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Topic Review
Role of 10-Hydroxy-2-decenoic Acid in Alzheimer’s Disease
Alzheimer’s disease (AD) represents a significant public health concern in modern society. Metabolic syndrome (MetS), which includes diabetes mellitus (DM) and obesity, represents a modifiable risk factor for AD. MetS and AD are interconnected through various mechanisms, such as mitochondrial dysfunction, oxidative stress, insulin resistance (IR), vascular impairment, inflammation, and endoplasmic reticulum (ER) stress. Therefore, it is necessary to seek a multi-targeted and safer approach to intervention. Thus, 10-hydroxy-2-decenoic acid (10-HDA), a unique hydroxy fatty acid in royal jelly, has shown promising anti-neuroinflammatory, blood–brain barrier (BBB)-preserving, and neurogenesis-promoting properties.
  • 1.4K
  • 01 Sep 2023
Topic Review
Pilot and Full-Scale Applications of P Recovery
Elevated phosphorus (P) levels in water sources can result in eutrophication, which in turn causes environmental pollution and adversely affects aquatic ecosystems. Additionally, there is a risk of P depletion due to intensive exploitation and utilization. Therefore, the sustainable and efficient use of P, waste reduction, and P recovery from waste sources have become urgent priorities.
  • 1.4K
  • 01 Nov 2023
Topic Review Peer Reviewed
High-Power Lasers
High-power lasers play an important role in modern science, industry, and medicine. A significant milestone was reached on 5 December 2022, when Inertial Confinement Nuclear Fusion (ICF) achieved scientific breakeven, releasing more energy than the input laser energy. Additionally, Extreme Ultraviolet Lithography (EUVL) has enabled the development of microchips with 3 nm process nodes, marking a leap in semiconductor technology. These examples, together with the recent achievement of 10 PW (1015 W) laser output, herald remarkable advancements in technology and science. Laser systems are broadly classified based on their operating regimes into two main categories: Continuous Wave (CW) operation, where the laser is continuously pumped and emits a steady beam of light, and the pulsed regime, in which the laser produces single or multiple pulses at various repetition rates. This review will primarily focus on pulsed laser systems, exploring their various types and recent technological advancements.
  • 1.4K
  • 09 Aug 2024
Topic Review
Bacterial–Fungal Interactions
At the cell-to-cell level, bacteria and fungi interact at many different levels of intimacy that can be considered from two perspectives: in terms of physical associations and in terms of molecular communication. More often than not, multiple mechanism of interaction can be employed by one microorganism. Cumulative cell-to-cell interactions among organisms belonging to very different taxa levels and origins, such as animals, protists, fungi, bacteria, archaea, and viruses, determine the overall microbial community activity in a given habitat. These interactions have an effect not just on their surrounding environment (i.e., microenvironment), but also influence large-scale fluxes and, thus, impact global ecosystem processes.
  • 1.4K
  • 25 Oct 2021
Topic Review
Applications of Bio-Epoxies in Composites
Despite the reliability of traditional epoxy systems, the increasing demand for sustainability has driven researchers and industries to explore new bio-based alternatives. Additionally, natural fibers have the potential to serve as environmentally friendly substitutes for synthetic ones, contributing to the production of lightweight and biodegradable composites. Enhancing the mechanical properties of these bio-composites also involves improving the compatibility between the matrix and fibers. In this sense, the use of bio-epoxy resins facilitates better adhesion of natural composite constituents, addressing sustainability and environmental concerns.
  • 1.4K
  • 11 Jan 2024
Topic Review
Phytochemicals JAK–STAT for IBD Treatment
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that consists of Crohn’s disease (CD) and ulcerative colitis (UC). Cytokines are thought to be key mediators of inflammation-mediated pathological processes of IBD. These cytokines play a crucial role through the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling pathways. Several small molecules inhibiting JAK have been used in clinical trials, and one of them has been approved for IBD treatment. Many anti-inflammatory phytochemicals have been shown to have potential as new drugs for IBD treatment.
  • 1.4K
  • 01 Jun 2021
Topic Review
Remote Assessment in Multiple Sclerosis
The provision and adoption of technological solutions and the sharing of information globally has the potential to drive knowledge acquisition and positively affect healthcare worldwide. Digital solutions offer great promise in delivering increasingly individualised, easily accessible, and effective healthcare, with the capacity to evolve with time and adapt to the changing needs of people living with MS (PLwMS) and health care providers (HCPs). The impact of the COVID-19 pandemic has given additional proof of such versatility and usefulness, highlighting how barriers can be overcome through the adoption of digital tools, where capturing digital data remotely may mean that symptom tracking can be maintained even when clinic visits are not possible.
  • 1.4K
  • 07 Oct 2021
Topic Review
NLP- and API-Sequence-Based Malware Detection and Classification Methodologies
The surge in malware threats propelled by the rapid evolution of the internet and smart device technology necessitates effective automatic malware classification for robust system security.
  • 1.4K
  • 24 Jan 2024
Topic Review
Soft Computing Applications
Air quality models simulate the atmospheric environment systems and provide increased domain knowledge and reliable forecasting. They provide early warnings to the population and reduce the number of measuring stations. Due to the complexity and non-linear behavior associated with air quality data, soft computing models became popular in air quality modeling (AQM). This study critically investigates, analyses, and summarizes the existing soft computing modeling approaches. Among the many soft computing techniques in AQM, this article reviews and discusses artificial neural network (ANN), support vector machine (SVM), evolutionary ANN and SVM, the fuzzy logic model, neuro-fuzzy systems, the deep learning model, ensemble, and other hybrid models. Besides, it sheds light on employed input variables, data processing approaches, and targeted objective functions during modeling. The discussion in this paper will help to determine the suitability and appropriateness of a particular model for a specific modeling context.
  • 1.3K
  • 22 Feb 2021
Topic Review
Exercise-Associated Hyponatremia and Dehydration
During the last few years, the numbers of competitors in endurance and ultra-endurance sports modalities have increased significantly. This type of competition is an extreme challenge for athletes. Therefore, they have an increased the risk of developing medical and nutritional problems like exercise-associated hyponatremia (EAH), dehydration (DH); the provision of misinformation to athletes about nutrient intake and hydration during competition was identified as the main cause. These problems can affect the performance and health status of the athlete during and post-competition. Several nutritional guidelines have been suggested that can prevent these adverse outcomes, and it is essential to individualize and adjust the nutritional intake and hydration status according to the characteristics of each competition.
  • 1.3K
  • 05 Nov 2020
Topic Review
TTN Gene
Titin
  • 1.3K
  • 04 Jan 2021
Topic Review
Toxin Genes of Bacillus cereus
Bacillus cereus is a ubiquitous soil bacterium responsible for two types of food-associated gastrointestinal diseases. While the emetic syndrome is caused by the cyclic depsipeptide cereulide, proteinaceous enterotoxins provoke the diarrheal disease. Here, an overview on the distribution of the main toxin genes/operons ces (encoding cereulide), hbl (encoding the tripartite hemolysin BL), nhe (encoding the tripartite non-hemolytic enterotoxin), and cytK (encoding the single protein cytotoxin K) within the B. cereus group is given.
  • 1.3K
  • 18 Feb 2021
Topic Review
Cluster-Based Coordination Polymers
Cluster-based coordination polymers (CCPs) are constructed from metal coordination clusters that are bridged by polytopic organic ligands forming multidimensional systems such as one-dimensional (1D) chains, two-dimensional (2D) layers, and three-dimensional (3D) metal-organic frameworks. Structurally well-defined polynuclear Mn(II,III)/Fe(III)-oxo pivalate and isobutyrate clusters recommend them-selves as extremely versatille building blocks where their ancillary coordination ligands are sufficiently flexible to allow the formation of a wide variety of 1D, 2D and 3D CCPs.
  • 1.3K
  • 07 May 2021
Topic Review
Fermented Foods and Gut Microbiota
Fermented foods and beverages are generally defined as products made by microbial organisms and enzymatic conversions of major and minor food components. Further to the commonly-recognized effects of nutrition on the digestive health and well-being, there is now strong evidence for the impact of fermented foods and beverages, produced or preserved by the action of microorganisms, on general health, namely their significance on the gut microbiota balance and brain functionality. 
  • 1.3K
  • 19 May 2021
Topic Review
Self-Assembling Nucleobase-Containing Peptides
The self-assembly of bio-inspired nanomaterials and biological nanostructures confers new properties and functions to conjugated biomaterials, such as the ability to respond to external stimuli. Nucleobase-containing peptides can be considered as aromatic peptides and, similar to these self-assembling structures, they can lead to interesting functional nanostructures as hereafter explained. Self-assembling nucleopeptides can form hydrogels based on supramolecular structures held by non-covalent molecular interactions occurring between the peptide segments, as well as π–π stacking and Watson–Crick interactions via complementary DNA bases.
  • 1.3K
  • 16 Jun 2021
Topic Review
Wearable Sensing Technologies
Standards for the fatigue testing of wearable sensing technologies are lacking. The majority of published fatigue tests for wearable sensors are performed on proof-of-concept stretch sensors fabricated from a variety of materials. Due to their flexibility and stretchability, polymers are often used in the fabrication of wearable sensors. Other materials, including textiles, carbon nanotubes, graphene, and conductive metals or inks, may be used in conjunction with polymers to fabricate wearable sensors.
  • 1.3K
  • 10 Aug 2021
Topic Review
Nucleotide-binding oligomerization domain 2
Nucleotide-binding oligomerization domain 2 (NOD2) is a cytoplasmic receptor that recognizes invading molecules and danger signals inside the cells.
  • 1.3K
  • 17 Aug 2021
Topic Review
Herpesvirus Infection in Strix Owls
The herpesvirus partial DNA polymerase gene was detected using polymerase chain reaction in oropharyngeal swabs of 16 out of 170 owls examined that were captured in or near nest boxes. Herpesvirus was detected in Ural owls (Strix uralensis), in both adults and young, but not in tawny owls (Strix aluco). In yellow-necked mice (Apodemus flavicollis), as the main prey of tawny owls and Ural owls in the area, herpesvirus was detected in the organs of 2 out of 40 mice captured at the same locations as the owls. Phylogenetic analysis showed that the herpesvirus sequences detected in the Ural owls differed from the herpesvirus sequences detected in the yellow-necked mice. The results indicate that herpesvirus infection exists in the breeding wild Ural owl population. However, herpesvirus-infected owls did not show any clinical or productivity deviances and, based on a phylogenetic comparison of detected herpesvirus sequences and sequences obtained from Genbank database, it seems that mice and other rodents are not the source of owl infections. The most probable transmission pathway is intraspecific, especially from adults to their chicks, but the origin of herpesvirus in owls remains to be investigated.
  • 1.3K
  • 22 Sep 2021
Topic Review
Temperature Management of Olive Fruit
The International Olive Council (IOC) defines virgin olive oils as “the oils obtained from the fruit of the olive tree (Olea europaea L.) solely by mechanical or other physical means under conditions, particularly thermal conditions, that do not lead to alterations in the oil, and which have not undergone any treatment other than washing, decantation, centrifugation and filtration.”. This definition underlines the importance and the strict relation between the fruit on the one side, and the obtained oil on the other. The quality of the latter depends to a large extent on the quality of the former. At the same time, the definition specifies the need to restrict to a minimum the treatments that can be applied before and during the extraction process and explicitly points to the importance of controlling the temperature during the processing.
  • 1.3K
  • 23 Sep 2021
Topic Review
Shotcrete
With the swift global development of tunnels, mines, subways, water conservancy and hydropower projects, and so on, shotcrete, as an advanced support method, is widely applied to surrounding rock control and roadway closure. Shotcrete is a kind of concrete formed by mixing concrete materials, such as gel material, aggregate, and so on, into the ejection equipment, by means of compressed air or other power transmission, and sprayed onto the spray surface at high speed. Shotcrete technology was first used in mining and civil engineering by the United States in 1914. It has a history of more than 100 years. 
  • 1.3K
  • 12 Nov 2021
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