Summary

Organic synthesis is the tool for the preparation of small molecules with interesting biological and medicinal properties—new compounds with activity against diseases affecting humankind today such as cancer, metabolic disorders, neurodegenerative disorders or infectious diseases, as well as new syntheses of known drugs. New bioactive compounds are designed and synthesized to target key metabolic reactions in pathological processes as the first steps toward drug discovery. The crosstalk between synthetic and medicinal chemists enable a high impact of new synthetic methodologies in drug discovery. The aim is to highlight the role that organic synthesis plays in developing methods that may be exploited for finding lead compounds and drugs by the pharmaceutical industry.

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Entries
Topic Review
Insight on Mercapto-Coumarins
Mercapto (or sulfanyl)-coumarins are heterocycles of great interest in the development of valuable active structures in material and biological domains. They represent a highly exploitable class of compounds that open many possibilities for further chemical transformations.
  • 626
  • 07 Apr 2022
Topic Review
Pincer Transition Metal Catalysts for Sustainability
Sustainable solutions are needed to avoid global warming and climate change. Homogeneous catalysis might play a fundamental role for this. Pincer-type complexes are promising in terms of stability, selectivity, efficiency and the use of mild reaction conditions. Pincer complexes have been used in many sustainable chemical reactions, for example hydrogen release and upconversion of CO2, N2, and biomass.
  • 1.0K
  • 08 Apr 2022
Topic Review
Starch-Based Biodegradable Films for Food Packaging
The use of biodegradable packaging material as an alternative to conventional petrochemical-based polymers is based on the environmental issues associated with conventional materials. Starch-based biodegradable films can be applied in food packaging. It was evident that starch stands out among biopolymers due to its abundance and cost effectiveness.
  • 2.9K
  • 07 Apr 2022
Topic Review
Stereoselective Promiscuous Reactions Catalyzed by Lipases
The ability of lipases to display activity beyond their physiological reactions, so-called “catalytic promiscuity”, has gained increasing interest in the last two decades as an important tool for expanding the application of these enzymes in organic synthesis. Some lipases have been shown to be effective in catalyzing a variety of C-C bond formation reactions and most of the investigations have been directed to the optimization of the products yield through a careful tuning of the experimental parameters. Despite the fact that new stereogenic carbons are formed in many of the tested reactions, the target products have been often obtained in racemic form and examples of an efficient asymmetric induction by the used lipases are quite limited.
  • 572
  • 25 Mar 2022
Topic Review
Diels–Alder Cycloaddition Reactions
Diels–Alder cycloaddition reaction is one of the most powerful strategies for the construction of six-membered carbocyclic and heterocyclic systems, in most cases with high regio- and stereoselectivity. An insight into the most relevant advances on sustainable Diels–Alder reactions since 2010 is provided. Various environmentally benign solvent systems are discussed, namely bio-based derived solvents, polyethylene glycol, deep eutectic solvents, supercritical carbon dioxide, water and water-based aqueous systems.
  • 1.1K
  • 25 Mar 2022
Topic Review
Zeolites as Catalyst Supports for Hydrocarbon Oxidation Reactions
Catalytic oxidation is a key technology for the conversion of petroleum-based feedstocks into useful chemicals (e.g., adipic acid, caprolactam, glycols, acrylates, and vinyl acetate) since this chemical transformation is always involved in synthesis processes. Zeolites are microporous, crystalline aluminosilicate materials known since 1756 when the stilbite structure was identified by the Swedish mineralogist Crönstedt. Zeolites and other related porous materials can be supports for organometallic or metallic active species. These materials are the most studied supports due to their combined properties of mechanical and thermal stability that allows it an easy regeneration and recycling. 
  • 786
  • 25 Mar 2022
Topic Review
Anticancer effects of Coumarin Sulfonamides
Coumarin is an important six-membered aromatic heterocyclic pharmacophore, widely distributed in natural products and synthetic molecules. The versatile and unique features of coumarin nucleus, in combination with privileged sulfonamide moiety, have enhanced the broad spectrum of biological activities. The research and development of coumarin, sulfonamide-based pharmacology, and medicinal chemistry have become active topics, and attracted the attention of medicinal chemists, pharmacists, and synthetic chemists. Coumarin sulfonamide compounds and analogs as clinical drugs have been used to cure various diseases with high therapeutic potency, which have shown their enormous development value. The diversified and wide array of biological activities such as anticancer, antibacterial, anti-fungal, antioxidant and anti-viral, etc. were displayed by diversified coumarin sulfonamides.
  • 902
  • 22 Mar 2022
Topic Review
Fluorescent Polymers Conspectus
The development of luminescent materials is critical to humankind. The Nobel Prizes awarded in 2008 and 2010 for research on the development of green fluorescent proteins and super-resolved fluorescence imaging are proof of this (2014). Fluorescent probes, smart polymer machines, fluorescent chemosensors, fluorescence molecular thermometers, fluorescent imaging, drug delivery carriers, and other applications make fluorescent polymers (FPs) exciting materials. 
  • 1.6K
  • 22 Mar 2022
Topic Review
Hybrid Organic–Inorganic Perovskite Halide Materials for Photovoltaics
Hybrid organic–inorganic perovskite (HOIP) photovoltaics have emerged as a promising new technology for the next generation of photovoltaics since their first development 10 years ago, and show a high-power conversion efficiency (PCE) of about 29.3%. The power-conversion efficiency of these perovskite photovoltaics depends on the base materials used in their development, and methylammonium lead iodide is generally used as the main component. Perovskite materials have been further explored to increase their efficiency, as they are cheaper and easier to fabricate than silicon photovoltaics, which will lead to better commercialization. Even with these advantages, perovskite photovoltaics have a few drawbacks, such as their stability when in contact with heat and humidity, which pales in comparison to the 25-year stability of silicon, even with improvements are made when exploring new materials. To expand the benefits and address the drawbacks of perovskite photovoltaics, perovskite–silicon tandem photovoltaics have been suggested as a solution in the commercialization of perovskite photovoltaics. This tandem photovoltaic results in an increased PCE value by presenting a better total absorption wavelength for both perovskite and silicon photovoltaics.
  • 511
  • 17 Mar 2022
Topic Review
Using CNSL for the Synthesis of Surfactants
Cashew Nut Shell Liquid (CNSL) is a promising non-edible renewable resource, directly extracted from the shell of the cashew nut. The interesting structure of CNSL and its components (cardanol, anacardic acid and cardol) lead to the synthesis of biobased surfactants. 
  • 1.6K
  • 10 Mar 2022
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