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Topic Review
Stress of Moving Homes
Moving homes has long been considered stressful, but how stressful is it? Researches try to utilise a micro-level individual dataset in the New Zealand Government’s Integrated Data Infrastructure (IDI) to reconstruct the Social Readjustment Rating Scale (SRRS) and thereby measure stress at a whole-of-population level. The effects of residential mobility on people’s mental well-being in the context of their stress-of-moving homes are examined.
  • 1.3K
  • 21 Nov 2022
Topic Review
Self-Healable Lithium-Ion Batteries
The inner constituents of lithium-ion batteries (LIBs) are easy to deform during charging and discharging processes, and the accumulation of these deformations would result in physical fractures, poor safety performances, and short lifespan of LIBs. The introduction of self-healing (SH) materials into electrodes or electrolytes can bring about great enhancements in their mechanical strength, thus optimizing the cycle stability of the batteries. Due to the self-healing property of these special functional materials, the fractures/cracks generated during repeated cycles could be spontaneously cured. 
  • 1.3K
  • 24 Nov 2022
Topic Review
Morphological Characterization of Capsules
Encapsulation is a process in which a micron-sized particle of the main substance is coated and surrounded by a wall/carrier material that insulates and protects the contents from the external environment. The resulting encapsulation product is called a capsule or encapsulate.
  • 1.3K
  • 18 May 2023
Topic Review
CRISPR-Based Technologies in Wine Yeasts
For the highly competitive wine market with new demands for improved wine quality and wine safety, it has become increasingly critical to develop new yeast strains. New possibilities arose for creating upgraded wine yeasts in the laboratory, resulting in the development of strains with better fermentation abilities, able to improve the sensory quality of wines and produce wines targeted to specific consumers, considering their health and nutrition requirements. However, only two genetically modified (GM) wine yeast strains are officially registered and approved for commercial use. Compared with traditional genetic engineering methods, CRISPR/Cas9 is described as efficient, versatile, cheap, easy-to-use, and able to target multiple sites.
  • 1.3K
  • 04 Aug 2023
Topic Review
Antibacterial Activity of Chitosan and Its Derivatives
This research illuminates the various methods of chitosan extraction, its antibacterial properties, and its multifarious applications in diverse sectors. The choice of method is dictated by multiple variables, including the desired properties of chitosan, resource availability, cost, and environmental footprint.
  • 1.3K
  • 21 Sep 2023
Topic Review
Mechanisms of Antibody Uptake into Central Nervous System
Antibodies (mAbs) are attractive molecules for their application as a diagnostic and therapeutic agent for diseases of the central nervous system (CNS). mAbs can be generated to have high affinity and specificity to target molecules in the CNS. Unfortunately, only a very small number of mAbs have been specifically developed and approved for neurological indications. This is primarily attributed to their low exposure within the CNS, hindering their ability to reach and effectively engage their potential targets in the brain.
  • 1.3K
  • 18 Oct 2023
Topic Review
Alveolar Type 2 Epithelial Cell Organoid Culture Methods
Lung diseases rank third in terms of mortality and represent a significant economic burden globally. Scientists have been conducting research to better understand respiratory diseases and find treatments for them. An ideal in vitro model must mimic the in vivo organ structure, physiology, and pathology. Organoids are self-organizing, three-dimensional (3D) structures originating from adult stem cells, embryonic lung bud progenitors, embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). These 3D organoid cultures may provide a platform for exploring tissue development, the regulatory mechanisms related to the repair of lung epithelia, pathophysiological and immunomodulatory responses to different respiratory conditions, and screening compounds for new drugs. To create 3D lung organoids in vitro, both co-culture and feeder-free methods have been used. However, there exists substantial heterogeneity in the organoid culture methods, including the sources of type 2 alveolar cells (AT2) cells, media composition, and feeder cell origins. 
  • 1.3K
  • 14 Nov 2023
Topic Review
Methods for Measuring Landslides
Landslides are among the most destructive geo-disasters, causing substantial property damage and safety problems worldwide. Defined as the gravitational movement of mass down a slope, they can result from various events such as severe precipitation, earthquakes, volcanic activity, and human activities.
  • 1.3K
  • 19 Jan 2024
Topic Review
Relationship of Artificial Intelligence, Advertising, and Generative Models
Although artificial intelligence technologies have provided valuable insights into the advertising industry, more comprehensive studies that properly examine the applications of AI in advertising using scientometric network analysis are needed.
  • 1.3K
  • 11 Mar 2024
Topic Review
Cofilin Signaling
Three ADF/cofilin family members are expressed in mammals: ADF, cofilin-1, and cofilin-2. The first member ADF (also known as destrin), encoded by the gene DSTN in humans, was initially identified in the chick brain. Cofilin was discovered as an actin-interacting protein in the porcine brain. Later, Ono et al. identified two mammalian variants of cofilin, non-muscle type (also known as cofilin-1 and n-cofilin) and muscle type (also known as cofilin-2 and m-cofilin). In humans, cofilin-1 and cofilin-2 are encoded by the genes CFL1 and CFL2, respectively. Different isoforms of ADF/cofilin have qualitatively similar but quantitatively different effects on actin dynamics. To be noted, both ADF and cofilin show cooperative binding with actin filaments. Interestingly, cofilin-1 comprises almost 90% of the total ADF/cofilin family in CNS. Cofilin can bind to both G-actin and F-actin, exhibiting stronger affinities for the ADP-bound actins than the ATP- or ADP-Pi-bound forms. Cofilin binding to F-actin induces actin subunit rotation, enhances Pi release along the filament, and promotes filament severing in a concentration-dependent manner.
  • 1.3K
  • 28 Oct 2021
Topic Review
Fracture Behaviors of Metallic Glasses
Fracture properties are crucial for the applications of structural materials. The fracture behaviors of crystalline alloys have been systematically investigated and well understood. The fracture behaviors of metallic glasses (MGs) are quite different from that of conventional crystalline alloys and have drawn wide interests.
  • 1.3K
  • 09 Nov 2020
Topic Review
MTR Gene
5-methyltetrahydrofolate-homocysteine methyltransferase
  • 1.3K
  • 23 Dec 2020
Topic Review
APC Gene
APC, WNT signaling pathway regulator
  • 1.3K
  • 24 Dec 2020
Topic Review
Extracellular Vesicles in Neurogenic Niches
Adult neurogenesis, involving the generation of functional neurons from adult neural stem cells (NSCs), occurs constitutively in discrete brain regions such as hippocampus, sub-ventricular zone (SVZ) and hypothalamus. The intrinsic structural plasticity of the neurogenic process allows the adult brain to face the continuously changing external and internal environment and requires coordinated interplay between all cell types within the specialized microenvironment of the neurogenic niche. NSC-, neuronal- and glia-derived factors, originating locally, regulate the balance between quiescence and self-renewal of NSC, their differentiation programs and the survival and integration of newborn cells. Extracellular Vesicles (EVs) are emerging as important mediators of cell-to-cell communication, representing an efficient way to transfer the biologically active cargos (nucleic acids, proteins, lipids) by which they modulate the function of the recipient cells. At present, little is known on the physiological role of EVs in neurogenic niches. 
  • 1.3K
  • 02 Jan 2021
Topic Review
Neuropeptide S System
The Neuropeptide S (NPS) system was discovered by a "reverse pharmacology" approach in search for the endogenous ligand of an orphan G protein-coupled receptor. Its peptide ligand and receptor are mainly found in the brain. Effects on anxiety and memory have been described for NPS, as well as genetic associations of the receptor gene with asthma and inflammatory diseases.
  • 1.3K
  • 25 May 2021
Topic Review
MIT for Uric Acid Determination
The application of molecular imprinting technology (MIT) is a fascinating way to obtain the highly selective analytical systems. The terminology of MIT is applicable to both (i) inorganic compounds as it was demonstrated on the silica gel-based system at the very beginning of the history of this technology and also for the (ii) polymeric compounds. In case of the MIT application for the systems based on the polymers, the obtained structures are called MIPs. Uric acid is a biologically active compound, which is found in human fluids (blood and urine). The increased (hyperuricemia) or decreased (hypouricemia) levels of uric acid in the blood and urine are linked to many diseases, including gout, diabetes (type 2), cardiovascular, kidney, and many other. MIPs are offering many analytical and/or technological advantages for electrochemical and some other analytical systems dedicated to the determination of uric acid, which is an important issue in biomedicine, environmental and food chemistry. 
  • 1.3K
  • 21 May 2021
Topic Review
Telomeres
To survive and reproduce, living organisms must maintain homeostasis both in unchallenged (normal) and challenged (stressful) contexts. This requires the evolution of powerful stress response mechanisms adapted to a particular ecosystem and to regular environmental fluctuations. Thus, these mechanisms may be very diverse within the tree of life. The pioneering work of Miroslav Radman on the stress response in bacteria demonstrated the rapid and adaptive value of changing mutation rates for rapid evolution (the mutator effect). In other words, to facilitate the survival of a species, whether it be to respond to a replication blockade or to a stressful environment, it is better to rapidly evolve by generating more mutations, some being possibly lethal, than to die immediately. We believe that this principle applies to the complex dynamics of telomeres in eukaryotes, which become altered in response to stress.
  • 1.3K
  • 02 Jun 2021
Topic Review
Abortion in Times of COVID-19
The COVID-19 health emergency has thrown the health systems of most European countries into a deep crisis, forcing them to call off and postpone all interventions deemed not essential or life-saving in order to focus most resources on the treatment of COVID-19 patients. To facilitate women who are experiencing difficulties in terminating their pregnancies in Italy, the Ministry of Health has adapted to the regulations in force in most European countries and issued new guidelines that allow medical abortion up to 63 days, i.e., 9 weeks of gestational age, without mandatory hospitalization. This decision was met with some controversy, based on the assumption that the abortion pill could “incentivize” women to resort to abortion more easily.
  • 1.3K
  • 19 Nov 2021
Topic Review
Micro/Baby-Greens and Mature Field Grown Vegetables
Micro/baby-greens are gaining popularity in human diets as functional foods that deliver superior nutritional values and health benefits to consumers. This study conducted multiple times between 2017 and 2019 under greenhouse conditions and in the field at Rutgers University, New Brunswick, New Jersey, USA, showed that micro/baby-greens from tropical spinach (Amaranthus sp.) and roselle (Hibiscus sabdariffa L.) are rich in digestible carbohydrates, digestible protein, and dietary fiber. 
  • 1.3K
  • 28 Jan 2022
Topic Review
Antioxidants in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease, intensifying impairments in cognition, behavior, and memory. Histopathological AD variations include extracellular senile plaques’ formation, tangling of intracellular neurofibrils, and synaptic and neuronal loss in the brain. Multiple evidence directly indicates that oxidative stress participates in an early phase of AD before cytopathology. Oxidative stress plays a crucial role in activating and causing various cell signaling pathways that result in lesion formations of toxic substances, which advances the disease. Antioxidants are widely preferred to combat oxidative stress, and those derived from natural sources, which are often incorporated into dietary habits, can play an important role in delaying the onset as well as reducing the progression of AD. However, this approach has not been extensively explored yet. Moreover, a combination of antioxidants in conjugation with a nutrient-rich diet might be more effective in tackling AD pathogenesis.
  • 1.3K
  • 10 Feb 2022
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