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Topic Review
Bioavailability of Thymol in Humans and Animals
Herbal additives may have possible health benefits in animals and humans, particularly thymol, whose phenolic group is responsiblefor the neutralisation of free radicals, and information concerning its detection through body action,bioavailability and mechanisms in rabbits. Plants containing thymol have been used in traditional medicine for the treatment of various diseases, such as cardiovascular diseases, cancer and diabetes. Although a great number of in vitro studies of cardiovascular and cancer diseases are available, in vivo studies that confirm these findings have not been sufficiently reported. To determine the beneficial dose, further clinical studies are necessary, with preclinical comprehensive research on animal models.
  • 1.4K
  • 22 Jun 2022
Topic Review
Oncogenic KRAS Mutations in Apoptosis and Autophagy Regulation
KRAS, one of the RAS protein family members, plays an important role in autophagy and apoptosis, through the regulation of several downstream effectors. In cancer cells, KRAS mutations confer the constitutive activation of this oncogene, stimulating cell proliferation, inducing autophagy, suppressing apoptosis, altering cell metabolism, changing cell motility and invasion and modulating the tumor microenvironment.
  • 1.4K
  • 21 Jul 2022
Topic Review
Rural Housing Rental Rates in China
Through recognition and mastery of the regional differences and influencing factors of China’s rural housing rental rates, we can better understand changes in the functional attributes of homesteads and deepen the reform of “separating rural land ownership rights, contract rights, and management rights” of homesteads. Accordingly, it can use village residence data from the China Labor-force Dynamics Survey to measure the degree of regional differences in rural housing rental rates at the province level and empirically analyze the influencing factors with villages (residences) as measuring unit. The study yields four main findings. First, rural housing rental behavior exists to varying degrees in the vast majority of provinces nationwide. Second, according to the spatial distribution pattern, rural housing rental rates are generally high in the eastern coastal region and low in the central, western, and northeastern regions, mainly reflecting unique characteristics of the eastern region. Third, although the level of economic development is important, it is not the only factor explaining regional differences in rural housing rental rates. Fourth, rural housing rental rates are mainly influenced by a combination of three types of factors: physiographic, socioeconomic, and village governance factors. Among them, factors such as proximity to suburban areas, the proportion of non-local permanent residents, annual per capita income, and village infrastructure conditions have significant positive effects, whereas factors such as distance from administrative centers, reliance on funding from the higher-level authority of the village committee, and the degree of harmony between villages and cadres have significant negative effects. 
  • 1.4K
  • 26 Aug 2022
Topic Review
Lockheed Martin CFR
The Lockheed Martin Compact Fusion Reactor (CFR) is a proposed nuclear fusion reactor project at Lockheed Martin’s Skunk Works. Its high-beta configuration, which implies that the ratio of plasma pressure to magnetic pressure is greater than or equal to 1 (compared to tokamak designs' 0.05), allows a compact fusion reactor (CFR) design and expedited development. The CFR chief designer and technical team lead, Thomas McGuire studied fusion as a source of space propulsion in response to a NASA desire to improve travel times to Mars.
  • 1.4K
  • 18 Oct 2022
Topic Review
Differential Privacy
Differential privacy is a statistical technique that aims to provide means to maximize the accuracy of queries from statistical databases while measuring (and, thereby, hopefully minimizing) the privacy impact on individuals whose information is in the database. Differential privacy was developed by cryptographers and is thus often associated with cryptography, and it draws much of its language from cryptography. Although differential privacy is often discussed in the context of identifying individuals whose information may be a database, identification and reidentification attacks are not included within the original differential privacy framework.
  • 1.4K
  • 25 Oct 2022
Topic Review
Lagosuchus
Lagosuchus is an extinct genus of avemetatarsalian archosaur from the Late Triassic of Argentina . The type species of Lagosuchus, Lagosuchus talampayensis, is based on a small partial skeleton recovered from the early Carnian-age Chañares Formation. The holotype skeleton of L. talampayensis is fairly fragmentary, but it does possess some traits suggesting that Lagosuchus was a probable dinosauriform, closely related to dinosaurs. A second potential species of Lagosuchus, L. lilloensis, is based on an assortment of slightly larger and more well-preserved fossils. These larger specimens have been considered much more diagnostic and informative than the original small L. talampayensis skeleton. As a result, some paleontologists have placed the larger specimens into a new genus, Marasuchus. Marasuchus is generally considered one of the more complete early dinosauriforms, useful for estimating ancestral traits for the origin of dinosaurs. This would also render Lagosuchus a nomen dubium, simply a name referring to a fossil which is too fragmentary to have a formal genus. However, other paleontologists support the argument that Lagosuchus is a valid genus, and that Marasuchus is a junior synonym of it.
  • 1.4K
  • 02 Nov 2022
Topic Review
Truth and Reconciliation Commission
A truth commission or truth and reconciliation commission is a commission tasked with discovering and revealing past wrongdoing by a government (or, depending on the circumstances, non-state actors also), in the hope of resolving conflict left over from the past. Truth commissions are, under various names, occasionally set up by states emerging from periods of internal unrest, civil war, or dictatorship. In both their truth-seeking and reconciling functions, truth commissions have political implications: they "constantly make choices when they define such basic objectives as truth, reconciliation, justice, memory, reparation, and recognition, and decide how these objectives should be met and whose needs should be served". According to one widely cited definition: "A truth commission (1) is focused on the past, rather than in ongoing events; (2) investigates a pattern of events that took place over a period of time; (3) engages directly and broadly with the affected population, gathering information on their experiences; (4) is a temporary body, with the aim of concluding with a final report; and (5) is officially authorized or empowered by the state under review". The term used in the Australian context of reconciliation with its Indigenous peoples is truth telling.
  • 1.4K
  • 28 Nov 2022
Topic Review
Pathophysiology of Parkinson's Disease
The pathophysiology of Parkinson's disease is death of dopaminergic neurons as a result of changes in biological activity in the brain with respect to Parkinson's disease (PD). There are several proposed mechanisms for neuronal death in PD; however, not all of them are well understood. Five proposed major mechanisms for neuronal death in Parkinson's Disease include protein aggregation in Lewy bodies, disruption of autophagy, changes in cell metabolism or mitochondrial function, neuroinflammation, and blood-brain barrier (BBB) breakdown resulting in vascular leakiness.
  • 1.4K
  • 28 Nov 2022
Topic Review
Antibodies and T Cells in Viral Infections
The vertebrate immune system functions to eliminate foreign nucleic acids that invade from infectious pathogens and malignant tumors. DNA/RNA motifs characteristic to microbes and cancer cells are recognized as "non-self" by the host innate immune system, represented by pattern-recognition receptors (PRRs), thereby being classified into microbe-associated molecular patterns (MAMPs). MAMPs participate in immune enhancement, which is a host strategy to eliminate invading cells. That is, a variety of PRRs recognize nucleic acid MAMPs. Of the Toll-like receptors (TLRs), TLR3 recognizes RNA double-stranded (ds) motifs such as viral dsRNA. TLR3 is particular in that 1. It is preferentially expressed in endosomes of antigen-presenting dendritic cells (CD141+ DCs), 2. It can be an exclusive target to induce cross-antigen presentation, 3. Several structured RNAs successfully attain endosomal TLR3 in antigen-presenting (CD141+) DCs. Here the researchers summarize the current status of TLR3 adjuvants designed to enter cells without transfection, minimize inflammatory side effects, and provide optimal immune enhancement.
  • 1.4K
  • 09 Jan 2023
Topic Review
3D Printed Integrated Sensors
The integration of 3D printed sensors into hosting structures has become a growing area of research due to simplified assembly procedures, reduced system complexity, and lower fabrication cost. Embedding 3D printed sensors into structures or bonding the sensors on surfaces are the two techniques for the integration of sensors. 
  • 1.4K
  • 26 Dec 2023
Topic Review
GnRH
GnRH receptors are expressed in other reproductive organs, such as the ovary and in tumors originating from the ovary. In ovarian cancer, GnRH is involved in the regulation of proliferation and metastasis. The effects on ovarian tumors can be indirect or direct. GnRH acts indirectly via the HPG axis and directly via GnRH receptors on the surface of ovarian cancer cells.
  • 1.4K
  • 07 Apr 2021
Topic Review
HIV-1 Entry and Membrane Fusion
HIV-1 (human immunodeficiency virus type 1) infection begins with the attachment of the virion to a host cell by its envelope glycoprotein (Env), which subsequently induces fusion of viral and cell membranes to allow viral entry. Upon binding to primary receptor CD4 and coreceptor (e.g., chemokine receptor CCR5 or CXCR4), Env undergoes large conformational changes and unleashes its fusogenic potential to drive the membrane fusion.
  • 1.4K
  • 05 May 2021
Topic Review
Lysosomes Support DNA Replication
Lysosomes, acidic, membrane-bound organelles, are not only the core of the cellular recycling machinery, but they also serve as signaling hubs regulating various metabolic pathways. Lysosomes maintain energy homeostasis and provide pivotal substrates for anabolic processes, such as DNA replication. Every time the cell divides, its genome needs to be correctly duplicated; therefore, DNA replication requires rigorous regulation. Challenges that negatively affect DNA synthesis, such as nucleotide imbalance, result in replication stress with severe consequences for genome integrity. The lysosomal complex mTORC1 is directly involved in the synthesis of purines and pyrimidines to support DNA replication.
  • 1.4K
  • 25 May 2021
Topic Review
Liver Injury and Macrophage Issue
The liver is an essential immunological organ due to its gatekeeper position to bypassing antigens from the intestinal blood flow and microbial products from the intestinal commensals. The tissue-resident liver macrophages, termed Kupffer cells, represent key phagocytes that closely interact with local parenchymal, interstitial and other immunological cells in the liver to maintain homeostasis and tolerance against harmless antigens. Upon liver injury, the pool of hepatic macrophages expands dramatically by infiltrating bone marrow-/monocyte-derived macrophages. The interplay of the injured microenvironment and altered macrophage pool skews the subsequent course of liver injuries. It may range from complete recovery to chronic inflammation, fibrosis, cirrhosis and eventually hepatocellular cancer.
  • 1.4K
  • 29 Jul 2021
Topic Review
Nitrogen, Phosphorus, and Invasive Alien Plants
Plant invasion is significantly affected by environmental factors in the recipient habitats and affects the stability and sustainable development of society. The invasiveness of alien plants may be increased by anthropogenic-mediated disturbances, such as fluctuations in nutrients caused by excessive emissions of nitrogen (N) and phosphorus (P). 
  • 1.4K
  • 07 Feb 2022
Topic Review
Peruvian Havana Embassy Crisis of 1980
On April 1, 1980, six Cuban citizens made their way into the Peruvian embassy in Havana, Cuba, instigating an international crisis over the diplomatic status of around 10,000 asylum-seeking Cubans who joined them over the following days. The Peruvian ambassador, Ernesto Pinto Bazurco Rittler, spearheaded the effort to protect Cubans, most of whom were disapproved of by Fidel Castro’s regime and were seeking protection at the embassy. This episode marked the start of the Cuban refugee crisis, which was followed by a series of diplomatic initiatives between various countries in both North and South America that tried to organize the fleeing of people from the island of Cuba to the United States and elsewhere. The embassy crisis culminated with the substantial exodus of 125,266 Cuban asylum-seekers during the Mariel Boatlift.
  • 1.4K
  • 14 Nov 2022
Topic Review
Unmanned Aerial Vehicles in Forest Health Monitoring
Unmanned aerial vehicles (UAVs) are platforms that have been increasingly used over the last decade to collect data for forest insect pest and disease (FIPD) monitoring. These machines provide flexibility, cost efficiency, and a high temporal and spatial resolution of remotely sensed data. 
  • 1.4K
  • 28 Jul 2022
Topic Review
Decoding CD271 in melanoma
The evolution of melanoma, the most aggressive type of skin cancer, is triggered bydriver mutations that are acquired in the coding regions of particularly BRAF (rat fibrosarcomaserine/threonine kinase, isoform B) or NRAS (neuroblastoma-type ras sarcoma virus) in melanocytes.Although driver mutations strongly determine tumor progression, additional factors are likelyrequired and prerequisite for melanoma formation. Melanocytes are formed during vertebratedevelopment in a well-controlled di erentiation process of multipotent neural crest stem cells(NCSCs). However, mechanisms determining the properties of melanocytes and melanoma cellsare still not well understood. The nerve growth factor receptor CD271 is likewise expressed inmelanocytes, melanoma cells and NCSCs and programs the maintenance of a stem-like and migratoryphenotype via a comprehensive network of associated genes. Moreover, CD271 regulates phenotypeswitching, a process that enables the rapid and reversible conversion of proliferative into invasive ornon-stem-like states into stem-like states by yet largely unknown mechanisms. Here, we summarizecurrent findings about CD271-associated mechanisms in melanoma cells and illustrate the role ofCD271 for melanoma cell migration and metastasis, phenotype-switching, resistance to therapeuticinterventions, and the maintenance of an NCSC-like state.
  • 1.4K
  • 28 Oct 2020
Topic Review
Polymer/Clay Nanocomposites
Clays and clay minerals are common natural materials, the unique properties of which have attracted the interest of the industry, especially because these materials are easily available, cheap, and non-toxic. Clays and clay minerals are widely used in many applications, such as in ceramic production, in the clarification of liquids, pollutant adsorbers, filler in composites and nanocomposites, soil amendments, in pharmacy, etc.
  • 1.4K
  • 18 Jan 2024
Topic Review
Value Co-Creation Cycle in Platform Businesses
Platform businesses, linking producers and consumers, have emerged as a very important industry. Meanwhile, value co-creation has become one of the critical issues concerning the operation of platform enterprises and the focus of researchers in this area. Platform businesses usually need to strengthen the interactions between all participants to maximize the commercial value. 
  • 1.4K
  • 26 May 2022
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