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Topic Review
Artificial-Intelligence-Based Clinical Decision Support Systems in Primary Care
Primary care stands as a cornerstone in healthcare, serving as the first point of contact and managing the most significant number of patients in the United States and worldwide. AI can mimic human reasoning and behavior and handle the increasing volume of medical data within healthcare systems. Machine learning (ML) is the most common AI technique used.
  • 169
  • 27 Mar 2024
Topic Review
Pathophysiological Basis of Mas-Related G Protein-Coupled Receptor X2
Mast cells (MCs) are immune cells that reside in tissues; particularly in the skin, and in the gastrointestinal and respiratory tracts. In recent years, there has been considerable interest in the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2), which is present on the surface of MCs and can be targeted by multiple exogenous and endogenous ligands. It is potentially implicated in non-IgE-mediated pseudoallergic reactions and inflammatory conditions such as asthma or atopic dermatitis.
  • 97
  • 27 Mar 2024
Topic Review
Hydrogels for Cardiac Repair and Regeneration
Cardiovascular disease (CVD), the leading cause of death globally, affects the heart and arteries with a variety of clinical manifestations, the most dramatic of which are myocardial infarction (MI), abdominal aortic aneurysm (AAA), and intracranial aneurysm (IA) rupture. In MI, necrosis of the myocardium, scar formation, and loss of cardiomyocytes result from insufficient blood supply due to coronary artery occlusion. Beyond stenosis, the arteries that are structurally and functionally connected to the cardiac tissue can undergo pathological dilation, i.e., aneurysmal dilation, with high risk of rupture. Aneurysms of the intracranial arteries (IAs) are more commonly seen in young adults, whereas those of the abdominal aorta (AAA) are predominantly seen in the elderly. IAs, unpredictably, can undergo rupture and cause life-threatening hemorrhage, while AAAs can result in rupture, internal bleeding and high mortality rate. In this clinical context, hydrogels, three-dimensional networks of water-seizing polymers, have emerged as promising biomaterials for cardiovascular tissue repair or protection due to their biocompatibility, tunable properties, and ability to encapsulate and release bioactive molecules.
  • 595
  • 27 Mar 2024
Topic Review
Effects of Astaxanthin on Cognitive Function in Humans
Astaxanthin is a potent antioxidant, which has been outlined to be beneficial for cognitive function both in vitro and in vivo. Astaxanthin has been researched in relation to various facets of cognitive function in humans, including episodic memory (visual and verbal stimuli), working memory/short-term memory, processing speed, response inhibition, cognitive shifting, and attention.
  • 202
  • 27 Mar 2024
Topic Review
Stem and Progenitor Cell for Ischemic Heart Disease
Despite improvements in contemporary medical and surgical therapies, cardiovascular disease (CVD) remains a significant cause of worldwide morbidity and mortality; more specifically, ischemic heart disease (IHD) may affect individuals as young as 20 years old. Typically managed with guideline-directed medical therapy, interventional or surgical methods, the incurred cardiomyocyte loss is not always completely reversible; however, recent research into various stem cell (SC) populations has highlighted their potential for the treatment and perhaps regeneration of injured cardiac tissue, either directly through cellular replacement or indirectly through local paracrine effects. Different stem cell (SC) types have been employed in studies of infarcted myocardium, both in animal models of myocardial infarction (MI) as well as in clinical studies of MI patients, including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), Muse cells, multipotent stem cells such as bone marrow-derived cells, mesenchymal stem cells (MSCs) and cardiac stem and progenitor cells (CSC/CPCs). These have been delivered as is, in the form of cell therapies, or have been used to generate tissue-engineered (TE) constructs with variable results. 
  • 172
  • 27 Mar 2024
Topic Review
Water Ice Resources on Shallow Subsurface of Mars
The planet Mars is the most probable among the terrestrial planets in our solar system to support human settlement or colonization in the future. The detection of water ice or liquid water on the shallow subsurface of Mars is a crucial scientific objective for both the Chinese Tianwen-1 and United States Mars 2020 missions, which were launched in 2020. Both missions were equipped with Rover-mounted ground-penetrating radar (GPR) instruments, specifically the RoPeR on the Zhurong rover and the RIMFAX radar on the Perseverance rover. The in situ radar provides unprecedented opportunities to study the distribution of shallow subsurface water ice on Mars with its unique penetrating capability. The presence of water ice on the shallow surface layers of Mars is one of the most significant indicators of habitability on the extraterrestrial planet.
  • 243
  • 27 Mar 2024
Topic Review
Blockchain-Based Traffic Bottleneck Management System
To alleviate traffic congestion, it is necessary to effectively manage traffic bottlenecks. In existing research, travel demand prediction for traffic bottlenecks is based on travel behavior assump￾tions, and prediction accuracy is low in practice. Thus, the effect of traffic bottleneck management strategies cannot be guaranteed. Management strategies are often mandatory, leading to problems such as unfairness and low social acceptance. To address such issues, this paper proposes managing traffic bottlenecks based on shared travel plans. To solve the information security and privacy prob￾lems caused by travel plan sharing and achieve information transparency, travel plans are shared and regulated by blockchain technology. To optimize the operation level of traffic bottlenecks, travel plan regulation models under scenarios where all/some travelers share travel plans are proposed and formulated as linear programming models, and these models are integrated into the blockchain with smart contract technology. Furthermore, travel plan regulation models are tested and verified using traffic flow data from the Su-Tong Yangtze River Highway Bridge, China. The results indicate that the proposed travel plan regulation models are effective for alleviating traffic congestion. The vehicle transfer rate and total delay rate increase as the degree of total demand increases; the vehicle transfer rate increases as the length of the time interval decreases; and the vehicle transfer rate and total delay rate increase as the number of vehicles not sharing their travel plans increases. By using the model and method proposed in this paper, the sustainability of urban economy, society, and environment can be promoted.
  • 158
  • 27 Mar 2024
Topic Review
Solar Wall Technology
Solar walls provide transformative solutions by harnessing solar energy to generate electricity, improve thermal comfort, and reduce energy consumption and emissions, contributing to zero-energy buildings and mitigating climate change. In hot and humid regions, solar walls can reduce indoor temperatures by 30% to 50%, significantly improving energy efficiency. Optimizing the performance of solar walls includes factors such as glazing, shading, solar orientation, ventilation, and catalytic techniques, allowing them to be adapted to different climates. Innovative solar wall variants that include photovoltaic panels, water storage, and phase-change materials offer multifunctionality and sustainability in building design and are in line with global energy efficiency and environmentally conscious goals.
  • 164
  • 27 Mar 2024
Topic Review
In Vivo/In Vitro Electrochemical Detection of Neurochemicals
Neurochemicals, crucial for nervous system function, influence vital bodily processes and their fluctuations are linked to neurodegenerative diseases and mental health conditions. Monitoring these compounds is pivotal, yet the intricate nature of the central nervous system poses challenges. Researchers have devised methods, notably electrochemical sensing with micro-nanoscale electrodes, offering high-resolution monitoring despite low concentrations and rapid changes. Implantable sensors enable precise detection in brain tissues with minimal damage, while microdialysis-coupled platforms allow in vivo sampling and subsequent in vitro analysis, addressing the selectivity issues seen in other methods.
  • 268
  • 27 Mar 2024
Topic Review
Coastal Acid-Sulfate Soils of Kalimantan, Indonesia
Coastal acid-sulfate soils are crucial for producing crops and thus, for food security. However, over time, these soil resources experience degradation, leading to higher agro-input, lower yields, and environmental hazards that finally threaten food security. The optimal use of this fragile resource is only attained by implementing vigorous integrated water–soil–crop management technologies amid the climate change impact. 
  • 285
  • 27 Mar 2024
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