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Topic Review
Murciano-Granadina Goats
Murciano-Granadina goat is one of the oldest and most representative livestock breeds of Spain. There are some references to its existence dating back to the fifteenth century, especially with respect to the Granadina population (Rodero et al. 1992). The first modern reference to the breed is dated in 1893 (Aragó 1893) but it considered Murciana and Granadina, whose names derivate from the Spanish provinces in which they were raised, as two separate breeds, a situation that was maintained until the first official recognition of the Spanish breeds in 1933. According to Aparicio (1947) both Murciana and Granadina breeds are modern evolutions of the European Capra aegagrus goat branch, so that they are very close to each other from an evolutionary point of view, but still they hold important genetic differences as it has been highlighted by the tests carried out with molecular markers by Martínez et al. (2010), differences which could support  their recognition as independent breeds. Anyway, the integration of these two original breeds into a single racial entity was strictly an administrative decision took in the seventies during the past century. In those years, the Spanish government decided to follow the international recommendation to fusion close breeds in order to obtain higher census that permitted to extend the intensity of selection and the consequent bigger genetic progress. Today this decision is severely criticized because it meant the erosion of the Granadina population, leading it near extinction, in spite of remarking the important adaptive capacity of this population to the altitude (more than 2500 m) and the heat and hydric stress. Presently, the new extensification of management systems and the effects of climatic change make the Granadina genotypes very demanded, which show the best performances under hard conditions.
  • 946
  • 16 Sep 2021
Topic Review
The Chemistry of Reactive Oxygen Species Revisited
Living species are continuously subjected to all extrinsic forms of reactive oxidants and others that are produced endogenously. There is extensive literature on the generation and effects of reactive oxygen species (ROS) in biological processes, both in terms of alteration and their role in cellular signaling and regulatory pathways. Cells produce ROS as a controlled physiological process, but increasing ROS becomes pathological and leads to oxidative stress and disease. The induction of oxidative stress is an imbalance between the production of radical species and the antioxidant defense systems, which can cause damage to cellular biomolecules, including lipids, proteins and DNA. Cellular and biochemical experiments have been complemented in various ways to explain the biological chemistry of ROS oxidants. However, it is often unclear how this translates into chemical reactions involving redox changes. 
  • 947
  • 30 Sep 2022
Topic Review
C-to-U RNA Editing
The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cytidine (C) or guanosine (G) to adenine (A), for which gene editing (editing of mutated genes) is a promising therapeutic technique. In C-to-Uridine (U) RNA editing, it converts the base C-to-U in RNA molecules and leads to nonsynonymous changes when occurring in coding regions; for G-to-A mutations, A-to-I editing occurs. Editing of C-to-U is not as physiologically common as that of A-to-I editing.
  • 950
  • 30 Sep 2022
Topic Review
Livestock CH4 Emissions with the Laser Methane Detector
The handheld, portable laser methane detector (LMD) was developed to detect gas leaks in industry from a safe distance. Since 2009, it has also been used to measure the methane (CH4) concentration in the breath of cattle, sheep, and goats to quantify their CH4 emissions.
  • 947
  • 19 Jan 2022
Topic Review
NRF2 Signaling Pathway in Cancer
Nuclear factor-erythroid 2-related factor 2 (NRF2) and its major negative modulator Kelch-like ECH-associated protein 1 (KEAP1) are main players of the cellular defense mechanisms against internal and external cell stressors.
  • 947
  • 26 May 2021
Topic Review
Fungi in Seed Germplasm Collections
Seeds can harbor a wide range of microorganisms, especially fungi, which can cause different sanitary problems. Seed quality and seed longevity may be drastically reduced by fungi that invade seeds before or after harvest. Seed movement can be a pathway for the spread of diseases into new areas. Some seed-associated fungi can also produce mycotoxins that may cause serious negative effects on humans, animals and the seeds themselves. Seed storage is the most efficient and widely used method for conserving plant genetic resources. The seed storage conditions used in gene banks, low temperature and low seed moisture content, increase seed longevity and are usually favorable for the survival of seed-borne mycoflora. Early detection and identification of seed fungi are essential activities to conserve high-quality seeds and to prevent pathogen dissemination.
  • 946
  • 06 Dec 2022
Topic Review
Buckwheat and Amaranth
Buckwheat and amaranth are two pseudocereals that have multiple uses, including for obtaining of malt and beer, that are grown in different parts of the world.
  • 946
  • 22 Mar 2022
Topic Review
Circulating Exosome Cargoes Contain Functionally Diverse Cancer Biomarkers
The indolent nature of some cancers makes early detection challenging, as such significant effort is placed on identifying circulating cancer biomarkers using minimally invasive, highly sensitive diagnostic assays. Biological fluids contain small extracellular vesicles including exosomes, which have many tissue origins. Cancer cells increase production and release of exosomes in the circulation to deliver biologically active compounds that can reprogram recipient cells, which potentially represent a valuable source of biomarkers.
  • 946
  • 28 Jul 2022
Topic Review
Photosensitive Substances
Photodynamic therapy (PDT) is part of photochemotherapy and requires the presence of a photosensitive substance (drug, PS), oxygen, and a powerful light source in the area of absorption of the PS used.
  • 946
  • 13 Apr 2021
Topic Review
Molecular Markers
Fungi are amongst the most abundant and diverse organisms. Despite being widely known for their adverse role in food spoilage or as pathogens for humans, animals, or plants, they also present several beneficial effects. Fungi contribute to human well-being due to their role as decomposers, degrading decay matter into smaller molecules which can be easily used by other ecosystem members. These organisms can produce medicinal compounds or modulate protective immune responses in human intestine. Fungi intervene in diverse food processes or act as a food supply. Due to fungal diversity, the unequivocal identification of these organisms is crucial to increasing their practical applications and decreasing their adverse effects.
  • 946
  • 02 Aug 2022
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