Topic Review
Contemporary Use of Intracytoplasmic Sperm Injection
Intracytoplasmic sperm injection (ICSI) has been used for severe male factor infertility and non-male factors, such as unexplained infertility or advanced maternal age, without robust scientific evidence. However, applying ICSI blindly is not free of potential detrimental consequences since novel studies report possible health consequences to offspring. DNA methylation and epigenetic alterations in sperm cells of infertile men might help explain some of the adverse effects reported in ICSI studies on reproductive health in future generations. 
  • 9
  • 17 May 2022
Topic Review
Hop
Hops is considered a short-day, temperate species, so the major challenge for the development of hop cultivation in Brazil, with high-yield capacity and with local typicity of bitterness and aroma, is the adaptation of cultivars to the photoperiod conditions in subtropical regions. 
  • 25
  • 17 May 2022
Topic Review
Shedding Light on the Complex Regulation of FGF23
Early research has suggested a rather straightforward relation between phosphate exposure, increased serum FGF23 (Fibroblast Growth Factor 23) concentrations and clinical endpoints.
  • 14
  • 17 May 2022
Topic Review
G-Quadruplex-Binding Proteins
G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with the potential to form G4s are abundant in regulatory regions of the genome including telomeres, promoters and 5′ non-coding regions, indicating they fulfill important genome regulatory functions. In recent years, an increasing number of G-quadruplex-binding proteins have been identified with biochemical experiments. G4-binding proteins are involved in vital cellular processes such as telomere maintenance, DNA replication, gene transcription, mRNA processing. Therefore, G4-binding proteins are also associated with various human diseases.
  • 15
  • 17 May 2022
Topic Review
Lactic Acid Bacteria against Mycotoxins
Mycotoxins (aflatoxin, ochratoxin, patulin, zearalenone, fumonisins, trichothecenes) are a large group of chemically diverse, non-protein, low-molecular secondary metabolites produced by molds. They constitute a global threat to human food and health. The generally regarded as safe (GRAS) status and long history as essential ingredients of fermented foods and probiotics make Lactic Acid Bacteria (LAB) a major biological tool against various food-related toxins. Numerous have shown studies LAB to be effective against all major mycotoxins.
  • 33
  • 17 May 2022
Topic Review
Chinese Wine Industry
After more than 40 years of development, China’s wine regulatory system has been constantly improved, from half-base wine standards to pure-juice fermented wine standards, and then to the establishment of a relatively complete and mature industry-standard system with product and manufacturing standards as the core and other relevant industry standards as accessories.
  • 5
  • 17 May 2022
Topic Review
Panel Products Made of Oil Palm Trunk
Oil palm plantations have expanded rapidly in Southeast Asia, particularly in Indonesia and Malaysia. A lot of products, including food and other edible products, oleo-chemicals, cosmetics, personal and household care, pharmaceutical products, and biodiesels are derived from palm oil, thus making them one of the most economically important plants.
  • 20
  • 17 May 2022
Topic Review
Rhizosphere
The rhizosphere serves as a hotspot for diverse microbial activity. It is an intricate ecosystem comprising nutrient-rich soil that surrounds the plant roots, which provides a pool for plant–microbe communication. The term “Rhizomicrobiome” is defined as a microbial community that is present in the rhizosphere. A variety of microorganisms reside within the rhizosphere, including bacteria, fungi, nematodes, protists, and invertebrates. Most of the microbiome studies within the context of rhizosphere signaling have been focused on the bacteria and fungi that make up the major portion of the rhizosphere microbiome.
  • 16
  • 17 May 2022
Topic Review
Nuclear protein in Testis
NUT (Nuclear protein in Testis) is a testis-specific factor originally discovered as a chromosomal fusion partner of BRD4 and BRD3, both members of the BET double bromodomain-containing family of proteins, in an aggressive cancer known as NUT Carcinoma (NC).
  • 16
  • 17 May 2022
Topic Review
Applications of Two-Photon Microscopy
Fluorescence microscopy has represented a crucial technique to explore the cellular and molecular mechanisms in the field of biomedicine. However, the conventional one-photon microscopy exhibits many limitations when living samples are imaged. The new technologies, including two-photon microscopy (2PM), have considerably improved the in vivo study of pathophysiological processes, allowing the investigators to overcome the limits displayed by previous techniques. 2PM enables the real-time intravital imaging of the biological functions in different organs at cellular and subcellular resolution thanks to its improved laser penetration and less phototoxicity. The development of more sensitive detectors and long-wavelength fluorescent dyes as well as the implementation of semi-automatic software for data analysis allowed to gain insights in essential physiological functions, expanding the frontiers of cellular and molecular imaging. The future applications of 2PM are promising to push the intravital microscopy beyond the existing limits. 
  • 11
  • 17 May 2022
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