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HandWiki. Pathophysiology of Parkinson's Disease. Encyclopedia. Available online: https://encyclopedia.pub/entry/36855 (accessed on 24 September 2026).
HandWiki. Pathophysiology of Parkinson's Disease. Encyclopedia. Available at: https://encyclopedia.pub/entry/36855. Accessed September 24, 2026.
HandWiki. "Pathophysiology of Parkinson's Disease" Encyclopedia, https://encyclopedia.pub/entry/36855 (accessed September 24, 2026).
HandWiki. (2022, November 28). Pathophysiology of Parkinson's Disease. In Encyclopedia. https://encyclopedia.pub/entry/36855
HandWiki. "Pathophysiology of Parkinson's Disease." Encyclopedia. Web. 28 November, 2022.
Pathophysiology of Parkinson's Disease
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The content is sourced from: https://handwiki.org/wiki/Medicine:Pathophysiology_of_Parkinson%27s_disease

The pathophysiology of Parkinson's disease is death of dopaminergic neurons as a result of changes in biological activity in the brain with respect to Parkinson's disease (PD). There are several proposed mechanisms for neuronal death in PD; however, not all of them are well understood. Five proposed major mechanisms for neuronal death in Parkinson's Disease include protein aggregation in Lewy bodies, disruption of autophagy, changes in cell metabolism or mitochondrial function, neuroinflammation, and blood-brain barrier (BBB) breakdown resulting in vascular leakiness.

neuronal death dopaminergic neurons biological activity

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