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Topic Review
Hypophosphatasia: a Rare Bone Disease
Hypophosphatasia (HPP) is a rare genetic disease characterized by a decrease in the activity of tissue non-specific alkaline phosphatase (TNSALP). TNSALP is encoded by the ALPL gene, which is abundantly expressed in the skeleton, liver, kidney, and developing teeth. HPP exhibits high clinical variability largely due to the high allelic heterogeneity of the ALPL gene. HPP is characterized by multisystemic complications, although the most common clinical manifestations are those that occur in the skeleton, muscles, and teeth. These complications are mainly due to the accumulation of inorganic pyrophosphate (PPi) and pyridoxal-5′-phosphate (PLP).
  • 1.4K
  • 10 May 2021
Topic Review
Injectable Hydrogels for Skin Wound
Functionalized biomaterials which are able to be implanted regardless of the wound deformity  and potentially embark the skin wound management by the ability to be bioinert, self-degradable and non invasive. These 3D network hold a unique characteristics which are able to mimic the skin extracellular matrix (ECM) and has been successfully proven to promote wound healing and skin regeneration.
  • 1.4K
  • 31 May 2021
Topic Review
Age-Related Alterations at Neuromuscular Junction
With advancing aging, a decline in physical abilities occurs, leading to reduced mobility and loss of independence. Although many factors contribute to the physio-pathological effects of aging, an important event seems to be related to the compromised integrity of the neuromuscular system, which connects the brain and skeletal muscles via motoneurons and the neuromuscular junctions (NMJs). NMJs undergo severe functional, morphological, and molecular alterations during aging and ultimately degenerate. The effect of this decline is an inexorable decrease in skeletal muscle mass and strength, a condition generally known as sarcopenia. Moreover, several studies have highlighted how the age-related alteration of reactive oxygen species (ROS) homeostasis can contribute to changes in the neuromuscular junction morphology and stability, leading to the reduction in fiber number and innervation. Increasing evidence supports the involvement of epigenetic modifications in age-dependent alterations of the NMJ. In particular, DNA methylation, histone modifications, and miRNA-dependent gene expression represent the major epigenetic mechanisms that play a crucial role in NMJ remodeling. It is established that environmental and lifestyle factors, such as physical exercise and nutrition that are susceptible to change during aging, can modulate epigenetic phenomena and attenuate the age-related NMJs changes.
  • 1.4K
  • 15 Jun 2021
Topic Review
Oral Bioavailability and Regulatory Aspects
Oral bioavailability refers to the extent a substance or drug becomes completely available to systemic circulation or to its intended biological destination(s) via the oral route. High oral bioavailability reduces the amount of a drug necessary to achieve a desired pharmacological effect, therefore reducing the risk of side-effects and toxicity. Low oral bioavailability results in low efficacy and is a major reason for drug candidates failing to reach the market. Hence, oral bioavailability is one of the most important properties in drug design and development.
  • 1.4K
  • 11 Oct 2021
Topic Review
Neuroplasticity
Neuroplasticity can be defined as the ability of the nervous system to modify its structure on the basis of different environmental changes and stimulation.
  • 1.4K
  • 28 Oct 2021
Topic Review
Air Pollution Affects Placental DNA Methylation
The Developmental Origins of Health and Disease (DOHaD) concept postulates that in utero exposures influence fetal programming and health in later life. Throughout pregnancy, the placenta plays a central role in fetal programming; it regulates the in utero environment and acts as a gatekeeper for nutrient and waste exchange between the mother and the fetus. Maternal exposure to air pollution, including heavy metals, can reach the placenta, where they alter DNA methylation patterns, leading to changes in placental function and fetal reprogramming. In this entry, we explore the current knowledge on placental DNA methylation changes associated with prenatal air pollution (including heavy metals) exposure and highlight its effects on fetal development and disease susceptibility.
  • 1.4K
  • 15 Nov 2021
Topic Review
Chronic Autoimmune Gastritis
Helicobacter pylori (HP) infection and the autoimmune inflammation of the gastric mucosa are recognized as the leading etiological factors of chronic atrophic gastritis, a disease associated with an increased risk of stomach cancer development. Additionally, in relation to HP-associated gastritis, there is international and national consensus on the diagnosis and treatment of infection; however, with regard to autoimmune inflammation, clinicians have faced diagnostic difficulties. At the same time, autoimmune inflammation of the gastric mucosa, in addition to the formation of atrophy and an increase in the risk of stomach cancer, carries additional risks, both in relation to neoplasms (neuroendocrine tumors) and in relation to the deficiency of a number of micronutrients with the involvement of other organs and systems.
  • 1.4K
  • 30 Nov 2021
Topic Review
Biliary Atresia
The term biliary atresia has substituted the original term of “extrahepatic biliary atresia”, which has been in use for several generations. The concept was related to the often-identified absence of gallbladder with an obliterated cord at the site the extrahepatic biliary system. It is now known that biliary atresia is a necro-inflammatory and fibro-obliterative process of both intrahepatic and extrahepatic biliary tract.
  • 1.4K
  • 11 Feb 2022
Topic Review
Nanomaterials for Optical Coherence Tomography in Nanodentistry
There is already a societal awareness of the growing impact of nanoscience and nanotechnology, with nanomaterials (with at least one dimension less than 100 nm) now incorporated in items as diverse as mobile phones, clothes or dentifrices. In the healthcare area, nanoparticles of biocompatible materials have already been used for cancer treatment or bioimaging enhancement. Nanotechnology in dentistry, or nanodentistry, has already found some developments in dental nanomaterials for caries management, restorative dentistry and orthodontic adhesives. 
  • 1.4K
  • 01 Mar 2022
Topic Review
Impact of Insecticide Resistance on Vector Competence
The capacity of insects to transmit pathogens is known as vector competence (VC). Evidence indicates that insecticide exposure and resistance increase the risk of pathogen transmission. Under this context, adverse effects such as epidemics in human populations or economic repercussions on crops will increase while current vector control efforts become entirely ineffective. However, studies also point to opposite effects where IR or exposure to insecticides reduces VC. To determine the impact of insecticide resistance (IR) on VC precisely, it is essential to establish reproducible experimental designs to reduce the presence of confusing variables that make the interpretation of results difficult. Therefore, although there is evidence related to the influence of IR on VC, more research is necessary.
  • 1.4K
  • 22 Apr 2022
Topic Review
German University of Administrative Sciences, Speyer
The German University of Administrative Sciences Speyer (German: Deutsche Universität für Verwaltungswissenschaften Speyer; sometimes referred to as Speyer University), is a national graduate school for administrative sciences and public management located in Speyer, Rhineland-Palatinate, Germany . Founded in 1947 by the French occupational authorities as a grande école, today it is operated under the joint responsibility of both the Federal Republic (Bund) and all 16 German states (Länder). It runs four Master's programs, grants doctoral degrees and habilitations, offers a postgraduate certificate program, and administers programs of executive education. The school is a major training ground for German and international senior government officials. Noted alumni and faculty include former President of Germany Roman Herzog, current Minister of Justice Christine Lambrecht, former President of the Bundesbank Helmut Schlesinger, former Prosecutor General of Germany Alexander von Stahl, and CEO of BASF Jürgen Strube. The school was founded in 1947 as the State Academy of Administrative Sciences Speyer (Staatliche Akademie für Verwaltungswissenschaften Speyer). In 1950 it was renamed the School of Administrative Sciences Speyer (Hochschule für Verwaltungswissenschaften Speyer) and after reunification became the German School of Administrative Sciences Speyer (Deutsche Hochschule für Verwaltungswissenschaften Speyer).
  • 1.4K
  • 14 Oct 2022
Topic Review
Firearm (Tool)
A firearm is primarily a weapon, but can be used as a tool to project either single or multiple objects at high velocity through a controlled explosion. The firing is achieved by the gases produced through rapid, confined burning of a propellant. This process of rapid burning is technically known as deflagration. In older firearms, this propellant was typically black powder, but modern firearms use smokeless powder, cordite, or other propellants. Many firearms such as mortars do not have rifled bores to impart spin to the projectile for improved flight stability, such as is seen with firearms used as weapons, although some are rifled. The lack of rifling can prevent tangling of grappling hook lines, buoy lines, and such, although some firearms intended for use at the longest ranges in these applications are rifled.
  • 1.4K
  • 19 Oct 2022
Topic Review
Gastrointestinal and Liver Complications in Diabetes Mellitus
The number of diabetes mellitus patients has increased in developing countries, along with obesity and sedentary lifestyle. Besides macroangiopathy and microangiopathy, damage to the nerve fibers of the peripheral nervous system is the most common chronic complication of diabetes. Digestive complications in diabetic patients represent a consequence of diabetic autonomic neuropathy involving the gastrointestinal tract, but unfortunately not always evaluated by diabetologists. Aside from the complications encountered in the digestive tract, patients with diabetes mellitus are prone to developing liver diseases.
  • 1.4K
  • 24 Oct 2022
Topic Review
Bücker Bü 131
The Bücker Bü 131 "Jungmann" (freshman, young man) was a German 1930s basic training aircraft which was used by the Luftwaffe during World War II.
  • 1.4K
  • 03 Nov 2022
Topic Review
Army Ground Mobility Vehicle
The M1297 Army Ground Mobility Vehicle (A-GMV or AGMV), previously just GMV, and formerly called the Ultra Light Combat Vehicle (ULCV), is a U.S. Army airdroppable light off-road vehicle for light infantry brigades. The A-GMV is produced by General Dynamics. The design is closely based on the M1288 GMV 1.1, which is itself based on the Flyer 72. In March 2015, the Army changed the name of the Ultra Light Combat Vehicle to the Ground Mobility Vehicle. A-GMV is intended to be carried internally in a CH-47 Chinook or externally by a UH-60 Black Hawk. In order to be survivable but transportable, the GMV would be lightly armored and use speed, maneuverability, and off-road mobility to avoid major threats. The A-GMV is configured to carry an airborne infantry combat squad of nine paratroopers, and their gear – a payload capacity of over 5,000 pounds (2,300 kg). The vehicle has an open design, modifiable into flexible configurations, by remote and manned turrets, armor, or arctic kits. The AGMV was a limited purchase through USSOCOM's GMV 1.1 program. The Infantry Squad Vehicle will be purchased in greater numbers.
  • 1.4K
  • 03 Nov 2022
Topic Review
The ABA/LANCL Hormone/Receptor System in Diabetes
Abscisic acid (ABA), long known as a plant stress hormone, is present and functionally active in organisms other than those pertaining to the land plant kingdom, including cyanobacteria, fungi, algae, protozoan parasites, lower Metazoa, and mammals. 
  • 1.4K
  • 30 Jan 2023
Topic Review
Network Biology Approaches in Alzheimer’s Disease
Alzheimer’s disease (AD) is a polygenic multifactorial neurodegenerative disease that is without a cure. There are some symptomatic treatments to manage the psychological symptoms but none of these drugs can halt disease progression. Additionally, many anti-AD drugs failed in late stages of clinical trials and many hypotheses surfaced to explain these failures, including the lack of clear understanding of disease pathways and processes. Different epigenetic factors have been implicated in AD pathogenesis; thus, they could serve as promising AD diagnostic biomarkers. Additionally, network biology approaches have been suggested as effective tools to study AD on the systems level and discover multi-target-directed ligands as novel treatments for AD.
  • 1.4K
  • 22 Feb 2023
Topic Review
Potential Applications of Silkworm Pupae
The nutritional composition of silkworms will likely have multiple implications for humans, animals, and the environment. The silkworm pupae attracted interest due to lipids and protein profiles. Furthermore, the valuable level of the essential fatty acids (alpha-linolenic and linoleic from the n-3 and n-6 family) results in significant physiological functions in the human body that support good health.
  • 1.4K
  • 21 Mar 2023
Topic Review
T regulatory cell (Treg)
Regulatory T cells (Tregs) are a subset of CD4+ T lymphocytes that possesses the capacity to suppress immune responses to ensure that the immune system’s response to foreign antigens and its response to self-antigens remains adequately balanced. This homeostatic balance ensures the immune system is inflammatory enough to respond sufficiently to foreign antigens, as well as neoantigens from cancer, and sufficiently counter-balanced or anti-inflammatory that inflammation does not get out of hand, leading to tissue damage or death. The immune-suppressive effects of Tregs regulate tumor immunity, antimicrobial resistance, allergy and transplantation. Tregs also play a central role in maintaining self-tolerance. Treg involvement in this mechanism is pivotal for protection from autoimmune diseases.
  • 1.4K
  • 26 Oct 2020
Topic Review
Archery Games
These novelty forms of archery are generally regarded as amusements, and, as such, are not governed by organizationally-sanctioned rules.
  • 1.4K
  • 04 Nov 2022
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