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Topic Review
Therapeutic Managements for Autoimmune Bullous Skin Disorders
Autoimmune bullous skin disorders are a group of disorders characterized by the formation of numerous blisters and erosions on the skin and/or the mucosal membrane, arising from autoantibodies against the intercellular adhesion molecules and the structural proteins. They can be classified into intraepithelial or subepithelial autoimmune bullous dermatoses based on the location of the targeted antigens. These dermatoses are extremely debilitating and fatal in certain cases, depending on the degree of cutaneous and mucosal involvement. Effective treatments should be implemented promptly. Glucocorticoids serve as the first-line approach due to their rapid onset of therapeutic effects and remission of the acute phase. Nonetheless, long-term applications may lead to major adverse effects that outweigh the benefits. Hence, other adjuvant therapies are mandatory to minimize the potential harm and ameliorate the quality of life.
  • 1.3K
  • 30 Jun 2022
Topic Review
Constituents and Identification of Super-Enhancers
Super-enhancers (SEs) are clusters of neighboring enhancers spanning over 10 kb with high-fold enhancer activity that drive cell-type specific gene expression. 3D genome organization enables SEs to interact with specific gene promoters and orchestrates their activity as evidenced by the high frequency of chromatin interactions at the genomic loci containing SEs. SEs contain many TF binding sites, and are heavily loaded with enhancer-associated chromatin features, such as master TFs (e.g., Oct4, Sox2, Nanog, and Klf4 in embryonic stem cells), RNA Pol II, MED1, and chromatin modifiers (p300 and BRD4). The recruited factors alter the chromatin structure, leading to interactions with promoters and RNA Pol II, a process mediated by enhancer–promoter looping. Phase separation may facilitate the assembly and function of SEs.
  • 1.3K
  • 29 Jun 2022
Topic Review
Genetic Analysis and Breeding of Cassava
Cassava (Manihot esculenta Crantz) is the sixth most important food crop and consumed by 800 million people worldwide. In Africa, cassava is the second most important food crop after maize and Africa is the worlds’ largest producer. Though cassava is not one of the main commodity crops in South Africa, it is becoming a popular crop among farming communities in frost-free areas, due to its climate-resilient nature. The potential of the available genetic and genomic resources for breeding and genetic improvement of cassava for enhanced resistance to biotic stresses are discussed.
  • 1.3K
  • 29 Jun 2022
Topic Review
Transponder Timing
Transponder timing (also called chip timing or RFID timing) is a technique for measuring performance in sport events. A transponder working on a radio-frequency identification (RFID) basis is attached to the athlete and emits a unique code that is detected by radio receivers located at the strategic points in an event. Prior to the use of this technology, races were either timed by hand (with operators pressing a stopwatch) or using video camera systems.
  • 1.3K
  • 27 Sep 2022
Topic Review
Nanocellulose’s Unique Characteristics as a Chemical Sensor
Composites can be derived from plant-based nanomaterials, among which is nanocellulose which has attracted significant attention as potential replacements for their more conventional petroleum-derived counterparts for use in chemical sensing applications.
  • 1.3K
  • 26 Oct 2022
Topic Review
Alpha-Thalassemia
Alpha-thalassemia (α-thalassemia, α-thalassaemia) is a form of thalassemia involving the genes HBA1 and HBA2. Thalassemias are a group of inherited blood conditions which result in the impaired production of hemoglobin, the molecule that carries oxygen in the blood. Normal hemoglobin consists of two alpha chains and two beta chains; in alpha-thalassemia, there is a quantitative decrease in the amount of alpha chains, resulting in fewer normal hemoglobin molecules. Furthermore, alpha-thalassemia leads to the production of unstable beta globin molecules which cause increased red blood cell destruction. The degree of impairment is based on which clinical phenotype is present (how many genes are affected).
  • 1.3K
  • 31 Oct 2022
Topic Review
UV-Vis Absorption Spectroelectrochemistry
Ultraviolet-visible (UV-Vis) absorption spectroelectrochemistry (SEC) is a multiresponse technique that analyzes the evolution of the absorption spectra in UV-Vis regions during an electrode process. This technique provides information from an electrochemical and spectroscopic point of view. In this way, it enables a better perception about the chemical system of interest. On one hand, molecular information related to the electronic levels of the molecules is obtained from the evolution of the spectra. On the other hand, kinetic and thermodynamic information of the processes is obtained from the electrochemical signal. UV-Vis absorption SEC allows qualitative analysis, through the characterization of the different present compounds, and quantitative analysis, by determining the concentration of the analytes of interest. Furthermore, it helps to determine different electrochemical parameters such as absorptivity coefficients, standard potentials, diffusion coefficients, electronic transfer rate constants, etc. Throughout history, reversible processes have been studied with colored reagents or electrolysis products. Nowadays, it is possible to study all kinds of electrochemical processes in the entire UV-Vis spectral range, even in the near infrared (NIR).
  • 1.3K
  • 31 Oct 2022
Topic Review
Oxide Minerals
The oxide mineral class includes those minerals in which the oxide anion (O2−) is bonded to one or more metal alloys. The hydroxide-bearing minerals are typically included in the oxide class. The minerals with complex anion groups such as the silicates, sulfates, carbonates and phosphates are classed separately. Simple oxides: Hydroxide subgroup:
  • 1.3K
  • 08 Nov 2022
Topic Review
Navy Mark IV
The Mercury space suit (or Navy Mark IV) was a full-body, high-altitude pressure suit originally developed by the B.F. Goodrich Company and the U.S. Navy for pilots of high-altitude fighter aircraft. It is best known for its role as the spacesuit worn for all manned Project Mercury spaceflights. The MK IV Full Pressure Suit ensemble was also used extensively by the US Navy from about 1959 through the early 1970s in aircraft such as the F-4 Phantom, A-3/A-5/RA-5C Vigilante, and F-8 Crusader.
  • 1.3K
  • 16 Nov 2022
Topic Review
Atari Assembler Editor
Atari Assembler Editor (sometimes written as Atari Assembler/Editor) is a ROM cartridge-based development system released by Atari, Inc. in 1981. It is used to edit, assemble, and debug 6502 programs for the Atari 8-bit family of home computers. It was programmed by Kathleen O'Brien of Shepardson Microsystems, the company which wrote Atari BASIC, and Assembler Editor shares many design concepts with that language. Assembly times are slow, making the cartridge challenging to use for larger programs. In the manual, Atari recommended the Assembler Editor as a tool for writing subroutines to speed up Atari BASIC, which would be much smaller than full applications. The Atari Macro Assembler was offered as an alternative with better performance and more features, such as macros, but it was disk-based, copy-protected, and did not include an editor or debugger. Despite the recommendation, commercial software was written using the Assembler Editor, such as the games Eastern Front (1941), Caverns of Mars, Galahad and the Holy Grail, and Kid Grid. The source code to the original Assembler Editor was licensed to Optimized Systems Software who shipped EASMD based on it.
  • 1.3K
  • 21 Nov 2022
Topic Review
Moberly–Jourdain Incident
The Moberly–Jourdain incident (also the Ghosts of Petit Trianon or Versailles, French: les fantômes du Trianon / les fantômes de Versailles) is a claim of time travel and hauntings made by Charlotte Anne Moberly (1846–1937) and Eleanor Jourdain (1863–1924). In 1911, Moberly and Jourdain published a book entitled An Adventure under the names of "Elizabeth Morison" and "Frances Lamont". Their book describes a visit they made to the Petit Trianon, a small château in the grounds of the Palace of Versailles where they claimed to have seen the gardens as they had been in the late eighteenth century as well as ghosts, including Marie Antoinette and others. Their story caused a sensation and was subject to much ridicule.
  • 1.3K
  • 22 Nov 2022
Topic Review
Phytochemical Groups in Bee Pollen and Bread
Bee products, viz., pollen (BP) and bread, are normally harvested from the flowering plants with the aid of bees. BP is further subjected to a fermentation process in bee hives to produce the more valuable and bioavailable BB. Owing to their nutritional and medicinal properties, bee products are considered as an important food supplements rich in macro-, micro-, and phytonutrients. Bee products are rich in carbohydrates, amino acids, vitamins, fatty acids, and minerals in addition to a myriad of phytonutrients such as phenolic compounds, anthocyanins, volatiles, and carotenoids.
  • 1.3K
  • 31 Jan 2023
Topic Review
Pharmacokinetics of Macrolide Antibiotics in Respiratory Infection
Macrolide antibiotics are important drugs to combat infections. The pharmacokinetics (PK) of these drugs are essential for the determination of their optimal dose regimens, which affect antimicrobial pharmacodynamics and treatment success. For most drugs, the measurement of their concentrations in plasma/serum is the surrogate for drug concentrations in target tissues for therapy.
  • 1.3K
  • 20 Apr 2023
Topic Review
Vertical Graphene
Vertical Graphene is obtained using the plasma-enhanced chemical vapor deposition (PECVD) method, and different VG types with other properties can be obtained by changing the process parameters. VG is part of the graphene family; properties such as excellent electrical conductivity, thermal conductivity, chemical stability, and a large, specific surface area make it suitable for biomedical applications. Examples of biomedical applications in which VG is used are biosensors, electrochemical sensors, modified surfaces for bone growth, regeneration, and for antimicrobial effects.
  • 1.3K
  • 04 May 2023
Topic Review
Emerging Residual Chlorine Quenchers
Disinfection by-products (DBPs) are the most common organic contaminants in tap water and are of wide concern because of their highly developmental toxic, cytotoxic, and carcinogenic properties. Researchers have attempted to find emerging chlorine quenchers. For inorganic DBPs (bromate, chlorate, and chlorite), sodium sulfite has been proven to be the ideal chlorine quencher. For organic DBPs, although ascorbic acid caused the degradation of some DBPs, it remains the ideal quenching agent for most known DBPs. Among the studied emerging chlorine quenchers, n-acetylcysteine (NAC), glutathione (GSH), and 1,3,5-trimethoxybenzene are promising for their application as the ideal chlorine quencher of organic DBPs. 
  • 1.3K
  • 05 May 2023
Topic Review
Building Information Modelling for Application in Geotechnical Engineering
Building Information Modeling (BIM) is the modern technology of digital transformation in architecture and engineering. The technology includes software and multi-disciplinary data processing procedures for designing, documentation and modeling.
  • 1.3K
  • 16 Jun 2023
Topic Review
Alkyl Chains Impact in Polymer-Based organic Solar Cells
The research for efficient organic materials organized in bulk heterojunction (BHJ) thin films for organic photovoltaics (OPVs) has shown a significant breakthrough. Desired structural organization can be attained through various strategies. Conjugated polymer-based bulk heterojunction solar cells have exhibited high power conversion efficiencies (PCEs). The role of side chain engineering in solution-processable conjugated polymers is taking a growing role in these record performances. 
  • 1.3K
  • 20 Sep 2023
Topic Review
A Multifactorial Approach for Sarcopenia Assessment
Sarcopenia refers to a progressive and generalized weakness of skeletal muscle as individuals age. Sarcopenia usually occurs after the age of 60 years and is associated with a persistent decline in muscle strength, function, and quality. A comparison of the risk factors associated with sarcopenia based on the European Working Group on Sarcopenia (1 and 2) in Older People, the Asian Working Group for Sarcopenia (1 and 2), the International Working Group on Sarcopenia, and the Foundation for the National Institutes of Health revealed no consistent patterns. Accordingly, the identification of a single risk factor for sarcopenia is unpredictable due to its “multifactorial” pathogenesis, with the involvement of a multitude of factors.
  • 1.3K
  • 29 Dec 2021
Topic Review
Anti-Haemonchus Contortus Vaccines Development
Haemonchosis/barber’s pole disease is a socio-economically important disease caused by one of the most pathogenic nematode parasite of ruminants called Haemonchus contortus. The control practices through anthelmintics, and resistance to these drugs demands for an effective, safe and durable vaccine against H. contortus.  During host-parasite relationship, parasites excrete and secrete large number of molecules into the host, which perform adversative immune-regulatory functions upon bindings to host immune cells. Various potential vaccine antigens have been tested by different ways and strategies applied in animal models, and significant progress has been made in the development of vaccines against H. contortus.
  • 1.3K
  • 28 Oct 2020
Topic Review
Mithramycin
Mithramycin is an antineoplastic antibiotic. The use of mithramycin has been previously limited by its narrow therapeutic window. Recent advances in semisynthetic methods have led to mithramycin analogs with improved pharmacological profiles. Mithramycin inhibits the activity of the transcription factor Sp1, which is closely linked with ovarian tumorigenesis and platinum-resistance.
  • 1.3K
  • 02 Feb 2021
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