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Topic Review
Gut Microbiota and Neuroinflammation in Liver Disease
Liver disease are associated with a wide spectrum of neurological changes, of which the best known is hepatic encephalopathy (HE). Historically, hyperammonemia, was considered the main etiological factor; however, studies demonstrated a key role of neuroinflammation in the development of neurological complications in this setting. Neuroinflammation is characterized by activation of microglial cells and brain secretion of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, which alter neurotransmission, leading to cognitive and motor dysfunction. Changes in the gut microbiota resulting from liver disease play a crucial role in the pathogenesis of neuroinflammation. Dysbiosis and altered intestinal permeability, resulting in bacterial translocation and endotoxemia, are responsible for systemic inflammation, which can spread to brain tissue and trigger neuroinflammation. In addition, metabolites derived from the gut microbiota can act on the central nervous system and facilitate the development of neurological complications, exacerbating clinical manifestations. 
  • 1.1K
  • 31 Jul 2023
Topic Review
Exercise Effects on Left Ventricular Remodeling in Patients
Left ventricular (LV) remodeling is a dynamic process, which is characterized by changes in ventricular size, shape, and wall thickness, thus altering myocardial geometry and function, and is considered as a negative prognostic factor in patients with heart failure (HF). Hypertension, type 2 diabetes (T2D), and obesity are strongly correlated with the development and the progression of LV remodeling, LV hypertrophy, and LV systolic and/or diastolic dysfunction. Indeed, the beneficial impact of exercise training on primary and secondary prevention of cardiovascular disease (CVD) has been well-established. Exercise training enhances functional capacity, muscle strength and endurance, cardiac function, and cardiac-related biomarkers among patients with established coronary artery disease (CAD) or HF, thus substantially improving their cardiovascular prognosis, survival rates, and need for rehospitalization. 
  • 1.1K
  • 12 Sep 2023
Topic Review
Women and Leadership in Higher Education
The theoretical postulates of gender studies demonstrate that inequality, when it comes to women, is more of a sociocultural construct than the result of nature. Gender inequality is typical of higher education, where inclusion of women was a milestone and where the “female advantage” phenomenon refers to the rise of women at this level. 
  • 1.1K
  • 07 Nov 2023
Topic Review
Pharmacomicrobiomics and Drug–Infection Interactions
Microorganisms have a close relationship with humans, whether it is commensal, symbiotic, or pathogenic. It has been documented that microorganisms may influence the response to drug therapy. Pharmacomicrobiomics is an emerging field that focuses on the study of how variations in the microbiome affect the disposition, action, and toxicity of drugs. Two additional sciences have been added to complement pharmacomicrobiomics, namely toxicomicrobiomics, which explores how the microbiome influences drug metabolism and toxicity, and pharmacoecology, which refers to modifications in the microbiome as a result of drug administration. Additionally, the concept of "drug-infection interaction" is included to describe the influence of pathogenic microorganisms on drug response. This entry analyzes in detail each of these concepts.
  • 1.1K
  • 05 Jan 2024
Topic Review
Precision Beekeeping Systems
Precision beekeeping (PB) systems have promising strength points and represent great opportunities for the development of beekeeping; however, they have some weaknesses, represented especially by the high purchasing costs and the low preparedness of the addressed operators, and imply some possible threats for beekeeping in terms of unrealistic perception of the apiary status if they applied to some hives only and a possible adverse impact on the honeybees’ colony itself.
  • 1.1K
  • 22 Jan 2024
Topic Review
Development and Growth of Intramuscular Fat in Cattle
Besides protein, beef contains a significant amount of fat. Intramuscular fat (IMF), also referred to as marbling fat, is the white fat deposited within skeletal muscle tissue. The content of intramuscular fat in the skeletal muscle, particularly the longissimus dorsi muscle, of cattle is a critical determinant of beef quality and value. Physiologically, IMF is believed to have similar functions to other fat depots in cattle, serving as an energy reserve and providing fuel during times of increased metabolic demand or inadequate nutrient supply. As food, IMF substantially enhances the texture and flavor of the meat and the overall satisfaction of consumers.
  • 1.1K
  • 27 Feb 2024
Topic Review
SARS-CoV-2 Infection and the Testis
Many studies have suggested that SARS-CoV-2, directly or indirectly, can affect the male reproductive system, although the underlined mechanisms have not been completely elucidated yet. The main data regarding the morphological alterations in the testes emerged from autoptic studies that revealed interstitial congestion, micro thrombosis, reduction of Sertoli, Leydig, and germinal cells, infiltrated immune cells, and atrophic seminiferous tubules consistent with orchitis. Furthermore, men with severe infection exhibit sperm parameter alterations, together with abnormalities of the hypothalamic–pituitary–testis axis, strongly suggesting that SARS-CoV-2 could increase the risk of male infertility.
  • 1.1K
  • 09 Mar 2023
Topic Review
Prone Positioning and COVID-19-Related Acute Respiratory Distress
The prone position is a non-invasive technique resulting from the mobilization of the patient, where the person is lying horizontally face down. This technique has been used since the 1970s, but it has gained great relevance in the last year owing to the COVID-19 pandemic with the use of invasive mechanical ventilation.
  • 1.1K
  • 15 Nov 2021
Topic Review
Tau Aggregates in the Brain
P-tau accumulates with age in a roughly hierarchical manner, but avoids abundance in the neocortex unless co-occurring with amyloid-β. Neurodegenerative tauopathies tend to have p-tau morphologies that differ from aging and Alzheimer’s disease. Tau isoforms (3R vs. 4R) have a tendency to vary with tauopathy phenotype for unknown reasons. Selective vulnerability to p-tau and spatial-temporal disconnect from amyloid-β are evident in aging. P-tau assessment at autopsy involves tissue decomposition, which may skew microanatomical observations toward limited biological meaning. Two major consensus guidelines for interpreting p-tau at autopsy emphasize the challenges of clinicopathologic correlation, and reinforce the observation that regional neurodegeneration is a better correlate of clinical signs than is proteinopathy.
  • 1.1K
  • 22 Dec 2020
Topic Review
SARS-CoV-2 Infection and Parkinson’s Disease Overlaps
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease after Alzheimer’s disease, globally. Dopaminergic neuron degeneration in substantia nigra pars compacta and aggregation of misfolded alpha-synuclein are the PD hallmarks, accompanied by motor and non-motor symptoms. Several viruses have been linked to the appearance of a post-infection parkinsonian phenotype. Coronavirus disease 2019 (COVID-19), caused by emerging severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, has evolved from a novel pneumonia to a multifaceted syndrome with multiple clinical manifestations, among which neurological sequalae appear insidious and potentially long-lasting.
  • 1.1K
  • 13 Sep 2022
Topic Review
Cribriform Patterned Lesions in the Prostate Gland
Cribriform glandular formations are characterized by a continuous proliferation of cells with intermingled lumina and can constitute a major or minor part of physiologic (normal central zone glands), benign (clear cell cribriform hyperplasia and basal cell hyperplasia), premalignant (high-grade prostatic intraepithelial neoplasia), borderline (atypical intraductal cribriform proliferation) or clearly malignant (intraductal, acinar, ductal and basal cell carcinoma) lesions. Each displays a different clinical course and variability in clinical management and prognosis. 
  • 1.1K
  • 24 Aug 2022
Topic Review
Collagen in Airway Mechanics
Collagen is the most abundant airway extracellular matrix component and is the primary determinant of mechanical airway properties. Abnormal airway collagen deposition is associated with the pathogenesis and progression of airway disease.
  • 1.1K
  • 20 Feb 2021
Topic Review
Vermicompost and Its Derivatives against Phytopathogenic Fungi
Vermicompost, a natural product obtained after decomposition of organic matter by the activity of earthworms, contribute to valuable bioavailable nutrients and use full microbes to increase soil fertility. The application of vermicompost in agriculture has resulted in remarkable improvements in crop yield as well as in crop health and nutritive qualities; it increases the soil mineral content, which enhances the survival of valuable microbes.
  • 1.1K
  • 19 Apr 2022
Topic Review
First Ray Mobility
Several methods have been described to quantify the first ray mobility. They have certain disadvantages (great size, sophistication, or lack of validation). The objective of this work was to study the validity and reliability of a new instrument for the measurement of first ray mobility. This new device has characteristics that make it possible to be used in daily clinical practice, such as simplicity, lightness, small size and ease of use. The results obtained suggest that the new instrument is valid and reliable.
  • 1.1K
  • 23 Apr 2021
Topic Review
Urban Resilience Assessment
This paper aims to provide a better understanding of the state of knowledge on urban resilience assessment through mapping the knowledge domain and highlighting emerging trends during different periods. The objects of study were 420 papers published in the Web of Science from 1998 to 2020. Science mapping was done using VOSviewer and CiteSpace, two widely known software tools for bibliometrics analysis and scientometric visualization. The results show that research published on urban resilience assessment was very limited and fragmented until 2009, and the focus has mainly been on risk mitigation and vulnerability assessment. The intellectual base grew between 2010 and 2014, when a paradigm shift from approaches based on robustness and reliability toward more adaptation-oriented approaches occurred. Finally, the annual publication trends have grown rapidly over the past five years and there has been more emphasis on climate change adaptation and flood resilience.
  • 1.1K
  • 27 Oct 2020
Topic Review
Hydrodynamically Closed Capillary Electrophoresis
Several research disciplines require fast, reliable and highly automated determination of pharmaceutically active compounds and their enantiomers in complex biological matrices. To address some of the challenges of Capillary Electrophoresis (CE), such as low concentration sensitivity and performance degradation linked to the adsorption and interference of matrix components, CE in a hydrodynamically closed system was evaluated using the model compounds Pindolol and Propranolol. Some established validation parameters such as repeatability of injection, efficiency, resolution and sensitivity were used to assess its performance, and it was found to be broadly identical to that of hydrodynamically opened systems. While some reduction in separation efficiency was observed, this was mainly due to dispersion caused by injection and it had no impact on the ability to resolve enantiomers of model compounds even when spiked into complex biological matrix such as blood serum. An approximately 18- to 23-fold increase in concentration sensitivity due to the employment of wide bore capillaries was observed. This brings the sensitivity of CE to a level similar to that of liquid chromatography techniques. In addition to this benefit and unlike in hydrodynamically opened systems, suppression of electroosmotic flow, which is essential for hydrodynamically closed systems practically eliminates the matrix effects that are linked to protein adsorption.
  • 1.1K
  • 29 Sep 2020
Topic Review
Central Serous Chorioretinopathy (CSC)
Central serous chioretinoapthy (CSC) is a common chorioretinal disorder characterized by an idiopathic retinal serous detachment of the retina, associated with one or multiple areas of leakage originating from the choroid through a defect in the retinal pigment epithelium (RPE), the outer blood–retina barrier. Several pharmacological treatment options have been investigated for its treatment; however, there is still no significant evidence about the role of pharmacological agents for the management of CSC. To date, photodynamic therapy (PDT) remains the gold standard.
  • 1.1K
  • 29 Sep 2020
Topic Review
Killer Yeasts
Killer yeast for the Biological Control of Postharvest Fungal Crop Diseases
  • 1.1K
  • 30 Nov 2020
Topic Review
Spondylothoracic Dysostosis
Spondylothoracic dysostosis is a condition characterized by malformation of the bones of the spine and ribs.
  • 1.1K
  • 23 Dec 2020
Topic Review
FGA Gene
Fibrinogen alpha chain
  • 1.1K
  • 25 Dec 2020
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