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Topic Review
Cell-Derived Vesicles for mRNA Delivery
The clinical translation of messenger mRNA (mRNA)-based therapeutics requires safe and effective delivery systems. Although considerable progress has been made on the development of mRNA delivery systems, many challenges, such as the dose-limiting toxicity and specific delivery to extrahepatic tissues, still remain. Cell-derived vesicles, a type of endogenous membranous particle secreted from living cells, can be leveraged to load mRNA during or after their biogenesis. They have received increasing interest for mRNA delivery due to their natural origin, good biocompatibility, cell-specific tropism, and unique ability to cross physiological barriers.
  • 612
  • 28 Dec 2022
Topic Review
Cell-Surface Interactions on Arginine-Rich CPPs Allow for Internalization
Cellular uptake of biologically active molecules is a significant obstacle to developing drug design and controlled drug delivery. For instance, it is hard for the monoclonal antibodies to penetrate the cell membrane and enter the cell due to their large molecular weight. Cell-penetrating peptides (CPPs) have been discovered to deliver chemical drugs, nucleic acids, and macromolecules to permeate cell membranes, creating a novel route for exogenous substances to enter cells.
  • 376
  • 24 Aug 2022
Topic Review
Cellular Solid Materials
Cellular solids are materials made up of cells with solid edges or faces that are piled together to fit a certain space. These materials are already present in nature and have already been utilized in the past. Some examples are wood, cork, sponge and coral. New cellular solids replicating natural ones have been manufactured, such as honeycomb materials and foams, which have a variety of applications because of their special characteristics such as being lightweight, insulation, cushioning and energy absorption derived from the cellular structure. Cellular solids have interesting thermal, physical and mechanical properties in comparison with bulk solids: density, thermal conductivity, Young’s modulus and compressive strength. This huge extension of properties allows for applications that cannot easily be extended to fully dense solids and offers enormous potential for engineering creativity. Their Low densities allow lightweight and rigid components to be designed, such as sandwich panels and large portable and floating structures of all types. Their low thermal conductivity enables cheap and reliable thermal insulation, which can only be improved by expensive vacuum-based methods. Their low stiffness makes the foams ideal for a wide range of applications, such as shock absorbers. Low strengths and large compressive strains make the foams attractive for energy-absorbing applications. Their main properties, applications (real and potential) and recent developments are presented, summarized and discussed.
  • 279
  • 17 Nov 2023
Topic Review
Cellulose
Cellulose is the main substance of a plant’s cell walls, helping plants to remain stiff and upright, hence, it can be extracted from plant sources, agriculture waste, animals, and bacterial pellicle. It is composed of polymer chains consisting of unbranched β (1,4) linked D glucopyranosyl units (anhydroglucose unit, AGU).
  • 6.8K
  • 07 Feb 2021
Topic Review
Cellulose Acetate and Silver Nanoparticles
Natural patterns and structures provide inspiration for scientists of diverse technological backgrounds to create artificial products (from different materials) with similar properties as naturally occurring products. One such pattern is the naturally occurring honeycomb-like pattern (HCP). The surfaces of products with this pattern consists of thousands of interconnected hexagonally formed cells that create an efficient structure with a large surface area. The HCP, due to its excellent properties, such as structural and mechanical strength, low density, and porosity, has found applications in several areas, including architecture, chemical engineering, mechanical engineering, and biomedicine. HCP-like structures have also been widely used as carriers in tissue engineering (TE).
  • 459
  • 04 Aug 2021
Topic Review
Cellulose Alcoholysis to Alkyl-levulinate Biofuels
Alkyl levulinates (ALs) represent outstanding bio-fuels and strategic bio-products within the context of the marketing of levulinic acid derivatives. In order to promote the market for these bio-products and, concurrently, the immediate development of new applications, it is necessary to speed up the intensification of their production processes. In this regard, today, it is possible to achieve this important issue only by using low-cost or, even better, waste biomasses, as starting feedstocks. Thus, the transition to the real biomass now represents a necessary choice for allowing the next ALs production on a larger scale. The improvement of the available synthetic strategies, the use of raw materials and the development of new applications for ALs can contribute to develop more intensified, greener and sustainable processes. 
  • 761
  • 16 Dec 2020
Topic Review
Cellulose and Cellulose Derivatives
Among the biomaterials, cellulose is the most abundant, cheap, sustainable, chemical reactive and modifiable natural macromolecular compound on the Earth. It is a carbohydrate homopolymer, which is composed of repeating long linear chains of β-anhydro-D-glucopyranose units, linked together by an ether bond between -OH group of C4, and the C1 carbon atom, via a β-1,4-glycosidic bond.
  • 1.5K
  • 10 Feb 2023
Topic Review
Cellulose Coarse-Grained
Cellulose is the most common biopolymer and widely used in our daily life. Due to its unique properties and biodegradability, it has been attracting increased attention in the recent years and various new applications of cellulose and its derivatives are constantly being found. The development of new materials with improved properties, however, is not always an easy task, and theoretical models and computer simulations can often help in this process.
  • 644
  • 27 Apr 2021
Topic Review
Cellulose Derivatives-Based Dressings for Wound-Healing Management
Notwithstanding the progress regarding wound-healing management, the treatment of the majority of skin lesions still represents a serious challenge for biomedical and pharmaceutical industries. Thus, the attention of the researchers has turned to the development of novel materials based on cellulose derivatives. Cellulose derivatives are semi-synthetic biopolymers, which exhibit high solubility in water and represent an advantageous alternative to water-insoluble cellulose. These biopolymers possess excellent properties, such as biocompatibility, biodegradability, sustainability, non-toxicity, non-immunogenicity, thermo-gelling behavior, mechanical strength, abundance, low costs, antibacterial effect, and high hydrophilicity. They have an efficient ability to absorb and retain a large quantity of wound exudates in the interstitial sites of their networks and can maintain optimal local moisture. Cellulose derivatives also represent a proper scaffold to incorporate various bioactive agents with beneficial therapeutic effects on skin tissue restoration. Due to these suitable and versatile characteristics, cellulose derivatives are attractive and captivating materials for the development of multiple biomedical and pharmaceutical applications, such as wound dressings, drug delivery devices, and tissue engineering.
  • 1.2K
  • 29 Mar 2022
Topic Review
Cellulose Fiber
Cellulose Fiber (CF) is one of the most abundant natural resources in the world, and it is widely found in agricultural residues, such as rice straw, rice husk, maize straw, bagasse, wood shavings, wood chips, bamboo chips, etc. These agricultural residues are mainly composed of cellulose, hemicellulose, lignin, pectin, wax and some water-soluble materials. Cellulose is the most important component of CF, and its chemical formula is (C6H10O5)n. 
  • 1.1K
  • 11 Feb 2022
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