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Topic Review
COVID-19 Diagnosis
The world is grappling with the coronavirus disease 2019 (COVID-19) pandemic, the causative agent of which is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 symptoms are similar to the common cold, including fever, sore throat, cough, muscle and chest pain, brain fog, dyspnoea, anosmia, ageusia, and headache.
  • 1.3K
  • 27 Jun 2022
Topic Review
Metabolic Reprogramming
Metabolic reprogramming is now recognized as a hallmark of cancer cells and supports cancer growth. Elucidating the underlying mechanisms of metabolic reprogramming in cancer cells may help identifying cancer targets and treatment strategies.
  • 1.3K
  • 20 Jan 2021
Topic Review
Heme Metabolism
Mitochondria are essential organelles of mammalian cells, often emphasized for their function in energy production, iron metabolism and apoptosis as well as heme synthesis. The heme is an iron-loaded porphyrin behaving as a prosthetic group by its interactions with a wide variety of proteins. These complexes are termed hemoproteins and are usually vital to the whole cell comportment, such as the proteins hemoglobin, myoglobin or cytochromes, but also enzymes such as catalase and peroxidases. The building block of porphyrins is the 5-aminolevulinic acid, whose exogenous administration is able to stimulate the entire heme biosynthesis route. In neoplastic cells, this methodology repeatedly demonstrated an accumulation of the ultimate heme precursor, the fluorescent protoporphyrin IX photosensitizer, rather than in healthy tissues.
  • 1.3K
  • 27 Jul 2022
Topic Review
Egyptian Honeybee
The Egyptian honeybee (Apis mellifera lamarckii) is one of the honeybee subspecies known for centuries since the ancient Egypt civilization. The subspecies of the Egyptian honeybee is distinguished by certain traits of appearance and behavior that were well-adapted to the environment and unique in a way that it is resistant to bee diseases, such as the Varroa disease. The subspecies is different than those found in Europe and is native to southern Egypt.
  • 1.3K
  • 21 Oct 2022
Topic Review
Smart ECM-Based Electrospun Biomaterials
Electrospinning is a well-known technique to produce fibers that mimic the three dimensional microstructural arrangements of the extracellular matrix fibers. Natural and synthetic polymers are used in the electrospinning process; moreover, a blend of them provides composite materials that have demonstrated the potential advantage of supporting cell function and adhesion. Recently, the decellularized extracellular matrix (dECM), which is the noncellular component of tissue that retains relevant biological cues for cells, has been evaluated as a starting biomaterial to realize composite electrospun constructs. The properties of the electrospun systems can be further improved with innovative procedures of functionalization with biomolecules. Among the various approaches, great attention is devoted to the “click” concept in constructing a bioactive system, due to the modularity, orthogonality, and simplicity features of the “click” reactions. Here, we provide an overview of current approaches that can be used to obtain biofunctional composite electrospun biomaterials and propose a design of a smart ECM-based electrospun system suitable for skeletal muscle tissue regeneration.
  • 1.3K
  • 24 Sep 2020
Topic Review
Polyphenols in Wine Authenticity
Polyphenols are a diverse group of compounds possessing various health-promoting properties that are of utmost importance for many wine sensory attributes. Apart from genetic and environmental parameters, the implementation of specific oenological practices as well as the subsequent storage conditions deeply affect the content and nature of the polyphenols present in wine. However, polyphenols are effectively employed in authenticity studies. Provision of authentic wines to the market has always been a prerequisite meaning that the declarations on the wine label should mirror the composition and provenance of this intriguing product. Nonetheless, multiple cases of intentional or unintentional wine mislabeling have been recorded alarming wine consumers who demand for strict controls safeguarding wine authenticity. The emergence of novel platforms employing instrumentation of exceptional selectivity and sensitivity along with the use of advanced chemometrics such as NMR (nuclear magnetic resonance)- and MS (mass spectrometry)-based metabolomics is considered as a powerful asset towards wine authentication.
  • 1.3K
  • 27 Oct 2020
Topic Review
Probiotic Lactobacillus in Anti-Ageing
Probiotics are defined as live microorganisms that confer a health benefit on the host when administered adequately. The most common probiotic strains are associated with the genera Lactobacillus and Bifidobacterium. Recent advancements have witnessed significant achievements in using Lactobacillus during animal studies in ageing models.
  • 1.3K
  • 22 Dec 2021
Topic Review
Cinnamon and Poultry Gut Health
Plant bioactive compounds, such as phytochemicals, in poultry diets, are gaining popularity due to their potential antioxidant and anti-microbial activities. Phytogenic feed additives (PFAs) have emerged as natural alternatives to antibiotic growth promotors and have great potential in the poultry industry. In recent years, cinnamon (one of the most widely used spices) has attracted attention from researchers as a natural product with numerous health benefits for poultry. The essential oils in cinnamon, in particular, are of interest because of their antioxidant, anti-microbial, anti-inflammatory, antifungal, and hypocholesterolaemic effects, in addition to their ability to stimulate digestive enzymes in the gut. This review mainly emphasizes the potential impact of cinnamon as a natural feed additive on overall gut health, nutrient digestibility, blood biochemical profile, gene expression, gut microbiota and immune response.
  • 1.3K
  • 26 Jul 2021
Topic Review
Postbiotics
Postbiotics include any substance released by or produced through the metabolic activity of the microorganism, which exerts a beneficial effect on the host, directly or indirectly. As postbiotics do not contain live microorganisms, the risks associated with their intake are minimized. Postbiotics play a vital role in the maturation of the immune system, affect barrier tightness and the intestinal ecosystem, and indirectly shape the structure of the microbiota. Postbiotics display pleiotropic effects, including their immunomodulatory, anti-inflammatory, antioxidant, and anti-cancer properties. As such, postbiotics may be useful in treating or preventing many disease entities, including those for which effective causal therapy has not yet been found.
  • 1.3K
  • 05 Nov 2020
Topic Review
PANoptosis
Consideration of the totality of biological effects from cell death in multiple studies has led to the conceptualization of PANoptosis, a unique inflammatory cell death pathway that integrates components from other cell death pathways. PANoptosis is implicated in driving innate immune responses and inflammation and cannot be individually accounted for by pyroptosis, apoptosis, or necroptosis alone. PANoptosis is regulated by multifaceted macromolecular complexes called PANoptosomes.
  • 1.3K
  • 02 Jun 2022
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