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Topic Review
Treadmill Training Interventions on Elders with Neurological Disorders
Stroke, one of the most common neurological disorders, is a leading cause of long-term disability in older adults. Brain damage due to stroke can lead to symptoms such as cognitive and motor impairments including pain, paralysis, poor balance, spasticity, muscle weakness, and ineffective gait patterns.
  • 905
  • 25 Mar 2022
Topic Review
Mediterranean Diet and COVID-19
Mediterranean Diet represents the traditional eating habits of populations living around the Mediterranean Sea, and it is associated with a lower risk of overall mortality and cancer incidence and cardiovascular diseases. Severe acute respiratory syndrome coronavirus 2 is a new pandemic, and represents a significant and critical threat to global human health.
  • 904
  • 13 Jan 2022
Topic Review
Regulation of EMT Process in Cancer Progression
A biological process called epithelial-mesenchymal transition (EMT) allows epithelial cells to change into mesenchymal cells and acquire some cancer stem cell properties. EMT contributes significantly to the metastasis, invasion, and development of treatment resistance in cancer cells. Current research has demonstrated that phytochemicals are emerging as a potential source of safe and efficient anti-cancer medications. Phytochemicals could disrupt signaling pathways related to malignant cell metastasis and drug resistance by suppressing or reversing the EMT process.
  • 902
  • 18 Jul 2023
Topic Review
Vaccine and Monkeypox
The monkeypox virus (MPV) is a double-stranded DNA virus belonging to the Poxviridae family, Chordopoxvirinae subfamily, and Orthopoxvirus genus. It was called monkeypox because it was first discovered in monkeys, in a Danish laboratory, in 1958. Preventing the transmission and infection of MPV is associated with different challenges. The primary strategy of prevention would be vaccination. 
  • 900
  • 24 Oct 2022
Topic Review
Preventing Postpartum Hemorrhage
Maternal hemorrhage is linked to adverse effects, such as anemia, hypovolemic shock, disseminated intravascular coagulation, acute respiratory distress, renal failure, impaired breastfeeding, and the worsening of existing diseases in mothers, which compromises both physical and psychological health .
  • 898
  • 16 Jun 2021
Topic Review
Effect of Sex Hormones on Migraine
Sex hormones and migraine are closely interlinked. Women report higher levels of migraine symptoms during periods of sex hormone fluctuation, particularly during puberty, pregnancy, and perimenopause. Ovarian steroids, such as estrogen and progesterone, exert complex effects on the peripheral and central nervous systems, including pain, a variety of special sensory and autonomic functions, and affective processing. A panel of basic scientists, when challenged to explain what was known about how sex hormones affect the nervous system, focused on two hormones: estrogen and oxytocin.
  • 898
  • 11 Mar 2024
Topic Review
COVID-19 during Gestation
COVID-19, the disease caused by SARS-CoV-2 has reached pandemic proportions worldwide, with considerable consequences for both health and the economy. In pregnant women, COVID-19 can alter the metabolic environment, iron metabolism, and oxygen supply of trophoblastic cells, and therefore have a negative influence on pregnant women and mechanisms of fetal development, with implications in the postnatal life. The purpose of this study was to investigate, for the first time, the effects of COVID-19 infection during pregnancy with regard to the oxidative/antioxidant status in mothers’ serum and placenta, together with placental iron metabolism. Results showed no differences in superoxide dismutase activity and placental antioxidant capacity. However, antioxidant capacity decreased in the serum of infected mothers. Catalase activity decreased in the COVID-19 group, while an increase in 8-hydroxy-2’-deoxyguanosine, hydroperoxides, 15-FT-isoprostanes, and carbonyl groups were recorded in this group. Placental vitamin D, E, and Coenzyme-Q10 also showed to be increased in the COVID-19 group. As for iron-related proteins, an up-regulation of placental DMT1, ferroportin-1, and ferritin expression was recorded in infected women. Due to the potential role of iron metabolism and oxidative stress in placental function and complications, further research is needed to explain the pathogenic mechanism of COVID-19 that may affect pregnancy, so as to assess the short-term and long-term outcomes in mothers’ and infants’ health.
  • 898
  • 28 Jan 2022
Topic Review
MicroRNAs for Predicting Cancer Patients’ Susceptibility to SARS-CoV-2
Coronavirus disease (COVID-19) is an infectious disease that is caused by a highly contagious and severe acute respiratory syndrome—coronavirus 2 (SARS-CoV-2). This infection started to spread across the world in 2019 and rapidly turned into a global pandemic, causing an urgent necessity for treatment strategies development. The mRNA vaccines against SARS-CoV-2 can trigger an immune response, providing genetic information that allows the production of spike glycoproteins. MiRNAs play a crucial role in diverse key cellular processes, including antiviral defense. Several miRNAs are described as key factors in SARS-CoV-2 human infection through the regulation of ACE2 levels and by the inhibition of SARS-CoV-2 replication and spike expression. Consequently, these molecules have been considered as highly promising biomarkers. In numerous human malignancies, it has been recognized that miRNAs expression is dysregulated. Since miRNAs can target SARS-CoV-2-associated mRNAs, in cancer patients, the deregulation of these molecules can impair the immune response to the vaccines. 
  • 897
  • 26 Aug 2022
Topic Review
Cultural Safety for LGBTQIA+ People
Although the concept of "cultural safety" as its origins in indigenous nursing care, there is support and rationale for applying this concept for LGBTQIA+ people as a population who experience health disparities due to barriers to access equitable care. Building on Mukerjee and colleagues' 5 "P" tenets (partnerships, personal activities of daily living, prevention of harm, patient centering, and purposeful self-reflection), reviewed studies on components of culturally safe care for LGBTQIA+ people revealed five themes: power-enhancing care; inclusive healthcare institutions; continuous education and research; promotion of visibility; and individualised care.
  • 895
  • 12 Aug 2022
Topic Review
Smoking Cessation Apps
Smoking cessation interventions are effective, but they are not easily accessible for all treatment-seeking smokers. Mobile health (mHealth) apps have been used in recent years to overcome some of these limitations. Smoking cessation apps can be used in combination with a face-to-face intervention (FFSC-Apps), or alone as general apps (GSC-Apps). Smartphone apps for smoking cessation could be promising tools. However, more research with an adequate methodological quality is needed to determine its effect. Nevertheless, smartphone apps’ high availability and attractiveness represent a great opportunity to reach large populations.
  • 894
  • 24 Dec 2021
Topic Review
Dental Plaque in Systemic Diseases
Periodontal diseases are not just simple bacterial infections, but rather complex diseases of multifactorial complexity. The connection between the subgingival microbes, the host immune, and inflammatory responses seems to be very clear. The mechanisms explaining the association between chronic periodontal disease and systemic diseases include a direct and an indirect route. The direct route results in ulceration in the lining of periodontal pockets, which can become a passage for bacteria into the systemic circulation. It leads to bacteremia, which allows bacteria to settle in distant organs aggravating existing disease conditions. The indirect route is based on the fact that chronic periodontal disease, being a significant source of inflammation, may play a role in other disease conditions in which inflammation is a major component.
  • 893
  • 13 Jan 2022
Topic Review
Common Vaccines against COVID-19
To date, multiple COVID-19 vaccines have been granted emergency use authorization, including inactivated vaccines, adenovirus-vectored vaccines, and nucleic acid vaccines. These vaccines have different technical principles, which will necessarily lead to differences in safety and efficacy.
  • 893
  • 21 Apr 2022
Topic Review
Vitamin D and Iron on Skeletal Muscle Health
Many nutrients are essential for skeletal muscle health including vitamin D and iron. These nutrients have been well-established to play a role in improving muscular strength, muscle mass, and muscle function in various populations such as youth, athletes, and older adults. Together, muscular strength, muscle mass, and muscle function are important components that make up “skeletal muscle health”. Beyond the role that these nutrients have on skeletal muscle health, emerging literature has reported a link between vitamin D action on pro-inflammatory cytokines and mechanisms behind iron regulation, which may physiologically play a role in skeletal muscle health.
  • 891
  • 12 Jul 2022
Topic Review
Crowd Management during COVID-19 with Artificial Intelligence
COVID-19 requires crowded events to enforce restrictions, aimed to contain the spread of the virus. However, we have seen numerous events not observing these restrictions, thus becoming super spreader events. In order to contain the spread of a human to human communicable disease, a number of restrictions, including wearing face masks, maintaining social distancing, and adhering to regular cleaning and sanitization, are critical. These restrictions are absolutely essential for crowded events. Some crowded events can take place spontaneously, such as a political rally or a protest march or a funeral procession. Controlling spontaneous crowded events, like a protest march, political rally, celebration after a sporting event, or concert, can be quite difficult, especially during a crisis like the COVID-19 pandemic.
  • 890
  • 14 Jan 2022
Topic Review
COVID-19 Pandemic on Employee Sleep Quality
COVID-19 was declared a pandemic on 11 March 2020, following a rapid, exponential increase in global cases. The COVID-19 pandemic was associated with depression, anxiety, sleep disturbances, distress, and suicidal ideations. This study explored the association of the COVID-19 pandemic and employee sleep quality at a healthcare technology and services organization.
  • 890
  • 07 Feb 2022
Topic Review
Virtual Care
Virtual care extends beyond the walls of healthcare organizations to provide care at a distance. Virtual care encompasses the provision of care using advanced video conferencing technology to support remote care that takes place between patients and providers and the use of virtual reality technology to simulate care environments. Some of virtual care’s use in healthcare includes application to pain and anxiety management, virtual consultations and follow-up visits, rehabilitation and therapy services, outpatient clinics, and emergency services.
  • 889
  • 23 Nov 2021
Topic Review
Soft Tissue Sarcomas Margin Assessment
Many classifications to assess margins status for soft tissue sarcomas are reported in the literature. Most of the series are heterogeneous and variable in size, making it difficult to compare results from study to study. 
  • 886
  • 26 Apr 2021
Topic Review
Nosocomial Infections and Role of Nanotechnology
Nosocomial infections, termed hospital-acquired infections (HAIs), are acquired from a healthcare or hospital setting. HAI is mainly caused by bacteria, such as Acinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Enterococci spp., Methicillin-resistant Staphylococcus aureus (MRSA), and many more. Due to growing antibacterial resistance, nanotechnology has paved the way for more potent and sensitive methods of detecting and treating bacterial infections.
  • 885
  • 09 Feb 2022
Topic Review
Myocardial Infarction and Immuno-Inflammatory Response in CAE
Coronary artery ectasia (CAE) is a relatively common coronary angiographic finding, with an incidence of 1.5–5% and geographical variations in prevalence. CAE has been associated with a male predominance. Anatomically, CAE more frequently affects the right coronary artery and the proximal one third of the vessels.
  • 885
  • 16 May 2022
Topic Review
Plant-Derived Substances for Oral Health Care Products
Plant extracts are the current trend in the market, but it is also essential to consider their antibacterial, antioxidant, and sensory characteristics. Plant essential oils are constituted by secondary metabolites, such as terpenes, phenols, and aldehydes with antibacterial, antioxidant, and flavoring properties. Other industries take advantage of the essential oil properties; some examples of their applications are found in the food, pharmaceutical, and cosmetic industries.
  • 884
  • 29 Mar 2022
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