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Topic Review
Traditional Management of Cancer
Cancer, a generic term for a large group of diseases, may affect any part of the body. It is one of the world’s most horrifying diseases triggered by uncontrolled cellular proliferation. The development and progression of cancer are caused by an oncogene, the tumor suppressor gene (TSG), and alterations of the microRNA gene.
  • 1.4K
  • 10 Aug 2021
Topic Review
Phosphate in Vascular Calcification
Inorganic phosphate is essential for a variety of cellular processes, such as energy metabolism, bone formation, and synthesis of biomolecules, including phospholipids and nucleic acids. However, elevated serum phosphorus has emerged as a key risk factor for vascular calcification.
  • 1.4K
  • 21 Dec 2021
Topic Review
Cold Plasma Treatment on Biopolymer-Based Films
Biopolymers, like polysaccharides and proteins, are sustainable and green materials with excellent film-forming potential. Bio-based films have gained a lot of attention and are believed to be an alternative to plastics in next-generation food packaging. Compared to conventional plastics, biopolymers inherently have certain limitations like hydrophilicity, poor thermo-mechanical, and barrier properties. Therefore, the modification of biopolymers or their films provide an opportunity to develop packaging materials with desired characteristics. Among different modification approaches, the application of cold plasma has been a very efficient technology to enhance the functionality and interfacial characteristics of biopolymers. Cold plasma is biocompatible, shows uniformity in treatment, and is suitable for heat-sensitive components.
  • 1.4K
  • 21 Feb 2022
Topic Review
AR for Human–Robot Collaboration/Cooperation in Industrial Applications
Augmented reality (AR): overlays virtual objects on the real-world environment and also provides the ability to interact with that environment. AR is any case in which an otherwise real environment is “augmented” by means of virtual (computer graphic) objects. With the continuously growing usage of collaborative robots in industry, the need for achieving a seamless human–robot interaction has also increased, considering that it is a key factor towards reaching a more flexible, effective, and efficient production line. As a prominent and prospective tool to support the human operator to understand and interact with robots, Augmented Reality (AR) has been employed in numerous human–robot collaborative and cooperative industrial applications. 
  • 1.4K
  • 12 Apr 2022
Topic Review
SMARCB1 in the Pathobiology of Epithelioid Sarcoma
SMARCB1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1) is a key component of the SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complexes. Functional inactivation of SMARCB1 is the only recurrent genetic alteration reported in so far in Epithelioid Sarcoma (ES), a very rare and aggressive mesenchymal tumor of unclear origin and uncertain lineage characterized by a prevalent epithelioid morphology.
  • 1.4K
  • 13 Sep 2022
Topic Review
Roles of Interferons in Human Endometrial Function
Endometriosis is an estrogen-dependent inflammatory disease that develops in reproductive-aged women who experience pelvic pain and infertility. Even though endometriosis is not a new disease, its molecular etiology has not been clearly elucidated. Defects in the immune system might be one of the factors that promote endometriosis progression. For example, elevated levels of proinflammatory cytokines are associated with endometriosis. Interferon is one of the cytokines that is elevated in endometriotic tissues compared with normal endometrium. 
  • 1.4K
  • 18 Nov 2022
Topic Review
Pap Smear Images Classification with Machine Learning
Cervical cancer is regularly diagnosed in women all over the world. This cancer is the seventh most frequent cancer globally and the fourth most prevalent cancer among women. Automated and higher accuracy of cervical cancer classification methods are needed for the early diagnosis of cancer. In addition, routine Pap smears could enhance clinical outcomes by facilitating the early diagnosis of cervical cancer. Liquid-based cytology (LBC)/Pap smears for advanced cervical screening is a highly effective precancerous cell detection technology based on cell image analysis, where cells are classed as normal or abnormal. Computer-aided systems in medical imaging have benefited greatly from extraordinary developments in artificial intelligence (AI) technology.
  • 1.4K
  • 02 Dec 2022
Topic Review
Cyclo- and Polyphosphazenes for Biomedical Applications
Cyclic and polyphosphazenes are extremely interesting and versatile substrates characterized by the presence of -P=N- repeating units. The chlorine atoms on the P atoms in the starting materials can be easily substituted with a variety of organic substituents, thus giving rise to a huge number of new materials for industrial applications. A wide variety of new phosphazene systems, either trimeric or polymeric, have been developed as biomaterials in view of different applications. The materials to apply in biomedical applications should be biocompatible.
  • 1.4K
  • 09 Dec 2022
Topic Review
Mechanism of CNTs Uptake by Cells and Spheroids
Cell spheroids (CSs) are three-dimensional models in vitro that have a microenvironment similar to tissues. Such three-dimensional cellular structures are of great interest in the field of nano biomedical research, as they can simulate information about the characteristics of nanoparticles (NPs) by avoiding the use of laboratory animals.
  • 1.4K
  • 28 Jan 2023
Topic Review
Edge Artificial Intelligence
Artificial Intelligence (Al) models are being produced and used to solve a variety of current and future business and technical problems. Therefore, AI model engineering processes, platforms, and products are acquiring special significance across industry verticals. For achieving deeper automation, the number of data features being used while generating highly promising and productive AI models is numerous, and hence the resulting AI models are bulky. Such heavyweight models consume a lot of computation, storage, networking, and energy resources. On the other side, increasingly, AI models are being deployed in IoT devices to ensure real-time knowledge discovery and dissemination. 
  • 1.4K
  • 09 Feb 2023
Topic Review
Efficiency  of a Hybrid  Energy Harvesting  for IoT
The Internet of Things (IoT) is a network of interconnected physical devices, vehicles, and buildings that are embedded with sensors, software, and network connectivity, enabling them to collect and exchange data. This exchange of data between the physical and digital worlds allows for a wide range of applications, from smart homes and cities to industrial automation and healthcare. However, a key challenge faced by IoT nodes is the limited availability of energy to support their operations. Typically, these nodes can only function for a few days based on their duty cycle. A solution that aims to ensure the sustainability of IoT applications by addressing this energy challenge is introduced. 
  • 1.4K
  • 14 Jul 2023
Topic Review
Carrageenan-Based Hard Capsules: Review
Carrageenan is used as a gelling agent in products, such as frozen foods, jellies and yogurt. Commercially, carrageenan has been produced in six different types based on their structures. Among the six polymers, κ-carrageenan is the most produced due to its high gelling ability caused by the C4 conformation on the 3,6-anhydro-D-galactopyranosyl that forms a helix-like structure. The formation of the helix structure is supported by the enormous number of –OH groups that form many hydrogen bonds.
  • 1.4K
  • 28 Sep 2021
Topic Review
α-Syn Structure, Aggregation, and Degradation in Parkinson’s Disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder. The classical behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and rigidity, as well as non-motor symptoms such as anosmia, depression, and cognitive impairment. Pathologically, the progressive loss of dopaminergic (DA) neurons in the substantia nigra (SN) and the accumulation of α-synuclein (α-syn)-composed Lewy bodies (LBs) and Lewy neurites (LNs) are key hallmarks.
  • 1.4K
  • 01 Dec 2022
Topic Review
Solid-State Welding of Steels
Welding is a joining process that permanently connects solid parts and forms components that cannot be divided without causing damage. Furthermore, welding is the most efficient and economical way to join similar or dissimilar materials with or without using filler material, heat, or external pressure. Welding can be processed in a variety of environments, including outdoors, inside, underwater, and even in outer space. The two main categories of welding methods, solid-state welding (SSW) and fusion welding, are processes to join metals. Fusion welding can be defined as the melting process of parent materials on facing surfaces with a filler material to form a weld bead. The fusion welding process comprises gas welding, arc welding, and intense-energy beam welding.
  • 1.4K
  • 06 Jan 2023
Topic Review
Nintedanib
Nintedanib is a synthetic orally active tyrosine kinase inhibitor, whose main action is to inhibit the receptors of the platelet-derived growth factor, fibroblast growth factor and vascular endothelial growth factor families.
  • 1.4K
  • 30 Sep 2021
Topic Review
Graphene-Based Nanomaterials in Environmental Analysis
Sample preparation is an essential and preliminary procedure of most chemical analyses. Due to the sample diversity, the selection of appropriate adsorbents for the effective preparation and separation of different samples turned out to be important for the methods. By exploiting the rapid development of material science, some novel adsorption materials, especially graphene-based nanomaterials, have shown supremacy in sample pretreatment. In this review, a discussion between these nanomaterials will be made, as well as some basic information about their synthesis. The focus will be on the different environmental applications that use these materials.
  • 1.4K
  • 11 May 2021
Topic Review
Lactic Acid Bacteria-Fermentable Cereal- and Pseudocereal- Based Beverages
Plant beverages are becoming more popular, and fermented cereal- or pseudocereal-based beverages are increasingly used as alternatives for fermented products made from cow milk. This review aimed to describe the basic components of cereal- or pseudocereal-based beverages and determine the feasibility of fermenting them with lactic acid bacteria (LAB) to obtain products with live and active LAB cells and increased dietary value. The technology used for obtaining cerealor pseudocereal-based milk substitutes primarily involves the extraction of selected plant material, and the obtained beverages differ in their chemical composition and nutritional value (content of proteins, lipids, and carbohydrates, glycemic index, etc.) due to the chemical diversity of the cereal and pseudocereal raw materials and the operations used for their production. Beverages made from cereals or pseudocereals are an excellent matrix for the growth of LAB, and the lactic acid fermentation not only produces desirable changes in the flavor of fermented beverages and the biological availability of nutrients but also contributes to the formation of functional compounds (e.g., B vitamins).
  • 1.4K
  • 24 Dec 2021
Topic Review
LC3-Associated Phagocytosis in Bacterial Infection
LC3-associated phagocytosis (LAP) is a noncanonical autophagy process reported in recent years and is one of the effective mechanisms of host defense against bacterial infection. During LAP, bacteria are recognized by pattern recognition receptors (PRRs), enter the body, and then recruit LC3 onto a single-membrane phagosome to form a LAPosome. LC3 conjugation can promote the fusion of the LAPosomes with lysosomes, resulting in their maturation into phagolysosomes, which can effectively kill the identified pathogens.
  • 1.4K
  • 15 Aug 2022
Topic Review
Microbiome, Non-Alcoholic Fat Liver Disease and Non-Alcoholic Steatohepatitis
Modifications in the microbiota caused by environmental and genetic reasons can unbalance the intestinal homeostasis, deregulating the host’s metabolism and immune system, intensifying the risk factors for the development and aggravation of non-alcoholic fat liver disease (NAFLD). The use of probiotics, prebiotics and synbiotics have been considered a potential and promising strategy to regulate the gut microbiota and produce beneficial effects in patients with liver conditions. 
  • 1.4K
  • 16 Aug 2022
Topic Review
Shibboleth Single Sign-on Architecture
Shibboleth is a single sign-on log-in system for computer networks and the Internet. It allows people to sign in using just one identity to various systems run by federations of different organizations or institutions. The federations are often universities or public service organizations. The Shibboleth Internet2 middleware initiative created an architecture and open-source implementation for identity management and federated identity-based authentication and authorization (or access control) infrastructure based on Security Assertion Markup Language (SAML). Federated identity allows the sharing of information about users from one security domain to the other organizations in a federation. This allows for cross-domain single sign-on and removes the need for content providers to maintain user names and passwords. Identity providers (IdPs) supply user information, while service providers (SPs) consume this information and give access to secure content.
  • 1.4K
  • 28 Oct 2022
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