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Topic Review
Komagataella phaffii Biotechnology
The need for a more sustainable society has prompted the development of bio-based processes to produce fuels, chemicals, and materials in substitution for fossil-based ones. In this context, microorganisms have been employed to convert renewable carbon sources into various products. The methylotrophic yeast Komagataella phaffii has been extensively used in the production of heterologous proteins. The obligate aerobic yeast Komagataella phaffii is a non-pathogenic certified and generally recognized as a safe (GRAS) microorganism. It is classified in the Saccharomycetales order and Saccharomycetaceae family. 
  • 1.4K
  • 10 Nov 2022
Topic Review
High-Risk Pregnancy
A high-risk pregnancy is one where the mother or the fetus has an increased risk of adverse outcomes compared to uncomplicated pregnancies. No concrete guidelines currently exist for distinguishing “high-risk” pregnancies from “low-risk” pregnancies, however there are certain studied conditions that have been shown to put the mother or fetus at a higher risk of poor outcomes. These conditions can be classified into three main categories: health problems in the mother that occur before she becomes pregnant, health problems in the mother that occur during pregnancy, and certain health conditions with the fetus. In 2012, the CDC estimated that there were approximately 65,000 pregnancies deemed "high-risk" in the United States.
  • 1.4K
  • 14 Nov 2022
Topic Review
CRISPR/Cas-Based Approaches to Study Schizophrenia
Genomic association studies have revealed the complex genetic architecture of schizophrenia (SZ) and other neurodevelopmental disorders (NDDs). High-throughput models, such as cells and their derivatives, are needed to decipher the molecular basis of SZ pathology. The time is coming for high-throughput genetic technologies based on CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)/Cas systems to manipulate multiple genomic targets. CRISPR/Cas tools make it possible to find and explore the complex relationship between genotype and phenotype of neuronal cells.
  • 1.4K
  • 29 Dec 2022
Topic Review
Kynurenine Pathway
Tryptophan metabolism plays an essential role in human health. In mammals, about 95% of dietary tryptophan is metabolized through the kynurenine pathway, which is associated with the development of several pathologies, including neurodegeneration. Some of the kynurenine pathway metabolites are agonists of the aryl hydrocarbon receptor involved in metabolic functions, inflammation, and carcinogenesis. 
  • 1.4K
  • 30 Nov 2023
Topic Review
Human-Hand-like Grippers
Robotics has gained substantial popularity and holds the potential to facilitate a myriad of remarkable tasks. Manipulation, which plays a pivotal role in the realm of robotics, constitutes an emerging and intricate field. In contemporary times, several materials, actuators, and fabrication techniques have been employed to develop grippers. 
  • 1.4K
  • 04 Dec 2023
Topic Review
Physical and Market Structure of Peer-to-Peer Trading Networks
A peer-to-peer (P2P) network is a distributed self-organising network that does not need to have central nodes, and each node can act as either a server or a client at any given time. The evolution of DERs and the principles of peer-to-peer networks have given rise to interest in the concept of P2P energy trading networks. In a P2P energy trading network, there are no intermediate energy suppliers. People are encouraged to share their energy surplus directly with their local communities. The energy surplus will be sold at an export price, and the additional electricity demand can be encouraged by a cheaper-than-normal retail price.
  • 1.4K
  • 27 Feb 2024
Topic Review
Exosomes in Motor Neurone Disease
Exosomes are attractive as vehicle systems for small therapeutic molecules and/or biomolecules including nucleic acids and proteins because of their lipid nature, presence of specific surface ligands (CD11b and CD18 receptors, integrins, tetraspanins) and ability to cross the blood–brain barrier. When compared to other drug delivery systems, exosomes have the distinct advantages of blood–brain barrier penetrance, longer duration in systemic circulation, tissue specificity that minimizes unwanted toxicity or off-target effects, stability of content, desirable biocompatibility and minimal toxicity issues. Techniques such as fusion expression, exosome membrane surface display and anchoring platforms have been used to attach peptides and biological ligands of interest to adhesion molecules, tetraspanins or integrins on exosome surface to ensure targeted delivery and enhanced uptake into desired cells.
  • 1.4K
  • 08 Nov 2021
Topic Review
Empowerment Dynamics in Health Management and Entrepreneurship
Empowerment dynamics refer to the processes and factors that enhance individuals' capacity to control their personal and professional lives. This concept is especially significant in various contexts, such as the health management of chronic patients and entrepreneurship, particularly in post-crisis scenarios like the COVID-19 pandemic. It encompasses access to resources, support, and opportunities that help individuals overcome challenges and achieve their objectives. A theoretical framework was developed through PhD research, elucidating the mechanisms behind these challenges and their implications for fostering diversity, social innovation, and sustainability. This approach not only compares chronic patients with entrepreneurs and validates the theoretical framework in a group of chronic patients but also proposes practical strategies to harness diversity, innovation, and entrepreneurship in post-crisis contexts.
  • 1.4K
  • 31 Oct 2024
Topic Review
Release of Microplastics from Masks
The global panic caused by COVID-19 has continued to increase people’s demand for masks. Due to inadequate management and disposal practice, these masks have entered the environment and release a large amount of microplastics (MPs), posing a serious threat to the environment and human health. 
  • 1.4K
  • 29 Aug 2022
Topic Review
Surface Chemistry of Paper
The surface chemistry of paper is responsible for many important paper properties, such as gloss, waterproofing, and printability. Many components are used in the paper-making process that affect the surface.
  • 1.4K
  • 11 Oct 2022
Topic Review
Hosts (File)
The computer file hosts is an operating system file that maps hostnames to IP addresses. It is a plain text file. Originally a file named HOSTS.TXT was manually maintained and made available via file sharing by Stanford Research Institute for the ARPANET membership, containing the hostnames and address of hosts as contributed for inclusion by member organizations. The Domain Name System, first described in 1983 and implemented in 1984, automated the publication process and provided instantaneous and dynamic hostname resolution in the rapidly growing network. In modern operating systems, the hosts file remains an alternative name resolution mechanism, configurable often as part of facilities such as the Name Service Switch as either the primary method or as a fallback method.
  • 1.4K
  • 15 Nov 2022
Biography
Erik Buell
Erik F. Buell (born April 2, 1950, in Pittsburgh, Pennsylvania) is the founder, former Chairman and Chief Technical Officer of the Buell Motorcycle Company, which eventually merged with Harley-Davidson Corp. Buell is a pioneer of modern race motorcycle technology. Buell is also the founder of Erik Buell Racing.[1] Erik Buell is now a co founder of VANGUARDSPARK - Electric Urban Mobility (Vangua
  • 1.4K
  • 28 Dec 2022
Topic Review
Wastewater Treatment by Catalytic Wet Peroxidation
Nowadays, there is an increasing interest in the development of promising, efficient, and environmentally friendly wastewater treatment technologies. Among them are the advanced oxidation processes (AOPs), in particular, catalytic wet peroxidation (CWPO), assisted or not by radiation. One of the challenges for the industrial application of this process is the development of stable and efficient catalysts, without leaching of the metal to the aqueous phase during the treatment. Gold catalysts, in particular, have attracted much attention from researchers because they show these characteristics. Recently, numerous studies have been reported in the literature regarding the preparation of gold catalysts supported on various supports and testing their catalytic performance in the treatment of real wastewaters or model pollutants by CWPO. This review summarizes this research; the properties of such catalysts and their expected effects on the overall efficiency of the CWPO process, together with a description of the effect of operational variables (such as pH, temperature, oxidant concentration, catalyst, and gold content). In addition, an overview is given of the main technical issues of this process aiming at its industrial application, namely the possibility of using the catalyst in continuous flow reactors. Such considerations will provide useful information for a faster and more effective analysis and optimization of the CWPO process.
  • 1.4K
  • 14 May 2020
Topic Review
Anti-Obesity Effects of Microalgae
Microalgae are prokaryotic or eukaryotic microscopic single-cell organisms, producing a great variety of compounds, such as photosynthetic pigments (carotenoids and chlorophylls), sterols, polyunsaturated fatty acids, vitamins, minerals, fiber, polysaccharides, enzymes, peptides, and toxins. In recent years, they have attracted great interest as a major source of bioactive medicinal products and food ingredients with anti-oxidant, anti-inflammatory, anti-cancer and anti-microbial properties. In most pre-clinical studies performed with Euglena gracilis, Phaeodactylum tricornutum, Spirulina maxima, Spirulina platensis, or Nitzschia laevis microalgae, positive anti-obesity effects have been addressed in animals submitted to an obesogenic feeding pattern. However, more research is warranted to determine which bioactive compound(s) are responsible for their anti-obesity effects, as well as to establish the mechanisms underlying those effects.
  • 1.4K
  • 14 Apr 2021
Topic Review
Parkinson’s genes in neurological disorders
Neurodevelopmental and late-onset neurodegenerative disorders present as separate entities that are clinically and neuropathologically quite distinct. However, recent evidence has highlighted surprising commonalities and converging features at the clinical, genomic, and molecular level between these two disease spectra. This is particularly striking in the context of autism spectrum disorder (ASD) and Parkinson’s disease (PD). Genetic causes and risk factors play a central role in disease pathophysiology and enable the identification of overlapping mechanisms and pathways. Several genes and genomic regions are highlighted, including SNCA (alpha-synuclein), PARK2 (parkin RBR E3 ubiquitin protein ligase), chromosome 22q11 deletion/DiGeorge region, and FMR1 (fragile X mental retardation 1) repeat expansion, which influence the development of both ASD and PD, with converging features related to synaptic function and neurogenesis. Both PD and ASD display alterations and impairments at the synaptic level, representing early and key disease phenotypes, which support the hypothesis of converging mechanisms between the two types of diseases. Therefore, understanding the underlying molecular mechanisms might inform on common targets and therapeutic approaches.
  • 1.4K
  • 24 Aug 2020
Topic Review
ω-3 PUFA on colon cancer
Substantial human and animal studies support the beneficial effects of ω-3 polyunsaturated fatty acids (PUFAs) on colonic inflammation and colorectal cancer (CRC). However, there are inconsistent results, which have shown that ω-3 PUFAs have no effect or even detrimental effects, making it difficult to effectively implement ω-3 PUFAs for disease prevention. A better understanding of the molecular mechanisms for the anti-inflammatory and anticancer effects of ω-3 PUFAs will help to clarify their potential health-promoting effects, provide a scientific base for cautions for their use, and establish dietary recommendations.
  • 1.4K
  • 17 Nov 2020
Topic Review
Crisis-focused Psychological Interventions
Public safety personnel (PSP) and frontline healthcare professionals (FHP) are frequently exposed to potentially psychologically traumatic events (PPTEs), and report increased rates of post-traumatic stress injuries (PTSIs). Despite widespread implementation and repeated calls for research, effectiveness evidence for organizational post-exposure PTSI mitigation services remains lacking.
  • 1.4K
  • 10 Dec 2020
Topic Review
Coloboma
Coloboma is an eye abnormality that occurs before birth. Colobomas are missing pieces of tissue in structures that form the eye. They may appear as notches or gaps in one of several parts of the eye, including the colored part of the eye called the iris; the retina, which is the specialized light-sensitive tissue that lines the back of the eye; the blood vessel layer under the retina called the choroid; or the optic nerves, which carry information from the eyes to the brain.
  • 1.4K
  • 24 Dec 2020
Topic Review
Learning for Unmanned Ground Vehicles
The problem of autonomous navigation of a ground vehicle in unstructured environments is both challenging and crucial for the deployment of this type of vehicle in real-world applications. We present a review on the recent contributions in the roboticsliterature adopting learning-based methods to solve the problem of environment perception andinterpretation with the final aim of the autonomous context-aware navigation of ground vehicles inunstructured environments.
  • 1.4K
  • 29 Apr 2021
Topic Review
Neisseria gonorrhoeae
Neisseria gonorrhoeae is a Gram-negative diplococcus which causes the sexually transmitted infection (STI) gonorrhea.
  • 1.4K
  • 24 Feb 2021
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