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Topic Review
Deep eutectic solvents in pharmaceutical synthesis
DES are mixtures of two or more compounds, able to form liquids upon mixing, with lower freezing points when compared to the individual constituents (eutectic mixtures). DES have been utilized in organic synthesis as green media thanks to the high potential to replace the classical solvents. In fact, since the DES are characterized by a network of hydrogen bonds, they have the possibility to dissolve solutes that can form hydrogen bonds and stabilize transition states. Furthermore, during the purification procedures, the addition of water to a DES (very soluble in water) causes the precipitation of organic products, facilitating the workup and avoiding the use of solvents for the extraction. 
  • 779
  • 04 Nov 2021
Topic Review
Textile-Based Mechanical Sensors
Innovations related to textiles-based sensors have drawn great interest due to their outstanding merits of flexibility, comfort, low cost, and wearability. Textile-based sensors are often tied to certain parts of the human body to collect mechanical, physical, and chemical stimuli to identify and record human health and exercise. Until now, much research and review work has been carried out to summarize and promote the development of textile-based sensors. As a feature, we focus on textile-based mechanical sensors (TMSs), especially on their advantages and the way they achieve performance optimizations
  • 1.1K
  • 04 Nov 2021
Topic Review
Wearable Functional Textiles
Wearable E-textile systems should be comfortable so that highest efficiency of their functionality can be achieved. The development of electronic textiles (functional textiles) as a wearable technology for various applications has intensified the use of flexible wearable functional textiles instead of wearable electronics. However, the wearable functional textiles still bring comfort complications during wear. The purpose of this review paper is to sightsee and recap recent developments in the field of functional textile comfort evaluation systems. For textile-based materials which have close contact to the skin, clothing comfort is a fundamental necessity.
  • 656
  • 03 Nov 2021
Topic Review
EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy
Glioma, particularly its most malignant form, glioblastoma multiforme (GBM), is the most common and aggressive malignant central nervous system tumor. The drawbacks of the current chemotherapy for GBM have aroused curiosity in the search for targeted therapies. Aberrantly overexpressed epidermal growth factor receptor (EGFR) in GBM results in poor prognosis, low survival rates, poor responses to therapy and recurrence, and therefore EGFR-targeted therapy stands out as a promising approach for the treatment of gliomas. In this context, a series of pentacyclic triterpene analogues were subjected to in vitro and in silico assays, which were conducted to assess their potency as EGFR-targeted anti-glioma agents. In particular, compound 10 was the most potent anti-glioma agent with an IC50 value of 5.82 µM towards U251 human glioblastoma cells. Taking into account its low cytotoxicity to peripheral blood mononuclear cells (PBMCs), compound 10 exerts selective antitumor action towards Jurkat human leukemic T-cells. This compound also induced apoptosis and inhibited EGFR with an IC50 value of 9.43 µM compared to erlotinib (IC50 = 0.06 µM). Based on in vitro and in silico data, compound 10 stands out as a potential orally bioavailable EGFR-targeted anti-glioma agent endowed with the ability to cross the blood–brain barrier (BBB).
  • 520
  • 03 Nov 2021
Topic Review
Cartilage Lubrication in Osteoarthritis
The remarkable lubrication properties of normal articular cartilage play an essential role in daily life, providing almost frictionless movements of joints. Alterations of cartilage surface or degradation of biomacromolecules within synovial fluid increase the wear and tear of the cartilage and hence determining the onset of the most common joint disease, osteoarthritis (OA).
  • 688
  • 03 Nov 2021
Topic Review
Cement Asphalt Emulsion Mortar Composites
CA mortar (sometimes abbreviated to CAM) is one of the major construction materials for slab ballastless track in high-speed railways; it is an intermediate layer flung within the space between the track slab and the trackbed (as depicted in) of CRTS I and CRTS II. Cement and asphalt mortar is an organic–inorganic composite material primarily composed of asphalt emulsion, cement, sand, water, and other chemical admixtures. This composite material possesses fascinating properties that are different from both concrete and asphalt material alone because it couples the strength of cement as well as the flexibility of asphalt material.
  • 1.1K
  • 03 Nov 2021
Topic Review
Liquid Crystal Waveguide Structures
Liquid crystal materials can be used to make either a core, in which light beams can be confined, or a cladding of optical waveguides.
  • 926
  • 02 Nov 2021
Topic Review
Fire Safety Performance of Polymer Composites
The growth of the use of polymer composite materials has been a phenomenon since 1960, with diverse applications in spacecraft, aircraft, boats, ship, automobiles, civil infrastructure, sporting goods, and consumer products. In addition, the use of composites will continue to grow in the coming years with emerging end-use such as large bridge structures, engine machinery, offshore platforms, computer hardware, and biomedicals devices. However, a critical challenge facing the growing use of polymer composites is their high combustibility.
  • 593
  • 02 Nov 2021
Topic Review
Hydroxyapatite Nanoparticles in Drug Delivery
A biomaterial is a synthetic material used to replace part of a living system or a material meant to be in contact with living tissue. In this sense, biomaterials can be categorized into polymers, liposomes, micelles, dendrimers, and calcium phosphate (CaP) nanoparticles, where each will show a different type of bioactivity. Hydroxyapatite (HAP) has been the gold standard in the biomedical field due to its composition and similarity to human bone. HAP nanoparticles have been used as vehicles for delivery due to their affinity to DNA, proteins, several drugs, and proper release activity.
  • 894
  • 02 Nov 2021
Topic Review
Electrospinning of Nanofibrous Membrane
Among the different fabrication approaches of nanofibrous membrane, electrospinning is considered as the most favorable and effective due to its advantages of controllable process, high production efficiency, and low cost.
  • 468
  • 01 Nov 2021
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