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Topic Review
Tyk2 Targeting in Immune-Mediated Inflammatory Diseases
Genetic linkage has related dysfunction of Tyrosine kinase 2 (Tyk2)—the first member of the Jak family that was described—to protection from psoriasis. Furthermore, Tyk2 dysfunction has been related to IMID prevention, without increasing the risk of serious infections; thus, Tyk2 inhibition has been established as a promising therapeutic target, with multiple Tyk2 inhibitors under development.
  • 3.8K
  • 20 Feb 2023
Topic Review
Child Sexual Abuse
Child sexual abuse, also called child molestation, is a form of child abuse in which an adult or older adolescent uses a child for sexual stimulation. Forms of child sexual abuse include engaging in sexual activities with a child (whether by asking or pressuring, or by other means), indecent exposure (of the genitals, female nipples, etc.), child grooming, or using a child to produce child pornography. Child sexual abuse can occur in a variety of settings, including home, school, or work (in places where child labor is common). Child marriage is one of the main forms of child sexual abuse; UNICEF has stated that child marriage "represents perhaps the most prevalent form of sexual abuse and exploitation of girls". The effects of child sexual abuse can include depression, post-traumatic stress disorder, anxiety, complex post-traumatic stress disorder, propensity to further victimization in adulthood, and physical injury to the child, among other problems. Sexual abuse by a family member is a form of incest and can result in more serious and long-term psychological trauma, especially in the case of parental incest. The global prevalence of child sexual abuse has been estimated at 19.7% for females and 7.9% for males. Most sexual abuse offenders are acquainted with their victims; approximately 30% are relatives of the child, most often brothers, fathers, uncles, or cousins; around 60% are other acquaintances, such as "friends" of the family, babysitters, or neighbors; strangers are the offenders in approximately 10% of child sexual abuse cases. Most child sexual abuse is committed by men; studies on female child molesters show that women commit 14% to 40% of offenses reported against boys and 6% of offenses reported against girls. The word pedophile is commonly applied indiscriminately to anyone who sexually abuses a child, but child sexual offenders are not pedophiles unless they have a strong sexual interest in prepubescent children. Under the law, child sexual abuse is often used as an umbrella term describing criminal and civil offenses in which an adult engages in sexual activity with a minor or exploits a minor for the purpose of sexual gratification. The American Psychological Association states that "children cannot consent to sexual activity with adults", and condemns any such action by an adult: "An adult who engages in sexual activity with a child is performing a criminal and immoral act which never can be considered normal or socially acceptable behavior."
  • 3.8K
  • 14 Nov 2022
Topic Review
Microbial Dynamics and Preservation of Kunu Drink
Kunu is a fermented non-alcoholic beverage consumed all over Nigeria. The drink is served as an alternative to alcohol due to its perceived extreme nourishing and therapeutic properties. Varieties of this beverage are determined mostly by the type of grain, the supplements, sensory additives used, and the process employed during its production. Dietary quality is paramount in nutritional well-being and a key factor in human overall health development. The nutritional quality of grains utilised for Kunu production makes the drink more appealing to a large growing population when compared to some other drinks. Some use Kunu drink as an infant weaning drink, thus serving as a priming beverage for infants due to its rich probiotic and nutritional properties. 
  • 3.8K
  • 28 Feb 2023
Topic Review
Power Posing
Power posing is a controversial self-improvement technique or "life hack" in which people stand in a posture that they mentally associate with being powerful, in the hope of feeling and behaving more assertively. Though the underlying science is strongly disputed, its promoters continue to argue that people can foster positive life changes simply by assuming a "powerful" or "expansive" posture for a few minutes before an interaction in which confidence is needed. One popular image of the technique in practice is that of candidates "lock[ing] themselves in bathroom stalls before job interviews to make victory V's with their arms." Power posing was first suggested in a 2010 paper by Dana R. Carney, Amy Cuddy, and Andy Yap in the journal Psychological Science, and came to prominence through a popular TED talk by Cuddy in 2012. However, in 2015 several researchers began reporting that the effect could not be replicated, and, in 2016, Carney issued a statement abandoning the theory. Cuddy, however, continued her research, claiming to have evidence that posture feedback can at least make people feel more powerful. Today, power posing is often cited as an example of the replication crisis in the sciences.
  • 3.8K
  • 01 Dec 2022
Topic Review
NIAS in Plastic Food Packaging
Several food contact materials (FCMs) contain non-intentionally added substances (NIAS), and most of the substances that migrate from plastic food packaging are unknown. Food packaging can contain NIAS as a result of the interactions between different substances in the packaging materials, between food content and substances (for example, additives) in FCM, from degradation processes and mainly from the impurities present in the raw materials used for FCM production. (EU) nº 10/2011 defines that “non-intentionally added substance means an impurity in the substances used or a reaction intermediate formed during the production process or a decomposition or reaction product”. Most NIAS are regularly detected when using high sensitivity analytical techniques, although the chemical structure of unknown compounds is often difficult to establish by conventional tools.
  • 3.8K
  • 01 Jul 2021
Topic Review
Interference Theory
The interference theory is a theory regarding human memory. Interference occurs in learning. The notion is that memories encoded in long-term memory (LTM) are forgotten and cannot be retrieved into short-term memory (STM) because either memory interferes, or hampers, the other. There is an immense number of encoded memories within the storage of LTM. The challenge for memory retrieval is recalling the specific memory and working in the temporary workspace provided in STM. Retaining information regarding the relevant time of encoding memories into LTM influences interference strength. There are two types of interference effects: proactive and retroactive interference.
  • 3.8K
  • 10 Nov 2022
Topic Review
Cross-Coupling-Reaction of Copper Carbene Intermediate with Terminal Alkyne
Copper-catalyzed cross-coupling reaction of a copper carbene intermediate with terminal alkynes was one of the most powerful protocols for the construction of C–C bonds. However, in early works, a mixture of alkynoates and allenoates was generated in combined moderate yields under harsh reaction conditions. Until 2004, Fu reported the first example of the copper-catalyzed coupling reaction of terminal alkynes with diazo esters or diazo amides to yield 3-alkynoate or 3-butynamide products selectively with minimal amount of allene byproducts under no-basic conditions. Consequently, a variety of copper-catalyzed coupling reactions of terminal alkynes with various carbene precursors have been developed independently.
  • 3.8K
  • 30 May 2022
Topic Review
Unique Prime
In recreational number theory, a unique prime or unique period prime is a certain kind of prime number. A prime p ≠ 2, 5 is called unique if there is no other prime q such that the period length of the decimal expansion of its reciprocal, 1 / p, is equal to the period length of the reciprocal of q, 1 / q. For example, 3 is the only prime with period 1, 11 is the only prime with period 2, 37 is the only prime with period 3, 101 is the only prime with period 4, so they are unique primes. In contrast, 41 and 271 both have period 5; 7 and 13 both have period 6; 239 and 4649 both have period 7; 73 and 137 both have period 8; 21649 and 513239 both have period 11; 53, 79 and 265371653 all have period 13; 31 and 2906161 both have period 15; 17 and 5882353 both have period 16; 2071723 and 5363222357 both have period 17; 19 and 52579 both have period 18; 3541 and 27961 both have period 20. Therefore, none of these is a unique prime. Unique primes were first described by Samuel Yates in 1980. The above definition is related to the decimal representation of integers. Unique primes may be defined and have been studied in any numeral base.
  • 3.8K
  • 20 Oct 2022
Topic Review
Impacts of Lighting on Psychology, Physiology, and Productivity
People spend almost 90% of their time in indoor environments. Indoor environment quality has begun to play a more important role in people’s daily lives. The impact on occupants of various environmental factors of buildings has been actively studied. Among them, lighting conditions have been shown to have a significant influence on all aspects of human life and health.
  • 3.8K
  • 30 Jun 2022
Topic Review
Alteplase
Alteplase (t-PA), a biosynthetic form of human tissue-type plasminogen activator (t-PA), is a thrombolytic medication, used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. It is given by injection into a vein or artery. Alteplase is the same as the normal human plasminogen activator produced in vascular endothelial cells and is synthesized via recombinant DNA technology in Chinese hamster ovary cells (CHO). Alteplase causes the breakdown of a clot by inducing fibrinolysis.
  • 3.8K
  • 31 Oct 2022
Topic Review
Epiphany (Feeling)
An epiphany (from the ancient Greek ἐπιφάνεια, epiphanea, "manifestation, striking appearance") is an experience of a sudden and striking realization. Generally the term is used to describe scientific breakthrough, religious or philosophical discoveries, but it can apply in any situation in which an enlightening realization allows a problem or situation to be understood from a new and deeper perspective. Epiphanies are studied by psychologists and other scholars, particularly those attempting to study the process of innovation. Epiphanies are relatively rare occurrences and generally follow a process of significant thought about a problem. Often they are triggered by a new and key piece of information, but importantly, a depth of prior knowledge is required to allow the leap of understanding. Famous epiphanies include Archimedes's discovery of a method to determine the volume of an irregular object ("Eureka!") and Isaac Newton's realization that a falling apple and the orbiting moon are both pulled by the same force.
  • 3.8K
  • 30 Nov 2022
Topic Review
Nimbarka Sampradaya
The Nimbarka Sampradaya (IAST: Nimbārka Sampradāya, Sanskrit निम्बार्क सम्प्रदाय), also known as the Hamsa Sampradāya, Kumāra Sampradāya, Catuḥ Sana Sampradāya and Sanakādi Sampradāya, is one of the four Vaiṣṇava Sampradāyas. It was founded by Nimbarka (c.7th century CE), and teaches the Vaishnava theology of Dvaitadvaita (dvaita-advaita) or "dualistic non-dualism." Dvaitadvaita states that humans are both different and non-different from Isvara, God or Supreme Being, and is also known as Bhedābheda (bheda-abheda) philosophy.
  • 3.8K
  • 10 Nov 2022
Topic Review
AKT and Related Signaling Pathways
Global environmental pollution has led to human exposure to ultraviolet (UV) radiation due to the damaged ozone layer, thereby increasing the incidence and death rate of skin cancer including both melanoma and non-melanoma. Overexpression and activation of V-akt murine thymoma viral oncogene homolog (AKT, also known as protein kinase B) and related signaling pathways are major factors contributing to many cancers including lung cancer, esophageal squamous cell carcinoma and skin cancer. Although BRAF inhibitors are used to treat melanoma, further options are needed due to treatment resistance and poor efficacy. Depletion of AKT expression and activation, and related signaling cascades by its inhibitors, decreases the growth of skin cancer and metastasis. Here we have focused the effects of AKT and related signaling (PI3K/AKT/mTOR) pathways by regulators derived from plants and suggest the need for efficient treatment in skin cancer therapy.
  • 3.8K
  • 28 Sep 2020
Topic Review
Iron and Iron Overload in Invasive Fungal Infections
Iron is an essential trace metal necessary for the reproduction and survival of fungal pathogens. The latter have developed various mechanisms to acquire iron from their mammalian hosts, with whom they participate in a continuous struggle for dominance over iron. Invasive fungal infections are an important problem in the treatment of patients with hematological malignancies, and they are associated with significant morbidity and mortality. The diagnosis of invasive clinical infections in these patients is complex, and the treatment, which must occur as early as possible, is difficult. There are several studies that have shown a possible link between iron overload and an increased susceptibility to infections. This link is also relevant for patients with hematological malignancies and for those treated with allogeneic hematopoietic stem cell transplantation. The role of iron and its metabolism in the virulence and pathogenesis of various invasive fungal infections is intriguing, and so far, there is some evidence linking invasive fungal infections to iron or iron overload. Clarifying the possible association of iron and iron overload with susceptibility to invasive fungal infections could be important for a better prevention and treatment of these infections in patients with hematological malignancies.
  • 3.8K
  • 11 Aug 2022
Topic Review
LGD Theory for Nanoscale Ferroelectrics
This is a entry of the Landau-Ginzburg-Devonshire (LGD) Theory applied for description of nanoscale ferroelectrics. The polarization switching kinetics of nanosized ferroelectric crystals and the transition between homogeneous and domain switching in the nanoscale ferroelectric films are considered. Homogeneous switching according to the Ginzburg-Landau-Devonshire (LGD) theory is possible only in two-dimensional (2D) ferroelectrics. The main condition for the applicability of the LGD theory in such systems is its homogeneity along the polarization switching direction. A review is given of the experimental results for two-dimensional (2D) films of a ferroelectric polymer, nanosized barium titanate nanofilms, and hafnium oxide-based films. For ultrathin 2D ferroelectric polymer films, the results are confirmed by first-principle calculations. Fitting of the transition region from homogeneous to domain switching by sigmoidal Boltzmann functions was carried out. Boltzmann function fitting data enabled us to estimate correctly the region sizes of the homogeneous switching in which the LGD theory is valid. These sizes contain several lattice constants or monolayers of a nanosized ferroelectrics.
  • 3.8K
  • 14 Jan 2021
Topic Review
Environmental Hydraulics
Environmental Hydraulics (EH) is the scientific study of environmental water flows and their related transport and transformation processes in natural water systems. 
  • 3.8K
  • 14 Apr 2021
Topic Review
Biomechanical Aspects at Dental Implant-Abutment Interfaces
The interface between a dental implant and an abutment is stabilized by two mechanical characteristics: a preload of an abutment screw and the friction between the contact surfaces of the implant and the abutment. These mechanical properties are quantitatively analyzed by using physical and mechanical formulas. The important thing is that such mechanical properties cause various biological phenomena when medical devices are inserted into human bodies. Some mechanical complications in dental implant prostheses are closely associated with biological complications.
  • 3.8K
  • 13 Jun 2023
Topic Review
Neurotransmitter Dysfunction in IBS
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose aetiology is still unknown. Most hypotheses point out the gut-brain axis as a key factor for IBS. The axis is composed of different anatomic and functional structures intercommunicated through neurotransmitters. 
  • 3.8K
  • 13 Aug 2021
Topic Review
Cerium Nitrate
Cerium nitrate refers to a family of nitrates of cerium in the three or four oxidation state. Often these compounds contain water, hydroxide, or hydronium ions in addition to cerium and nitrate. Double nitrates of cerium also exist.
  • 3.8K
  • 27 Sep 2022
Topic Review
Courage
Courage (also called bravery or valor) is the choice and willingness to confront agony, pain, danger, uncertainty, or intimidation. Valor is courage or bravery, especially in battle. Physical courage is bravery in the face of physical pain, hardship, even death, or threat of death; while moral courage is the ability to act rightly in the face of popular opposition, shame, scandal, discouragement, or personal loss. The classical virtue of fortitude (andreia, fortitudo) is also translated "courage", but includes the aspects of perseverance and patience. In the Western tradition, notable thoughts on courage have come from philosophers Socrates, Plato, Aristotle, Aquinas, and Kierkegaard, as well as Christian beliefs and texts. In the Hindu tradition, mythology has given many examples of bravery, valor and courage, with examples of both physical and moral courage exemplified. In the Eastern tradition, some thoughts on courage were offered by the Tao Te Ching.
  • 3.8K
  • 28 Oct 2022
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