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Topic Review
Hope in Nursing Care
Hope is a central concept within the nursing literature, which is crucial towards the development of nursing knowledge. Nursing teams play a crucial role in exploring the meaning of hope and promoting hope among patients and their families. 
  • 1.4K
  • 25 Oct 2023
Topic Review
Landolt Indicator Values in Modern Research
The conservation of biodiversity and ecosystem sustainability is essential for human well-being. An important tool for addressing this issue is ecological indicators. 
  • 1.4K
  • 02 Apr 2024
Topic Review
Wine Aroma and Flavor Compounds from Fermentative Origin
Wine sensory experience includes flavor, aroma, color, and (for some) even acoustic traits, which impact consumer acceptance. The quality of the wine can be negatively affected by the presence of off-flavors and aromas, dubious colors, or sediments present in the bottle or glass after pouring (coloring matter that precipitates or calcium bitartrate crystals). Flavor profiles of wines result from many variations in vineyard and winery production, including grape selection, winemaker’s knowledge and technique, and tools used to produce wines with a specific flavor. 
  • 1.4K
  • 13 Sep 2023
Topic Review
Image Fusion Methods
Image fusion is the generation of an informative image that contains complementary information from the original sensor images, such as texture details and attentional targets. Existing methods have designed a variety of feature extraction algorithms and fusion strategies to achieve image fusion. 
  • 1.4K
  • 26 Jan 2024
Topic Review
Steroid Induced Hyperglycaemia in Hospital
Oral hypoglycaemic agents (OHAs) might be an adequate choice in inpatients with stable and non-critical disease and mild hyperglycaemic excursions. In those with significant hyperglycaemia and severe illness, insulin remains the treatment of choice in the hospital setting as also suggested by the current guidelines for inpatient diabetes management.
  • 1.4K
  • 21 Jun 2021
Topic Review
Circular RNAs
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in adults in developed countries. CVD encompass many diseased states including hypertension, coronary artery disease and atherosclerosis. Studies in animal models and human studies have elucidated the contribution of many genetic factors, including non-coding RNAs. Non-coding RNAs are RNAs not translated into protein, involved in gene expression regulation post-transcriptionally and implicated in CVD. These include long non-coding RNAs. Of these, circular RNAs (circRNAs) and micro RNAs. CircRNAs are created by the back-splicing of pre-messenger RNA and have been underexplored as contributors to CVD. These circRNAs may also act as biomarkers of human disease as they can be extracted from whole blood, plasma, saliva and seminal fluid. CircRNAs have recently been implicated in various disease processes, including hypertension and other cardiovascular disease. This review article will explore the promising and emerging roles of circRNAs as potential biomarkers and therapeutic targets in CVD, in particular hypertension.
  • 1.4K
  • 06 Nov 2020
Topic Review
Alzheimer’s Disease, Breast, Prostate Cancer
Noncommunicable diseases, such as Alzheimer’s disease, breast and prostate cancer, are becoming increasingly prevalent in Western countries. To better elucidate the onset and evolution of these pathologies and ultimately design new preventive and therapeutic strategies, research activities focused on these biomedical areas have been supported by the European Union in the last two decades. While research has globally contributed increasing our understanding of the pathological mechanisms underlying these diseases, the failure rate in drug development still remains very high. Nowadays, it is important to monitor contribution to innovation and impact of funded research by means of defined indicators.
  • 1.4K
  • 28 Jul 2020
Topic Review
Electronic Noses in COPD
Exhaled breath analysis is a non-invasive method to study lung diseases, and electronic noses have been extensively used in breath research. Studies with electronic noses have proved that the pattern of exhaled volatile organic compounds is different in COPD. More recent investigations have reported that electronic noses could potentially distinguish different endotypes (i.e., neutrophilic vs. eosinophilic) and are able to detect microorganisms in the airways responsible for exacerbations. This entry reviews the published literature on electronic noses and COPD and help in identifying methodological, physiological, and disease-related factors which could affect the results.
  • 1.4K
  • 27 Jul 2023
Topic Review
Nutraceutical Curcumin
Curcumin is a principal bioactive phenolic compound of the spice turmeric, in regard to various human and animal herpesvirus infections and inflammation connected with these diseases. Curcumin was explored with potent antiherpetic actions against herpes simplex virus type 1 and type 2, human cytomegalovirus, Kaposi’s sarcoma-associated herpesvirus, Epstein–Barr virus, bovine herpesvirus 1, and pseudorabies virus. 
  • 1.4K
  • 07 Mar 2021
Topic Review
Sympathetic Activation after Myocardial Infarction
Myocardial infarction often leads to progressive structural and electrophysiologic remodeling of the left ventricle. Histological and functional studies have demonstrated extensive alterations of sympathetic nerve endings at the peri-infarct area and flow-innervation mismatches that create a highly arrhythmogenic milieu.
  • 1.4K
  • 26 Jun 2021
Topic Review
Asthma Pathogenesis
Asthma is a widespread chronic disease of the bronchopulmonary system with a heterogeneous course due to the complex etiopathogenesis. Natural-climatic and anthropogenic factors play an important role in the development and progression of this pathology. 
  • 1.4K
  • 28 Jul 2021
Topic Review
FAK as Promising Cancer Therapy
FAK is an intracellular non-receptor tyrosine kinase that promotes tumor cell growth by controlling cell adhesion, migration, proliferation, and survival. Therefore, targeting FAK is considered to be a promising cancer therapy with small molecules.
  • 1.4K
  • 03 Aug 2021
Topic Review
Tregs in IBD
Inflammatory bowel disease (IBD) is a complex inflammatory chronic and pathological condition that includes Crohn’s disease (CD) and Ulcerative colitis (UC). CD primarily affects the small and large intestine whereas the prime targets for UC are colon and rectum. Immune sentinel subsets of CD4+ T cells such as Th (T helper cells)-1, Th2, Th17, and regulatory T cells (Tregs) play a crucial role in the pathogenesis of IBD. Immunological balance between effector Th cells and Trges is essential for maintaining immune-homeostasis. Immunoregulatory Trges are characterized by the expression of transcription factor Forkhead box P3 (Foxp3), and surface marker CD25, and are functionally immunosuppressive & important for immune tolerance. Therapeutic arrangement based on Tregs is important to address the systemic inflammatory and autoimmune diseases such as IBD and rheumatoid arthritis.
  • 1.4K
  • 11 Aug 2021
Topic Review
AhR in the Hallmarks of Brain Aging
AhR, a member of the basic helix-loop-helix (bHLH)-PAS superfamily, performs various functions within the brain. It is an ancient protein that possesses shared functions and structures across various species in the evolutionary tree. It is widely distributed in various regions of the brain, such as the hippocampus, the cortex, and the hypothalamus, and its expression changes during the course of brain development.
  • 1.4K
  • 20 Oct 2021
Topic Review
Si-Based GeSn
A literature survey revealed that GeSn materials have numerous potential applications, including Si-based, integrated high-efficiency light sources; high-mobility electronic devices; low-cost Si-based high-performance shortwave infrared (SWIR) imaging sensors; Si-based photovoltaics; optical signal encoding in the mid-infrared range; high-performance logic applications; Si-based integrated thermoelectrics as wearable devices; Si-based spintronics; Si-based integrated reconfigurable dipoles; and Si-based quantum computing. GeSn-related fundamental research and development applications have also been extensively investigated. 
  • 1.4K
  • 14 Mar 2022
Topic Review
Multifaceted Effects of Lycopene
Lycopene is a pigment belonging to the group of carotenoids and it is among the most carefully studied antioxidants found especially in fruit and vegetables. As a carotenoid, lycopene exerts beneficial effects on human health by protecting lipids, proteins, and DNA from damage by oxidation. Lycopene is a powerful oxygen inactivator in the singlet state.
  • 1.4K
  • 17 Nov 2021
Topic Review
VR Technology to the Training of Paramedics
The virtual world has long been a focus not only of the gaming sphere, but also of the manufacturing and educational industries. The virtual world and its technology have many advantages, the basic ones being, for example, the use of experiential learning, with which the human brain can remember some things better and faster. It was due to the advantages of virtual reality technology that we decided to create an educational system on safety and health at work, and we focused on the healthcare segment due to the COVID-19 pandemic.
  • 1.4K
  • 14 Apr 2022
Topic Review
Factors envolved in Coal Slurry Flocculation Process
Coal slurry is a mixture of finely grained coal and other minerals suspended and/or sediment in the water, generated during the coal preparation processes, accounting for more than half of mining operating cost. Dewatering technology is simultaneously confronted with obstacles and possibilities, and it may yet be improved as the crucial step for reducing the ultimate processing cost. Coagulation/flocculation is a process in which solid and liquid parts of a solution are separated using different types of coagulants and flocculants.
  • 1.4K
  • 08 Apr 2022
Topic Review
New Treatment Strategies for IgA Nephropathy
Immunoglobulin A nephropathy (IgAN) is a rare autoimmune disorder and the leading cause of biopsy-reported glomerulonephritis (GN) worldwide. Disease progression is driven by the formation and deposition of immune complexes composed of galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1 autoantibodies (anti-Gd-IgA1 antibodies) in the glomeruli, where they trigger complement-mediated inflammation that can result in loss of kidney function and end-stage kidney disease (ESKD). 
  • 1.4K
  • 01 Sep 2022
Topic Review
Bi-Directional Text
Bi-directional text is text containing text in both text directionalities, both right-to-left (RTL or dextrosinistral) and left-to-right (LTR or sinistrodextral). It generally involves text containing different types of alphabets, but may also refer to boustrophedon, which is changing text directionality in each row. Some writing systems of the world, including the Arabic and Hebrew scripts or derived systems such as the Persian, Urdu, and Yiddish scripts, are written in a form known as right-to-left (RTL), in which writing begins at the right-hand side of a page and concludes at the left-hand side. This is different from the left-to-right (LTR) direction used by the dominant Latin script. When LTR text is mixed with RTL in the same paragraph, each type of text is written in its own direction, which is known as bi-directional text. This can get rather complex when multiple levels of quotation are used. Many computer programs fail to display bi-directional text correctly. For example, the Hebrew name Sarah (שרה) is spelled: sin (ש) (which appears rightmost), then resh (ר), and finally heh (ה) (which should appear leftmost). Note: Some web browsers may display the Hebrew text in this article in the opposite direction.
  • 1.4K
  • 11 Nov 2022
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