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Topic Review
Augmented Reality in Minimally Invasive Surgery Procedures
Augmented reality (AR) technology is gaining increasing interest in the development of minimally invasive surgery (MIS) procedures. The main application areas can be divided into three main groups: Navigation, education and training, and user-environment interfaces. Although AR-guided navigation systems do not yet offer a precision advantage, benefits include improved ergonomics and visualization, as well as reduced surgical time and blood loss. Benefits are also seen in improved education and training conditions and improved user environment interfaces, which may indirectly influence MIS procedures. Controlled studies with large case numbers and standardized outcome parameters and reporting are lacking to confirm the added value for clinical use.
  • 314
  • 04 May 2023
Topic Review
New Opportunities for miRNAs in Translational Medicine
miRNAs are small noncoding RNAs that control gene expression at the posttranscriptional level. It has been recognised that miRNA dysregulation reflects the state and function of cells and tissues, contributing to their dysfunction. The identification of hundreds of extracellular miRNAs in biological fluids has underscored their potential in the field of biomarker research. In addition, the therapeutic potential of miRNAs is receiving increasing attention in numerous conditions. On the other hand, many operative problems including stability, delivery systems, and bioavailability, still need to be solved. In this dynamic field, biopharmaceutical companies are increasingly engaged, and ongoing clinical trials point to anti-miR and miR-mimic molecules as an innovative class of molecules for upcoming therapeutic applications. 
  • 242
  • 04 May 2023
Topic Review
Neuropathological Mechanisms Underlying the Development of Depression
Major depressive disorder is a severe neuropsychiatric disease driven by various hereditary, environmental, and psychological factors. It disables normal functioning and quality of life. 
  • 224
  • 04 May 2023
Topic Review
Plant-Derived Exosome-like Nanoparticle as Biomolecules
Plant-derived exosome-like nanoparticles (PDENs) comprise various bioactive biomolecules. As an alternative cell-free therapeutic approach, they have the potential to deliver nano-bioactive compounds to the human body, and thus lead to various anti-inflammatory, antioxidant, and anti-tumor benefits.
  • 649
  • 04 May 2023
Topic Review
Hirschsprung-Associated Enterocolitis
Despite the significant progress that has been made in terms of understanding the pathophysiology and risk factors of Hirschsprung-associated enterocolitis (HAEC), the morbidity rate has remained unsatisfactorily stable, and clinical management of the condition continues to be challenging.
  • 351
  • 04 May 2023
Topic Review
Hypercalciuria and Urolithiasis
The link between hypercalciuria (HC) and urolithiasis (UL) has its roots in studies dated about one century ago. In 1939, Flocks RH reported on increased levels of calcium in the urine of stone former (SF) patients, supporting a direct role of increased urinary calcium concentration in the pathogenesis of UL. From then onward, a growing interest in the research field has been witnessed to better define the mechanisms and pathogenetic factors of HC, also suggesting diagnostic methodologies, easily executable in the real world of clinical medicine.
  • 258
  • 04 May 2023
Topic Review
Role of Metabolomics in B-Cell Non-Hodgkin’s Lymphoma Diagnosis
A wide range of histological as well as clinical properties are exhibited by B-cell non-Hodgkin’s lymphomas. These properties could make the diagnostics process complicated. The diagnosis of lymphomas at an initial stage is essential because early remedial actions taken against destructive subtypes are commonly deliberated as successful and restorative. New possibilities are now open for diagnosing cancer with the help of metabolomics. The study of all the metabolites synthesised in the human body is called “metabolomics.” A patient’s phenotype is directly linked with metabolomics, which can help in providing some clinically beneficial biomarkers and is applied in the diagnostics of B-cell non-Hodgkin’s lymphoma. In cancer research, it can analyse the cancerous metabolome to identify the metabolic biomarkers. 
  • 450
  • 03 May 2023
Topic Review
Mechanisms of Neurorespiratory Toxicity Induced by Fentanyl Analogs
In 2020, fentanyl and its analogs contributed to ~65% of drug-attributed fatalities in the USA, with a threatening increasing trend during the last ten years. These synthetic opioids used as potent analgesics in human and veterinary medicine have been diverted to recreational aims, illegally produced and sold. Like all opioids, central nervous system depression resulting from overdose or misuse of fentanyl analogs is characterized clinically by the onset of consciousness impairment, pinpoint miosis and bradypnea. However, contrasting with what observed with most opioids, thoracic rigidity may occur rapidly with fentanyl analogs, contributing to increasing the risk of death in the absence of immediate life support. Various mechanisms have been proposed to explain this particularity associated with fentanyl analogs, including the activation of noradrenergic and glutamatergic coerulospinal neurons and dopaminergic basal ganglia neurons. Due to the high affinities to the mu-opioid receptor, the need for more elevated naloxone doses than usually required in morphine overdose to reverse the neurorespiratory depression induced by fentanyl analogs has been questioned. 
  • 365
  • 03 May 2023
Topic Review
Radionuclides and Radiolabelled Peptides for Cancer Therapeutics
Radiopharmaceutical therapy, which can detect and treat tumours simultaneously, was introduced more than 80 years ago, and it has changed medical strategies with respect to cancer. Many radioactive radionuclides have been developed, and functional, molecularly modified radiolabelled peptides have been used to produce biomolecules and therapeutics that are vastly utilised in the field of radio medicine. Advanced technologies, such as conjugation of functional peptides or incorporation of radionuclides into chelating ligands, have been developed for advanced radiopharmaceutical cancer therapy. New radiolabelled conjugates for targeted radiotherapy have been designed to deliver radiation directly to cancer cells with improved specificity and minimal damage to the surrounding normal tissue. The development of new theragnostic radionuclides, which can be used for both imaging and therapy purposes, allows for more precise targeting and monitoring of the treatment response. The increased use of peptide receptor radionuclide therapy (PRRT) is also important in the targeting of specific receptors which are overexpressed in cancer cells.
  • 245
  • 03 May 2023
Topic Review
Machine Learning and Artificial Intelligence
Machine learning (ML) is a type of artificial intelligence (AI) consisting of algorithmic approaches that enable machines to solve problems deprived of explicit computer programming. 
  • 1.2K
  • 28 Apr 2023
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