadvantages of Commercial Rootstocks for Peaches
Prunus is a genus from the Rosaceae family that encompasses about 230 species that are widely distributed across the world. Three-quarters of the Prunus species are native to Asia, Europe, and North America, and the remaining other species are native to the subtropical and tropical forests of Asia, Africa, South America, and Australia. The most common recent ancestor of Amygdalus was widespread from West Asia to Eastern Asia (China) ~50 million years ago, with a subsequent diversification into almonds in West Asia and peaches in Eastern Asia.
  • 3.0K
  • 15 Jul 2022
Topic Review
Go90
Go90 was an American Internet television service and mobile app owned and operated by Verizon Communications. The service was positioned as a mobile-oriented "social entertainment platform" targeted primarily towards millennials, featuring a mixture of new and acquired content from various providers. The service was available exclusively within the United States, although as of March 2018 some of its content became available internationally via Tumblr. Following an unsuccessful launch (which content partners credited to a lack of firm content strategies), resulting managerial turnover (including a relaunch of the service by the staff of Verizon acquisition and former competitor Vessel), Including acquisitions that became the basis of the service (such as Intel's OnCue project, and later Vessel), it was estimated that Verizon had spent $1.2 billion on the service.
  • 3.0K
  • 08 Nov 2022
Topic Review
Control Strategy for High Speed On/off Valves
Digital hydraulic technology is considered to be a potential solution to replace traditional hydraulic servo control technology in the “Industry 4.0” era. Digital valves mainly consist of incremental digital valves and high speed on/off valves (HSV), of which the former have been abandoned by academia and industry due to its low-frequency and tendency to become out-of-step. 
  • 3.0K
  • 28 Jan 2023
Topic Review
The Impact of Airbnb Brand on Consumer Involvement
Airbnb is one of the leading businesses in the hospitality industry, and is one of the fastest growing corporations in sharing economy services. The brand operates on a marketplace platform, and connects travelers with hosts all over the world. Trust is essential for purchase intentions, particularly online, and the degree of involvement determines whether or not the brand is committed to its promises. In the context of Airbnb, users pay for their services online, and are allowed to present reviews for future travelers. Unlike other business models, Airbnb has to preserve its image by providing innovative and quality services for travelers, especially in the hospitality industry, where the product attributes only differ slightly. With Airbnb’s rapid growth, the aspects of brand personality become critical when establishing a positive brand image and positioning the company as a platform that provides unique experiences to its users and possesses a distinct identity.
  • 3.0K
  • 20 Jul 2022
Topic Review
Wild Turkey
The wild turkey (Meleagris gallopavo) is an upland ground bird native to North America, one of two extant species of turkey, and the heaviest member of the order Galliformes. It is the ancestor to the domestic turkey, which was originally derived from a southern Mexican subspecies of wild turkey (not the related ocellated turkey). Although native to North America, the turkey probably got its name from the domesticated variety being imported to Britain in ships coming from the Levant via Spain. The British at the time therefore associated the wild turkey with the country Turkey and the name prevails. An alternative theory posits that another bird, a guinea fowl native to Madagascar introduced to England by Turkish merchants, was the original source, and that the term was then transferred to the New World bird by English colonizers with knowledge of the previous species.
  • 3.0K
  • 16 Nov 2022
Topic Review
Integration of Offshore Wind with Tidal Energy
Reducing the cost of electricity generation and integrating renewable energy sources are two essential factors in encouraging the development of novel ideas to tackle the lack of enough electricity and proposing alternatives for fossil fuels. Compared with onshore wind energy resources, offshore wind fields have many advantages, such as persistent wind, faster-flowing speed, higher uniformity, and longer available time per year, flat sea surface, and low turbulence intensity, which promotes the vigorous development of the offshore wind power industry.
  • 3.0K
  • 09 Dec 2022
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