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Topic Review
Road Anomaly Detection, Deep Learning-Based Methods and Visual-SLAM
The proliferation of autonomous vehicles (AVs) emphasises the pressing need to navigate challenging road networks riddled with anomalies like unapproved speed bumps, potholes, and other hazardous conditions, particularly in low- and middle-income countries. These anomalies not only contribute to driving stress, vehicle damage, and financial implications for users but also elevate the risk of accidents. A significant hurdle for AV deployment is the vehicle’s environmental awareness and the capacity to localise effectively without excessive dependence on pre-defined maps in dynamically evolving contexts.
  • 1.5K
  • 23 Oct 2023
Topic Review
Plant Microbial Fuel Cells
PubMed (NCBI) has pointed to an exponential growth of publications on the subject of a “biofuel cell” in the first decade of our century, and this interest persisted throughout the following years. It should be noted that biofuel elements based on microorganisms (microbial fuel cells, MFCs) are a promising technology to produce bioelectricity since they simultaneously solve the problems of contamination with anthropogenic organic waste, which can be used by microorganisms as a source of carbon and energy.
  • 1.5K
  • 27 Feb 2024
Topic Review
Myotonia Congenita
Myotonia congenita (MC) is a rare disorder characterized by stiffness and weakness of the limb and trunk muscles. Mutations in the SCN4A gene encoding the alpha-subunit of the voltage-gated sodium channel Nav1.4 have been reported to be responsible for sodium channel myotonia (SCM). The Nav1.4 channel is expressed in skeletal muscles, and its related channelopathies affect skeletal muscle excitability, which can manifest as SCM, paramyotonia, and periodic paralysis. In this study, the missense mutation p.V445M was identified in two individual families with MC. To determine the functional consequences of having a mutated Nav1.4 channel, whole-cell patch-clamp recording of transfected Chinese hamster ovary cells was performed. Evaluation of the transient Na+ current found that a hyperpolarizing shift occurs at both the activation and inactivation curves with an increase of the window currents in the mutant channels. The Nav1.4 channel’s co-expression with the Navβ4 peptide can generate resurgent Na+ currents at repolarization following a depolarization. The magnitude of the resurgent currents is higher in the mutant than in the wild-type (WT) channel. Although the decay kinetics are comparable between the mutant and WT channels, the time to the peak of resurgent Na+ currents in the mutant channel is significantly protracted compared with that in the WT channel. These findings suggest that the p.V445M mutation in the Nav1.4 channel results in an increase of both sustained and resurgent Na+ currents, which may contribute to hyperexcitability with repetitive firing and is likely to facilitate recurrent myotonia in SCM patients.
  • 1.5K
  • 29 Oct 2020
Topic Review
HEV Biology and Pathogenesis
Hepatitis E virus (HEV) is one of the causative agents for liver inflammation across the world. HEV is a positive-sense single-stranded RNA virus. Human HEV strains mainly belong to four major genotypes in the genus Orthohepevirus A, family Hepeviridae. Among the four genotypes, genotype 1 and 2 are obligate human pathogens, and genotype 3 and 4 cause zoonotic infections. HEV infection with genotype 1 and 2 mainly presents as acute and self-limiting hepatitis in young adults. However, HEV infection of pregnant women with genotype 1 strains can be exacerbated to fulminant hepatitis, resulting in a high rate of case fatality. As pregnant women maintain the balance of maternal-fetal tolerance and effective immunity against invading pathogens, HEV infection with genotype 1 might dysregulate the balance and cause the adverse outcome. Furthermore, HEV infection with genotype 3 can be chronic in immunocompromised patients, with rapid progression, which has been a challenge since it was reported years ago. The virus has a complex interaction with the host cells in downregulating antiviral factors and recruiting elements to generate a conducive environment of replication. The virus-cell interactions at an early stage might determine the consequence of the infection. In this study, advances in HEV virology, viral life cycle, viral interference with the immune response, and the pathogenesis in pregnant women are discussed, and perspectives on these aspects are presented.
  • 1.5K
  • 22 Feb 2021
Topic Review
Gellan
Gellan is a water-soluble gum that structurally exists as a tetrasaccharide comprised of 20% glucuronic acid, 60% glucose and 20% rhamnose, for which various food, non-food and biomedical applications have been reported.
  • 1.5K
  • 08 May 2021
Topic Review
Telomerase in Age-Related Macular Degeneration
Age-related macular degeneration (AMD), the main cause of vision loss in the elderly, is associated with oxidation in the retina cells promoting telomere attrition. Activation of telomerase was reported to improve macular functions in AMD patients. The catalytic subunit of human telomerase (hTERT) may directly interact with proteins important for senescence, DNA damage response, and autophagy, which are impaired in AMD. hTERT interaction with mTORC1 (mTOR (mechanistic target of rapamycin) complex 1) and PINK1 (PTEN-induced kinase 1) activates macroautophagy and mitophagy, respectively, and removes cellular debris accumulated over AMD progression. Ectopic expression of telomerase in retinal pigment epithelium (RPE) cells lengthened telomeres, reduced senescence, and extended their lifespan. 
  • 1.5K
  • 09 Jul 2021
Topic Review
Tungsten in Soil
Tungsten (W) occurs naturally in soils and the Earth’s crust is the most important source of this element. Tungsten reserves have been estimated to be approximately 3.1 Mt in ore deposits, where the metal exists mainly as a component of several minerals, such as wolframite (Fe, MnWO4) and scheelite (CaWO4).
  • 1.5K
  • 26 Jul 2021
Topic Review
α-Synuclein in Gene Expression
α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson’s disease (PD) via a gain-of-function mechanism. Because of this, several recent strategies propose to decrease α-Syn levels in PD patients.
  • 1.5K
  • 13 Aug 2021
Topic Review
PARP in DNA Damage Repair
Poly (ADP-ribose) polymerases (PARP) 1-3 are well-known multi-domain enzymes, catalysing the covalent modification of proteins, DNA, and themselves. They attach mono- or poly-ADP-ribose to targets using NAD+ as a substrate. Poly-ADP-ribosylation (PARylation) is central to the important functions of PARP enzymes in the DNA damage response and nucleosome remodelling. Activation of PARP happens through DNA binding via zinc fingers and/or the WGR domain. Modulation of their activity using PARP inhibitors occupying the NAD+ binding site has proven successful in cancer therapies. For decades, studies set out to elucidate their full-length molecular structure and activation mechanism. 
  • 1.5K
  • 02 Sep 2021
Topic Review
Exogenous Bioactive Peptides and Aging in Rodent Models
Bioactive peptides are short peptides consisting of 2-20 amino acid residues. They have positive effects on body functions and generally have antibacterial, antihypertensive, antioxidant, and anti-inflammatory effects. Some exogenous bioactive peptides have been shown to have promising anti-aging effects. These exogenous peptides may have a mechanism similar to endogenous peptides, and some can even regulate the release of endogenous active peptides and play a synergistic role with endogenous active peptides.
  • 1.5K
  • 24 Feb 2022
Topic Review
Sustainable Entrepreneurship
Sustainable entrepreneurship is venturing to shift business practices towards environmental and social sustainability. It gained popularity worldwide, particularly in the US and Europe, due to promoting regulations for some sustainability areas, the availability of impact investment, and the large-scale entrepreneurial ecosystem of the country.
  • 1.5K
  • 06 Apr 2022
Topic Review
Effects of Sound Perception in Plants
Plants have long been considered passive, static, and unchanging organisms, but this view is finally changing. More and more knowledge is showing that plants are aware of their surroundings, and they respond to a surprising variety of stimuli by modifying their growth and development. Plants extensively communicate with the world around them, above and below ground. Although communication through mycorrhizal networks and Volatile Organic Compounds has been known for a long time, acoustic perception and communication are somehow a final frontier of research. Perhaps surprisingly, plants not only respond to sound, they actually seem to emit sound as well. Roots emit audible clicks during growth, and sounds are emitted from xylem vessels, although the nature of these acoustic emissions still needs to be clarified. Even more interesting, there is the possibility that these sounds carry information with ecological implications, such as alerting insects of the hydration state of a possible host plant, and technological implications as well. Monitoring sound emissions could possibly allow careful monitoring of the hydration state of crops, which could mean significantly less water used during irrigation. 
  • 1.5K
  • 08 Oct 2022
Topic Review
D0 Experiment
The DØ experiment (sometimes written D0 experiment, or DZero experiment) consists of a worldwide collaboration of scientists conducting research on the fundamental nature of matter. DØ was one of two major experiments (the other is the CDF experiment) located at the world's second highest-energy accelerator, the Tevatron Collider at the Fermilab in Batavia, Illinois, USA. The research is focused on precise studies of interactions of protons and antiprotons at the highest available energies. It involves an intense search for subatomic clues that reveal the character of the building blocks of the universe.
  • 1.5K
  • 11 Oct 2022
Topic Review
High-Energy Methods for Pretreatment of Mineral Complexes
Pulsed power technologies have been proposed based on the conversion of energy into a short-pulsed form and exposing geomaterials (minerals, rocks, and ores) to strictly dosed high-power pulsed electric and magnetic fields, beams of charged particles, microwave radiation, neutrons and X-ray quanta, and low-temperature plasma flows. Such pulsed energy impacts are promising methods for the pretreatment of refractory mineral feeds (refractory ores and concentration products) to increase the disintegration, softening, and liberation performance of finely disseminated mineral complexes, as well as the contrast between the physicochemical and process properties of mineral components. The most important research and practical developments in the application of high-energy effects in the beneficiation and deep processing of complex ores are described. Examples are given of the implementation of various methods for processing minerals, ores, and concentrates, including accelerated electron flow, microwave (UHF) and laser treatment, high-intensity magnetic and electric (HVP) fields, high-power nanosecond electromagnetic pulses, and low-temperature plasma of dielectric barrier discharge, enabling a higher performance of the concentration processes for refractory mineral feeds.
  • 1.5K
  • 17 Oct 2022
Topic Review
Active Evidence-Based Learning in Engineering Education
Implementing active learning methods in engineering education is becoming the new norm and is seen as a prerequisite to prepare future engineers not only for their professional life, but also to tackle global issues. Teachers at higher education institutions are expected and encouraged to introduce their students to active learning experiences, such as problem-, project-, and more recently, challenge-based learning. 
  • 1.5K
  • 09 Nov 2022
Topic Review
Chemical Ionization
Chemical ionization (CI) is a soft ionization technique used in mass spectrometry. This was first introduced by Burnaby Munson and Frank H. Field in 1966. This technique is a branch of gaseous ion-molecule chemistry. Reagent gas molecules (often methane or ammonia) are ionized by electron ionization to form reagent ions, which subsequently react with analyte molecules in the gas phase to create analyte ions for analysis by mass spectrometry. Negative chemical ionization (NCI), charge-exchange chemical ionization, atmospheric-pressure chemical ionization (APCI) and atmospheric pressure photoionization (APPI) are some of the common variants of the technique. CI mass spectrometry finds general application in the identification, structure elucidation and quantitation of organic compounds as well as some utility in biochemical analysis. Samples to be analyzed must be in vapour form, or else (in the case of liquids or solids), must be vapourized before introduction into the source.
  • 1.5K
  • 28 Nov 2022
Biography
Imogen Coe
Imogen Ruth Coe (born 30 November 1962) is a British-born biochemist. Educated in the United Kingdom and the United States, Coe has taught at York University in Canada. She is a professor of biochemistry and founding dean of the Faculty of Science at Toronto Metropolitan University (previously Ryerson University) in Toronto. Coe grew up near Cambridge, and attended the Perse School for Girls.
  • 1.5K
  • 29 Nov 2022
Topic Review
Surgical Anatomy of the Upper Abdomen
Cytoreductive surgery (CRS) is the cornerstone of treating advanced ovarian cancer. Approximately 60–70% of patients with advanced ovarian cancer will have involvement in the upper abdomen or the supracolic compartment of the abdominal cavity. Though the involvement of this region results in poorer survival compared, complete cytoreduction benefits overall survival, making upper-abdominal cytoreduction an essential component of CRS for advanced ovarian cancer. The upper abdomen constitutes several vital organs and large blood vessels draped with the parietal or visceral peritoneum, common sites of disease in ovarian cancer. A surgeon treating advanced ovarian cancer should be well versed in upper-abdominal cytoreduction techniques, including diaphragmatic peritonectomy and diaphragm resection, lesser omentectomy, splenectomy with or without distal pancreatectomy, liver resection, cholecystectomy, and suprarenal retroperitoneal lymphadenectomy. Other procedures such as clearance of the periportal region, Glisson’s capsulectomy, clearance of the superior recess of the lesser sac, and Morrison’s pouch are essential as these regions are often involved in ovarian cancer. 
  • 1.5K
  • 03 Jan 2023
Topic Review
Elastodontic Appliances
The term “functional appliance” refers to a lot of orthodontic appliances initially designed primarily to correct Class II malocclusion; their use received much acclaim in Europe in the 20th century but not in the USA, where Angle’s philosophy, which put in the foreground the need to achieve an ideal dental occlusion with a fixed multibrackets device, was preferred. Elastodontics, therefore, aims to solve skeletal and functional problems in the growth period. Still, at the same time, it represents an extraordinary instrument to readjust the vertical dimension in the adult patient for prosthetic purposes. Elastodontics is a new therapeutic approach that uses removable appliances made with an elastomeric material to produce light and elastic forces to correct malocclusion, aligning them and reducing potential risk factors that can affect growth. This therapy simplifies or eliminates a possible and subsequent orthodontic intervention because it facilitates balanced growth, reduces the number of extractions, and increases stability during treatment. If you change the function through the re-education of behaviour, you will also change the shape. The main purpose of the functional treatment is to “guide” the proper growth of the bone bases by stimulating the perioral muscles and neuromuscular system.
  • 1.5K
  • 15 Aug 2023
Topic Review
Research Progress on Cu–15Ni–8Sn Alloys
The Cu–15Ni–8Sn (C72900) alloy is a typical spinodal hardened copper alloy engineered for high strength, elasticity, and stress relaxation resistance. Compared with Cu-Be alloy, the comprehensive properties of Cu-15Ni-8Sn alloy are equal, and it has no toxicity during manufacturing and processing. In addition, the properties of Cu-15Ni-8Sn alloy are much better than those of Cu-Be alloy at high temperature.
  • 1.5K
  • 06 Sep 2023
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