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Topic Review
Preceramic Polymers for Additive Manufacturing of Silicate Ceramics
The utilization of preceramic polymers (PCPs) to produce both oxide and non-oxide ceramics has caught significant interest, owing to their exceptional characteristics. Diverse types of polymer-derived ceramics (PDCs) synthesized by using various PCPs have demonstrated remarkable characteristics such as exceptional thermal stability, resistance to corrosion and oxidation at elevated temperatures, biocompatibility, and notable dielectric properties, among others. The application of additive manufacturing techniques to produce PDCs opens up new opportunities for manufacturing complex and unconventional ceramic structures with complex designs that might be challenging or impossible to achieve using traditional manufacturing methods. This is particularly advantageous in industries like aerospace, automotive, and electronics. 
  • 1.3K
  • 19 Dec 2023
Topic Review
High Mobility Group Box 1
The High Mobility Group Box 1 (HMGB1) is the most abundant nuclear nonhistone protein that is involved in transcription regulation. In addition, HMGB1 has previously been found as an extracellularly acting protein enhancing neurite outgrowth in cultured neurons. Although HMGB1 is widely expressed in the developing central nervous system of vertebrates and invertebrates, its function in the developing mouse brain is poorly understood. Here, we have analyzed developmental defects of the HMGB1 null mouse forebrain, and further examined our findings in ex vivo brain cell cultures. We find that HMGB1 is required for the proliferation and differentiation of neuronal stem cells/progenitor cells. Enhanced apoptosis is also found in the neuronal cells lacking HMGB1. Moreover, HMGB1 depletion disrupts Wnt/β-catenin signaling and the expression of transcription factors in the developing cortex, including Foxg1, Tbr2, Emx2, and Lhx6. Finally, HMGB1 null mice display aberrant expression of CXCL12/CXCR4 and reduced RAGE signaling. In conclusion, HMGB1 plays a critical role in mammalian neurogenesis and brain development.
  • 1.3K
  • 27 Oct 2020
Topic Review
A Survey about Foster Family
       Being a foster family consists of a continuous process influenced by several aspects. It involves challenges and demands. But also daily rewards. It is critical that more families be encouraged to become foster carers and also that experienced carers stay in the system to create a sustainable foster care programme. We found three types of foster families, classified according to their will to leave or remain in foster care—unconditional, hesitant, or retired. The support team are determinant for success in every stage. 
  • 1.3K
  • 19 Apr 2021
Topic Review
X-linked adrenal Hypoplasia Congenita
X-linked adrenal hypoplasia congenita is a disorder that mainly affects males. It involves many hormone-producing (endocrine) tissues in the body, particularly a pair of small glands on top of each kidney called the adrenal glands. These glands produce a variety of hormones that regulate many essential functions in the body.
  • 1.3K
  • 24 Dec 2020
Topic Review
Butyrate
Butyrate emerged because it might have a potential in alleviating obesity and related comorbidities. 
  • 1.3K
  • 09 Mar 2021
Topic Review
LAT1 and ASCT2 Related microRNAs
The development and progression of colorectal cancer (CRC) have been associated with genetic and epigenetic alterations and more recently with changes in cell metabolism. Amino acid trans-porters are key players in tumor development, and it is described that tumor cells upregulate some AA transporters in order to support the increased amino acid (AA) intake to sustain the tumor additional needs for tumor growth and proliferation through the activation of several signaling pathways. LAT1 and ASCT2 are two AA transporters involved in the regulation of the mTOR pathway that has been reported as upregulated in CRC. Some attempts have been made in order to develop therapeutic approaches to target these AA transporters, however none have reached the clinical setting so far. MiRNA-based therapies have been gaining increasing attention from pharmaceutical companies and now several miRNA-based drugs are currently in clinical trials with promising results.
  • 1.3K
  • 16 Mar 2021
Topic Review
Preeclampsia and Therapeutic Approaches
Preeclampsia (PE) is a serious pregnancy complication, affecting about 5–7% of pregnancies worldwide and is characterized by hypertension and damage to multiple maternal organs, primarily the liver and kidneys. PE usually begins after 20 weeks’ gestation and, if left untreated, can lead to serious complications and lifelong disabilities—even death—in both the mother and the infant. As delivery is the only cure for the disease, treatment is primarily focused on the management of blood pressure and other clinical symptoms. The pathogenesis of PE is still not clear. Abnormal spiral artery remodeling, placental ischemia and a resulting increase in the circulating levels of vascular endothelial growth factor receptor-1 (VEGFR-1), also called soluble fms-like tyrosine kinase-1 (sFlt-1), are believed to be among the primary pathologies associated with PE. sFlt-1 is produced mainly in the placenta during pregnancy and acts as a decoy receptor, binding to free VEGF (VEGF-A) and placental growth factor (PlGF), resulting in the decreased bioavailability of each to target cells. Despite the pathogenic effects of increased sFlt-1 on the maternal vasculature, recent studies from our laboratory and others have strongly indicated that the increase in sFlt-1 in PE may fulfill critical protective functions in preeclamptic pregnancies.
  • 1.3K
  • 11 Jun 2021
Topic Review
Fabricating Lattice Structures via 3D-Printing
Over time, the fabrication of lattice, porous structures has always been a controversial field for researchers and practitioners. Such structures could be fabricated in a stochastic way, thus, with limited control over the actual porosity percentage. The emerging technology of 3D printing, offered an automated process that did not require the presence of molds and operated on a layer-by-layer deposition basis, provided the ability to fabricate almost any shape through a variety of materials and methods under the umbrella of the ASTM terminology “additive manufacturing”. In the field of biomedical engineering, the technology was embraced and adopted for relevant applications, offering an elevated degree of design freedom. Applications range in the cases where custom-shaped, patient-specific items have to be produced. Scaffold structures were already a field under research when 3D printing was introduced. These structures had to act as biocompatible, bioresorbable and biodegradable substrates, where the human cells could attach and proliferate. In this way, tissue could be regenerated inside the human body. One of the most important criteria for such a structure to fulfil is the case-specific internal geometry design with a controlled porosity percentage. 3D printing technology offered the ability to tune the internal porosity percentage with great accuracy, along with the ability to fabricate any internal design pattern.
  • 1.3K
  • 17 Jun 2021
Topic Review
JAK/STAT in Interstitial Lung Diseases
Janus kinases (JAK) are a group of intracellular tyrosine kinases (JAK1, JAK2, JAK3, TYK2) that are crucial in signal transduction initiated by a wide range of membrane receptors. Signal transducer and activator of transcription (STAT) comprises a family of 7 members (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6), which function as transcription factors. The JAK/STAT signaling pathway controls multiple cellular processes that are essential for cell homeostasis.Between the different JAK/STAT isoforms, it appears that JAK2/STAT3 are predominant, initiating cellular changes observed in ILDs.
  • 1.3K
  • 25 Jun 2021
Topic Review
Resveratrol in Aging COVID-19 Patients
COVID-19 symptoms are highly heterogeneous, and the patient may be asymptomatic or may present with mild to severe or fatal symptoms. Factors, such as age, sex, and comorbidities, are key determinants of illness severity and progression. Aging is accompanied by multiple deficiencies in interferon production by dendritic cells or macrophages in response to viral infections, resulting in dysregulation of inflammatory immune responses and excess oxidative stress. Age-related dysregulation of immune function may cause a more obvious pathophysiological response to SARS-CoV-2 infection in elderly patients and may accelerate the risk of biological aging, even after recovery. Resveratrol is a potent antioxidant with antiviral activity. 
  • 1.3K
  • 14 Sep 2021
Topic Review
Ficus carica Fruits
Ficus caricaL. (fig) is a species of the very large number of the genusFicusbelonging to the Moraceae famil, characterized by milky latex in all parenchymatous tissue, unisexual flowers, anatropous ovules and aggregated drupes or achenes. Figs are infruitescences—the true fruits of the fig are located inside the fig or siconio, which are called achenes.
  • 1.3K
  • 28 Sep 2021
Topic Review
Interstitial Telomeric-like Repeats (ITR)
Interstitial telomeric repeat (ITR) sites, also known as interstitial telomeric sequences (ITSs), consist of tandem repeats of telomeric motifs that are located within intrachromosomal regions, including repeats located close to the centromeres and the ones found between the centromeres and the telomeres.
  • 1.3K
  • 10 Dec 2021
Topic Review
Industrial Robotics
The industrial robotics sector is one of the most quickly growing industrial divisions, providing standardised technologies suitable for various automation processes. In most applications, industrial robots form bigger units as robotic cells or automated/autonomous manufacturing lines.
  • 1.3K
  • 13 Jan 2022
Topic Review
Factors Influencing Usage Behavior on Mobile Health Applications
As people pay more attention to health, mobile health applications (mHealth apps) are becoming popular. These apps offer health services that run on mobile devices to help improve users’ health behaviors. However, few studies explore what motivates users to continue to use these apps. 
  • 1.3K
  • 10 Feb 2022
Topic Review
A Paraoxonase for All Seasons
Paraoxonases (PON) are a multigene family consisting of three enzymes, PON1, PON2, and PON3, located on human chromosome 7 (7q21.3–22.1). All three PONs have been shown to act as antioxidants and consequently have anti-inflammatory effects in various disease states such as atherosclerosis and cardiovascular diseases.
  • 1.3K
  • 12 Apr 2022
Topic Review
Intensity-Modulated Polymer Optical Fiber-Based Refractive Index Sensor
The simple and highly sensitive measurement of the refractive index (RI) of liquids is critical for designing the optical instruments and important in biochemical sensing applications. Intensity modulation-based polymer optical fiber (POF) RI sensors have a lot of advantages including low cost, easy fabrication and operation, good flexibility, and working in the visible wavelength.
  • 1.3K
  • 25 Apr 2022
Topic Review
Xylosma G. Forst. Genus
Xylosma G. Forst. is a genus of plants belonging to the Salicaceae family with intertropical distribution in America, Asia, and Oceania. Of the 100 accepted species, 22 are under some level of conservation risk. Around 13 species of the genus used as medicinal plants were found, mainly in Central and South America, with a variety of uses, among which antimicrobial is the most common.
  • 1.3K
  • 18 May 2022
Topic Review
Shinsen
Shinsen (神饌 shinsen) are offerings given up to Shinto shrines or kamidana in Japan . They are also called mike or minie. The annual festivals carried out at different times of the year originated from Shinto rituals and festivals. As part of the ritual, locals would offer up food that had received a special blessing to welcome the kami ("gods" or "spirits"). Food offered up could range from their staple of rice to seafood, food foraged from the mountains, seasonal foods, local specialties, or food connected to the enshrined kami. At the end of the ritual, the offered food is eaten together to gain a sense of unity with the kami, and to gain their blessing and protection. The rite is known as naorai.
  • 1.3K
  • 28 Sep 2022
Topic Review
Metastable Inner-Shell Molecular State
Metastable Innershell Molecular State (MIMS) is a class of ultra-high-energy short-lived molecules have the binding energy up to 1,000 times larger and bond length up to 100 times smaller than typical molecules. MIMS is formed by inner-shell electrons that are normally resistant to molecular formation. However, in stellar conditions, the inner-shell electrons become reactive to form molecular structures (MIMS) from combinations of all elements in the periodic table. MIMS upon dissociation can emit x-ray photons with energies up to 100 keV at extremely high conversion efficiencies from compression energy to photon energy. MIMS is predicted to exist and dominate radiation processes in extreme astrophysical environments, such as large planet cores, star interiors, and black hole and neutron star surroundings. There, MIMS is predicted to enable highly energy-efficient transformation of the stellar compression energy into the radiation energy. The right schematic illustration shows the proposed four stages of the K-shell MIMS (K-MIMS) formation and x-ray generation process. Stage I: Individual atoms are subjected to the stellar compression and ready for absorbing the compression energy. Stage II: The outer electron shells fuse together under increasing "stellar" pressure. Stage III: At the peak pressure, via pressure ionization K-shell orbits form the K-MIMS, which is vibrationally hot and encapsulated by a Rydberg-like pseudo-L-Shell structure. Stage IV: The K-MIMS cools down by ionizing ("boiling-off") a number of pseudo-L-shell electrons and subsequent optical decay by emitting an x-ray photon. The dissociated atoms return their original atoms states and are ready for absorbing the compression energy. MIMS also can be readily produced in laboratory and industrial environments, such as hypervelocity particle impact, laser fusion and z-machine. MIMS can be exploited for highly energy-efficient production of high intensity x-ray beams for a wide range of innovative applications, such as photolithography, x-ray lasers, and inertial fusion.
  • 1.3K
  • 18 Oct 2022
Topic Review
Crowns of Power
Crowns of Power, also referred to as CoP, is a 3D fantasy-themed massively multiplayer online role-playing game (MMORPG) released in 2008 by Rampid Interactive, LLC. the game closed in 2010 and was later purchased in 2017 by Conkered Gaming LLC. Crowns of Power takes place in the 3D fantasy world of Arder, a magical world in the center of the universe in which magic prevails. Crowns of Power is mostly known for its unique class system and smaller world populations, creating a unique sense of community unlike any other.
  • 1.3K
  • 19 Oct 2022
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