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Topic Review
Atypical Antipsychotics and Metabolic Syndrome
Atypical antipsychotics (AAPs) are commonly prescribed medications to treat schizophrenia, bipolar disorders and other psychotic disorders. However, they might cause metabolic syndrome (MetS) in terms of weight gain, dyslipidemia, type 2 diabetes (T2D), and high blood pressure, which are responsible for reduced life expectancy and poor adherence. Importantly, there is clear evidence that early metabolic disturbances can precede weight gain, even if the latter still remains the hallmark of AAPs use. In fact, AAPs interfere profoundly with glucose and lipid homeostasis acting mostly on hypothalamus, liver, pancreatic β-cells, adipose tissue, and skeletal muscle. Their actions on hypothalamic centers via dopamine, serotonin, acetylcholine, and histamine receptors affect neuropeptides and 5′AMP-activated protein kinase (AMPK) activity, thus producing a supraphysiological sympathetic outflow augmenting levels of glucagon and hepatic glucose production. In addition, altered insulin secretion, dyslipidemia, fat deposition in the liver and adipose tissues, and insulin resistance become aggravating factors for MetS. In clinical practice, among AAPs, olanzapine and clozapine are associated with the highest risk of MetS, whereas quetiapine, risperidone, asenapine and amisulpride cause moderate alterations. The new AAPs such as ziprasidone, lurasidone and the partial agonist aripiprazole seem more tolerable on the metabolic profile. However, these aspects must be considered together with the differences among AAPs in terms of their efficacy, where clozapine still remains the most effective. Intriguingly, there seems to be a correlation between AAP’s higher clinical efficacy and increase risk of metabolic alterations. Finally, a multidisciplinary approach combining psychoeducation and therapeutic drug monitoring (TDM) is proposed as a first-line strategy to avoid the MetS. In addition, pharmacological treatments are discussed as well.
  • 1.2K
  • 23 Mar 2021
Topic Review
In situ DIC for AM
A critical review is presented of in situ full-field measurements provided by digital image correlation (DIC) for inspecting and enhancing additive manufacturing (AM) processes. The principle of DIC is firstly recalled and its applicability during different AM processes systematically addressed. Relevant customisations of DIC in AM processes are highlighted regarding optical system, lighting and speckled pattern procedures. A perspective is given in view of the impact of in situ monitoring regarding AM processes based on target subjects concerning defect characterisation, evaluation of residual stresses, geometric distortions, strain measurements, numerical modelling validation and material characterisation. Finally, a case study on in situ measurements with DIC for wire and arc additive manufacturing (WAAM) is presented emphasizing opportunities, challenges and solutions.
  • 1.2K
  • 21 Apr 2021
Topic Review
Journal Inorganics
Inorganics (ISSN 2304-6740; CODEN: INORCW) is an international, scientific, peer-reviewed, open access journal of inorganic chemistry published monthly online by MDPI.  It has been indexed in Chemical Abstracts, Scopus, and Web of Science.
  • 1.2K
  • 26 Sep 2021
Topic Review
EEF2K
Eukaryotic elongation factor 2 kinase (eEF2K or Ca2+/calmodulin-dependent protein kinase, CAMKIII) is a new member of an atypical α-kinase family different from conventional protein kinases that is now considered as a potential target for the treatment of cancer. 
  • 1.2K
  • 22 Apr 2021
Topic Review
Bioenergy Supply Chain Resilience
Learning about the new concept of bioenergy supply chain resilience is necessary to have continues development in renewable energy industries. In this regard, realizing the relevant research gap(s), suggestion(s), future directions, etc. play the undeniable roles in optimizing the quality and quantity of managerial and non-managerial performance in the relevant fields.
  • 1.2K
  • 30 Jun 2021
Topic Review
Peroxidase Mimetic Nanozymes in Cancer
Peroxidase (POD) mimetic nanozymes converts endogenous H2O2 to water (H2O) and reactive oxygen species (ROS) in a hypoxic tumor microenvironment is a fascinating approach.
  • 1.2K
  • 31 Aug 2021
Topic Review
Osteopontin Levels in Human Milk
Breast milk is a unique source of nutrients that is physiologically tailored to meet the changing needs of the infant during the first six or more months of life. In addition to providing optimal energy and nutrition, breast milk optimally manages the transition of the neonate to extrauterine life through a combination of bioactive proteins, lipids, oligosaccharides, and immunomodulatory components.
  • 1.2K
  • 01 Dec 2021
Topic Review
Design of Liquid-Crystalline Elastomeric Fluorescent Force Sensors
Liquid single crystal elastomers (LSCEs) containing carbazole fluorogenic components alter their luminescence when they are stretched along the director direction. The differential luminescent behavior arises from the distinct interaction between the carbazole fluorophores and their local environment before and after the application of the mechanical input. Indeed, the uniaxial deformation of the material, along its anisotropic direction, forces a closer mesogen–fluorophore interaction, which leads to the quenching of the carbazole luminescence. Importantly, this intermolecular interaction is intimately related to the intrinsic order present in the LSCE. As a result, the amount of light emitted by the material in the form of fluorescence diminishes upon deformation. Thus, the application of mechanical stimuli to liquid-crystalline elastomers furnishes to two interconvertible states for the system with distinct optical properties (with either different emission color or fluorescence intensity). The initial state of the material is completely restored once the applied force is removed. In this way, this kind of macromolecular system can transduce mechanical events into detectable and processable optical signals, thus, having great potential as optical force sensors. In this context, the realization of the distinct structural factors that govern the interactions established between the mesogenic and fluorogenic units at the supramolecular level upon deformation is essential for the development of efficient LSCE-based force sensors. In fact, not only the density of carbazole units and their connection to the main polymer backbone, but also the presence of long range molecular order in the system and the type of mesophase exhibited by the LSCE are key factors for the conception of efficient force sensors based on these self-organized polymer networks.
  • 1.2K
  • 20 Dec 2021
Topic Review
RNA Structure and RNA–RNA Interactions
Complex RNA–RNA interactions are increasingly known to play key roles in numerous biological processes from gene expression control to ribonucleoprotein granule formation. By contrast, the nature of these interactions and characteristics of their interfaces, especially those that involve partially or wholly structured RNAs, remain elusive. This entry describes different modalities of RNA–RNA interactions with an emphasis on those that depend on secondary, tertiary, or quaternary structure, and highlight a two-way relationship between RNA structure and interactions.
  • 1.2K
  • 12 Jan 2022
Topic Review
Microalgal Biomass-polymer Blends
Since the invention of plastics and the development of mass production, plastic demand has increased exponentially annually. Despite their easy processability and economically viable merits, the management of plastic waste has always been a contentious issue due to their non-biodegradable properties, resulting in significant damage to the environment. Although the share of bioplastics in the plastic market remains low, eco-friendly and abundant amounts of bioplastics are considered to be sufficient alternatives to replace preexisting plastics. Chlorella and Spirulina are the primary sources for bioplastics from microalgae due to their easy processability. Although the replacement of artificially synthesized existing plastics with 100% microalgal bioplastics could be ideal when it comes to environmentally friendly plastics, the physical and mechanical properties, such as tensile strength, glass transition temperature, and elongation at break, of 100% bioplastics are inferior to those of commercially available plastics. Another option to tackle these issues is to blend microalgae with polymers, namely microalgal biomass-polymer composites. These blended composites are hybrid-type plastics that have both properties of each component. The general properties of these blends depend on the ratio between the amount of microalgae biomass and those of the polymer. In general, a higher polymer content in biomass-polymer composites results in better performance, especially in terms of tensile strength and elongation at break. The required level of biomass contents in authorized bioplastics depends on individual national regulations. Korean government suggest that the percent of biomass in biomass-polymer composites should be over 30 wt% to be considered as an eco-friendly bioplastic. According to our investigation, the contents of microalgae in most composites remain less than 30 wt%, implying that further studies to increase the proportion of microalgae in the composites should be conducted to boost the commercialization of microalgae-based biocomposites.
  • 1.2K
  • 24 Jan 2022
Topic Review
Serbian Traditional Goat Cheese
Serbian goat cheese, quality relies on the use of milk collected from animals reared in organic farming systems. This organic milk contains more dry matter and nutrients; hence, its usage leads to the obtention of dairy products with exceptional nutritional and functional properties. Goat’s milk harbors a specific taste, and it is known to cause less allergic reactions than cow’s milk. The absence of adverse reactions is due to its low or minimal level of the αs1-casein fraction. Goat’s milk is generally more easily digested (the fat globules are smaller) and represents a good source of calcium, phosphorus and vitamins.
  • 1.2K
  • 26 Jan 2022
Topic Review
SARS-CoV-2 Intermittent Virulence
Pandemic viruses do not always show decreased virulence. Instead, it appears there is an evolutionary equilibrium between transmissibility and virulence. It can be termed this concept “intermittent virulence”. There is a high possibility that new virulent variants will arise in the near future, although it is improbable that SARS-CoV-2’s virulence will be the same as was seen during the alpha or delta waves, due to the fact that the human population has reached a sufficient level of herd immunity through natural infection or due to the vaccination programs. The most recent global mortality data raised the question of whether this pandemic is really over. Furthermore, it is uncertain when the endemic phase will begin. Darwin’s words: “the survival of the fittest” are still valid, and the virus will continue killing nonvaccinated old people, vaccinated old people, and those with comorbidities.
  • 1.2K
  • 08 Aug 2022
Topic Review
Ctty (Command)
This article presents a list of commands used by DOS operating systems, especially as used on x86-based IBM PC compatibles (PCs). Other DOS operating systems are not part of the scope of this list. In DOS, many standard system commands were provided for common tasks such as listing files on a disk or moving files. Some commands were built into the command interpreter, others existed as external commands on disk. Over the several generations of DOS, commands were added for the additional functions of the operating system. In the current Microsoft Windows operating system, a text-mode command prompt window, cmd.exe, can still be used.
  • 1.2K
  • 29 Sep 2022
Topic Review
Caregiver Burden
Caregiver burden is the stress which is perceived by caregivers due to the home care situation. The subjective burden is considered to be one of the most important predictors of negative outcomes from the home care situation.
  • 1.2K
  • 10 Oct 2022
Topic Review
Trinity: Souls of Zill O’ll
Trinity: Souls of Zill O’ll, known in Japan as Trinity: Zill O'll Zero (トリニティ ジルオール ゼロ, Toriniti Jiru Ōru Zero), is an action fantasy role-playing video game developed by Omega Force, set in part of the Zill O'll series, which had previously appeared on PlayStation, PlayStation 2 and PlayStation Portable. The game is a prequel, taking place five years before the events in Zill O'll. Downloadable content that included additional quests and alternate costumes for the main party was released exclusively in Japan.
  • 1.2K
  • 27 Oct 2022
Topic Review
Hoffstetterius
Hoffstetterius is an extinct genus of toxodontid notoungulate mammal, belonging to the subfamily Toxodontinae whose remains were discovered in the Middle to Late Miocene (Mayoan to Montehermosan) Mauri Formation in the La Paz Department in Bolivia. The only described species is the type Hoffstetterius imperator.
  • 1.2K
  • 04 Nov 2022
Topic Review
Blockchain and Smart Contracts
With the fast development of blockchain technology in the latest years, its application in scenarios that require privacy, such as health area, have become encouraged and widely discussed. An architecture to ensure the privacy of health-related data, which are stored and shared within a blockchain network in a decentralized manner, through the use of encryption with the Rivest-Shamir-Adleman (RSA), Elliptic Curve Cryptography (ECC), and Advanced Encryption Standard (AES) algorithms.
  • 1.2K
  • 11 Nov 2022
Topic Review
Tutor
A tutor, formally also called an academic tutor, is a person who provides assistance or tutelage to one or more people on certain subject areas or skills. The tutor spends a few hours on a daily, weekly, or monthly basis to transfer their expertise on the topic or skill to the student. Tutoring can take place in different settings,
  • 1.2K
  • 23 Nov 2022
Topic Review
Matrix Metallopeptidase
Matrix metallopeptidases (MMPs), also known as matrix metalloproteinases or matrixins, are metalloproteinases that are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily. Collectively, these enzymes are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense. They were first described in vertebrates (1962), including humans, but have since been found in invertebrates and plants. They are distinguished from other endopeptidases by their dependence on metal ions as cofactors, their ability to degrade extracellular matrix, and their specific evolutionary DNA sequence. Recently matrix metalloproteinases have been proposed as markers of many pathological conditions for their ability to degrade extracellular matrix components and remodel tissues. Herein, MMPs have been reported as one of the main factors of cancer progression and metastasis formation. This led to the emerging research field in biosensors development for the detection of such enzymes.
  • 1.2K
  • 23 Nov 2022
Topic Review
Wall-Associated Kinase
Wall-Associated Kinase (WAKs) are one of many classes of plant proteins known to serve as a medium between the extracellular matrix (ECM) and cytoplasm of cell walls. They are serine-threonine kinases that contain epidermal growth factor (EGF) repeats, a cytoplasmic kinase and are located in the cell walls. They provide a linkage between the inner and outer surroundings of cell walls. WAKs are under a group of receptor-like kinases (RLK) that are actively involved in sensory and signal transduction pathways especially in response to foreign attacks by pathogens and in cell development. On the other hand, pectins are an abundant group of complex carbohydrates present in the primary cell wall that play roles in cell growth and development, protection, plant structure and water holding capacity. Pectins are rich in galacturonic acids (OGs) and present in the middle lamellae in plant tissues where they provide strength, flexibility and adhesion between plant cells. Commercially and within the food industry, they are used as gels and stabilizers for desserts and juices. The role of WAKs in cell walls as pectin receptors is vital to a variety of functions involved with cell differentiation, form and host-pathogen relations.
  • 1.2K
  • 25 Nov 2022
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