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Topic Review
Cutaneous Flavonoid Delivery System
Flavonoids are one of the vital classes of natural polyphenolic compounds abundantly found in plants. Due to their wide range of therapeutic properties, which include antioxidant, anti-inflammatory, photoprotective, and depigmentation effects, flavonoids have been demonstrated to be promising agents in the treatment of several skin disorders. However, their lipophilic nature and poor water solubility invariably lead to limited oral bioavailability. In addition, they are rapidly degraded and metabolized in the human body, hindering their potential contribution to the prevention and treatment of many disorders. Thus, to overcome these challenges, several cutaneous delivery systems have been extensively studied. Topical drug delivery besides offering an alternative administration route also ensures a sustained release of the active compound at the desired site of action. Incorporation into lipid or polymer-based nanoparticles appears to be a highly effective approach for cutaneous delivery of flavonoids with good encapsulation potential and reduced toxicity.
  • 731
  • 22 Apr 2022
Topic Review
Plasma Electrolytic Oxidation Coating
Plasma electrolytic oxidation (PEO) is an effective surface modification method for producing ceramic oxide layers on metals and their alloys. Although inorganic electrolytes are widely used in PEO, the organic additives have received considerable interest in the last decade due to their roles in improving the final voltage and controlling spark discharging, which lead to significant improvements in the performance of the obtained coatings. 
  • 731
  • 30 Mar 2021
Topic Review
Imogolite Nanotubes
Imogolite nanotubes (INTs) represent a model of nanoplatforms with an untapped potential for advanced technological applications. Easily synthesized by sol-gel methods, these nanotubes are directly obtained with a monodisperse pore size. Coupled with the possibility to adjust their surface properties by using straightforward functionalization processes, INTs form a unique class of diameter-controlled nanotubes with functional interfaces. 
  • 729
  • 22 Jun 2021
Topic Review
Betulin
Betulin is an important triterpenoid substance isolated from birch bark, which, together with its sulfates, exhibits important bioactive properties. Using the potentiometric titration method, the product of acidity constants K1 and K2 of a solution of the betulin disulfate H+ form has been found to be 3.86 × 10–6 ± 0.004. It has been demonstrated by the thermal analysis that betulin and the betulin disulfate sodium salt are stable at temperatures of up to 240 and 220 °C, respectively. 
  • 728
  • 28 Feb 2022
Topic Review
Gelatin-Based Hybrid Scaffolds
Gelatin is a biopolymer with interesting properties that have greatly attracted the attention of many biomedical researchers, such as low antigenicity, good biodegradability, and biocompatibility in the physiological environment. The gelatin-based materials offer excellent characteristics of wound dressings. The fast degradation time and highly hydrophilic surface make gelatin inappropriate as a base material for the development of wound dressings.
  • 729
  • 08 Sep 2021
Topic Review
Lead-Free Perovskite Single Crystals
Lead-free perovskites have received remarkable attention because of their nontoxicity, low-cost fabrication, and spectacular properties including controlled bandgap, long diffusion length of charge carrier, large absorption coefficient, and high photoluminescence quantum yield. Compared with the widely investigated polycrystals, single crystals have advantages of lower trap densities, longer diffusion length of carrier, and extended absorption spectrum due to the lack of grain boundaries, which facilitates their potential in different fields including photodetectors, solar cells, X-ray detectors, light-emitting diodes, and so on. 
  • 728
  • 30 Nov 2021
Topic Review
Oxidative Catalytic Processes for APIs and Precursors Preparation
Active pharmaceutical ingredients (APIs) can be defined as those biological compounds used for the detection, prevention, and treatment of different types of diseases. Asymmetric oxidation processes have constituted a valuable tool for the synthesis of APIs, especially for the preparation of optically active sulfoxides, compounds with interesting biological properties. Biocatalyzed reactions usually occur with high efficiency, excellent selectivity, good yields, environmental sustainability, and lower costs, which make them more attractive from an industrial perspective. However, it must be taken into account that these procedures also present some drawbacks, such as the (relatively) high substrate specificity of biocatalysts or the low substrate loadings required due to their generally low solubility in water.
  • 728
  • 10 Apr 2023
Topic Review
Ocimum Species
Ocimum is known to be one of the medicinal plants that have been used traditionally by local people. This plant contains components of secondary metabolites such as phenolics, flavonoids, steroids, terpenoids, and alkaloids.
  • 728
  • 31 Oct 2022
Topic Review
Graphitic Nanocup Architectures
Graphitic nanocup architectures are low aspect ratio hollow graphitic nanostructure that can be precisely controlled and modified for various applications. 
  • 727
  • 26 Oct 2020
Topic Review
Fluorescent Organic Small Molecule Probes
Fluorescence imaging technology provides a visual tool for medicine, showing great potential in the fields of molecular biology, cellular immunology and oncology. In recent years, organic fluorescent probes have attracted much attention in the bioanalytical field. Among various organic fluorescent probes, fluorescent organic small molecule probes (FOSMPs) have become a research hotspot due to their excellent physicochemical properties, such as good photostability, high spatial and temporal resolution, as well as excellent biocompatibility. FOSMPs have proved to be suitable for in vivo bioimaging and detection. 
  • 727
  • 17 Jan 2023
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