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Topic Review
Diagnosis of Serous Cystadenoma
Incidental pancreatic cysts are highly prevalent, with management dependent on the risk of malignant progression. Serous cystadenomas (SCAs) are the most common benign pancreatic cysts seen on imaging. They have typical morphological patterns but may also show atypical features that mimic precancerous and cancerous cysts.
  • 1.4K
  • 07 Dec 2023
Topic Review
Brown Bear
The Brown Bear (Ursus arctos), a formidable and iconic member of the Ursidae family, is one of the most widespread bear species, exhibiting a remarkable adaptability to diverse habitats across the Northern Hemisphere. Renowned for its distinctive hump on the shoulders, powerful build, and a range of fur colors from light brown to nearly black, the Brown Bear is a symbol of strength and resilience in the wild. This large carnivore plays a crucial role in shaping ecosystems, influencing prey populations, and contributing to the overall biodiversity of its habitats.
  • 1.4K
  • 08 Feb 2024
Topic Review
Dairy Cow Health and Methane Emissions
The dairy industry is facing criticism for its role in exacerbating global GHG emissions, as climate change becomes an increasingly pressing issue. These emissions mostly originate from methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2). An optimal strategy involves the creation of an economical monitoring device to evaluate methane emissions from dairy animals.
  • 1.4K
  • 13 Mar 2024
Topic Review
MDA5 Deficiency
MDA5 deficiency is a disorder of the immune system (immunodeficiency) that leads to recurrent, severe infections of the lungs and airways (respiratory tract) beginning in infancy.
  • 1.4K
  • 24 Dec 2020
Topic Review
Guidelines for Using Antipruritic Drugs in Dogs
Pruritus is defined as an unpleasant sensation that provokes the desire to scratch. Pruritus is a common clinical sign of many skin disorders and is the most common complaint in canine dermatology. Pruritic skin diseases can affect the quality of life (QoL) of dogs and their owners. The first indication for the use of antipruritic drugs is, of course, allergies, notably canine atopic dermatitis (AD). However, in pruritic infections or parasitic dermatoses, the speed of action and the level of efficacy of etiological treatments vary and, to improve the QoL of both the dog and the owner, the use of an additional symptomatic antipruritic drugs in addition to etiological treatment sometimes makes sense after obtaining a clear diagnosis.
  • 1.4K
  • 13 Apr 2022
Topic Review
May 30: Voltaire Died in Paris
Voltaire was the pen name of François-Marie Arouet, a French Enlightenment writer, historian, and philosopher renowned for his wit, intellectual prowess, and vigorous criticism of institutional authority, particularly the Church and the French monarchy. He is considered one of the most significant voices of the Enlightenment era, advocating for reason, civil liberties, and secular governance. Voltaire's literary legacy includes satirical novels, historical works, philosophical treatises, and thousands of letters that shaped the development of modern thought.
  • 1.4K
  • 28 May 2025
Topic Review
BPES
Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) is a condition that mainly affects development of the eyelids. People with this condition have a narrowing of the eye opening (blepharophimosis), droopy eyelids (ptosis), and an upward fold of the skin of the lower eyelid near the inner corner of the eye (epicanthus inversus). In addition, there is an increased distance between the inner corners of the eyes (telecanthus). Because of these eyelid abnormalities, the eyelids cannot open fully, and vision may be limited.
  • 1.4K
  • 04 Jan 2021
Topic Review
Vitreous Substitute
The ideal vitreous substitute should mimic the native vitreous in terms of both structure and function such as transparency, biocom-patibility, elasticity, easy injectability, except for its liquefication and biodegradability with age. Current vitreous substitutes are used in order to maintain certain criterias such as optical and biomechanical properties and intraocular pressure. Therefore, extensive research with biomaterials is underway taking into consideration its composition, structure and physiological properties as well to overcome the downside of the currently used tamponades.
  • 1.4K
  • 15 Jan 2021
Topic Review
Biotechnology for COVID-19 Diagnosis
To date, six human coronaviruses have been identified: α-coronaviruses (HCoVs-NL63, HCoVs-229E), β-coronaviruses (HCoVs-OC43, HCoVs-HKU1), severe acute respiratory syndrome-CoV (SARS-CoV), and Middle East respiratory syndrome-CoV (MERS-CoV). After the SARS-CoV-1 epidemic, the world is living a new threat to human health since December 2019—the SARS-CoV-2 or the COVID-19 pandemic. The emergence of the novel coronavirus is associated with an atypical pneumonia that has led to 90,176,569 infections and 1,936,617 deaths worldwide, as of 10 January 2021. Structurally, SARS-CoV-2 is an enveloped RNA(Ribonucleic acid) virus comprising a spike protein (S), a hemagglutinin-esterase dimer (HE), a membrane glycoprotein (M), an envelope protein (E), and a nucleocapsid protein (N). It has been demonstrated that the mechanism of the viral infection requires angiotensin-converting enzyme 2 (ACE2) binding to the protein S with high affinity. Highly expressed in the endothelial cells of the cardiovascular system and kidneys, this human receptor is used by the virus as an entry to invade target cells. Currently, immunoassays are the most popular diagnostic tools available in the market and used in medical structures. Basically, these methods use antibodies as bioreceptors targeting capsid proteins or whole viruses. In serological testing, capsid proteins are used as viral antigens to bind the immunoglobulins generated by the patient against the pathogen. Antibodies are usually obtained from animal immunization with N, S, or E protein or from the blood samples of patients who are infected [14]. In addition to the commercialized ELISA kits and rapid tests, several research reports have described novel immunoassays and immunosensors for coronavirus detection. We discuss in this part the principle of these methods as well as the most important results.
  • 1.4K
  • 21 Apr 2021
Topic Review
Dioxin
Dioxins and related compounds are environmental xenobiotics that are dangerous to human life, due to the accumulation and persistence in the environment and in the food chain. Cancer, reproductive and developmental issues, and damage to the immune system and endocrine system are only a few examples of the impact of such substances in everyday life. 
  • 1.4K
  • 06 Jan 2022
Topic Review
Genital Tract Microbiome of Cattle
The term microbiota refers to the entire population of microorganisms that colonizes a particular location and includes not just bacteria, but also other microbes such as fungi, archaea, viruses, and protozoans. Cows have bacteria inhabiting the uterus even before calving and establish a unique endometrial microbiome within 20 min of calving where the microbiome is similar between cows that develop metritis and cows without endometritis until at least the second day postpartum.
  • 1.4K
  • 23 Feb 2022
Topic Review
Wireless Charging for Electric Vehicles
Wireless charging modules for electric vehicles (EVs) are being increasingly studied. Two techniques of transferring power to EVs via charging systems can be used: conductive charging and wireless charging. Some notable studies, as presented in this work, focused on developing more effective wireless-charging modules for electric vehicles to pave the way for the creation of more sustainable urban transportation. It is also important to note that attaining this sustainable urban mobility is dependent on using clean energy sources (like solar photovoltaic). As a result, some techniques were discussed to supplement wireless charging and hence reduce the size of the needed energy storage device for urban mobility.
  • 1.4K
  • 02 Mar 2022
Topic Review
Enterocin as a Biopreservative for Raw Meat Products
Food preservation is a method used to handle and treat food products to slow down food spoilage and subsequently reduce the risk of foodborne illness. Nowadays, the demand for natural preservatives over chemical preservatives in food is increasing due to the awareness of consuming healthy food products without the risk of harmful side effects. Thus, the research and development of preservation techniques, referred to as biopreservation, is growing rapidly. In biopreservation methods, microorganisms that are known as lactic acid bacteria (LAB) and their antimicrobial substances are used to extend shelf life and maintain the nutritional value of foods. Among the most studied LAB are from the genus Enterococcus, which produces a bacteriocin called enterocin. Bacteriocins are ribosomal-synthesized antimicrobial peptides that are capable of inhibiting the growth of pathogenic bacteria that cause spoilage in food. LAB is generally regarded as safe (GRAS) for human consumption. 
  • 1.4K
  • 11 Apr 2022
Topic Review Video
‘Teratoid’ Hepatoblastoma
Liver neoplasms are quite rare in childhood. They often involve 6.7 cases per 10 million children aged 18 years or younger. Hepatoblastoma (HB) is the most frequent tumor, but this neoplasm’s rarity points essentially to the difficulty of performing biologic studies and large-scale therapeutic trials. On the pathological ground, HB is separated into an entirely epithelial neoplasm or a mixed neoplasm with epithelial and mesenchymal components. This last category has been further subdivided into harboring teratoid features or not. The ‘teratoid’ HB includes a mixture of components with heterologous origin.
  • 1.4K
  • 24 Apr 2022
Topic Review
Breeding Diploid F1 Hybrid Potatoes
Diploid potatoes can be converted from an outbreeding species, in which self-pollination is prevented by a gametophytic self-incompatibility system, into one where self-pollination is possible, either through a dominant self-incompatibility inhibitor gene (Sli) or knockout mutations in the incompatibility locus.
  • 1.4K
  • 29 Apr 2022
Topic Review
Miles-Phillips Mechanism
In physical oceanography and fluid mechanics, the Miles-Phillips mechanism describes the generation of wind waves from a flat surface by the use of two distinct mechanisms. Both mechanisms are applied on the gravity-capillary waves and have in common that waves are generated by a resonance phenomenon. The Miles mechanism is based on the hypothesis that waves arise as an instability of the sea-atmosphere system. The Phillips mechanism assumes that turbulent eddies in the atmospheric boundary layer induce pressure fluctuations at the sea surface.
  • 1.4K
  • 13 Oct 2022
Topic Review
Quantitative Electroencephalogram
Over many decades, clinical, systemic, and cognitive neuroscience have produced a large and diverse body of evidence for the potential utility of brain activity (measured by electroencephalogram—EEG) for neurology and psychiatry. These data are enormous and essential information often gets buried, leaving many researchers stuck with outdated paradigms.
  • 1.4K
  • 27 Oct 2022
Topic Review
DUF1220
DUF1220 is a protein domain that shows a striking human lineage-specific (HLS) increase in copy number and may be involved in human brain evolution. The protein domain has also been liked to several neurogenetic disorders such as Schizophrenia and increased severity of autism. The DUF1220 domain name has recently been changed to the Olduvai domain based on data obtained since initial discovery of the domain. The copy number of DUF1220 domains increases generally as a function of a species evolutionary proximity to humans. The increase in the number of copies that are present in connection with DUF1220 also seem to have a direct correlation with several phenotypes of the brain including the increase in brain size as seen through evolution. DUF1220 copy number is the highest in humans (~289, with some person-to-person variations) and shows the largest HLS increase in copy number (an additional 160 copies) of any protein coding region in the human genome. DUF1220 copy number is reduced in African great apes (estimated 125 copies in chimpanzees), further reduced in orangutan (92) and Old World monkeys (35), single- or low-copy in non-primate mammals and absent in non-mammals. DUF1220 domains are approximately 65 amino acids in length and are encoded by a two-exon doublet. In the human genome DUF1220 sequences are located primarily on chromosome 1 in region 1q21.1-q21.2, with several copies also found at 1p36, 1p13.3, and 1p12. Sequences encoding DUF1220 domains show rhythmicity, resonance and signs of positive selection, especially in primates, and are expressed in several human tissues including brain, where their expression is restricted to neurons.
  • 1.4K
  • 31 Oct 2022
Topic Review
New Vrindaban
New Vrindaban is an unincorporated area and an ISKCON (Hare Krishna) intentional community located in Marshall County, West Virginia, United States, near Moundsville. The town consists of 1,204 acres (4.87 km2) (of which 0.1 km² is of water), and several building complexes, homes, apartment buildings, and businesses including the Sri Sri Radha Vrindaban Chandra Temple (RVC Temple) and Prabhupada's Palace of Gold. New Vrindaban was founded in 1968 under the direct guidance of A.C. Bhaktivedanta Swami Prabhupada, founder of ISKCON, by his disciple Kirtanananda Swami. It is named for the Indian city of Vrindavan.
  • 1.4K
  • 31 Oct 2022
Topic Review
Ethical Arguments Regarding Torture
Ethical arguments have arisen regarding torture, and its debated value to society. Despite worldwide condemnation and the existence of treaty provisions that forbid it, some countries still use it. The ethical assertion that torture is a tool is at question.
  • 1.4K
  • 01 Nov 2022
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