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Topic Review
Thin Filament Structure and Assembly
The actin containing tropomyosin and troponin decorated thin filaments form one of the crucial components of the contractile apparatus in muscles. The thin filaments are organized into densely packed lattices interdigitated with myosin-based thick filaments. The crossbridge interactions between these myofilaments drive muscle contraction, and the degree of myofilament overlap is a key factor of contractile force determination.
  • 3.2K
  • 18 May 2022
Topic Review
Probiotic Bacillus subtilis in Human Applications
Bacillus subtilis has been used for more than 50 years in many different industrial applications, including farming, precision fermentation, and probiotic supplements. It is particularly attractive as a probiotic because of its ability to form shelf-stable, acid-resistant spores that lend to diverse applications in the food system. B. subtilis is the most ubiquitous species of the genus and can be isolated from a broad variety of environments including animal and human gastrointestinal (GI) tracts.
  • 3.2K
  • 02 Feb 2024
Topic Review Peer Reviewed
Negative Influence of Social Media on Children’s Diets: A Systematic Review
The widespread use of social media among children has raised concerns about its impact on their dietary habits and health. This systematic review investigates the negative effects of social media on children’s diets to inform evidence-based interventions and policies. A search of peer-reviewed studies from 2020 to 2024 was conducted using PubMed, Web of Science, and Scopus. Studies involving children aged 5–18 and examining social media’s influence on diet were included. Two independent reviewers screened the studies, and data extraction and quality assessment were done using standardized methods. Of 945 identified studies, 25 met the inclusion criteria. The key themes included (1) exposure to unhealthy food advertisements, (2) peer influence promoting energy-dense, nutrient-poor foods, (3) distorted body image perceptions leading to unhealthy eating, and (4) reduced mealtime quality due to social media distractions. Stronger associations were observed for marketing exposure and peer influence on food choices. The review highlights social media’s negative effects on children’s diets, emphasizing the need for interventions, stricter food marketing regulations, and educational programs to enhance media literacy. Future research should explore the long-term impacts and protective factors to guide policies for creating healthier digital environments for children.
  • 3.2K
  • 22 Nov 2024
Topic Review
Integrated Management
Integrated management is a socially defined concept that is interpreted and understood in a variety of ways.
  • 3.2K
  • 29 Nov 2022
Topic Review
Redoutable-Class Submarine (1931)
The Redoutable-class submarines were a group of 31 submarines built between 1924 and 1937 for the French Navy. Most of the class saw service during the Second World War. The class is also known in French as the Classe 1 500 tonnes, and they were designated as "First Class submarines", or "large submarine cruisers". They are known as the Redoutable class in reference to the lead boat Redoutable, in service from 1931 to 1942. The class is divided into two sub-class series, Type I, known as Le Redoutable and Type II, Pascal. Modern submarines when they were designed, they quickly became outdated, and were approaching obsolescence by the beginning of the Second World War. The conditions of the Armistice of 22 June 1940 prevented the Vichy government from carrying out a modernization programme. 24 out of the 29 units that served in the war were lost. Used in the defence of the Second French colonial empire under the Vichy regime, submarines of the class saw action against Allied offensives at the Battles of Dakar, Libreville and Madagascar. Many of the submarines of the class came under Allied control after the Allied landings in North Africa. Few however saw much further active service after this due to a period of refitting and alterations done in the United States between February 1943 and March 1945. One exception was Casabianca, which took part in the liberation of Corsica. The surviving submarines were largely used for training purposes after the war, with the last of them being disarmed in 1952.
  • 3.2K
  • 29 Nov 2022
Topic Review
CD33 Expression
Acute myeloid leukemia (AML), the most frequent acute leukemia in adults, has been historically treated with infusional cytarabine (ara-c) + daunorubicin (3 + 7) for at least 40 years. The first “target therapy” to be introduced was the monoclonal anti-CD33 gemtuzumab ozogamicin (GO) in 2004.
  • 3.2K
  • 29 Jul 2021
Topic Review
Multivariate Mutual Information
In information theory there have been various attempts over the years to extend the definition of mutual information to more than two random variables. The expression and study of multivariate higher-degree mutual-information was achieved in two seemingly independent works: McGill (1954) who called these functions “interaction information”, and Hu Kuo Ting (1962) who also first proved the possible negativity of mutual-information for degrees higher than 2 and justified algebraically the intuitive correspondence to Venn diagrams .
  • 3.2K
  • 18 Oct 2022
Topic Review
Human–Environment Relationships: Culture and Pedagogy
Human culture can be regarded as the general context where the human–environment relationships take place and develop. Interestingly, studies on human culture and cultural evolution have been enriched with some novel perspectives that appear to dovetail with recent developments in evolutionary biology. All this allows a fresh and promising understanding of the fundamentals of human-environment interaction, according to which the environment can be shown to exert a pedagogical role for humanity, and humanity can be understood as a species modifying the environment to the aim of modifying itself.
  • 3.2K
  • 23 Feb 2022
Topic Review
Chaldean Oracles
The Chaldean Oracles are a set of spiritual and philosophical texts widely used by Neoplatonist philosophers from the 3rd to the 6th century C.E. While the original texts have been lost, they have survived in the form of fragments consisting mainly of quotes and commentary by Neoplatonist writers. They were likely to have originally formed a single mystery-poem, which may have been in part compiled, in part received via trance, by Julian the Chaldean, or more likely, his son, Julian the Theurgist in the 2nd century C.E. Later Neoplatonists, such as Iamblichus and Proclus, rated them highly. The 4th-century Emperor Julian (not to be confused with Julian the Chaldean or Julian the Theurgist) suggests in his Hymn to the Magna Mater that he was an initiate of the God of the Seven Rays, and was an adept of its teachings. When Christian Church Fathers or other Late Antiquity writers credit "the Chaldeans", they are probably referring to this tradition. An analysis of the Chaldean Oracles demonstrates an inspiration for contemporary gnostic teachings: fiery emanations initiate from the transcendental First Paternal Intellect, from whom the Second Intellect, the Demiurge comprehends the cosmos as well as himself. Within the First Intellect, a female Power, designated Hecate, is, like Sophia, the mediating World-Soul. At the base of all lies created Matter, made by the Demiurgic Intellect. The matter farthest from the Highest God (First Father / Intellect) was considered a dense shell from which the enlightened soul must emerge, shedding its bodily garments. A combination of ascetic conduct and correct ritual are recommended to free the soul from the confines of matter and limitations, and to defend it against the demonic powers lurking in some of the realms between Gods and mortals.
  • 3.2K
  • 14 Nov 2022
Topic Review Peer Reviewed
Fungi in a One Health Perspective
Fungi constitute a diverse group with highly positive and negative impacts in different environments, having several natural roles and beneficial applications in human life, but also causing several concerns. Fungi can affect human health directly, but also indirectly by being detrimental for animal and plant health, influencing food safety and security. Climate changes are also affecting fungal distribution, prevalence, and their impact on different settings. Searching for sustainable solutions to deal with these issues is challenging due to the complex interactions among fungi and agricultural and forestry plants, animal production, environment, and human and animal health. In this way, the “One Health” approach may be useful to obtain some answers since it recognizes that human health is closely connected to animal and plant health, as well as to the shared environment. This review aims to explore and correlate each of those factors influencing human health in this “One Health” perspective. Thus, the impact of fungi on plants, human, and animal health, and the role of the environment as an influencing factor on these elements are discussed.
  • 3.2K
  • 24 Jul 2023
Topic Review
Tualang Honey
Tualang honey is a wild polyfloral honey produced by Apis dorsata. This honey is named after one of the tallest tropical rainforest trees, the Koompassia excelsa tree (known locally as the Tualang tree), where bees build their hives. The bees collect nectar from plants in the tropical rain forest in the North-eastern region of Peninsular Malaysia in Kedah.
  • 3.2K
  • 25 Feb 2021
Topic Review
WebRTC
WebRTC (Web Real-Time Communication) is a free and open-source project providing web browsers and mobile applications with real-time communication (RTC) via application programming interfaces (APIs). It allows audio and video communication to work inside web pages by allowing direct peer-to-peer communication, eliminating the need to install plugins or download native apps. Supported by Apple, Google, Microsoft, Mozilla, and Opera, WebRTC specifications have been published by the World Wide Web Consortium (W3C) and the Internet Engineering Task Force (IETF). According to the webrtc.org website, the purpose of the project is to "enable rich, high-quality RTC applications to be developed for the browser, mobile platforms, and IoT devices, and allow them all to communicate via a common set of protocols".
  • 3.2K
  • 25 Oct 2022
Topic Review
Pathogenesis of Urinary Tract Infections
Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, occurring in both community and healthcare settings. Although the clinical symptoms of UTIs are heterogeneous and range from uncomplicated (uUTIs) to complicated (cUTIs), most UTIs are usually treated empirically. Bacteria are the main causative agents of these infections, although more rarely, other microorganisms, such as fungi and some viruses, have been reported to be responsible for UTIs.
  • 3.2K
  • 21 Jun 2023
Topic Review
The Factors Impacting Commuting Time
Commuting time holds a significant role in people’s daily routines, representing the duration spent traveling between home and work in the context of daily time use. In the context of rapid urbanization in developing countries, commuting time is increasing. However, excessive commuting time can have significant economic, social, and environmental consequences. For example, longer commuting time hampers per capita income growth and reduces productivity. It also impedes social interactions among residents, leading to a decline in social and economic vitality. Moreover, commuting accounts for a large proportion of urban transportation demand and is closely linked to urban carbon emissions. Additionally, it has detrimental effects on both physical and mental health, as well as the well-being of individuals. Therefore, it is crucial to investigate the factors that influence commuting time in order to mitigate its continual increase.
  • 3.2K
  • 29 Aug 2023
Topic Review
Progress of 2D Semiconductor-based photocatalysts
A complete view of basic principles and mechanisms with regard to improving the structure stability, physical and chemical properties of the low dimensional semiconductor-based photocatalysts is presented here. Various 2D semiconductor-based photocatalysts show a high electrochemical property and photocatalytic performance due to their ultrathin character, high specific surface area with more activity sites, tunable bandgap to absorb sunlight and versatile options in structural assembly with other nanosheets. At present, most photocatalysts still need rare or expensive noble metals to improve the photocatalytic activity, which inhibits their commercial-scale application extremely. Thus, developing less costly, earth-abundant semiconductor-based photocatalysts with the efficient conversion of sunlight energy remains the primary challenge. A concise overview of different types of 2D semiconductor-mediated photocatalysts is given to figure out the advantages and disadvantages for mentioned semiconductor-based photocatalysis, including the structural property and stability, synthesize method, electrochemical property, and optical properties for H2/O2 production half-reaction along with overall water splitting.
  • 3.2K
  • 21 Oct 2020
Topic Review
1998–99 Ecuador Economic Crisis
The 1998–99 Ecuador economic crisis was a period of economic instability that resulted from a combined inflationary-currency crisis, financial crisis, fiscal crisis, and sovereign debt crisis. Severe inflation and devaluation of the Ecuadorian sucre lead to President Jamil Mahuad announcing on January 9, 2000 that the US dollar would be adopted as the national currency. Poor economic conditions and subsequent protests against the government resulted in the 2000 Ecuadoran coup d’état in which Jamil Mahuad was forced to resign and was replaced by his Vice President, Gustavo Noboa.
  • 3.2K
  • 08 Oct 2022
Topic Review
In-Wheel Motor Drive Systems for Electric Vehicles
There has been significant attention given to the electrification of transportation due to concerns about fossil fuel depletion and environmental pollution. Conventional drive systems typically include a clutch, reduction gear, and mechanical differential, which results in power loss, noise, vibration, and additional maintenance. However, in-wheel motor drive technology eliminates the need for these components, providing benefits such as higher system efficiency, improved wheel control, and increased passenger comfort.
  • 3.2K
  • 21 Aug 2023
Topic Review
Analysis of Point Machines and Monitoring Systems
Point machines are the actuators for railway switching and crossing systems that guide trains from one track to another. Hence, the safe and reliable behavior of point machines are pivotal for rail transportation. Scholars and researchers have attempted to deploy various kinds of sensors on point machines for anomaly detection and/or incipient fault detection using date-driven algorithms. However, challenges arise when deploying condition monitoring and fault detection to trackside point machines in practical applications. 
  • 3.2K
  • 25 Oct 2023
Topic Review
Debaryomyces Hansenii in Sausages, Dry-Meat
Debaryomyces hansenii is a hemiascomycetous yeast of undoubted biotechnological importance. It is a heterogeneous yeast species able to grow under extreme conditions, such as high salt or relatively alkaline pH levels. This yeast has high respiratory and low fermentative activity. It ferments with important variations, depending on the strain and growth conditions used. Briefly, some examples of its beneficial effects are the production of xylitol, lipases, and exopeptidases important in the food industry, and of thermophilic β-glucosidases essential to produce fuel alcohol. Debaryomyces hansenii is, most probably, the most abundant yeast found in sausages and dry-meat products manufactured all around the world.
  • 3.2K
  • 04 Aug 2021
Topic Review
Least Developed Countries
The Least Developed Countries (LDCs) is a list of developing countries that, according to the United Nations, exhibit the lowest indicators of socioeconomic development, with the lowest Human Development Index ratings of all countries in the world. The concept of LDCs originated in the late 1960s and the first group of LDCs was listed by the UN in its resolution 2768 (XXVI) of 18 November 1971. A country is classified among the Least Developed Countries if it meets three criteria: (1) Poverty – adjustable criterion based on GNI per capita averaged over three years. (As of 2018) a country must have GNI per capita less than United States dollar 1,025 to be included on the list, and over $1,230 to graduate from it. (2) Human resource weakness (based on indicators of nutrition, health, education and adult literacy). (3) Economic vulnerability (based on instability of agricultural production, instability of exports of goods and services, economic importance of non-traditional activities, merchandise export concentration, handicap of economic smallness, and the percentage of population displaced by natural disasters). As of 2018, 47 countries are classified as LDC, while five have been upgraded between 1994 and 2017. The WTO recognizes the UN list of LDCs in toto. 
  • 3.2K
  • 17 Oct 2022
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