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Kurek-Górecka, A. Dental Plaque in Systemic Diseases. Encyclopedia. Available online: https://encyclopedia.pub/entry/18125 (accessed on 28 March 2024).
Kurek-Górecka A. Dental Plaque in Systemic Diseases. Encyclopedia. Available at: https://encyclopedia.pub/entry/18125. Accessed March 28, 2024.
Kurek-Górecka, Anna. "Dental Plaque in Systemic Diseases" Encyclopedia, https://encyclopedia.pub/entry/18125 (accessed March 28, 2024).
Kurek-Górecka, A. (2022, January 12). Dental Plaque in Systemic Diseases. In Encyclopedia. https://encyclopedia.pub/entry/18125
Kurek-Górecka, Anna. "Dental Plaque in Systemic Diseases." Encyclopedia. Web. 12 January, 2022.
Dental Plaque in Systemic Diseases
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Periodontal diseases are not just simple bacterial infections, but rather complex diseases of multifactorial complexity. The connection between the subgingival microbes, the host immune, and inflammatory responses seems to be very clear. The mechanisms explaining the association between chronic periodontal disease and systemic diseases include a direct and an indirect route. The direct route results in ulceration in the lining of periodontal pockets, which can become a passage for bacteria into the systemic circulation. It leads to bacteremia, which allows bacteria to settle in distant organs aggravating existing disease conditions. The indirect route is based on the fact that chronic periodontal disease, being a significant source of inflammation, may play a role in other disease conditions in which inflammation is a major component.

dental plaque SARS-CoV-2 infection

1. Cardiovascular System

Cardiovascular diseases (CVD) are defined as disorders of the heart and blood vessels. An underlying cause of CVD is atherosclerosis. Atherosclerosis is a chronic, vascular inflammatory condition that results in lipids deposition in the arterial wall. The periodontal infections and cardiovascular diseases are related to each other. Many studies have shown that periodontitis usually results in higher systemic levels of C-reactive protein, interleukin (IL)-6, and neutrophils. Increasing inflammatory activity in atherosclerotic lesions, which potentially increases the risk for cardiac or cerebrovascular events may be the result of elevated inflammatory factors. Inflammation as a result of periodontitis increases systemic inflammation and oxidative stress, which contributes to and increases the already chronic inflammation present and in this way contributes to atherosclerosis and CVD [1][2][3]. It has been proven that some bacteria isolated from oral cavity may be associated with platelet aggregation, as far as bacterial infections may also contribute to the acute thromboembolic events. Oral bacteria involved in periodontal disease can infect blood vessels or in some other way promote plaque formation and, thus, CVD [4].

2. Musculoskeletal System

Chronic periodontitis is associated with a higher risk of suffering from rheumatoid arthritis. The interrelationship between systemic osteoporosis, oral bone loss, tooth loss, and risk factors for these conditions has been observed, because a remarkable similarity in the pathogenesis of periodontal diseases and rheumatoid arthritis exists. In addition, periodontal disease is thought to be an initiative factor of the autoimmune inflammatory response, which is highly connected with rheumatoid arthritis [5][6][7].

3. Respiratory System and SARS-CoV-2 Infection

Poor oral hygiene and periodontitis influence the incidence of pulmonary infections. The link between dental plaque and SARS-CoV-2 infection is based on direct and indirect mechanisms. The direct mechanism is related with angiotensin-converting enzyme II (ACE-2) receptors and is associated with greater expression of ACE-2 receptors by the altered oral microbiome [8]. It is known that ACE-2 receptors play a key role in SARS-CoV-2 entry into host cells. Therefore, a greater expression of ACE-2 receptors promotes SARS-CoV-2 infection on the epithelial cells of oral mucosa. Moreover, a colonization of dental plaque by respiratory pathogens could lead to aspiration of oral bacteria capable of causing pneumonia into the lungs. Other known mechanisms in periodontitis include alteration of the mucus surface by salivary enzymes, destruction of salivary pellicles by periodontal disease-associated enzymes and alteration of respiratory epithelium by cytokines from periodontal disease, also facilitating the infection of the epithelium by respiratory pathogens [3][9][10]. The oral cavity constitutes a reservoir for respiratory pathogens, therefore patients with dental plaque or periodontitis may be more likely to develop severe pneumonia [11][12][13]. The second, indirect mechanism is related to inflammatory pathways and bacterial superinfections [12]. The greater synthesis of cytokines and chemokines appears in the gingiva, which lead to increased levels of proinflammatory cytokines in the patient’s serum. Cytokines may alter the respiratory epithelium and lead to infection by respiratory pathogens such as SARS-CoV-2. Virus activates an immune response causing a “cytokine storm” [14]. Due to cytokine release syndrome, the hypercytokinemia is responsible for complications such as lung injury, hypercoagulation, multiorgan failure, and shock, during COVID-19. The inflammatory pathways that are involved in conditions such as diabetes, hypertension, obesity, or cardiovascular disease are the same that we observe in periodontal diseases. It is suggested, that there is a strong association between main comorbidities and increased risk of complications and death from COVID-19, and it may be connected with altered oral biofilms and periodontal disease. Moreover, indirect mechanism is based on bacterial superinfections. It is clear that altered microbiom lead to aspiration of microorganisms associated with oral diseases into lower respiratory tract and cause respiratory infections and potentially post-viral bacterial complications [15][16].

4. Diabetes

Studies have shown that periodontal disease may be a risk factor for diabetes, but it is suggested that the relationship between diabetes and periodontal disease runs both ways: chronic infection and inflammatory response [4]. Severe periodontal disease can increase glucose levels, contributing to increased periods of time when the body functions with hyperglycemia. This puts people with diabetes at increased risk for diabetic complications. Pancreas cells responsible for insulin production can be damaged or destroyed by the chronic high levels of cytokines. It may induce Type 2 diabetes, even in otherwise healthy individuals with no other risk factors for diabetes. Therefore, periodontal diseases are responsible for aggravate insulin resistance and affect glycemic control [17][18][19][20][21][22].

5. Alzheimer’s Disease

Recent comprehensive oral-health studies demonstrate the relationship between oral pathogen, inflammation, and Alzheimer’s disease (AD). In response to oral bacterial infection, pro-inflammatory cytokines are produced by the host [23]. Therefore, the increased level of cytokines lead to inflammation and may contribute to the brain inflammation that occurs among patients with Alzheimer’s disease. Moreover, dental plaque leads to periodontal diseases and changed microbiome. Periodontal pathogens such as Porphyromonas gingivalis and Treponema dentricola produce lipopolysaccharide (LPS). LPS constitutes a virulence factor and plays an important role in brain inflammatory process. Therefore, inflammation is a major factor responsible for neurodegeneration among patients [24]. Besides LPS, also gingipains are released by Porphyromonas gingivalis. Gingipains are classified as collagenases and trypsin-like cysteine proteinases and they are secreted by all strains of Porphyromonas gingivalis. Gingipains together with LPS can proteolytically activate kinases such as glycogen synthase kinase-3 β (GSK-3β), which phosphorylates neuronal tau protein [25]. Phosphorylated tau is an important agent, especially since the intraneuronal cytoskeletal alterations precede the formation of amyloid in patients with AD [26]. Additionally, periodontal pathogens such as Treponema dentricola and Chlamydia pneumonia were detected in postmortem brains derived from patients with Alzheimer’s disease. Moreover, Porphyromonas gingivalis is responsible for the peripheral and cerebral immune responses. Therefore, researchers put forward a hypothesis, that pathogens from oral cavity may invade the brain by crossing the brain–blood barrier. Periodontal pathogens may be associated with symptoms of Alzheimer’s disease [18]Figure 1).
Figure 1. Impact of poor oral health on systemic diseases.

References

  1. Wojtkowska, A.A.; Wysokinski, A. Periodontitis and prevalence of cardiovascular diseases. Chor. Serca Naczyń 2015, 12, 289–294. (In Polish)
  2. Kaur, N.; Kaur, N.; Sarangal, V. A study to evaluate the correlation of serum albumin levels with chronic periodontitis. Ind. J. Dent. Res. 2015, 26, 11–14. Available online: https://www.ijdr.in/article.asp?issn=0970-9290;year=2015;volume=26;issue=1;spage=11;epage=14;aulast=Kaur (accessed on 2 October 2020).
  3. Knypl, K. Pharmacotherapy of arterial hypertension: Antagonists of angiotensin receptors AT1. Med. Rodz. 2001, 2, 58–60. (In Polish)
  4. Liccardo, D.; Cannavo, A.; Spagnuolo, G.; Ferrara, N.; Cittadini, A.; Rengo, C.; Rengo, G. Periodontal disease: A risk factor for diabetes and cardiovascular disease. Int. J. Mol. Sci. 2019, 20, 1414.
  5. Yiqiang, Q.; Zao, W.; Yafang, L.; Yafei, H.; Yanheng, Z.; Xuanping, C. Rheumatoid arthritis risk in periodontitis patients: A systematic review and meta-analysis. Jt. Bone Spine 2020, 87, 556–564.
  6. Ceccarelli, F.; Saccucci, M.; Di Carlo, G.; Lucchetti, R.; Pilloni, A.; Pranno, N.; Luzzi, V.; Valesini, G.; Polimeni, A. Periodontitis and rheumatoid arthritis: The same inflammatory mediators? Mediat. Inflamm. 2019, 2019, 6034546.
  7. Mercado, F.; Marshall, R.I.; Klestov, A.C.; Bartold, P.M. Is there a relationship between rheumatoid arthritis and periodontal disease? J. Clin. Periodontol. 2000, 27, 267–272.
  8. Richardson, S.; Hirsch, J.S.; Narasimhan, M.; Crawford, J.M.; McGinn, T.; Davidson, K.W.; Northwell COVID-19 Research Consortium. Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area. JAMA 2020, 323, 2052–2059.
  9. Cao, W.; Li, T. COVID-19: Towards understanding of pathogenesis. Cell Res. 2020, 30, 367–369.
  10. Xu, H.; Zhong, L.; Deng, J.; Peng, J.; Dan, H.; Zeng, X.; Li, T.; Chen, Q. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int. J. Oral Sci. 2020, 12, 8.
  11. Takahashi, Y.; Watanabe, N.; Kamio, N.; Kobayashi, R.; Iinuma, T.; Imai, K. Aspiration of periodontopathic bacteria due to poor oral hygiene potentially contributes to the aggravation of COVID-19. J. Oral Sci. 2021, 63, 1–3.
  12. Takahashi, Y.; Watanabe, N.; Kamio, N.; Yokoe, S.; Suzuki, R.; Sato, S.; Iinuma, T.; Imai, K. Expression of the SARS-CoV-2 receptor ACE2 and proinflammatory cytokines induced by the periodontopathic bacterium fusobacterium nucleatum in human respiratory epithelial cells. Int. J. Mol. Sci. 2021, 22, 1352.
  13. Gupta, S.; Mohindra, R.; Chauhan, P.; Singla, V.; Goyal, K.; Sahni, V.; Gaur, R.; Verma, D.K.; Ghosh, A.; Soni, R.K.; et al. SARS-CoV-2 detection in gingival crevicular fluid. J. Dent. Res. 2021, 100, 187–193.
  14. Hojyo, S.; Uchida, M.; Tanaka, K.; Hasebe, R.; Tanaka, Y.; Murakami, M.; Hirano, T. How COVID-19 induces cytokine storm with high mortality. Inflamm. Regen. 2020, 40, 1–7.
  15. Kurek-Górecka, A.; Walczyńska-Dragon, K.; Felitti, R.; Nitecka, A.; Baron, S.; Olczyk, P. the influence of propolis on dental plaque reduction and the correlation between dental plaque and severity of COVID-19 complications—A literature review. Molecules 2021, 26, 5516.
  16. Sampson, V.; Kamona, N.; Sampson, A. Could there be a link between oral hygiene and the severity of SARS-CoV-2 infections? Brit. Dent. J. 2020, 228, 971–975.
  17. Stanko, P.; Izakovicova; Holla, L. Bidirectional association between diabetes mellitus and inflammatory periodontal disease. A review. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub. 2014, 158, 35–38.
  18. Bui, F.; Almeida-da-Silva, C.L.C.; Huynh, B.; Trinh, A.; Liu, J.; Woodward, J.; Asadi, H.; Ojcius, D.M. Association between periodontal pathogens and systemic disease. Biomed J. 2019, 42, 27–35.
  19. Chapple, I.L.; Genco, R.; Working Group 2 of the Joint EFP/AAP Workshop. Diabetes and periodontal diseases: Consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J. Periodontol. 2013, 84, S106–S112.
  20. Siddiqi, A.; Zafar, S.; Sharma, A.; Quaranta, A. Diabetes mellitus and periodontal disease: The call for interprofessional education and interprofessional collaborative care—A systematic review of the literature. J. Interprof. Care 2020, 8, 1–9.
  21. Dicembrini, I.; Serni, L.; Monami, M.; Caliri, M.; Barbato, L.; Cairo, F.; Mannucci, E. Type 1 diabetes and periodontitis: Prevalence and periodontal destruction-a systematic review. Acta Diabetol. 2020, 57, 1405–1412.
  22. Grigoriadis, A.; Räisänen, I.T.; Pärnänen, P.; Tervahartiala, T.; Sorsa, T.; Sakellari, D. Prediabetes/diabetes screening strategy at the periodontal clinic. Clin. Exp. Dent. Res. 2021, 7, 85–92.
  23. Borsa, L.; Dubois, M.; Sacco, G.; Lupi, L. Analysis the link between periodontal diseases and Alzheimer’s disease: A systematic review. Int. J. Environ. Res. Public Health 2021, 18, 9312.
  24. Poole, S.; Singhrao, S.K.; Kesavalu, L.; Curtis, M.A.; Crean, S. Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer’s disease brain tissue. J. Alzheim. Dis. 2013, 36, 665–677.
  25. Sansores-España, D.; Carrillo-Avila, A.; Melgar-Rodriguez, S.; Díaz-Zuñiga, J.; Martínez-Aguilar, V. Periodontitis and Alzheimer’s disease. Med. Oral. Patol. Oral. Cir. Bucal. 2021, 26, 43–48.
  26. Kanagasingam, S.; Chukkapalli, S.S.; Welbury, R.; Singhrao, S.K. Porphyromonas gingivalis is a strong risk factor for Alzheimer’s disease. J Alzheimers Dis. Rep. 2020, 4, 501–511.
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