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Topic Review
Galleria mellonella Immune System
The study of pathogenicity and virulence of fungal strains, in vivo in the preclinical phase, is carried out through the use of animal models belonging to various classes of mammals (rodents, leproids, etc.). Although animals are functionally more similar to humans, these studies have some limitations in terms of ethics (animal suffering), user-friendliness, cost-effectiveness, timing (physiological response time) and logistics (need for adequately equipped laboratories). A good in vivo model must possess some optimal characteristics to be used, such as rapid growth, small size and short life cycle. For this reason, insects, such as Galleria mellonella (Lepidoptera), Drosophila melanogaster (Diptera) and Bombyx mori (Lepidoptera), have been widely used as alternative non-mammalian models. Due to their simplicity of use and low cost, the larvae of G. mellonella represent an optimal model above all to evaluate the virulence of fungal pathogens and the use of antifungal treatments (either single or in combination with biologically active compounds). A further advantage is also represented by their simple neuronal system limiting the suffering of the animal itself, their ability to survive at near-body ambient temperatures as well as the expression of proteins able to recognise combined pathogens following the three R principles (replacement, refinement and reduction). 
  • 171
  • 12 Mar 2024
Topic Review
Neoantigen mRNA Vaccine in Hepatocellular Carcinoma Treatment
A neoantigen mRNA vaccine is a personalized cancer vaccine that aims to target neoantigens. Neoantigens are unique antigens found on the surface of cancer cells due to somatic mutations. These genetic alterations are unique to each patient’s cancer, and the neoantigen mRNA vaccine is formulated by analyzing the patient’s tumor genome to pinpoint the mutations responsible for generating the neoantigens. The vaccine is then designed to encode these neoantigens, which are produced by the mutations, and delivered to the patient’s immune system via mRNA.
  • 118
  • 12 Mar 2024
Topic Review
Microalgae Cultivation Techniques and Growth Conditions
Microalgae, constituting a wide range of photosynthetic organisms, span from fundamental blue-green algae (cyanobacteria/prokaryotes) to complex seaweeds, rendering them one of the most diverse groups in the biological kingdom.
  • 361
  • 12 Mar 2024
Topic Review
Freezing Effect and Bystander Effect
As a passive and defensive response to a stressful event, freezing is characterized by a reduction in body movements, bradycardia (a decrease in heart rate), and an increase in muscle tone. The phenomenon of freezing is commonly linked with fear and is believed to enhance processes related to perception and attention, which help in identifying signals that dictate suitable actions. The phenomenon of bystander inaction, commonly referred to as the bystander effect or bystander apathy, is a psychological and social occurrence where an individual observing an emergency situation fails to assist the person in distress.
  • 459
  • 12 Mar 2024
Topic Review
Machine Learning for Evidence-Based Telehealth and Smart Care
Clinical studies have utilized machine learning in telehealth and smart care for disease management, self-management, and managing health issues like pulmonary diseases, heart failure, diabetes screening, and intraoperative risks. Machine learning combined with the application of evidence-based practices in healthcare can enhance telehealth and smart care strategies by improving quality of personalized care, early detection of health-related problems, patient quality of life, patient-physician communication, resource efficiency and cost-effectiveness. 
  • 278
  • 12 Mar 2024
Topic Review
Infraocclusion in the Primary and Permanent Dentition
The gradual movement of a tooth away from the occlusal plane is called infraocclusion or reinclusion. Reincluded teeth are most often deciduous molars, and permanent teeth are less frequently affected. Depending on the level of the infraocclusion, the severity of the disorder is classified as mild, moderate, or severe. The etiology of the phenomenon is not fully known. Tooth submerging can lead to serious complications, such as abnormal position of adjacent teeth, displacement of the bud of the permanent successor, shortening of the dental arch, or developmental disturbances of alveolar process. 
  • 144
  • 12 Mar 2024
Topic Review
Applications of Hydrogels as Wound Dressings
Hydrogels are polymeric materials that possess a set of characteristics meeting various requirements of an ideal wound dressing, making them promising for wound care. These features include, among others, the ability to absorb and retain large amounts of water and the capacity to closely mimic native structures, such as the extracellular matrix, facilitating various cellular processes like proliferation and differentiation. The polymers used in hydrogel formulations exhibit a broad spectrum of properties, allowing them to be classified into two main categories: natural polymers like collagen and chitosan, and synthetic polymers such as polyurethane and polyethylene glycol. 
  • 228
  • 12 Mar 2024
Topic Review
Damage Detection in FRP-Reinforced Concrete Elements
Fiber-Reinforced Polymer (FRP) composites have emerged as a promising alternative to conventional steel reinforcements in concrete structures owing to their benefits of corrosion resistance, higher strength-to-weight ratio, reduced maintenance cost, extended service life, and superior durability. 
  • 92
  • 12 Mar 2024
Topic Review Peer Reviewed
Proto-Neurons from Abiotic Polypeptides
To understand the origins of life, we must first gain a grasp of the unresolved emergence of the first informational polymers and cell-like assemblies that developed into living systems. Heating amino acid mixtures to their boiling point produces thermal proteins that self-assemble into membrane-bound protocells, offering a compelling abiogenic route for forming polypeptides. Recent research has revealed the presence of electrical excitability and signal processing capacities in proteinoids, indicating the possibility of primitive cognitive functions and problem-solving capabilities. This review examines the characteristics exhibited by proteinoids, including electrical activity and self-assembly properties, exploring the possible roles of such polypeptides under prebiotic conditions in the emergence of early biomolecular complexity. Experiments showcasing the possibility of unconventional computing with proteinoids as well as modelling proteinoid assemblies into synthetic proto-brains are given. Proteinoids’ robust abiogenic production, biomimetic features, and computational capability shed light on potential phases in the evolution of polypeptides and primitive life from the primordial environment.
  • 391
  • 12 Mar 2024
Topic Review
Immunotherapy in Cervical and Endometrial Cancer
Gynecological cancers pose a significant burden on women’s health worldwide, necessitating innovative treatment approaches. Immunotherapy has emerged as a promising strategy, harnessing the body’s immune system to combat cancer. 
  • 147
  • 12 Mar 2024
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