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Topic Review
Infections in Disorders of Immune Regulation
Primary immune regulatory disorders (PIRDs) constitute a spectrum of inborn errors of immunity (IEIs) that are primarily characterized by autoimmunity, lymphoproliferation, atopy, and malignancy. In PIRDs, infections are infrequent compared to other IEIs. While susceptibility to infection primarily stems from antibody deficiency, it is sometimes associated with additional innate immune and T or NK cell defects. The use of immunotherapy and chemotherapy further complicates the immune landscape, increasing the risk of diverse infections. Recurrent sinopulmonary infections, particularly bacterial infections such as those associated with staphylococcal and streptococcal organisms, are the most reported infectious manifestations. Predisposition to viral infections, especially Epstein–Barr virus (EBV)-inducing lymphoproliferation and malignancy, is also seen. Notably, mycobacterial and invasive fungal infections are rarely documented in these disorders. Knowledge about the spectrum of infections in these disorders would prevent diagnostic delays and prevent organ damage. 
  • 105
  • 22 Mar 2024
Topic Review
Microbiota–Immunity–Hormone Interactions on Autoimmune Diseases and Infection
The immune system has to develop to defend against pathogens while simultaneously tolerating the beneficial microorganisms that coexist symbiotically with the host. Moreover, the microbiota in the large intestine plays a significant role in preserving mucosal and systemic homeostasis. The interaction between the large intestine microbiota and local immune cells is crucial for directing specific immune responses and, consequently, for performing immunomodulatory functions.
  • 127
  • 21 Mar 2024
Topic Review
Weld Pool Formation in Keyhole Plasma Arc Welding
The Keyhole Plasma Arc Welding (KPAW) process utilizes arc plasma highly constricted by a water-cooled cupper nozzle to produce great arc pressure for opening a keyhole in the weld pool, achieving full penetration to the thick plate. However, advanced control of welding is known to still be difficult due to the complexity of the process mechanism, in which thermal and dynamic interactions among the arc, keyhole, and weld pool are critically important. In KPAW, two large eddies are generally formed in the weld pool behind the keyhole by plasma shear force as the dominant driving force. These govern the heat transport process in the weld pool and have a strong influence on the weld pool formation process. The weld pool flow velocity is much faster than those of other welding processes such as Tungsten Inert Gas (TIG) welding and Gas Metal Arc (GMA) welding, enhancing the heat transport to lower the weld pool surface temperature. Since the strength and direction of this shear force strongly depend on the keyhole shape, it is possible to control the weld pool formation process by changing the keyhole shape by adjusting the torch design and operating parameters. If the lower eddy is relatively stronger, the heat transport to the bottom side increases and the penetration increases. However, burn-through is more likely to occur, and heat transport to the top side decreases, causing undercut. In order to realize further sophistication of KPAW, a deep theoretical understanding of the process mechanism is essential. 
  • 234
  • 21 Mar 2024
Topic Review
Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties
Terahertz radiation falls within the spectrum of hydrogen bonding, molecular rotation, and vibration, as well as van der Waals forces, indicating that many biological macromolecules exhibit a strong absorption and resonance in this frequency band. Research has shown that the terahertz radiation of specific frequencies and energies can mediate changes in cellular morphology and function by exciting nonlinear resonance effects in proteins. However, current studies have mainly focused on the cellular level and lack systematic studies on multiple levels. Moreover, the mechanism and law of interaction between terahertz radiation and neurons are still unclear. 
  • 193
  • 21 Mar 2024
Topic Review
Classification and Hemodynamic Definitions of Pulmonary Hypertension
Pulmonary hypertension (PH) refers to a pathologic elevation of the mean pulmonary artery pressure (mPAP) and is associated with increased morbidity and mortality in a wide range of medical conditions. These conditions are classified according to similarities in pathophysiology and management in addition to their invasive hemodynamic profiles. The 2022 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension present the newest clinical classification system and includes significant updates to the hemodynamic definitions. Pulmonary hypertension is now hemodynamically defined as an mPAP > 20 mmHg, reduced from the previous threshold of ≥25 mmHg, due to important insights from both normative and prognostic data. Pulmonary vascular resistance has been extended into the definition of pre-capillary pulmonary hypertension, with an updated threshold of >2 Wood Units (WU), to help differentiate pulmonary vascular disease from other causes of increased mPAP. Exercise pulmonary hypertension has been reintroduced into the hemodynamic definitions and is defined by an mPAP/cardiac output slope of >3 mmHg/L/min between rest and exercise. While these new hemodynamic thresholds will have a significant impact on the diagnosis of pulmonary hypertension, no evidence-based treatments are available for patients with mPAP between 21–24 mmHg and/or PVR between 2–3 WU or with exercise PH. 
  • 99
  • 21 Mar 2024
Topic Review
Genetic Transformation of Forest Trees
Forests represent a vital natural resource and play a crucial role in climate regulation and maintaining biodiversity. However, the growth and development of forest trees are increasingly challenged by rising environmental pressures, particularly detrimental abiotic stressors. To address these challenges, genetic transformation technologies have emerged as effective solutions. Despite various difficulties in genetic transformation for forest trees, including prolonged life cycles, genetic diversity, interspecies variations, and complex regeneration systems, significant research progress has been achieved in tree gene editing, transgenic technology, and methods for delivering exogenous molecules. These technologies have the potential to enhance tree quality, increase productivity, and improve resistance to abiotic stress. 
  • 170
  • 21 Mar 2024
Topic Review
The Plethora of Microbes with Anti-Inflammatory Activities
Inflammation, which has important functions in human defense systems and in maintaining the dynamic homeostasis of the body, has become a major risk factor for the progression of many chronic diseases. Although the applied medical products alleviate the general status, they still exert adverse effects in the long term. For this reason, the solution should be sought in more harmless and affordable agents. Microorganisms offer a wide range of active substances with anti-inflammatory properties. They confer important advantages such as their renewable and inexhaustible nature.
  • 164
  • 21 Mar 2024
Topic Review
Urban Computing Framework for Smart and Sustainable Neighborhoods
Urban computing is the incorporation of computing, sensors, and actuation technology into urban life. In Saudi Arabia, the neighborhoods lack an integrated approach to social, economic, and environmental values, thereby creating consequences, such as inefficient mobility, poor environmental protection, low quality of life, and inadequate services or facilities. Saudi Arabia was used as a case study to develop an urban computing framework for smart sustainable neighborhood. 
  • 247
  • 21 Mar 2024
Topic Review Peer Reviewed
The Effects of SARS-CoV-2 on the Angiopoietin/Tie Axis and the Vascular Endothelium
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can cause potentially life-threatening coronavirus disease (COVID-19). COVID-19 is a multisystem disease and is associated with significant respiratory distress, systemic hyperinflammation, vasculitis, and multi-organ failure. SARS-CoV-2 causes the deterioration of numerous systems, with increasing evidence implying that COVID-19 affects the endothelium and vascular function. The endothelium is important for preserving vascular tone and homeostasis. The overactivation and dysfunction of endothelial cells are significant outcomes of severity in patients with COVID-19. The Angiopoietin 1/Tie 2 pathway plays an important role in endothelium quiescence and vessel stability. The disruption of Angiopoietin/Tie balance affects the vessel contact barrier and leads to vessel leakage, and this in turn causes endothelial dysfunction. Although vascular instability through SARS-CoV-2 is associated with endothelial dysfunction, it is still not understood if the virus affects the Angiopoietin/Tie axis directly or via other mechanisms such as cytokine storm and/or immune response associated with the infection. This review provides an overview of the impact SARS-CoV-2 has on endothelial function and more specifically on the Angiopoietin/Tie pathway.
  • 449
  • 21 Mar 2024
Topic Review
The Single Toxin Origin of Alzheimer’s Disease
New data suggest that the aggregation of misfolded native proteins initiates and drives the pathogenic cascade that leads to Alzheimer’s disease (AD) and other age-related neurodegenerative disorders. Researchers propose a unifying single toxin theory of brain neurodegeneration that identifies new targets and approaches to the development of disease-modifying treatments. An extensive body of genetic evidence suggests soluble aggregates of beta-amyloid (Aβ) as the primary neurotoxin in the pathogenesis of AD. New insights from fluid biomarkers, imaging, and clinical studies provide further evidence for the decisive impact of toxic Aβ species in the initiation and progression of AD.
  • 140
  • 21 Mar 2024
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