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Topic Review
Link between Diabetes, Pancreatic Tumors, and miRNAs
Despite significant progress in medicine, pancreatic cancer is one of the most tardily diagnosed cancer and is consequently associated with a poor prognosis and a low survival rate. The asymptomatic clinical picture and the lack of relevant diagnostic markers for the early stages of pancreatic cancer are believed to be the major constraints behind an accurate diagnosis of this disease. Furthermore, underlying mechanisms of pancreatic cancer development are still poorly recognized. It is well accepted that diabetes increases the risk of pancreatic cancer development, however the precise mechanisms are weakly investigated. Studies are focused on microRNAs as a causative factor of pancreatic cancer. 
  • 213
  • 29 Jun 2023
Topic Review
Medical Applications of Molecular Biotechnologies in Hashimoto’s Thyroiditis
Hashimoto’s thyroiditis (HT) is a gender autoimmune disease that is manifested by chronic inflammation of the thyroid. Clinical trial studies (CTSs) use molecular biotechnologies (MB) to approach HT appearance. 
  • 314
  • 29 Jun 2023
Topic Review
Angiostrongylus cantonensis in the Definitive Rodent Host
Human angiostrongylosis is an emerging zoonosis caused by the larvae of three species of metastrongyloid nematodes of the genus Angiostrongylus, with Angiostrongylus cantonensis (Chen, 1935) being dominant across the world. Its obligatory heteroxenous life cycle includes rats as definitive hosts, mollusks as intermediate hosts, and amphibians and reptiles as paratenic hosts. In humans, the infection manifests as Angiostrongylus eosinophilic meningitis (AEM) or ocular form.
  • 481
  • 29 Jun 2023
Topic Review
Heme Interactions
Heme (Fe2+-protoporphyrin IX) is a pigment of life, and as a prosthetic group in several hemoproteins, it contributes to diverse critical cellular processes. Direct interactions of extracellular heme with alternative pathway complement components (APCCs) may be implicated molecularly in diverse conditions at sites of abnormal cell damage and vascular injury. 
  • 296
  • 29 Jun 2023
Topic Review
RNA Interference Past and Future Applications in Plants
Antisense RNA was observed to elicit plant disease resistance and post-translational gene silencing (PTGS). The universal mechanism of RNA interference (RNAi) was shown to be induced by double-stranded RNA (dsRNA), an intermediate produced during virus replication. Plant viruses with a single-stranded positive-sense RNA genome have been instrumental in the discovery and characterization of systemic RNA silencing and suppression.  Application of exogenously applied dsRNA is proving to be a potent strategy for delivery to improve crop performance.
  • 429
  • 29 Jun 2023
Topic Review
The Brain at High Altitude
The brain requires over one-fifth of the total body oxygen demand for normal functioning. At high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain, affecting voluntary spatial attention, cognitive processing, and attention speed after short-term, long-term, or lifespan exposure. Molecular responses to HA are controlled mainly by hypoxia-inducible factors.
  • 527
  • 29 Jun 2023
Topic Review
The Beta-Globin Locus and the Hemoglobin Switching
Beta-hemoglobinopathies are the most common genetic disorders worldwide, caused by a wide spectrum of mutations in the β-globin locus, and associated with morbidity and early mortality in case of patient non-adherence to supportive treatment. Allogeneic transplantation of hematopoietic stem cells (allo-HSCT) used to be the only curative option, although the indispensable need for an HLA-matched donor markedly restricted its universal application. Hereditary persistence of fetal hemoglobin (HPFH), a syndrome characterized by increased γ-globin levels, when co-inherited with β-thalassemia or SCD, converts hemoglobinopathies to a benign condition with mild clinical phenotype.The evolution of gene therapy approaches made possible the ex vivo delivery of a therapeutic β- or γ- globin gene into patient-derived hematopoietic stem cells followed by the transplantation of corrected cells into myeloablated patients, having led to high rates of transfusion independence (thalassemia) or complete resolution of painful crises (sickle cell disease-SCD).  
  • 266
  • 29 Jun 2023
Topic Review
Monoclonal Antibodies: Structure and Function
Monoclonal antibodies are among the most effective tools for detecting tumor-associated antigens. The U.S. Food and Drug Administration (FDA) has approved more than 36 therapeutic antibodies for developing novel alternative therapies that have significant success rates in fighting cancer. 
  • 289
  • 29 Jun 2023
Topic Review
Sources of HM Contamination in Arable Lands
Heavy metals and metalloids (HMs) are environmental pollutants, most notably cadmium, lead, arsenic, mercury, and chromium. When HMs accumulate to toxic levels in agricultural soils, these non-biodegradable elements adversely affect crop health and productivity. The toxicity of HMs on crops depends upon factors including crop type, growth condition, and developmental stage; nature of toxicity of the specific elements involved; soil physical and chemical properties; occurrence and bioavailability of HM ions in the soil solution; and soil rhizosphere chemistry. HMs can disrupt the normal structure and function of cellular components and impede various metabolic and developmental processes. 
  • 293
  • 29 Jun 2023
Topic Review
Plant Secondary Metabolites Involved in Biotic Stress Tolerance
Plant secondary metabolites are categorized into terpenoids (such as saponin), phenolics (such as flavones, lignin, isoorientin, tannin, flavonoids, and glyceollin), and nitrogen compounds (such as sinigrin and dhurrin). Different secondary metabolites show different metabolisms, which help to suppress the growth and development of herbivores. Phenolic metabolites with volatile compounds repel herbivores and protect the plant.
  • 373
  • 29 Jun 2023
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