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Topic Review
Sugarcane Supply Chain in the Brazilian Midwest Region
The sugarcane supply chain is one of the main contributors to economic development in many countries. However, it is necessary to consider the relationship of this supply chain with the environment in order to reduce/mitigate adverse environmental impacts. Using fertilizers and pesticides and burning crops during harvest severely threaten the sustainability of this supply chain.
  • 109
  • 08 Mar 2024
Topic Review
Phage Display Technology in Monoclonal Antibody Production
The groundbreaking work of John McCafferty and Sir Gregory Winter in developing phage display technology revolutionized the discovery of human antibodies, paving the way for diverse applications. Since then, numerous phage-derived antibodies have been successfully developed and advanced into clinical studies, resulting in the approval of more than a dozen therapeutic antibodies. These antibodies have demonstrated efficacy across a spectrum of medical conditions, ranging from autoimmune diseases to various cancers.
  • 183
  • 08 Mar 2024
Topic Review
Fluoxetine for Comorbidities such as Depression and Diabetes
Among the most widespread pathologies, obesity, which is often associated with diabetes, is constantly increasing in incidence, and in parallel, neurodegenerative and mood disorders are increasingly affecting many people. For years, these pathologies have been so frequently observed in the population in a concomitant way that they are considered as comorbidities. In fact, common mechanisms are certainly at work in the etiology of these pathologies. Fluoxetine was discovered in the 1970s. Initially called LY110140, it was described as a selective 5-HT reuptake inhibitor.
  • 226
  • 07 Mar 2024
Topic Review
E-Procurement Procedures in Construction Supply Chains
The growing interest in digitalization signals a need for technology-oriented supply chain operations in the construction industry. Electronic procurement (e-procurement) aims to convert traditional procurement approaches into web-based/online platforms.
  • 134
  • 07 Mar 2024
Topic Review
Sonothrombolysis for Ischemic Stroke
Stroke is a major cause of death and disability globally, with ischemic stroke being the predominant mechanism. While spontaneous recanalization may occur, significant neuronal injury would have occurred in the interim. Intravenous thrombolysis administered within the first 4.5 h after stroke onset and endovascular thrombectomy within 24 h in patients with a salvageable penumbra improves functional independence. Ultrasound has been shown in both in vivo and in vitro models to enhance clot lysis, even more-so in the presence of thrombolytic agents. The use of transcranial Doppler and transcranial color-coded Doppler ultrasound in acute IS has been reported in case series, case-controlled studies, and clinical trials. While ultrasound at a frequency of 300 kHz increases the risk of intracranial hemorrhage, the 2 MHz range ultrasound aids thrombolysis and improves recanalization without significantly increasing the risk of symptomatic intracranial hemorrhage. Despite this, functional independence was not increased in clinical trials, nor was a benefit shown with the adjunctive use of microbubbles or microspheres. Nonetheless, newer technologies such as endovascular ultrasound, endovascular delivery of microbubbles, and thrombolytic-filled microbubbles await clinical trials. More evidence is needed before sonothrombolysis can be routinely used in the hyperacute management of ischemic stroke.
  • 131
  • 07 Mar 2024
Topic Review
Biologic Therapy for Inflammatory Bowel Disease Patients
Many patients with inflammatory bowel disease (IBD) experience a loss of effectiveness to biologic therapy (i.e., anti-TNF therapy, etc.). Therefore, in addition to the adverse effects of the treatment, these patients also face failure to achieve and maintain remission. Immunogenicity, the process of production of antibodies to biological agents, is fundamental to the evolution of loss of response to treatment in IBD patients.
  • 93
  • 07 Mar 2024
Topic Review
Protonic Ceramic Electrolysis Cells Design for NH3 Synthesis
The application of protonic ceramic electrolysis cells (PCECs) for ammonia (NH3) synthesis has been evaluated over the past 14 years. While nitrogen (N2) is the conventional fuel on the cathode side, various fuels such as methane (CH4), hydrogen (H2), and steam (H2O) have been investigated for the oxygen evolution reaction (OER) on the anode side. Because H2 is predominantly produced through CO2-emitting methane reforming, H2O has been the conventional carbon-free option thus far. Although the potential of utilizing H2O and N2 as fuels is considerable, studies exploring this specific combination remain limited. 
  • 210
  • 07 Mar 2024
Topic Review
Phosphorus HotSpots in Crop Plants on the Farm
Phosphorus resources, both in phosphate rocks and in the soil, are limited. However, effective food production is not possible without the use of P fertilizers. Recognizing and eliminating or at least ameliorating factors (hot spots) that interfere with the uptake and use of phosphorus (P) by crop plants is of key importance for effective use of both P and nitrogen (N) on the farm. Plants have developed many adaptation mechanisms to their environment, i.e., soil low in available phosphorus. The most important ones include the secretion of organic compounds into the rhizosphere and the association of plant roots with microorganisms. A classic example is mycorrhiza. These mechanisms can be used by the farmer to sequentially select plants in the crop rotation. The uptake of inorganic P (Pi) by plants from the soil is reduced by environmental (temperature and water) and soil factors (low content of available phosphorus, soil acidity, soil compaction). These factors are responsible for the growth and size of the root system. Mitigating these negative effects improves the efficiency of phosphorus uptake from the soil. The second group of critical factors, limiting both root growth and availability of phosphorus, can be effectively controlled using simple measures (for example, lime).
  • 134
  • 07 Mar 2024
Topic Review
Coastal Assessment and MAM of Sea Level Rise
Sea level rise (SLR) is one of the most pressing challenges of climate change and has drawn noticeable research interest. Factors induced by global climate change, such as temperature increase, have resulted in both direct and indirect changes in sea levels at different spatial scales. Various climatic and non-climatic events contribute to sea level changes, posing risks to coastal and low-lying areas. Nevertheless, changes in sea level are not uniformly distributed globally due to several regional factors such as wave actions, storm surge frequencies, and tectonic land movement. The high exposure to those factors increases the vulnerability of subjected areas to SLR impacts. The impacts of events induced by climate change and SLR are reflected in biophysical, socioeconomic, and environmental aspects. Different indicator-based and model-based approaches are used to assess coastal areas’ vulnerabilities, response to impacts, and implementation of adaptation and mitigation measures. Various studies have been conducted to project future SLR impacts and evaluate implemented protection and adaptation approaches, aiding policymakers in planning effective adaptation and mitigation measures to reduce damage.
  • 221
  • 07 Mar 2024
Topic Review
Ultra-High-Performance Concrete (UHPC) Piles and Splicing Options
Conventional driven piles are made from steel, concrete, timber, or composite materials. These piling options have limitations with respect to corrosion, durability, driveablity, and performance. Ultra-High-Performance Concrete (UHPC) pile is a new alternative that has already been adopted by various state Departments of Transportation in the United States for addressing the limitations that exist with conventional piles. UHPC piles are made of a cementitious composite material mixture that possesses exceptional properties such as higher strength, low capillary porosity, and high resistance to corrosion, making them a suitable option for use as a deep foundation. For several reasons, it is necessary to cast piles with a shorter length and splice them at the site to reach the desired lengths.
  • 117
  • 07 Mar 2024
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