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Topic Review
Lipoxygenases and Arachidonic Acid in Glioblastoma Multiforme
Glioblastoma multiforme is a brain tumor with a very unfavorable prognosis, where the vast majority of patients do not survive a year after diagnosis. Arachidonic acid ARA C20:4n-6 in humans is not synthesized de novo but from linoleic acid C18:2n-6 in the polyunsaturated fatty acid (PUFA) biosynthesis pathway. In addition to the cyclooxygenases (COX) pathway, PUFA can be transformed with lipoxygenases (LOX). These enzymes exhibit dioxygenase activity, catalyzing the insertion of a hydroperoxyl group into a PUFA, most commonly ARA 20:4n-6.
  • 1.2K
  • 10 Feb 2023
Topic Review
Electrochemical Aptasensors for Detection of Neurodegenerative Diseases Biomarkers
Neurodegenerative diseases (NDs) are becoming a major global health problem. They constitute an incurable diverse group of disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous system. There is an enormous unmet demand worldwide for methods for the early detection of ND biomarkers. Among the various approaches reported so far, biosensors are powerful analytical implements that have been applied to detect biomarkers of NDs. Electrochemical aptasensors have been at the forefront of this development not only thanks to their low cost and simple design but also due to advances in nanomaterials modifying the surface of the transducers involved.
  • 1.2K
  • 13 Feb 2023
Topic Review
Fluoroquinolones Used in Therapy
Antibacterial fluoroquinolones (FQs) are frequently used in treating infections. However, the value of FQs is debatable due to their association with severe adverse effects (AEs). The Food and Drug Administration (FDA) issued safety warnings concerning their side-effects in 2008, followed by the European Medicine Agency (EMA) and regulatory authorities from other countries.
  • 1.2K
  • 17 Mar 2023
Topic Review
Obesity and Wound Healing
Chronic wounds represent nowadays a major challenge for both clinicians and researchers in the regenerative setting. Obesity represents one of the major comorbidities in patients affected by chronic ulcers and therefore diverse studies aimed at assessing possible links between these two morbid conditions are currently ongoing. In particular, adipose tissue has recently been described as having metabolic and endocrine functions rather than serving as a mere fat storage deposit. In this setting, adipose-derived stem cells, a peculiar subset of mesenchymal stromal/stem cells (MSCs) located in adipose tissue, have been demonstrated to possess regenerative and immunological functions with a key role in regulating both adipocyte function and skin regeneration.
  • 1.2K
  • 24 Mar 2023
Topic Review
A Smart City Platform Based on Digital Twin
Monitoring and decision support within a smart city platform entails the utilization of technological tools to gather and analyse data from diverse sensors and information sources dispersed across the urban environment. The data gathered encompass several aspects, such as traffic patterns, air quality measurements, noise pollution levels, energy usage, and other related factors. The term digital twin (DT) has become very popular in recent years. DT is a critical technology that enables digital transformation in the industry to digitize physical assets. Digital representation of physical assets can allow opportunities to develop new business models or acquire broad ideas. Today, there is hardware that uses Augmented Reality (AR) technology that enables the adoption of new ways of human–machine interaction and information visualization in various use cases.
  • 1.2K
  • 11 Oct 2023
Topic Review
EIS and IRT for Evaluating Lithium Batteries
During lithium-ion batteries (LIBs) ordinary operation, safety concerns are related to the possibility of overheating and, in extreme cases, to the risk of fire or explosion. Hence, it is crucial to implement proper safety measures in the design, manufacturing, and in the second life of LIBs, through a proper design of thermal management systems or short circuit protection. Regarding their durability, LIBs can face degradation over time due to repeated charge–discharge cycles. This might affect their charge retention capacity and their lifespan. Hence, ongoing research is being conducted to improve these aspects through advancements in materials, electrode design, and battery management systems. LIB development focuses on improving their efficiency by using environmentally friendly materials. The non-destructive testing (NDT) of LIBs can be classified into several categories. The commonly accepted taxonomy is based on their underlying physical principle of measurement, e.g., electromagnetic waves, thermal waves, mechanical waves, etc.
  • 1.2K
  • 16 Nov 2023
Topic Review
Artificial Intelligence for Smart Grids in Smart Manufacturing
Smart manufacturing is not only beneficial to optimize product manufacturing processes with minimum costs, but also conducts product life cycle management to reduce energy consumption. Sustainable and smart manufacturing involves improving the efficiency and environmental sustainability of various manufacturing operations such as resource allocation, data collecting and monitoring, and process control. 
  • 1.2K
  • 04 Dec 2023
Topic Review
Nanoparticle-Based Treatment Approaches for Skin Cancer
Nanoparticles (NPs)—defined as particles with one dimension < 100 nm—have emerged as promising drug delivery systems for such antineoplastic drugs, owing to their enhanced targeting, permeability, and retention. NPs have further shown great promise in overcoming multidrug resistance and cytotoxicity barriers intrinsic to current targeted treatment modalities, with considerable variance attributed to their classification.
  • 1.2K
  • 02 Apr 2024
Topic Review
Neuromuscular Junction as an Entity of Nerve-Muscle Communication
One of the crucial systems severely affected in several neuromuscular diseases is the loss of effective connection between muscle and nerve, leading to a pathological non-communication between the two tissues. The neuromuscular junction (NMJ) represents the critical region at the level of which muscle and nerve communicate. Defects in signal transmission between terminal nerve endings and muscle membrane is a common feature of several physio-pathologic conditions including aging and Amyotrophic Lateral Sclerosis (ALS). Nevertheless, controversy exists on whether pathological events beginning at the NMJ precede or follow loss of motor units.
  • 1.2K
  • 31 Mar 2022
Topic Review
Thyroid Cancer from the Tumor-Suppressor Genes Perspective
Thyroid cancer is the most frequent endocrine malignancy and accounts for approximately 1% of all diagnosed cancers. A variety of mechanisms are involved in the transformation of a normal tissue into a malignant one. Loss of tumor-suppressor gene (TSG) function is one of these mechanisms. By identifying alterations in these genes and their protein products, people can understand the thyroid cancer-related gene changes for the development of diagnostic, prognostic, and therapeutic strategies for this cancer.
  • 1.2K
  • 31 May 2022
Topic Review
Pheochromocytomas and Paragangliomas
Pheochromocytomas and paragangliomas are rare catecholamine producing tumors. Early diagnosis is crucial to avoid life threatning complications. Surgical resection of the tumor is the only curative option. Preoperative management consists of alpha blockade and correction of intravascular volume.
  • 1.2K
  • 05 Nov 2020
Topic Review
Fosfomycin as Partner Drug
Fosfomycin is being increasingly prescribed intravenously for multidrug‐resistant bacterial infections, usually administered as a partner drug. The knowledge of fosfomycin pharmacodynamicinteractions (synergistic, additive, indifferent and antagonistic effect) is fundamental for a properclinical management of severe bacterial infections. We performed a systematic review to point outfosfomycin’s synergistic properties.
  • 1.2K
  • 02 Nov 2020
Topic Review
Safe Reuse of Wastewater Irrigation
Due to climate change, two-thirds of mankind will face water scarcity by 2025, while by 2050, global food production must increase by at least 50% to feed 9 billion people. To overcome water scarcity, 15 million m3/day of untreated wastewater is used globally for crop irrigation, polluting the soil with pathogens, heavy metals and excess salts. Since 10% of the global population consumes food from crops irrigated with wastewater, pathogens transmitted through the food chain cause diseases especially in young children and women. We emphasize that irrigation offers real perspectives for large-scale recovery of wastewater, helping to reduce the deficit and conserve water resources, and increasing food safety, with the express mention that investments must be made in wastewater treatment plants and wastewater must be properly treated before recovery, to limit the risks on human health and the environment. 
  • 1.2K
  • 23 Nov 2020
Topic Review
Evolution of Non-Polio Enteroviruses
Enteroviruses (EVs) are positive-sense RNA viruses, with over 50,000 nucleotide sequences publicly available as of October 9th, 2020. While most human infections are typically associated with mild respiratory symptoms, several different EV types have also been associated with severe human disease, especially acute flaccid paralysis (AFP), particularly with endemic members of the EV-B species and two pandemic types—EV-A71 and EV-D68—that appear to be responsible for recent widespread outbreaks. Phylogenetic analysis of the EV genus shows the evolutionary relatedness of different EV types. 
  • 1.2K
  • 16 Dec 2020
Topic Review
Liquid Biopsies on Breast Cancer
Breast cancer is the most common cancer among women worldwide. In the clinic today, imaging techniques like mammography and tissue biopsies are used to diagnose breast cancer. Even though these methods are important in primary diagnosis, they have limitations when it comes to longitudinal monitoring of residual disease after treatment, disease progression, therapy responses, and disease recurrence. Circulating cancer-derived material, including circulating cancer cells (CTCs), circulating DNA (ctDNA), and biomolecules encapsulated in extracellular vesicles,  acquired through liquid biopsies are currently focus of research as diagnostic, prognostic, and predictive biomarkers in breast cancer.
  • 1.2K
  • 08 Jan 2021
Topic Review
TKI Involved in Muscle Wasting
Low muscle mass is significantly associated with low tolerability of chemotherapy and poor survival. In this context, despite the great strides in the treatment of cancer, targeted therapies such as tyrosine kinase inhibitors (TKIs) could exacerbate loss of muscle mass in cancer patients. In the last decades, the impact of muscle mass wasting during TKI treatment on clinical outcomes has been put under the spotlights. We evaluated different molecular pathways of TKIs potentially involved in muscle wasting assessing the effects of different TKI therapies – such as sorafenib, regorafenib, sunitinib, lenvatinib - on muscle mass, and highlighted their potential clinical implications. The assessment of muscle mass from CT imaging could be helpful in predicting toxicity and prognosis in patients treated with TKI such as sorafenib. An early recognition of low muscle mass and an effective personalized nutritional support could prevent or attenuate muscle mass wasting. However, the role of nutrition is still overlooked and future clinical trials are needed to find the optimal nutritional support to countermeasure muscle mass depletion during TKI therapy.
  • 1.2K
  • 04 Apr 2021
Topic Review
Propolis in Periodontal Disease
Propolis is a natural substance produced by bees which has proven useful for treating periodontal disease. 
  • 1.2K
  • 25 Feb 2021
Topic Review
Cell-Free DNA
Cell-free DNA (cfDNA) testing, is an emerging “liquid biopsy” tool for noninvasive lymphoma detection, and an increased amount of data are now available to use this technique with accuracy, especially in classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL). The advantages of cfDNA include simplicity of repeated blood sample acquisition over time; dynamic, noninvasive, and quantitative analysis; fast turnover time; reasonable cost; and established consistency with results from tumor genomic DNA. cfDNA analysis offers an easy method for genotyping the overall molecular landscape of pediatric and adult cHL and may help in cases of diagnostic difficulties between cHL and other lymphomas.
  • 1.2K
  • 10 Mar 2021
Topic Review
Gastric Polyps and Gastric Cancer
Gastric cancer is still an important disease causing many deaths worldwide, although there has been a marked reduction in prevalence during the last few decades. The decline in gastric cancer prevalence is due to a reduction in Helicobacter pylori infection which has occurred for at least 50 years. The most probable mechanism for the carcinogenic effect of H. pylori is hypergastrinemia since H. pylori infected individuals do not have increased risk of gastric cancer before the development of oxyntic atrophy. When atrophy has developed, the carcinogenic process continues independent of H. pylori. Autoimmune gastritis also induces oxyntic atrophy leading to marked hypergastrinemia and development of ECL cell neoplasia as well as adenocarcinoma. Similarly, long-term treatment with efficient inhibitors of acid secretion like the proton pump inhibitors (PPIs) predisposes to ECL cell neoplasia of a different degree of malignancy. Contrasting the colon where most cancers develop from polyps, most polyps in the stomach have a low malignant potential. Nevertheless, gastric polyps may also give rise to cancer and have some risk factors and mechanisms in common with gastric cancer.
  • 1.2K
  • 22 Jun 2021
Topic Review
Radiotherapy-Induced Ovarian Damage
Fertility preservation is an emerging discipline, which is of substantial clinical value in the care of young patients with cancer. Chemotherapy and radiation may induce ovarian damage in prepubertal girls and young women. Although many studies have explored the mechanisms implicated in ovarian toxicity during cancer treatment, its molecular pathophysiology is not fully understood.
  • 1.2K
  • 23 Jul 2021
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