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Topic Review
Xanthones, A Promising Anti-Inflammatory Scaffold
Inflammation is the body’s self-protective response to multiple stimulus, from external harmful substances to internal danger signals released after trauma or cell dysfunction. Many diseases are considered to be related to inflammation, such as cancer, metabolic disorders, aging, and neurodegenerative diseases.  Xanthones, a unique scaffold with a 9H-Xanthen-9-one core structure, widely exist in natural sources. Till now, over 250 xanthones were isolated and identified in plants from the families Gentianaceae and Hypericaceae. Many xanthones have been disclosed with anti-inflammatory properties on different models, either in vitro or in vivo.
  • 690
  • 17 Nov 2021
Topic Review
Research Progress on Preparation Methods of Skutterudites
Thermoelectric material is a new energy material that can realize direct conversion of thermal energy and electric energy. It has important and wide applications in the fields of the recycling of industrial waste heat and automobile exhaust, efficient refrigeration of the next generation of integrated circuits and full spectrum solar power generation. Skutterudites thermoelectric material has attracted much attention because of their excellent electrical transport performance in the medium temperature region. In order to obtain skutterudites thermoelectric materials with excellent properties, it is indispensable to choose an appropriate preparation method.
  • 690
  • 28 Sep 2022
Topic Review
Inorganic Nanoparticles in BC Therapy
Photodynamic therapy (PDT) is an alternative modality to conventional cancer treatment, whereby a specific wavelength of light is applied to a targeted tumor, which has either a photosensitizer or photochemotherapeutic agent localized within it. This light activates the photosensitizer in the presence of molecular oxygen to produce phototoxic species, which in turn obliterate cancer cells. The incidence rate of breast cancer (BC) is regularly growing among women, which are currently being treated with methods, such as chemotherapy, radiotherapy, and surgery. These conventional treatment methods are invasive and often produce unwanted side effects, whereas PDT is more specific and localized method of cancer treatment. The utilization of nanoparticles in PDT has shown great advantages compared to free photosensitizers in terms of solubility, early degradation, and bio-distribution, as well as far more effective intercellular penetration and uptake in targeted cancer cells. 
  • 689
  • 13 Apr 2021
Topic Review
Polymer Composites Carbonaceous Materials Coated
Carbon fibre reinforced polymer composites have high mechanical properties that make them exemplary engineered materials to carry loads and stresses. Coupling fibre and matrix together require good understanding of not only fibre morphology but also matrix rheology. One way of having a strongly coupled fibre and matrix interface is to size the reinforcing fibres by means of micro- or nanocarbon materials coating on the fibre surface. Common coating materials used are carbon nanotubes and nanofibres and graphene, and more recently carbon black (colloidal particles of virtually pure elemental carbon) and graphite. There are several chemical, thermal, and electrochemical processes that are used for coating the carbonous materials onto a carbon fibre surface. Sizing of fibres provides higher interfacial adhesion between fibre and matrix and allows better fibre wetting by the surrounded matrix material.
  • 689
  • 08 Oct 2021
Topic Review
Secondary Metabolites of Purpureocillium lilacinum
Fungi can synthesize a wealth of secondary metabolites, which are widely used in the exploration of lead compounds of pharmaceutical or agricultural importance. Beauveria, Metarhizium, and Cordyceps are the most extensively studied fungi in which a large number of biologically active metabolites have been identified. However, relatively little attention has been paid to Purpureocillium lilacinum. P. lilacinum are soil-habituated fungi that are widely distributed in nature and are very important biocontrol fungi in agriculture, providing good biological control of plant parasitic nematodes and having a significant effect on Aphidoidea, Tetranychus cinnbarinus, and Aleyrodidae. At the same time, it produces secondary metabolites with various biological activities such as anticancer, antimicrobial, and insecticidal. 
  • 689
  • 13 Jan 2022
Topic Review
Non-Intumescent Flame-Retardant Coating
Fire-retardant coatings, common materials for fire protection of buildings, are widely used in the construction industry. Because they do not change the nature of the matrix, while greatly improving the ability of the matrix to resist flame propagation, they significantly reduce the fire hazard of buildings. Flame-retardant coatings are divided into NIFRC and IFRC , depending on whether the flame-retardant coating expands when heated. NIFRCs are generally composed of inorganic materials that can prevent the return of the heat and oxygen supply to the combustible matrix during the heating process of the polymer and, at the same time, prevent the transfer of combustible gas generated by the pyrolysis of the matrix to the flame, thus protecting the polymer matrix. According to the literature reports, NIFRCs for RPUF mainly include hydrogel/sol, aerogel, ceramic materials, etc.
  • 689
  • 19 Apr 2023
Topic Review
Electron Transfer and Proton Loss of Conventional Carotenoids
Carotenoids are a large and diverse group of compounds that have been shown to have a wide range of potential health benefits. While some carotenoids have been extensively studied, numerous others have not received as much attention. In numerous studies, using EPR (electron paramagnetic resonance) techniques in correlation with DFT (density functional theory) calculations, researchers have characterized about 20 conventional carotenoids - their electron transfer from the carotenoid molecule to form the radical cation, and further proton loss from the radical cation to form neutral radicals (radicals with no charge). Several conventional carotenoids are briefly discussed here.
  • 689
  • 28 Jun 2023
Topic Review
Rosemary for Natural Antioxidants and Anticancer Agents
Rosmarinus officinalis L. compounds, especially its main polyphenolic compounds, carnosic acid (CA) and rosmarinic acid (RA), influence various facets of cancer biology, making them valuable assets in the ongoing fight against cancer. These two secondary metabolites exhibit formidable antioxidant properties that are a pivotal contributor against the development of cancer.
  • 689
  • 03 Jan 2024
Topic Review
Salvigenin
Phytochemical analysis of the Iranian plant Achillea wilhelmsii led to the isolation of 17 pure secondary metabolites belonging to the classes of sesquiterpenoids and phenolics. Two of these compounds, named wilhemsin (7) and wilhelmsolide (9), are new sesquiterpenoids, and the first shows undescribed structural features. Their structures were elucidated through extensive spectroscopic analysis, mainly based on 1D and 2D NMR, and chemical derivatization. Starting from plant traditional use and previous reports on the activity of the plant extracts, all the pure compounds were evaluated on endpoints related to the treatment of metabolic syndrome. The sesquiterpene hanphyllin (8) showed a selective cholesterol-lowering activity (−12.7% at 30 µM), santoflavone (13) stimulated glucose uptake via the GLUT transporter (+16.2% at 30 µM), while the trimethoxylated flavone salvigenin (14) showed a dual activity in decreasing lipid levels (−22.5% palmitic acid biosynthesis at 30 µM) and stimulating mitochondrial functionality (+15.4% at 30 µM). 
  • 688
  • 13 Aug 2021
Topic Review
Cartilage Lubrication in Osteoarthritis
The remarkable lubrication properties of normal articular cartilage play an essential role in daily life, providing almost frictionless movements of joints. Alterations of cartilage surface or degradation of biomacromolecules within synovial fluid increase the wear and tear of the cartilage and hence determining the onset of the most common joint disease, osteoarthritis (OA).
  • 688
  • 03 Nov 2021
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