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Topic Review
The Role of microRNAs in Neurological Pathologies
MicroRNAs (miRNAs) are small non-coding RNA molecules that are 18–25 nucleotides long (22 nucleotides on average) and involved in the transcriptional and post-transcriptional regulation of gene expression by RNA interference, which is of great interest to molecular biologists, geneticists, and biochemists. These molecules are mainly present intracellularly, but there is also an extracellular (circulating) microRNA fraction. The existence and functions of more than 2500 human miRNAs are known. 
  • 1.2K
  • 29 Aug 2023
Topic Review
Active Transport and Solute Transporters
A phospholipid membrane covers all living cells, forming an impenetrable barrier circumvented by solute transporters in the cell membrane. These proteins comprise energy-requiring systems, called active transporters, and those not requiring energy, called passive transporters. The major facilitator superfamily harbors thousands of transport proteins found in all living organisms, from bacteria to humans. Alignments of multiple amino acid sequences uncovered highly conserved sequence motifs are known to play important functional roles. One of these conserved sequences, the antiporter sequence motif or motif C, participates in the molecular mechanism of antimicrobial efflux in cancer cells and bacterial pathogens.
  • 1.2K
  • 03 Nov 2023
Topic Review
Definition and Uses of Biocompatibility in Different Fields
Using the term “biomaterial” is more logical when referring to healthcare-related materials. This includes materials used to fabricate various medical tools and devices, such as those used in implants and surgery procedures. Therefore, for a material to be referred to as a “biomaterial”, it must follow the definition assigned by the National Institute of Health Consensus Development Conference of November 1982, which states that “any substance (other than a drug) or combination of substances, synthetic or natural in origin, which can be used for any period of time, as a whole or as a part of a system that treats, augments, or replaces any tissue, organ, or function of the body”.
  • 1.2K
  • 10 Nov 2023
Topic Review
100% Renewable Electricity in Indonesia
Researchers investigate an Indonesian energy decarbonization pathway using mostly solar photovoltaics. An hourly energy balance analysis using ten years of meteorological data was performed for a hypothetical solar-dominated Indonesian electricity system for the consumption of 3, 6 and 10 megawatt-hours (MWh) per capita per year (compared with current consumption of 1 MWh per capita per year). This research showed that Indonesia’s vast solar potential combined with its vast capacity for off-river pumped hydro energy storage could readily achieve 100% renewable electricity at low cost. The levelized cost of electricity (LCOE) for a balanced solar-dominated system in Indonesia was found to be in the range of 77–102 USD/MWh.
  • 1.2K
  • 29 Jan 2024
Topic Review
Modeling of Business Intelligence Systems using Potential Determinants and Theories
Race towards industry 4.0 increases the hyper competition and puts pressure on organizations to integrate the advanced technologies. Business intelligence system (BIS) is one of the top prioritized technologies that attracted the significant attention of policy-makers and industry experts due to its ability to provide more informed and intelligent knowledge for decision-making processes. It is evident by literature that organizations and industries are prone to integrate the BIS at large scale, but more than 70% BIS projects fail to give the expected results. Hence, it is pertinent to explore the significant determinants that influence the BIS adoption and acceptance in organizations. Although previous literature did not have any comprehensive review relevant to the individual, technological, organizational, and environmental determinants. Therefore, the current study tries to narrow this gap by a systematic literature review (SLR) of 84 studies that were published during the period of 2011–2020. A total of 93 determinants are identified based on content analysis by using text mining techniques of Yoshikoder and human coding skills. The identified determinants are ranked according to their frequency of use. A theoretical framework has been developed with potential determinants and theories. The study results will enrich the recent BIS literature and improve the understanding of practitioners’ decision-making processes to leverage maximum value from the adoption of BIS.
  • 1.2K
  • 28 Oct 2020
Topic Review
X-linked Chondrodysplasia Punctata 1
X-linked chondrodysplasia punctata 1 is a disorder of cartilage and bone development that occurs almost exclusively in males. Chondrodysplasia punctata is an abnormality that appears on x-rays as spots (stippling) near the ends of bones and in cartilage.
  • 1.2K
  • 24 Dec 2020
Topic Review
Sewage Sludge as Soil Amendment
Overexploitation of resources makes the reutilization of waste a focal topic of modern society, and the question of the kind of wastes that can be used is continuously raised. Sewage sludge (SS) is derived from the wastewater treatment plants, considered important underused biomass, and can be used as a biofertilizer when properly stabilized due to the high content of inorganic matter, nitrate, and phosphorus. However, a wide range of pollutants can be present in these biosolids, limiting or prohibiting their use as biofertilizer, depending on the type and origin of industrial waste and household products. Long-term applications of these biosolids could substantially increase the concentration of contaminants, causing detrimental effects on the environment and induce hyperaccumulation or phytotoxicity in the produced crops.
  • 1.2K
  • 11 Mar 2021
Topic Review
Small-Cell Lung Cancer
Small-cell lung cancer (SCLC) is an aggressive type of cancer with an incidence of about 15% among lung cancers and has a very poor prognosis due to its rapid development of resistance to chemo- and radiotherapies. Unlike the increase in personalized approaches to the clinical care of patients with non-small-cell lung cancer (NSCLC), clinical protocols for SCLC still mainly depend on the stage of the disease, prior therapies, and lack of specific molecular support. This approach was mainly due to the idea of SCLC as a monolithic entity with common genetic features, which was strictly linked to the lack of an adequate quantity of tissue samples in this inoperable class of patients, for the lack of a clear and comprehensive biological profile presented an obstacle.
  • 1.2K
  • 22 Sep 2021
Topic Review
Uncoupling Aging from Chronological Time
Cellular life evolved from simple unicellular organisms that could replicate indefinitely, being essentially ageless. At this point, life split into two fundamentally different cell types: the immortal germline representing an unbroken lineage of cell division with no intrinsic endpoint and the mortal soma, which ages and dies. We consider aging as a process not fixed to the pace of chronological time but one that can speed up or slow down depending on the rate of intrinsic cellular clocks. Moreover germline factor reprogramming might be used to slow the rate of aging and potentially reverse it by causing the clocks to tick backward. Therefore, reprogramming may eventually lead to therapeutic strategies to treat degenerative diseases by altering aging itself, the one condition common to us all.
  • 1.2K
  • 15 Jun 2025
Topic Review
Cytokinesis in Eukaryotic Cells
The duplication cycle is the fascinating process that, starting from a cell, results in the formation of two daughter cells and it is essential for life. Cytokinesis is the final step of the cell cycle, it is a very complex phase, and is a concert of forces, remodeling, trafficking, and cell signaling. All of the steps of cell division must be properly coordinated with each other to faithfully segregate the genetic material and this task is fundamental for generating viable cells. Given the importance of this process, molecular pathways and proteins that are involved in cytokinesis are conserved from yeast to humans.
  • 1.2K
  • 20 May 2021
Topic Review
Permaculture
The solutions-based design framework of permaculture exhibits transformative potential, working to holistically integrate natural and human systems toward a more just society. The term can be defined and applied in a breadth of ways, contributing to both strengths and weaknesses for its capacity toward change. We find that permaculture casts a wide net that participants grapple with in their own work. They engaged in a negotiation process of how they associate or disassociate themselves with the term, recognizing that it can be both unifying and polarizing. Further, there was noted concern of permaculture’s failure to cite and acknowledge its rootedness in Indigenous knowledge, as well as distinguish itself from Indigenous alternatives. We contextualize these findings within the resounding call for a decolonization of modern ways of living and the science of sustainability, of which permaculture can be critically part of.
  • 1.2K
  • 25 May 2021
Topic Review
Sinonasal Squamous Cell Carcinoma
Sinonasal squamous cell carcinomas are a group of diverse tumors affecting the nasal cavity and paranasal sinuses. As a direct consequence of their rarity and heterogeneity, diagnosis is challenging, and treatment does not follow universally accepted protocols.
  • 1.2K
  • 29 Mar 2022
Topic Review
Aldehyde Dehydrogenase
Chronic hyperglycemia and hyperlipidemia hamper beta cell function, leading to glucolipotoxicity. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) detoxifies reactive aldehydes, such as methylglyoxal (MG) and 4-hydroxynonenal (4-HNE), derived from glucose and lipids, respectively. 
  • 1.2K
  • 11 Nov 2021
Topic Review
CaSR-Regulated microRNAs
The calcium sensing receptor (CaSR) is a unique G protein-coupled receptor (GPCR) activated by extracellular Ca2+ and by other physiological cations, aminoacids, and polyamines. CaSR is the main controller of the extracellular Ca2+ homeostatic system by regulating parathyroid hormone (PTH) secretion and, in turn, Ca2+ absorption and resorption. Recent advances highlight novel signaling pathways activated by CaSR signaling involving the regulation of microRNAs (miRNAs). 
  • 1.2K
  • 16 Dec 2021
Topic Review
Environmental Governance in Urban Watersheds
Cities depend on several watersheds’ ecosystems as the main source of ecosystem services for urban populations; however, this connection is not visible to decision-makers and citizens. The current governance structures do not contemplate the integrated management of the urban-rural territory by watershed; they establish few spaces for citizen participation, and limit the transparency of information.
  • 1.2K
  • 25 Jan 2022
Topic Review
Serum Albumin for Magnetic Nanoparticles Coating
Magnetic nanoparticles (MNPs) have great potential in biochemistry and medical science. In particular, iron oxide nanoparticles have demonstrated a promising effect in various biomedical applications due to their high magnetic properties, large surface area, stability, and easy functionalization. However, colloidal stability, biocompatibility, and potential toxicity of MNPs in physiological environments are crucial for their in vivo application. In this context, many research articles focused on the possible procedures for MNPs coating to improve their physic-chemical and biological properties. The fabrication strategy of biocompatible iron oxide nanoparticles using human serum albumin (HSA) is viable. HSA is mainly a transport protein with many functions in various fundamental processes. It is a highly potential candidate for nanoparticles coating and theranostics area and can provide biocompatibility, prolonged blood circulation, and possibly resolve the drug-resistance cancer problem. 
  • 1.2K
  • 10 Mar 2022
Topic Review
Valuing Ecosystem Services for Agricultural Total Factor Productivity
The United Nations (UN) Millennium Ecosystem Services Assessment (MA) defines ecosystem services as the benefits people obtain from ecosystems. These include provisioning services such as food and water; regulating services such as regulation of floods, drought, land degradation, and disease; supporting services such as soil formation and nutrient cycling; and cultural services such as recreational, spiritual, religious, and other nonmaterial benefits. Agriculture and ecosystem services are closely intertwined, giving rise to the term “agro-ecosystem” to denote the complex relationships between agricultural production and surrounding ecosystems. Total factor productivity (TFP), also termed multifactor productivity (MFP), relates total output quantity to total input quantity to provide an aggregate measure of economic performance. Total Factor Productivity (TFP) provides a general framework for modeling agricultural production and constructing aggregate index measures to allow for the multilateral assessment of agricultural productivity.
  • 1.2K
  • 11 Apr 2022
Topic Review
ML-Based Classification Algorithms for SCIM
In industry, electric motors such as the squirrel cage induction motor (SCIM) generate motive power and are particularly popular due to their low acquisition cost, strength, and robustness. Along with these benefits, they have minimal maintenance costs and can run for extended periods before requiring repair and/or maintenance. Early fault detection in SCIMs, especially at low-load conditions, further helps minimize maintenance costs and mitigate abrupt equipment failure when loading is increased. 
  • 1.2K
  • 28 Jun 2022
Topic Review
Formation of Carcinogens in Processed Meat
Meat is a rich source of various nutrients. However, it needs processing before consumption, what in turn generates formation of carcinogenic compounds, i.a., polycyclic aromatic hydrocarbons (PAH), nitrosamines (NOCs), and the most mutagenic heterocyclic aromatic amines (HAAs). It was widely found that many factors affect the content of carcinogens in processed meat.
  • 1.2K
  • 01 Aug 2022
Topic Review
Thermodynamic Aspects Governing Shape Memory Elastomers
Shape memory elastomers have revolutionised the world since their introduction in the 20th century. The ability to tailor chemical structures to produce a family of materials in wide-ranging forms with versatile properties has propelled them to be ubiquitous.
  • 1.2K
  • 02 Sep 2022
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