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Topic Review
Traditional Fermented Foods in Korea
Fermented foods are loved and enjoyed worldwide and are part of a tradition in several regions of the world. Koreans have traditionally had a healthy diet since people in this region have followed a fermented-foods diet for at least 5000 years. Fermented-product footprints are evolving beyond boundaries and taking the lead in the world of food. Fermented foods, such as jang (fermented soybean products), kimchi (fermented vegetables), jeotgal (fermented fish), and vinegar (liquor with grain and fruit fermentation), are prominent fermented foods in the Korean culture.
  • 2.2K
  • 09 Dec 2022
Topic Review
Luminogens with Aggregation-Induced Emission
Luminogens with aggregation-induced emission (AIEgens) have been widely applied in the field of photodynamic therapy. Among them, aggregation-induced emission photosensitizers (AIE–PSs) are demonstrated with high capability in fluorescence and photoacoustic bimodal imaging, as well as in fluorescence imaging-guided photodynamic therapy. They not only improve diagnosis accuracy but also provide an efficient theranostic platform to accelerate preclinical translation as well.
  • 2.2K
  • 21 Jan 2021
Topic Review
Hereditary Hemochromatosis
The environment and the human genome are closely entangled and many genetic variations that occur in human populations are the result of adaptive selection to ancestral environmental (mainly dietary) conditions. However, the selected mutations may become maladaptive when environmental conditions change, thus becoming candidates for diseases. Hereditary hemochromatosis (HH) is a potentially lethal disease leading to iron accumulation mostly due to mutations in the HFE gene. Indeed, homozygosity for the C282Y HFE mutation is associated with the primary iron overload phenotype. However, both penetrance of the C282Y variant and the clinical manifestation of the disease are extremely variable, suggesting that other genetic, epigenetic and environmental factors play a role in the development of HH, as well as, and in its progression to end-stage liver diseases. Alcohol consumption and dietary habits may impact on the phenotypic expression of HFE-related hemochromatosis. Indeed, dietary components and bioactive molecules can affect iron status both directly by modulating its absorption during digestion and indirectly by the epigenetic modification of genes involved in its uptake, storage and recycling. Thus, the premise of this review is to discuss how environmental pressures led to the selection of HFE mutations and whether nutritional and lifestyle interventions may exert beneficial effects on HH outcomes and comorbidities.
  • 2.2K
  • 13 Nov 2021
Topic Review
Membrane Protein
Membrane proteins are polypeptides integrated into or associated with biological membranes. They are present at roughly equal weight to phospholipids in plasma membranes of cells, in outer membranes of bacteria, mitochondria, chloroplasts and in other organelles. Membrane proteins govern the active functions of membranes, such as transport, signalling, asymmetry and polarisation. Membrane proteins follow characteristic folding patterns and have hydrophobic domains that make them compatible with the amphipathic lipid biayers.
  • 2.2K
  • 24 Dec 2020
Topic Review
Runx2 and Osteoblasts
Runx2 is essential for osteoblast differentiation, chondrocyte maturation, and transdifferentiation of terminally differentiated chondrocytes into osteoblasts. During osteoblast differentiation, Runx2 is weakly expressed in uncommitted mesenchymal cells, and its expression is upregulated in preosteoblasts, reaches the maximal level in immature osteoblasts, and is down-regulated in mature osteoblasts. Runx2 enhances the proliferation of osteoblast progenitors by directly regulating Fgfr2 and Fgfr3. Runx2 enhances the proliferation of suture mesenchymal cells and induces their commitment into osteoblast lineage cells through the direct regulation of hedgehog (Ihh, Gli1, and Ptch1), Fgf (Fgfr2 and Fgfr3), Wnt (Tcf7, Wnt10b, and Wnt1), and Pthlh (Pthr1) signaling pathway genes, and Dlx5. Runx2 heterozygous mutation causes open fontanelle and sutures because more than half of the Runx2 gene dosage is required for the induction of these genes in suture mesenchymal cells. Runx2 induces the proliferation of osteoblast progenitors and their differentiation into osteoblasts through reciprocal regulation via major signaling pathways, including Fgf, hedgehog, Wnt, and Pthlh, and transcription factors, including Sp7 and Dlx5. Runx2 also regulates the expression of bone matrix protein genes, including Col1a1, Col1a2, Spp1, and Bglap/Bglap2. Bglap/Bglap2 (osteocalcin) aligns biological apatite parallel to the collagen fibrils, which is important for bone strength, but osteocalcin does not play a role as a hormone in the pancreas, testis, and muscle. 
  • 2.2K
  • 22 Apr 2021
Topic Review
Water Footprint in Steel Industries
Steelmaking is a water-intensive process. The mean water intake against each ton of steel manufactured is ascertained as between 2 and 20 m3. Primarily, the stated requirement is in the form of make-up water to compensate for evaporation and mechanical losses and does not contribute to wastewater generation. Conversely, unit operations, such as rolling, continuous casting, pickling, etc., generate highly complex wastewater rich in polycyclic aromatic hydrocarbons (PAH), cyanide, ammonia, non-consumed acids, benzene, toluene, xylene, oil, grease, etc. 
  • 2.2K
  • 15 Jun 2023
Topic Review
Transformation of Natural Philosophy
Is there any reason, to believe a modern natural philosophy makes sense? The history of natural philosophy is marked by the search for principles that determine all beings independently whether they are abiotic matter or living organisms. Empirical data on the key features of life contradict even the possibility to find such principles because life in contrast to abiotic matter offers some main characteristics that are completely absent on abiotic planets. This means, if a modern natural philosophy should have any benefit it must be divided into a natural philosophy of physics or cosmology and a natural philosophy of life. If it is possible to give an updated definition of life, empirically based, non-reductive, non-mechanistic and without metaphysical assumptions, this would be an appropriate basis for a global consensus how future of humans may be generated in symbiosis with global biosphere. If we think on billions invested in health and drug research a new natural philosophy of life could orientate future of research on health and new drugs and avoid misinvestments.
  • 2.2K
  • 09 Nov 2020
Topic Review
Sulfate-Reducing Bacteria
Sulfate-reducing bacteria (SRB) are a group of anaerobic microorganisms that can be present in the environment and gastrointestinal tract as a part of the intestinal microbiome and can be involved in inflammatory bowel diseases (IBDs), including ulcerative colitis in the human and animals.
  • 2.2K
  • 07 Feb 2021
Topic Review
Michelia × alba (M. alba)
Michelia × alba (M. alba) is a flowering tree best known for its essential oil, which has long been used as a fragrance ingredient for perfume and cosmetics. 
  • 2.2K
  • 10 Jun 2022
Topic Review
Cyanophyceae
Cyanobacteria (/saɪˌænoʊbækˈtɪəri.ə/), also known as Cyanophyta, are a phylum of Gram-negative bacteria that obtain energy via photosynthesis. The name cyanobacteria refers to their color (from grc κυανός (kuanós) 'blue'), which similarly forms the basis of cyanobacteria's common name, blue-green algae.[note 1] They appear to have originated in a freshwater or terrestrial environment. Sericytochromatia, the proposed name of the paraphyletic and most basal group, is the ancestor of both the non-photosynthetic group Melainabacteria and the photosynthetic cyanobacteria, also called Oxyphotobacteria. Cyanobacteria use photosynthetic pigments, such as carotenoids, phycobilins, and various forms of chlorophyll, which absorb energy from light. Unlike heterotrophic prokaryotes, cyanobacteria have internal membranes. These are flattened sacs called thylakoids where photosynthesis is performed. Phototrophic eukaryotes such as green plants perform photosynthesis in plastids that are thought to have their ancestry in cyanobacteria, acquired long ago via a process called endosymbiosis. These endosymbiotic cyanobacteria in eukaryotes then evolved and differentiated into specialized organelles such as chloroplasts, chromoplasts, etioplasts, and leucoplasts, collectively known as plastids. Cyanobacteria are the first organisms known to have produced oxygen. By producing and releasing oxygen as a byproduct of photosynthesis, cyanobacteria are thought to have converted the early oxygen-poor, reducing atmosphere into an oxidizing one, causing the Great Oxidation Event and the "rusting of the Earth", which dramatically changed the composition of the Earth's life forms. The cyanobacteria Synechocystis and Cyanothece are important model organisms with potential applications in biotechnology for bioethanol production, food colorings, as a source of human and animal food, dietary supplements and raw materials. Cyanobacteria produce a range of toxins known as cyanotoxins that can pose a danger to humans and animals.
  • 2.2K
  • 01 Nov 2022
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