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Topic Review
Barrier Membrane in Regenerative Therapy
Guided bone and tissue regeneration remains an integral treatment modality to regenerate bone surrounding teeth and dental implants. Barrier membranes have been developed and produced commercially to allow space for bone regeneration and prevent the migration of unwanted cells. Ideal membrane properties, including biocompatibility, sufficient structural integrity and suitable shelf life with easy clinical application, are important to ensure good clinical regenerative outcomes. Membranes have various types, and their clinical application depends on the origin, material, structure and properties. 
  • 1.2K
  • 11 May 2022
Topic Review
Constructionism (Learning Theory)
Constructionist learning is the creation by learners of mental models to understand the world around them. Constructionism advocates student-centered, discovery learning where students use what they already know, to acquire more knowledge. Students learn through participation in project-based learning where they make connections between different ideas and areas of knowledge facilitated by the teacher through coaching rather than using lectures or step-by-step guidance. Further, constructionism holds that learning can happen most effectively when people are active in making tangible objects in the real world. In this sense, constructionism is connected with experiential learning and builds on Jean Piaget's epistemological theory of constructivism. Seymour Papert defined constructionism in a proposal to the National Science Foundation titled Constructionism: A New Opportunity for Elementary Science Education as follows: Some scholars have tried to describe constructionism as a "learning-by-making" formula but, as Seymour Papert and Idit Harel say at the start of Situating Constructionism, it should be considered "much richer and more multifaceted, and very much deeper in its implications than could be conveyed by any such formula." Papert's ideas became well known through the publication of his seminal book Mindstorms: Children, Computers, and Powerful Ideas (Basic Books, 1980). Papert described children creating programs in the Logo educational programming language. He likened their learning to living in a "mathland" where learning mathematical ideas is as natural as learning French while living in France.
  • 1.2K
  • 11 Oct 2022
Topic Review
J-Proteins in the Chloroplast
The J-proteins, also called DNAJ-proteins or heat shock protein 40 (HSP40), are one of the famous molecular chaperones. J-proteins, HSP70s and other chaperones work together as constitute ubiquitous types of molecular chaperone complex, which function in a wide variety of physiological processes. J-proteins are widely distributed in major cellular compartments. 
  • 1.2K
  • 13 Oct 2022
Topic Review
Deep Anomaly Detection for In-Vehicle Monitoring
Deep learning approaches to the detection of visual data instances that markedly digress from regular sequences have been mostly focusing on outdoor video-surveillance scenarios, mainly regarding abnormal behaviour and suspicious or abandoned object detection. However, with the increasing importance of public and shared transportation for urban mobility, it becomes imperative to provide autonomous intelligent systems capable of detecting abnormal behaviour that threatens passenger safety. In-vehicle monitoring becomes particularly relevant for Shared Autonomous Vehicles, which do not have a driver responsible for assuring the well-being and safety of passengers; such vehicles must be accompanied by reliable autonomous in-vehicle surveillance systems.
  • 1.2K
  • 17 Oct 2022
Topic Review
Use Case Points
Use Case Points (UCP) is a software estimation technique used to forecast the software size for software development projects. UCP is used when the Unified Modeling Language (UML) and Rational Unified Process (RUP) methodologies are being used for the software design and development. The concept of UCP is based on the requirements for the system being written using use cases, which is part of the UML set of modeling techniques. The software size (UCP) is calculated based on elements of the system use cases with factoring to account for technical and environmental considerations. The UCP for a project can then be used to calculate the estimated effort for a project.
  • 1.2K
  • 18 Oct 2022
Topic Review
Pervasive Developmental Disorder
The diagnostic category pervasive developmental disorders (PDD), as opposed to specific developmental disorders (SDD), is a group of disorders characterized by delays in the development of multiple basic functions including socialization and communication. The pervasive developmental disorders include autism, Asperger syndrome, pervasive developmental disorder not otherwise specified (PDD-NOS, i.e., all autism spectrum disorders [ASD]), childhood disintegrative disorder (CDD), overactive disorder associated with mental retardation and stereotyped movements, and Rett syndrome. The first four of these disorders are commonly called the autism spectrum disorders; the last disorder is much rarer, and is sometimes placed in the autism spectrum and sometimes not. The terminology PDD and ASD is often used interchangeably and varies depending on location. The two have overlapping definitions but are defined differently by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-V), and the International Classification of Diseases, 10th edition (ICD-10). DSM-V removed PDD as a diagnosis and replaced it with ASD and the relative severity of the condition. ICD-10 on the other hand labels ASD as a pervasive developmental disorder with the subtypes previously mentioned. The onset of pervasive developmental disorders occurs during infancy, but the condition is usually not identified until the child is around three years old. Parents may begin to question the health of their child when developmental milestones are not met, including age appropriate motor movement and speech production. There is a division among doctors on the use of the term PDD. Many use the term PDD as a short way of saying PDD-NOS (pervasive developmental disorder not otherwise specified). Others use the general category label of PDD because they are hesitant to diagnose very young children with a specific type of PDD, such as autism. Both approaches contribute to confusion about the term, because the term PDD actually refers to a category of disorders and is not a diagnostic label.
  • 1.2K
  • 27 Oct 2022
Topic Review
Aqueous Prostaglandin Eye Drop Formulations
Glaucoma is one of the leading causes of irreversible blindness worldwide. It is characterized by progressive optic neuropathy in association with damage to the optic nerve head and, subsequently, visual loss if it is left untreated. Among the drug classes used for the long-term treatment of open-angle glaucoma, prostaglandin analogues (PGAs) are the first-line treatment and are available as marketed eye drop formulations for intraocular pressure (IOP) reduction by increasing the trabecular and uveoscleral outflow. PGAs have low aqueous solubility and are very unstable (i.e., hydrolysis) in aqueous solutions, which may hamper their ocular bioavailability and decrease their chemical stability. Additionally, treatment with PGA in conventional eye drops is associated with adverse effects, such as conjunctival hyperemia and trichiasis. It has been a very challenging for formulation scientists to develop stable aqueous eye drop formulations that increase the PGAs’ solubility and enhance their therapeutic efficacy while simultaneously lowering their ocular side effects.
  • 1.2K
  • 28 Oct 2022
Topic Review
Late Glacial Interstadial
The Late Glacial Interstadial (LGI) c.14,670 to c.12,890 BP represents the first pronounced warming since the end of the Last Glacial Maximum (LGM). Human populations, which had previously forced into refuge areas, gradually begin to repopulate the Northern Hemisphere's Eurasian landmass and eventually populate North America via Beringia for the first time. Evidence for its occurrence stems from two main types of analysis. The first is the use of oxygen isotope stages (OIS) gathered from stratified deep-sea sediment cores. Samples are gathered and measured for change in isotope levels to determine temperature fluctuation for given periods of time. The second is a proxy measurement, the observation of certain reappearing fauna and flora fossils that can survive only in temperate climates, thus indicating warming trends for a given geographic area. Archaeological evidence of settlement and resettlement in certain areas by humans also serve as proxy measurements. Towards the end of OIS 2 in which the Last Glacial Maximum occurs, the deep-sea sediment cores indicate a gradually warming climate, and the reappearance of certain warm-weather flora and fauna remains throughout the Northern Hemisphere correlate with that trend. The Late Glacial Interstadial was followed by a severe decline in temperatures during the Younger Dryas from c.12,890 to c.11,650 BP.
  • 1.2K
  • 14 Nov 2022
Topic Review
Multiple Input Multiple Output Systems
Multiple Input Multiple Output (MIMO) systems have been gaining significant attention from the research community due to their potential to improve data rates.
  • 1.2K
  • 17 Nov 2022
Topic Review
Myron Ebell
Myron Ebell is a climate change denier who serves as the Director of Global Warming and International Environmental Policy at the Competitive Enterprise Institute (CEI), a libertarian advocacy group based in Washington, D.C. He is also the chairman of the Cooler Heads Coalition, a loose coalition formed in 1997 which presents itself as "focused on dispelling the myths of global warming by exposing flawed economic, scientific, and risk analysis". In September 2016, he was appointed by then Republican presidential candidate Donald Trump to lead his transition team for the United States Environmental Protection Agency (EPA). In these organizations, Ebell has been central in promoting climate change denial, distributing his views to the media and politicians. Ebell, who is not a scientist, has been described as a climate change skeptic, a climate contrarian and a climate change denier. Ebell claims that he advocates "for sensible energy policies that benefit everyone. Instead of policies that simply reacts [sic] to alarmism."
  • 1.2K
  • 21 Nov 2022
Topic Review
Soil in Dogu'a Tembien
The soils of the Dogu’a Tembien woreda (district) in Tigray (Ethiopia) reflect its longstanding agricultural history, highly seasonal rainfall regime, relatively low temperatures, an extremely great variety in lithology (with dominance of basalts and limestone) and steep slopes. Outstanding features in the soilscape are the fertile highland Vertisols and Phaeozems in forests.
  • 1.2K
  • 23 Nov 2022
Topic Review
Natural Products against DDP-Induced Apoptosis
Cisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Noncoding RNAs (ncRNAs), a class of epigenetic processes, are molecules that regulate gene expression under physiological and pathological conditions. MicroRNAs (miRNAs) are the most characterized class of ncRNAs and are engaged in many cellular processes. DDP-induced nephrotoxicity can present in a several ways, but the most common and serious presentation is acute kidney injury (AKI), which occurs in 20–30% of patients.
  • 1.2K
  • 25 Nov 2022
Topic Review
Mobile Agents in the Medical Care Domain
A mobile agent is a software application that moves naturally among hosts in a uniform and non-uniform environment; it starts with one host and then moves onto the next in order to divide data between clients. The mobile paradigm is utilized in a wide assortment of medical care applications such as the medical information of a patient, the recovery of clinical information, the incorporation of information pertaining to their wellbeing, dynamic help, telemedicine, obtaining clinical data, patient administration, and so on. The accompanying security issues have grown in tandem with the complexity and improvements in mobile agent technologies. As mobile agents work in an insecure environment, their security is a top priority when communicating and exchanging data and information. Data integrity, data confidentiality and authentication, on-repudiation, denial of service, and access control, are all key security concerns with mobile agent migration.
  • 1.2K
  • 01 Dec 2022
Topic Review
Blockchain Overview
Blockchain technology integrates a hash algorithm, digital signature, point-to-point transmission, consensus mechanism, and other existing technologies, so it is characterized by anti-fraud, traceability, security, and trust. Supply chain refers to the network chain structure formed by upstream and downstream enterprises involved in the activities of providing products or services to end users in the process of production and circulation. 
  • 1.2K
  • 01 Dec 2022
Topic Review
ACE2 Signaling Pathway and Processing during COVID-19 Infection
ACE2 (angiotensin-converting enzyme) can be described as an enzyme, a transporter, and through its role as a receptor.
  • 1.2K
  • 13 Jan 2023
Topic Review
Logistics Innovations in Response to the COVID-19 Pandemic
The disruptions caused by the COVID-19 pandemic have forced many companies in the logistics sector to innovate, or even transform their business and underlying processes. Closing borders, limited supply and manpower, and continuous changes in regulations challenged many logistics firms to innovate. 
  • 1.2K
  • 17 Feb 2023
Topic Review
Influencing Factors of Heat Generation
Rubber composites are extensively used in industrial applications for their exceptional elasticity. The fatigue temperature rise occurs during operation, resulting in a serious decline in performance. Reducing heat generation of the composites during cyclic loading will help to avoid substantial overheating that most likely results in the degradation of materials. Influencing factors of heat generation are highlighted, including the Payne effect, Mullins effect, interface interaction, crosslink density, bond rubber content, and fillers. 
  • 1.2K
  • 20 Feb 2023
Topic Review
Cardiac Damage in Chagas Disease
Chagas disease is a complex zoonosis. Its natural history involves the interaction of transmitting arthropods with wild, peridomestic, and domestic mammals, and it has a great diversity of transmission forms. In a vertebrate host, the disease has two clinical phases: an acute phase and a chronic one; the former evolves without demonstrated pathology and can last 10–20 years. After this phase, some patients progress to the chronic symptomatic phase, in which they develop mainly cardiac lesions. The lesions in this cardiomyopathy involve several cardiac tissues, mainly the myocardium, and in severe cases, the endocardium pericardium; this can cause pleural effusion, which may evolve into sudden death, which is more frequent in cases with dilated heart disease and severe heart failure.
  • 1.2K
  • 02 Mar 2023
Topic Review
Internet-of-Things-Based Smart Monitoring System
With technological advancements, smart health monitoring systems are gaining growing importance and popularity. Today, business trends are changing from physical infrastructure to online services. With the restrictions imposed during COVID-19, medical services have been changed. The concepts of smart homes, smart appliances, and smart medical systems have gained popularity. The Internet of Things (IoT) has revolutionized communication and data collection by incorporating smart sensors for data collection from diverse sources.
  • 1.2K
  • 29 May 2023
Topic Review Video
Gene Therapies for Epilepsy
Epilepsy is a complex neurological disorder affecting millions worldwide, with a substantial number of patients facing drug-resistant epilepsy. Conventional antiseizure medications (ASMs) have been the cornerstone of epilepsy management, providing significant relief to a large number of patients In the context of epilepsy, gene therapy holds the potential to address the underlying genetic abnormalities that give rise to seizure disorders. By targeting specific genes associated with epilepsy, gene therapy aims to restore normal cellular function and inhibit seizure generation, providing a promising avenue for the development of novel and more targeted epilepsy treatments.
  • 1.2K
  • 26 Sep 2023
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