Topic Review
Novel Advances in Treatment of Meningiomas
Meningiomas are extra-axial, slow-growing, and (usually) benign tumors. These tumors arise from meningothelial cells of the arachnoid layer, so they can be encountered anywhere this type of cell is localized.
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  • 26 Sep 2023
Topic Review
Tumor-Derived Extracellular Vesicles in Anti-Cancer Therapies
The infiltration of primary tumors and metastasis formation at distant sites strongly impact the prognosis and the quality of life of cancer patients. Current therapies including surgery, radiotherapy, and chemotherapy are limited in targeting the complex cell migration mechanisms responsible for cancer cell invasiveness and metastasis. Extracellular vesicles (EVs) are lipid-enveloped particles involved in inter-tissue and inter-cell communication. Tumor-derived extracellular vesicles (TDEVs) impact cancer cell migration. They can not only be considered as a target for cancer therapy but can also be used for the development of anti-tumor therapeutic strategies.
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  • 26 Sep 2023
Topic Review
Base Excision Repair Mechanisms
Base excision repair (BER) corrects forms of oxidative, deamination, alkylation, and abasic single-base damage that appear to have minimal effects on the helix. Since its discovery in 1974, the field has grown in several facets: mechanisms, biology and physiology, understanding deficiencies and human disease, and using BER genes as potential inhibitory targets to develop therapeutics.
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  • 26 Sep 2023
Topic Review
Human Triosephosphate Isomerase as Potential Target in Cancer
Cancer involves a series of diseases where cellular growth is not controlled. Cancer is a leading cause of death worldwide, and the burden of cancer incidence and mortality is rapidly growing, mainly in developing countries. Many drugs are currently used, from chemotherapeutic agents to immunotherapy, among others, along with organ transplantation. Treatments can cause severe side effects, including remission and progression of the disease with serious consequences. Increased glycolytic activity is characteristic of cancer cells. Triosephosphate isomerase is essential for net ATP production in the glycolytic pathway.
  • 13
  • 26 Sep 2023
Topic Review
Plant Growth Promotion Using Bacillus cereus
Plant growth-promoting bacteria (PGPB) appear to be a sensible competitor to conventional fertilization, including mineral fertilizers and chemical plant protection products. Undoubtedly, one of the most interesting bacteria exhibiting plant-stimulating traits is, more widely known as a pathogen, Bacillus cereus. Several environmentally safe strains of B. cereus have been isolated and described, including B. cereus WSE01, MEN8, YL6, SA1, ALT1, ERBP, GGBSTD1, AK1, AR156, C1L, and T4S. These strains have been studied under growth chamber, greenhouse, and field conditions and have shown many significant traits, including indole-3-acetic acid (IAA) and aminocyclopropane-1-carboxylic acid (ACC) deaminase production or phosphate solubilization, which allows direct plant growth promotion. It includes an increase in biometrics traits, chemical element content (e.g., N, P, and K), and biologically active substances content or activity, e.g., antioxidant enzymes and total soluble sugar. Hence, B. cereus has supported the growth of plant species such as soybean, maize, rice, and wheat. Importantly, some B. cereus strains can also promote plant growth under abiotic stresses, including drought, salinity, and heavy metal pollution.
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  • 26 Sep 2023
Topic Review
DnaA and Hyperstructure Dynamics in the Cell Cycle
The DnaA protein has long been considered to play the key role in the initiation of chromosome replication in modern bacteria.
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  • 26 Sep 2023
Topic Review
In Vitro Embryogenesis and Gastrulation Using Stem Cells
During early mammalian embryonic development, fertilized one-cell embryos develop into pre-implantation blastocysts and subsequently establish three germ layers through gastrulation during post-implantation development. Stem cells have emerged as a powerful tool to study embryogenesis and gastrulation without the need for eggs, allowing for the generation of embryo-like structures known as synthetic embryos or embryoids. These in vitro models closely resemble early embryos in terms of morphology and gene expression and provide a faithful recapitulation of early pre- and post-implantation embryonic development. Synthetic embryos can be generated through a combinatorial culture of three blastocyst-derived stem cell types, such as embryonic stem cells, trophoblast stem cells, and extraembryonic endoderm cells, or totipotent-like stem cells alone. 
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  • 26 Sep 2023
Topic Review
Chitin and Chitosan in Alcoholic and Non-Alcoholic Beverage
The natural biopolymer chitin and its deacetylated derivative chitosan are abundant in nature. They are obtained from different sources, including the crustacean shells and the cell walls of fungi. Chitin and chitosan have various applications in the beverage industry, such as a flocculent to improve the clarification process, reduce metals and contaminates, and extend shelf-life. They are also used as material for immobilizing microorganisms and enzymes, allowing bioprocesses to develop that preserve the quality of alcoholic and non-alcoholic beverages. 
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  • 25 Sep 2023
Topic Review
Red Fruits Composition
Red fruits are not only a source of vitamins but are also a rich source of minerals (phosphorus, calcium, iron, potassium, magnesium, manganese, sodium, and copper). Shows sweet cherry, blackberry, blueberry, raspberry, and strawberry mineral composition.
  • 13
  • 25 Sep 2023
Topic Review
β-Lactams
Ceftaroline fosamil is an N-phosphono prodrug of the fifth generation cephalosporin derivative ceftaroline, presenting two amino side groups located at positions 3 and 7, respectively.
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  • 25 Sep 2023
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