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Topic Review
Growth Hormone and IGF1 Actions in Kidney
Growth hormone (GH) exerts multiple effects on different organs including the kidneys, either directly or via its main mediator, insulin-like-growth factor-1 (IGF-1).
  • 1.5K
  • 17 Dec 2021
Topic Review
Lactic Acid Bacteria from Vagina
During the selection process of probiotics for vaginal applications, twenty-five lactic acid bacteria (LAB) isolates from human vagina belonging to six different species were tested for antimicrobial resistance by a microdilution method. Gene-specific PCR amplifications proved the strains carry no acquired antibiotic resistance genes, except for a tet(W) gene present in two tetracycline-susceptible Bifidobacterium bifidum strains. Genome analysis of a selected set of strains showed no other acquired resistance determinants. The tet(W) of B. bifidum was inactive by the insertion of two guanine residues in the middle of the gene. Surprisingly, the inactive gene became active and functional very easily, providing resistance to tetracycline and remaining stable afterward. LAB intended to be used in health applications must be free of acquired antimicrobial resistance genes; these could be spread and transferred to human pathogens.
  • 1.5K
  • 29 Oct 2020
Topic Review
Antimicrobial Peptides with Antiendotoxin
A strategy was described to design antimicrobial peptides (AMPs) with enhanced salt resistance and antiendotoxin activities by linking two helical AMPs with the Ala-Gly-Pro (AGP) hinge. Among the designed peptides, KR12AGPWR6 demonstrated the best antimicrobial activities even in high salt conditions (NaCl ~300 mM) and possessed the strongest antiendotoxin activities. These activities may be related to hydrophobicity, membrane-permeability, and α-helical content of the peptide. Amino acids of the C-terminal helices were found to affect the peptide-induced permeabilization of LUVs, the α-helicity of the designed peptides under various LUVs, and the LPS aggregation and size alternation. A possible model was proposed to explain the mechanism of LPS neutralization by the designed peptides. These findings could provide a new approach for designing AMPs with enhanced salt resistance and antiendotoxin activities for potential therapeutic applications.
  • 1.5K
  • 26 Oct 2020
Topic Review
Electrospun PVC Nanofibers
Electrospun PVC Nanofibers means PVC nanofibers manufactured by electrospinning.
  • 1.5K
  • 19 Feb 2021
Topic Review
Data-Driven Production Logistics
A data-driven approach in production logistics is adopted as a response to challenges such as low visibility and system rigidity. within data-driven production logistics, data is the backbone of the system and all the components are bound together with data. Any decision is made based on data rather than intuition or even experience. All production logistics related activities are supported by data, which is constantly collected from data sources such as machines, human resources, sensors, actuators, etc. A data-driven approach facilitates transition towards a smart, autonomous production logistics system.
  • 1.5K
  • 28 Apr 2021
Topic Review
Chestnuts
Chestnuts (Castanea spp.) are trees of relevant economic interest in the agro-sylvicultural contexts of mountain regions throughout the temperate zone, particularly in the northern hemisphere.
  • 1.5K
  • 18 May 2021
Topic Review
Salicylic Acid and Mitochondrial ROS
Different abiotic and biotic stresses lead to the production and accumulation of reactive oxygen species (ROS) in various cell organelles such as in mitochondria, resulting in oxidative stress, inducing defense responses or programmed cell death (PCD) in plants. In response to oxidative stress, cells activate various cytoprotective responses, enhancing the antioxidant system, increasing the activity of alternative oxidase and degrading the oxidized proteins. Oxidative stress responses are orchestrated by several phytohormones such as salicylic acid (SA). The biomolecule SA is a key regulator in mitochondria-mediated defense signaling and PCD, but the mode of its action is not known in full detail.
  • 1.5K
  • 11 Jun 2021
Topic Review
Radiological Investigation of French Fossils
The accurate investigation of uranium-containing fossils in a museum of the City of Basel showed the following crucial points: 1 Storage of uranium-containing minerals or fossils may lead to elevated radon exposures for the staff. The monitoring of the room air is recommended: Eventual taken measures will reduce the exposure to radon (permanent air ventilation, airtight storage of contaminated objects). 2 The handling and preparation of such contaminated objects may lead to significant doses by inhalation of radioactive dust. Such work should not be envisaged without special precautions. These could be wearing protective mask and gloves, working in a clean-bench.
  • 1.5K
  • 04 Jul 2021
Topic Review
Oleuropein in Non-Communicable Diseases
Growing scientific literature data suggest that the intake of natural bioactive compounds plays a critical role in preventing or reducing the occurrence of human chronic non-communicable diseases (NCDs), such as neuro- and cardiovascular diseases, diabetes mellitus and cancer. Oleuropein, the main phenolic component of Olea europaea L., has attracted scientific attention for its several health beneficial properties such as antioxidant, anti-inflammatory, cardio- and neuro-protective, and anti-cancer. This entry contains data from the current literature concerning the effect of oleuropein in NCDs not only due to its putative antioxidant and anti-inflammatory activities, but also to its other peculiar actions such as autophagy inducer and amyloid fibril growth inhibitor and, finally, as anti-cancer agent. Despite the increasing number of published studies, looking at the health effects of oleuropein, there is limited clinical evidence focused on the benefits of this polyphenol as a nutraceutical product in humans, and many problems are still to be resolved about its bioavailability, bioaccessibility, and dosage. Thus, future clinical randomized trials are needed to establish the relation between the beneficial effects and the mechanisms of action occurring in the human body in response to the intake of oleuropein.
  • 1.5K
  • 27 Sep 2021
Topic Review
Sustainability Education in China’s Junior Geography Curriculum
Sustainability education (SE), also known as education for sustainability (EfS) or education for SD (ESD), is recognized as an internal element of the fourth (i.e., quality education) of the seventeen United Nations’ (UN) SD goals and has been incorporated into school curricula around the world. China is no exception. As one of the pioneer countries in advocating environmental protection, the Chinese government has called for a paradigm shift in pedagogies that should be problem-solving-based and sustainability-centered.
  • 1.5K
  • 28 Feb 2022
Topic Review
Energy Saving Devices for Hydrogen Fuel Cell Ships
Energy saving devices (ESDs) for ships are more important than ever, as implementation of rules and regulations restrict the use of fossil fuels while promoting zero-emission technology. Researchers aims to bridge that gap by firstly identifying the new challenges that a hydrogen-powered propulsion system brings forth and then reviewing the quantitative energy saving capability and qualitive additional benefits of individual existing and emerging ESDs in standalone and combination, with recommendations for the most applicable ESD combinations with hydrogen-powered waterborne transport presented to maximise energy saving and minimise the negative impact on the propulsion system components
  • 1.5K
  • 28 Mar 2022
Topic Review
Agricultural Big Data Architectures and Climate Change
Climate change is currently one of agriculture’s main problems in achieving sustainability. It causes drought, increased rainfall, and increased diseases, causing a decrease in food production. In order to combat these problems, Agricultural Big Data contributes with tools that improve the understanding of complex, multivariate, and unpredictable agricultural ecosystems through the collection, storage, processing, and analysis of vast amounts of data from diverse heterogeneous sources.
  • 1.5K
  • 06 Jul 2022
Topic Review
Liquid–Liquid Phase Separation in Metabolic Diseases
Liquid–liquid phase separation (LLPS) is a reversible and dynamical biophysical process where homogeneous biomacromolecules spontaneously de-mix into two coexisting liquid phases (a condensed phase and a dilute phase) through transient multivalent macromolecular interactions.
  • 1.5K
  • 10 Oct 2022
Topic Review
Pomeranian Language
The Pomeranian language (Polish: pomorszczyzna or język pomorski, German: Pomoranisch or die pomoranische Sprache) is in the Pomeranian group of Lechitic languages (Polish: grupa pomorska języków lechickich, German: die pomoranische Gruppe der lechischen Sprachen) within the West Slavic languages. In medieval contexts, it refers to the dialects spoken by the Slavic Pomeranians. In modern contexts, the term is sometimes used synonymously with "Kashubian" and may also include extinct Slovincian. The name Pomerania comes from Slavic po more, which means "[land] by the sea".
  • 1.5K
  • 20 Oct 2022
Topic Review
Kleptomania
Kleptomania is the inability to resist the urge to steal items, usually for reasons other than personal use or financial gain. First described in 1816, kleptomania is classified in psychiatry as an impulse control disorder. Some of the main characteristics of the disorder suggest that kleptomania could be an obsessive-compulsive spectrum disorder, but also share similarities with addictive and mood disorders. The disorder is frequently under-diagnosed and is regularly associated with other psychiatric disorders, particularly anxiety, eating disorders, alcohol and substance use. Patients with kleptomania are typically treated with therapies in other areas due to the comorbid grievances rather than issues directly related to kleptomania. Over the last 100 years, a shift from psychotherapeutic to psychopharmacological interventions for kleptomania has occurred. Pharmacological treatments using selective serotonin reuptake inhibitors (SSRIs), mood stabilizers and opioid receptor antagonists, and other antidepressants along with cognitive behavioral therapy, have yielded positive results. However, there have also been reports of kleptomania induced by selective serotonin reuptake inhibitors (SSRIs).
  • 1.5K
  • 21 Nov 2022
Topic Review
Expanded Polytetrafluoroethylene Membranes
Coated stents are defined as innovative stents surrounded by a thin polymer membrane based on polytetrafluoroethylene (PTFE)useful in the treatment of numerous vascular pathologies. Endovascular methodology involves the use of such devices to restore blood flow in small-, medium- and large-calibre arteries, both centrally and peripherally. These membranes cross the stent struts and act as a physical barrier to block the growth of intimal tissue in the lumen, preventing so-called intimal hyperplasia and late stent thrombosis. PTFE for vascular applications is known as expanded polytetrafluoroethylene (e-PTFE) and it can be rolled up to form a thin multilayer membrane expandable by 4 to 5 times its original diameter. This membrane plays an important role in initiating the restenotic process because wrapped graft stent could be used as the treatment option for trauma devices during emergency situations and to treat a number of pathological vascular disease.
  • 1.5K
  • 27 Feb 2023
Topic Review
Anterior Knee Displacement during Different Barbell Squat Techniques
Based on seminal research from the 1970s and 1980s, the myth that the knees should only move as far anterior during the barbell squat until they vertically align with the tips of the feet in the sagittal plane still exists. However, the role of both the hip joint and the lumbar spine, which are exposed to high peak torques during this deliberate restriction in range of motion, has remained largely unnoticed in the traditional literature. More recent anthropometric and biomechanical studies have found disparate results regarding anterior knee displacement during barbell squatting. For a large number of athletes, it may be favorable or even necessary to allow a certain degree of anterior knee displacement in order to achieve optimal training outcomes and minimize the biomechanical stress imparted on the lumbar spine and hip. Overall, restricting this natural movement is likely not an effective strategy for healthy trained individuals.
  • 1.5K
  • 25 Apr 2023
Topic Review
Natural Polymers for Encapsulating Urea
Increases in food production to meet global food requirements lead to an increase in the demand for nitrogen (N) fertilizers, especially urea, for soil productivity, crop yield, and food security improvement. To achieve a high yield of food crops, the excessive use of urea has resulted in low urea-N use efficiency and environmental pollution. One promising alternative to increase urea-N use efficiency, improve soil N availability, and lessen the potential environmental effects of the excessive use of urea is to encapsulate urea granules with appropriate coating materials to synchronize the N release with crop assimilation. Chemical additives, such as sulfur-based coatings, mineral-based coatings, and several polymers with different action principles, have been explored and used for coating the urea granule. However, their high material cost, limited resources, and adverse effects on the soil ecosystem limit the widespread application of urea coated with these materials. 
  • 1.5K
  • 16 May 2023
Topic Review
Current Source Inverter Power Converters in Photovoltaic Systems
Grid converters play a central role in renewable energy conversion. Current source inverter (CSI) can play a pivotal role in ensuring the seamless conversion of solar-generated energy with the electricity grid, thereby facilitating stable and reliable integration of solar photovoltaic systems.
  • 1.5K
  • 01 Nov 2023
Topic Review
Resuscitation of Viable but Nonculturable Bacteria
The viable but nonculturable (VBNC) state is a survival strategy for bacteria when encountered with unfavorable conditions. Under favorable environments such as nutrient supplementation, external stress elimination, or supplementation with resuscitation-promoting substances, bacteria will recover from the VBNC state, which is termed “resuscitation”.
  • 1.5K
  • 03 Jan 2023
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