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Topic Review
Citrus-Derived Polymethoxylated Flavones
Several reports have shown that polymethoxylated flavones (PMFs) derived from citrus fruit, such as nobiletin, tangeretin, and 3,3′,4′,5,6,7,8-heptamethoxyflavone, are promising molecules for the prevention of neurodegenerative and neurological disorders. In various animal models, PMFs have been shown to have a neuroprotective effect and improve cognitive dysfunction with regard to neurological disorders by exerting favorable effects against their pathological features, including oxidative stress, neuroinflammation, neurodegeneration, and synaptic dysfunction as well as its related mechanisms.
  • 1.4K
  • 22 Jan 2021
Topic Review
Tunneling Nanotubes
Tunneling nanotubes (TNTs) are recognized long membrane nanotubes connecting distance cells. In the last decade, growing evidence has shown that these subcellular structures mediate the specific transfer of cellular materials, pathogens, and electrical signals between cells. As intercellular bridges, they play a unique role in embryonic development, collective cell migration, injured cell recovery, cancer treatment resistance, and pathogen propagation. Although TNTs have been considered as potential drug targets for treatment, there is still a long way to go to translate the research findings into clinical practice.
  • 1.4K
  • 10 Mar 2021
Topic Review
Nanofiber-Based Face Masks and Respirators
Wearing face masks, use of respirators, social distancing, and practicing personal hygiene are all measures to prevent the spread of coronavirus disease (COVID-19). This pandemic has revealed the deficiency of face masks and respirators across the world. Therefore, significant efforts are needed to develop air filtration and purification technologies, as well as innovative, alternative antibacterial and antiviral treatment methods. It has become urgent—in order for humankind to have a sustainable future—to provide a feasible solution to air pollution, particularly to capture fine inhalable particulate matter in the air.
  • 1.4K
  • 24 Aug 2021
Topic Review
Zinc Dyshomeostasis and Parkinson’s Disease
Zinc and other heavy metals have received considerable attention in neurodegenerative diseases because of their cytotoxicity. The role of zinc in the pathogenesis of PD is not straightforward because of its numerous and complex function. Both deficiency and excess of zinc have been incriminated in the development of the disease, though overwhelming evidence favor the later mechanism.
  • 1.4K
  • 20 May 2021
Topic Review
Targeting PAI-1 for Potential Therapies
Hypofibrinolysis is a key abnormality in diabetes and contributes to the adverse vascular outcome in this population. Plasminogen activator inhibitor (PAI)-1 is an important regulator of the fibrinolytic process and levels of this antifibrinolytic protein are elevated in diabetes and insulin resistant states. This review describes both the physiological and pathological role of PAI-1 in health and disease, focusing on the mechanism of action as well as protein abnormalities in vascular disease with special focus on diabetes. Attempts at inhibiting protein function, using different techniques, are also discussed including direct and indirect interference with production as well as inhibition of protein function. Developing PAI-1 inhibitors represents an alternative approach to managing hypofibrinolysis by targeting the pathological abnormality rather than current practice that relies on profound inhibition of the cellular and/or acellular arms of coagulation, and which can be associated with increased bleeding events. The review offers up-to-date knowledge on the mechanisms of action of PAI-1 together with the role of altering protein function to improve hypofirbinolysis. Developing PAI-1 inhibitors may form for the basis of future new class of antithrombotic agents that reduce vascular complications in diabetes.
  • 1.4K
  • 31 May 2021
Topic Review
Single-Molecule Labeling and Imaging Strategies
Single-molecule imaging is emerging as a revolutionary approach to studying fundamental questions in plants. However, compared with its use in animals, the application of single-molecule imaging in plants is still underexplored. 
  • 1.4K
  • 31 May 2021
Topic Review
RSTS
The Rubinstein-Taybi syndrome (RSTS) is a rare congenital developmental disorder characterized by a typical facial dysmorphism, distal limb abnormalities, intellectual disability, and many additional phenotypical features. It occurs at between 1/100,000 and 1/125,000 births.
  • 1.4K
  • 22 Sep 2021
Topic Review
Group 3 Medulloblastoma
Medulloblastoma is the most common malignant pediatric brain tumor, which accounts for approximately 20% of all childhood brain tumors.
  • 1.4K
  • 26 Sep 2021
Topic Review
Decapods Crustaceans Amylase
Decapod crustaceans are a very diverse group and have evolved to adapt to a broad variety of diets. However, α-amylases have been more thoroughly studies in herbivore and omnivore species, both from an evolutionary/ecological and applied (i.e., aquaculture) point of view, while information on α-amylases from carnivorous species is scarce. Diverse studies revealed that enzyme sequences and overall architecture is highly conserved among decapods. 
  • 1.4K
  • 21 Oct 2021
Topic Review
International Migration from (Anglophone) Cameroon
In Africa, international migration to the Global North is often interpreted as a means to achieve upward social mobility. This article highlights the importance of considering the socio-economic and political transformations that form migration aspirations, especially among African youths. Simultaneously, increasing restrictive migration regimes impacts the extent to which migrants can meet the clauses in the moral economy of migration in their origin communities. We focus on (Anglophone) Cameroon, where international migration is referred to as “bushfalling”. A person who migrates to a Western society desires or is expected to return home to share the wealth he/she has accumulated. This interpretation of migration forms different perspectives regarding migrants and guides expectations towards returned migrants. However, little is known on how these expectations are defined and redefined in the society of return. Based on focus group discussions conducted among local community members, we show that the expectations were guided by the visa regimes of destination countries. Moreover, successful returnees were defined by their ability to be visible and create an impact after return. Thus, this article contributes more broadly to an African perspective on the meaning and impact of return migration.
  • 1.4K
  • 18 Jan 2022
Topic Review
Existing Waste-To-Energy Technologies
Energy is a critical element in human existence, and is essential to a society’s sustainable economic growth. Globally, fossil fuels have been the primary source of electrical generation. Technologies that can efficiently recover energy from waste with little to no environmental damage have been considered as alternatives for conventional fossil fuel generation. The conversion pathways utilized in waste-to-energy (MSW) technologies may be classified into two main categories: thermochemical and biochemical. The thermochemical pathway involves the conversion of MSW feedstock to energy (electricity, heat, and value-added products) under high temperatures. It is most commonly utilized for dry waste with a larger proportion of nonbiodegradable material (a low water content). Combustion (incineration), gasification, and pyrolysis are the most common technologies under thermochemical conversion of MSW. Biochemical processes are optimal for wastes with a high proportion of biodegradable organic materials and a high moisture/water content that promotes microbial activity. Anaerobic digestion (AD) and methane recovery from a controlled environment in landfills are the most common technologies under the biochemical pathway.
  • 1.4K
  • 26 Aug 2022
Topic Review
Secrets of Flavonoid Synthesis in Mushroom Cells
Flavonoids are chemical compounds that occur widely across the plant kingdom. They are considered valuable food additives with pro-health properties, and their sources have also been identified in other kingdoms. Especially interesting is the ability of edible mushrooms to synthesize flavonoids. Mushrooms are usually defined as a group of fungal species capable of producing macroscopic fruiting bodies, and there are many articles considering the content of flavonoids in this group of fungi. Whereas the synthesis of flavonoids was revealed in mycelial cells, the ability of mushroom fruiting bodies to produce flavonoids does not seem to be clearly resolved. This entry, as an overview of the latest key scientific findings on flavonoids in mushrooms, outlines and organizes the current state of knowledge on the ability of mushroom fruiting bodies to synthesize this important group of compounds for vital processes. Putting the puzzle of the current state of knowledge on flavonoid biosynthesis in mushroom cells together, a universal scheme of studies to unambiguously decide whether the fruiting bodies of individual mushrooms are capable of synthesizing flavonoids that was proposed.
  • 1.4K
  • 24 Oct 2022
Topic Review
Pathogenicity and Immunogenicity of Adenovirus
Adenovirus is formed of an icosahedral protein shell measuring 90 nm and harboring linear double-stranded DNA (dsDNA) that belongs to the genus Mastadenovirus of the Adenoviridae family. Most people have been infected by adenovirus, leading to lifelong immunity.
  • 1.4K
  • 26 Oct 2022
Topic Review
Mobilization of Arsenic
One of the most significant elements in the environment is arsenic (As). It is a hazardous metalloid that causes contamination of soil and water supplies as a result of numerous anthropogenic and natural sources.
  • 1.4K
  • 25 Oct 2022
Topic Review
Physiological Roles of CoQ10 in Humans
Coenzyme Q10 (CoQ10) is a compound with a crucial role in mitochondrial bioenergetics and membrane antioxidant protection. Despite the ubiquitous endogenous biosynthesis, specific medical conditions are associated with low circulating CoQ10 levels. However, previous studies of oral CoQ10 supplementation yielded inconsistent outcomes. In this text, previous CoQ10 trials are reviewed, either single or in combination with other nutrients, and stratified the study participants according to their metabolic statuses and medical conditions. The CoQ10 supplementation trials in elders reported many favorable outcomes. However, the single intervention was less promising when the host metabolic statuses were worsening with the likelihood of multiple nutrient insufficiencies, as in patients with an established diagnosis of metabolic or immune-related disorders. On the contrary, the mixed CoQ10 supplementation with other interacting nutrients created more promising impacts in hosts with compromised nutrient reserves. Furthermore, the results of either single or combined intervention will be less promising in far-advanced conditions with established damage, such as neurodegenerative disorders or cancers. With the limited high-level evidence studies on each host metabolic category, it could only be concluded that the considerations of whether to take supplementation varied by the individuals’ metabolic status and their nutrient reserves. Further studies are warranted.
  • 1.4K
  • 15 Nov 2022
Topic Review
Health Information on the Internet
Health information on the Internet refers to all health-related information communicated through or available on the Internet.
  • 1.4K
  • 16 Nov 2022
Topic Review
The bHLH Transcription Factor Family in Plants
Plant basic helix-loop-helix (bHLH) transcription factors are involved in many physiological processes, and they play important roles in the abiotic stress responses. bHLH transcription factors are among the superfamilies that are commonly found in plants and animals. The conserved bHLH domain contains approximately 60 amino acids (aa), including a basic DNA binding region and two amphipathic α-helices that are separated by a loop region with a variable length. The basic region consists of the first 15 amino acids. Most bHLH proteins have a glutamic acid residue at position 9 (E9), which can interact with the CA nucleotides in the DNA sequence.
  • 1.4K
  • 02 Feb 2023
Topic Review
Phage Therapy for Resistant Staphylococcus aureus Infections
The production and use of antibiotics increased significantly after the Second World War due to their effectiveness against bacterial infections. However, bacterial resistance also emerged and has now become an important global issue. Those most in need are typically high-risk and include individuals who experience burns and other wounds, as well as those with pulmonary infections caused by antibiotic-resistant bacteria, such as Pseudomonas aeruginosa, Acinetobacter sp, and Staphylococcus sp. With investment to develop new antibiotics waning, finding and developing alternative therapeutic strategies to tackle this issue is imperative. One option remerging in popularity is bacteriophage (phage) therapy. 
  • 1.4K
  • 07 Mar 2023
Topic Review
Methanol as a Clean Energy Carrier
Clean methanol can play an important role in achieving net zero emission targets by decarbonizing the energy and chemical sectors. Conventionally, methanol is produced by using fossil fuel as raw material, which releases a significant amount of greenhouse gases (GHGs) into the environment. Clean methanol, which is produced by hydrogen (H2) from renewable sources (green H2) and captured carbon dioxide (CO2), is totally free from the influence of fossil fuel. Due to its vast applications, clean methanol has potential to substitute for fossil fuels while preventing further GHGs emissions. Renewable energy sources such as solar, wind and biomass should be utilized for producing green H2, while CO2 captured from air, and more likely from point emission sources, can be recycled to produce clean methanol. After producing methanol from CO2 and H2, the removal of by-product water by distillation is a big challenge due its high energy consumption. An alternative approach for this methanol-water separation is membrane technology, which is an energy saving option. Water-selective zeolite membranes can separate water post-synthesis, as well as during the synthesis. Production efficiency of methanol can be enhanced by utilizing zeolite membranes inside the methanol synthesis reactor. Furthermore, CO2 conversion as well as methanol selectivity, purity and yield can also be increased significantly by selectively removing by-product water using a zeolite membrane reactor.
  • 1.4K
  • 21 Apr 2023
Topic Review Video
Graph Burning
The graph burning problem is a relatively new combinatorial optimization problem that helps quantify a graph's vulnerability. It is defined in terms of a fundamental diffusion model.
  • 1.4K
  • 21 Jul 2023
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