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Topic Review
Decellularization of Full-Thickness Abdominal Wall For Reconstructive Surgery
Background: Functional restoration of abdominal wall defects represent one of the fundamental challenges of reconstructive surgery. Synthetic grafts or crosslinked animal-derived biological grafts are characterized by significant adverse reactions, which are mostly observed after their implantation. The aim of this study was to evaluate the efficacy of the decellularization protocol to produce a completely acellular full-thickness abdominal wall scaffold. Methods: Full-thickness abdominal wall samples were harvested from Wistar rats and submitted to a 3 cylce decellularization process. Histological, analysis was applied to evaluate the effect of the decellularization protocol. Mechanical testing and immunogenicity assessment were also performed. Results: Histological analysis results showed the efficient decellularization abdominal wall samples after the 3rd cycle. Decellularized abdominal wall scaffolds were characterized by good biomechanical properties Conclusion: The data presented herein confirm the effective production of rat-derived full-thickness abdominal wall scaffold. Expanding this approach will allow the exploitation of the capacity of the proposed decellularization protocol in producing acellular abdominal wall scaffolds from larger animal models or human cadaveric donors. In this way, the utility of biological scaffolds with preserved in vivo remodelling properties may be one step closer to its application in clinical studies.
  • 53
  • 29 Jun 2024
Topic Review
Breaking Down the Between Alcohol Addiction Mental Clarity
Did you know that about 20% of American adults have an alcohol use disorder?
  • 30
  • 28 Jun 2024
Topic Review
Listeria monocytogenes Biofilms in Food-Associated Environments
Listeria monocytogenes (LM) is a bacterial pathogen responsible for listeriosis, a foodborne illness associated with high rates of mortality (20–30%) and hospitalisation. It is particularly dangerous among vulnerable groups, such as newborns, pregnant women and the elderly. The persistence of this organism in food-associated environments for months to years has been linked to several devastating listeriosis outbreaks. It may also result in significant costs to food businesses and economies. 
  • 285
  • 26 Jun 2024
Topic Review
Uses of Magnetic Fields for Health Applications
Early life on Earth evolved in the contexts of temperature, available elements, and molecules (including water), as well as the biophysical boundary conditions of the planet. The latter include gravity (1 g), exogenous and endogenous radiation from particles from beyond Earth and radioactive elements on Earth, and magnetic fields due to the planet’s magnetic field and local concentrations of molecules such as iron. Humans and other animals, plants, and microorganisms have been exposed to a variety of magnetic fields other than the geomagnetic field of Earth and deposits of ferro materials. Magnetic fields, static or electromagnetic, have been used in attempts to improve outcomes for the repair of a variety of tissues.
  • 453
  • 19 Jun 2024
Topic Review
Tumoroid
The term “tumoroid” means “tumor-like organoid”: tumoroids typically derive from primary tumors harvested from oncological patients and they can mimic human tumor microenvironment (TME); nowadays, they are considered a promising tool for cost-effective studies on novel anticancer drugs to be used in precision medicine in the field of oncology.
  • 4.3K
  • 18 Jun 2024
Topic Review Peer Reviewed
The Evolutionary System of the Biosphere and the Metameric Concept of Its Evolution: From the Past to the Future
We offer a detailed description of our previously published new concept of the evolution of the biosphere as an integral system of its states over time, united by development trends. The structure of the biosphere is considered as a hierarchical fractal system, and the elementary unit of the biosphere is an ecosystem. The fractal structure of the biosphere corresponds to the emergent principle: each lower level is an element of a more complex system and has its own properties. The proposed concept of biosphere evolution is based on the general categories of dialectics: states and interstates, continuity and discreteness, reproducibility and uniqueness. The evolutionary history of the biosphere is a metameric picture of changing states and interstates. The most important feature of the biosphere organization in space–time is a complex system of continua. The development of an integral biospheric system occurs in a time continuum: in the biosphere, the differences between the early and subsequent states are quite significant and obvious. Moreover, these differences are associated with fundamental complications, development, which is, in fact, evolution. The states of the biosphere in certain periods are linked by trends that form an evolutionary system. Continuing states, when the system remains self-identical for a long period, are replaced by new states through interstates. Based on the principle of actualism, the problems of the biosphere’s future and evolutionary trends of the biosphere under anthropogenic impact are considered.
  • 254
  • 28 May 2024
Biography
Kadir Mısıroğlu
Türk Bilgesi Kadir Mısıroğlu (𐱅𐰇𐰼𐰜:𐰋𐰃𐰠𐰏𐰾𐰃:𐰴𐰑𐰼:𐰢𐰃𐰽𐰺𐰆𐰍𐰞𐰆) (24 January 1933 – 5 May 2019) was a Turkish historian, lawyer, writer, and publisher.[1][2][3] [4][5] His character is integrated with the fez. Radical Islamist and Ottomanist. He is known for his outspoken stance against Mustafa Kemal's reforms and Kemalism.[6][7] Ka
  • 1.7K
  • 23 May 2024
Topic Review
Helicobacter pylori infection, pathogenicity, and therapeutic advances
A primer on Helicobacter pylori virulence factors, pathogenicity, gastric conditions that are caused by infection, and treatment modalities. This entry is adapted from the peer-reviewed paper 10.3390/pathogens13050392
  • 466
  • 17 May 2024
Topic Review
Sustainable and innovative processing for safe (healthy) foods
Sustainable and innovative technologies involving high-pressure processing (HPP), high-pressure homogenization (HPH), high-pressure carbon dioxide (HPCD), pulsed electric fields (PEF), ultrasounds (US), and microwaves (MV), among others, as well as traditional methods of food treatment like heating, fermentation, and drying or smoking are increasingly applied in food preservation and the modification of selected physicochemical or sensory properties. The aim of this Special Issue is to highlight new challenges in the treatment of food for obtaining traditional or new but safe products, including functional foods, with high or modified nutritional (bioaccessibility and bioavailability) and sensory values.
  • 376
  • 15 May 2024
Topic Review
Applications of Gellan Gum
Gellan gum (GG) is a linear, negatively charged exopolysaccharide that is biodegradable and non-toxic. When metallic ions are present, a hard and transparent gel is produced, which remains stable at a low pH. It exhibits high water solubility, can be easily bio-fabricated, demonstrates excellent film/hydrogel formation, is biodegradable, and shows biocompatibility. These characteristics render GG a suitable option for use in food, biomedical, and cosmetic fields.
  • 308
  • 13 May 2024
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