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Zhou, V. APC Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4708 (accessed on 21 September 2026).
Zhou V. APC Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4708. Accessed September 21, 2026.
Zhou, Vicky. "APC Gene" Encyclopedia, https://encyclopedia.pub/entry/4708 (accessed September 21, 2026).
Zhou, V. (2020, December 24). APC Gene. In Encyclopedia. https://encyclopedia.pub/entry/4708
Zhou, Vicky. "APC Gene." Encyclopedia. Web. 24 December, 2020.
APC Gene
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/apc

APC, WNT signaling pathway regulator

genes

References

  1. Brueckl WM, Ballhausen WG, Förtsch T, Günther K, Fiedler W, Gentner B, Croner R, Boxberger F, Kirchner T, Hahn EG, Hohenberger W, Wein A. Genetic testing forgermline mutations of the APC gene in patients with apparently sporadic desmoidtumors but a family history of colorectal carcinoma. Dis Colon Rectum. 2005Jun;48(6):1275-81.
  2. Ceol CJ, Pellman D, Zon LI. APC and colon cancer: two hits for one. Nat Med.2007 Nov;13(11):1286-7.
  3. Cohen MM Jr. Molecular dimensions of gastrointestinal tumors: some thoughtsfor digestion. Am J Med Genet A. 2003 Nov 1;122A(4):303-14. Review.
  4. Couture J, Mitri A, Lagace R, Smits R, Berk T, Bouchard HL, Fodde R, Alman B, Bapat B. A germline mutation at the extreme 3' end of the APC gene results in asevere desmoid phenotype and is associated with overexpression of beta-catenin inthe desmoid tumor. Clin Genet. 2000 Mar;57(3):205-12.
  5. Fodde R. The APC gene in colorectal cancer. Eur J Cancer. 2002May;38(7):867-71. Review.
  6. Goss KH, Groden J. Biology of the adenomatous polyposis coli tumor suppressor.J Clin Oncol. 2000 May;18(9):1967-79. Review.
  7. Jaiswal AS, Balusu R, Narayan S. Involvement of adenomatous polyposis coli in colorectal tumorigenesis. Front Biosci. 2005 May 1;10:1118-34. Review.
  8. Järvinen HJ, Peltomäki P. The complex genotype-phenotype relationship infamilial adenomatous polyposis. Eur J Gastroenterol Hepatol. 2004 Jan;16(1):5-8.
  9. Lips DJ, Barker N, Clevers H, Hennipman A. The role of APC and beta-catenin inthe aetiology of aggressive fibromatosis (desmoid tumors). Eur J Surg Oncol. 2009Jan;35(1):3-10. doi: 10.1016/j.ejso.2008.07.003.
  10. Middleton SB, Frayling IM, Phillips RK. Desmoids in familial adenomatouspolyposis are monoclonal proliferations. Br J Cancer. 2000 Feb;82(4):827-32.
  11. Näthke IS. The adenomatous polyposis coli protein: the Achilles heel of thegut epithelium. Annu Rev Cell Dev Biol. 2004;20:337-66. Review.
  12. Scott RJ, Froggatt NJ, Trembath RC, Evans DG, Hodgson SV, Maher ER. Familialinfiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation. Hum Mol Genet. 1996 Dec;5(12):1921-4.
  13. Sena P, Saviano M, Monni S, Losi L, Roncucci L, Marzona L, De Pol A.Subcellular localization of beta-catenin and APC proteins in colorectalpreneoplastic and neoplastic lesions. Cancer Lett. 2006 Sep 28;241(2):203-12.
  14. Senda T, Shimomura A, Iizuka-Kogo A. Adenomatous polyposis coli (Apc) tumorsuppressor gene as a multifunctional gene. Anat Sci Int. 2005 Sep;80(3):121-31.Review.
  15. Tejpar S, Michils G, Denys H, Van Dam K, Nik SA, Jadidizadeh A, Cassiman JJ.Analysis of Wnt/Beta catenin signalling in desmoid tumors. Acta GastroenterolBelg. 2005 Jan-Mar;68(1):5-9. Review.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Vicky Zhou
View Times: 1.3K
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 24 Dec 2020
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