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Topic Review
Mechanism of Bone Loss Induced by Iron Deficiency
Iron is a vital component of various enzymes involved in many biological processes, including oxygen transport, DNA biosynthesis, and cellular energy generation. Moreover, the biological activity of iron depends mainly on its efficient electron transfer properties. It has the ability to accept or donate electrons during the conversion between ferric iron (Fe3+) and ferrous iron (Fe2+), thereby functioning as a catalytic cofactor in various biochemical reactions. Therefore, iron is necessary for the growth, proliferation, and differentiation of bone cells, especially for osteoblasts and osteoclasts. In addition, hypoxia caused by iron deficiency can also lead to the activity and function disorder of bone cells. With respect to bone metabolism, iron is involved in the synthetic process of collagen and vitamin D metabolism.
  • 1.5K
  • 12 Apr 2023
Topic Review
Magnetic Characterization of Planar Magnetics
High-power density and high-efficiency power converters have become popular in a wide range of industrial applications including telecommunications, automotive, aerospace, and data processing. When it comes to achieving high power density, it is inevitable that switch-mode power converters will need to be utilized. High-frequency power-conversion applications are increasingly using planar magnetic devices to replace traditional transformers and inductors.
  • 1.5K
  • 25 Apr 2023
Topic Review
Air Quality in Mainland Southeast Asia
Air pollution, notably particulate matter pollution, has become a serious concern in Southeast Asia. The combustion of biomass has been recognized to considerably increase air pollution problems from particulate matter in this region. Consequently, its effect on people in this area is significant. 
  • 1.5K
  • 28 Jun 2023
Topic Review
Chronic Myeloid Leukemia
The therapeutic approach to Chronic Myeloid Leukemia (CML) has changed since the advent of the tyrosine kinase inhibitor (TKI) imatinib, which was then followed by the second generation TKIs dasatinib, nilotinib, and, finally, by ponatinib, a third-generation drug. At present, these therapeutic options represent the first-line treatment for adults. Based on clinical experience, imatinb, dasatinib, and nilotinib have been approved for children even though the studies that were concerned with efficacy and safety toward pediatric patients are still awaiting more specific and high-quality data.
  • 1.5K
  • 05 Nov 2020
Topic Review
Interleukin-6
Interleukin-6 (IL-6) is a cytokine of a pro-inflammatory nature, and it can be produced by various cell types of the immune system as well as by some nonimmune cells, including fibroblasts. IL-6 is cytokine important for the initial phase of immune response that is recognized by 2 types of receptor. Overproduction of IL-6 is associated with aging, chronic inflammation, cancer and severe viral infections such is COVID-19.  This molecule is not produced by immune cells but also by cancer-associated fibroblasts and cancer cells. Control of its production or inhibition of IL-6 receptors could have the therapeutic consequences. 
  • 1.5K
  • 26 Nov 2020
Topic Review
Li-ion Batteries
With the ever-growing energy storage notably due to the electric vehicle market expansion and stationary applications, one of the challenges of lithium batteries lies in the cost and environmental impacts of their manufacture. The main process employed is the solvent-casting method, based on a slurry casted onto a current collector. The disadvantages of this technique include the use of toxic and costly solvents as well as significant quantity of energy required for solvent evaporation and recycling. A solvent-free manufacturing method would represent significant progress in the development of cost-effective and environmentally friendly lithium-ion and lithium metal batteries.
  • 1.5K
  • 11 Jan 2022
Topic Review
MicroRNA
MicroRNA (miRNAs) are short, single-stranded ncRNAs that can be measured in biofluids as minimally invasive biomarkers of disease, including cancer. Their reliable measurement however is challenging, therefore several methods are being developed for miRNA quantitation. Here the technologies currently in use or being developed for quantitation of miRNAs are described.
  • 1.5K
  • 05 Mar 2021
Topic Review
PBK/TOPK
T-lymphokine-activated killer cell-originated protein kinase (TOPK, also known as PDZ-binding kinase or PBK) plays a crucial role in cell cycle regulation and mitotic progression. Abnormal overexpression or activation of TOPK has been observed in many cancers, including colorectal cancer, triple-negative breast cancer, and melanoma, and it is associated with increased development, dissemination, and poor clinical outcomes and prognosis in cancer. Moreover, TOPK phosphorylates p38, JNK, ERK, and AKT, which are involved in many cellular functions, and participates in the activation of multiple signaling pathways related to MAPK, PI3K/PTEN/AKT, and NOTCH1; thus, the direct or indirect interactions of TOPK make it a highly attractive yet elusive target for cancer therapy. Small molecule inhibitors targeting TOPK have shown great therapeutic potential in the treatment of cancer both in vitro and in vivo, even in combination with chemotherapy or radiotherapy. Therefore, targeting TOPK could be an important approach for cancer prevention and therapy.
  • 1.5K
  • 22 Sep 2021
Topic Review
Flavonoids as α-Glucosidase Inhibitors
Flavonoids are found ubiquitously in plants and represent ~60% of all dietary (poly)phenolic compounds. Flavonols, a sub-class of flavonoids, are present in onions, kale, apples, berries, leeks and broccoli. Some flavonols excreted in urine can be used as biomarkers of flavonol intake and are significantly associated with a lower T2D risk. Many flavonoids extracted from plants inhibit α-amylase and α-glucosidase activities in vitro, and improve postprandial glycaemia in diabetic animal models and limited human studies. Very few studies have reported on the inhibition of isomaltase, however. The disaccharide isomaltose is rarely present in nature but is commonly added as low-caloric food sweeteners in industrial-scale production, or produced from amylopectin hydrolysis to α-limit dextrins. Studies assessing the isomaltase inhibitory potential by flavonoids and acarbose are therefore of interest.
  • 1.5K
  • 28 Sep 2021
Topic Review
Dendritic Spine
Dendritic spines are small, bulbous protrusions along neuronal dendrites where most of the excitatory synapses are located. Dendritic spine density in normal human brain increases rapidly before and after birth achieving the highest density around 2–8 years. Density decreases during adolescence, reaching a stable level in adulthood. The changes in dendritic spines are considered structural correlates for synaptic plasticity as well as the basis of experience-dependent remodeling of neuronal circuits. Alterations in spine density correspond to aberrant brain function observed in various neurodevelopmental and neuropsychiatric disorders. Dendritic spine initiation affects spine density. In this review, we discuss the importance of spine initiation in brain development, learning, and potential complications resulting from altered spine initiation in neurological diseases. Current literature shows that two Bin Amphiphysin Rvs (BAR) domain-containing proteins, MIM/Mtss1 and SrGAP3, are involved in spine initiation. We review existing literature and open databases to discuss whether other BAR-domain proteins could also take part in spine initiation. Finally, we discuss the potential molecular mechanisms on how BAR-domain proteins could regulate spine initiation. 
  • 1.5K
  • 24 Sep 2021
Topic Review
NF-κB-Dependent and -Independent IκBα Functions
IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.
  • 1.5K
  • 19 Oct 2021
Topic Review
Nanomaterials for IoT Sensing Platforms and Point-of-Care Applications
Herein, state-of-the-art research advances in South Korea regarding the development of chemical sensing materials and fully integrated Internet of Things (IoT) sensing platforms were comprehensively reviewed for verifying the applicability of such sensing systems in point-of-care testing (POCT). Various organic/inorganic nanomaterials were synthesized and characterized to understand their fundamental chemical sensing mechanisms upon exposure to target analytes. Moreover, the applicability of nanomaterials integrated with IoT-based signal transducers for the real-time and on-site analysis of chemical species was verified. 
  • 1.5K
  • 17 Jan 2022
Topic Review
Neutrophil Extracellular Trap-Driven Occlusive Diseases
The discovery of neutrophil extracellular trap (NET) formation as a part of the defense mechanisms of the innate immune system has provided new insights into the pathologies of various diseases. Nowadays, NET formation is considered a double-edged sword, as NET remnants induce inflammation and aggregated NETs (aggNETs) reportedly occlude tubular structures like vessels or ducts. In this regard, elucidating the mechanism of NET-dependent occlusions is crucial for the development of new therapeutic approaches.
  • 1.5K
  • 22 Apr 2022
Topic Review
Flies as Vectors of Bacterial Pathogens
The unique biology of flies and their omnipresence in the environment of people and animals makes them ideal candidates to be important vectors of antimicrobial resistance genes. Consequently, there has been increasing research on the bacteria and antimicrobial resistance genes that are carried by flies and their role in the spread of resistance.
  • 1.5K
  • 22 Jun 2022
Topic Review
Information and Communication Technology Systems and Innovation
Entrepreneurship has become increasingly important for innovation and economic growth. The connection of innovation and entrepreneurship to Information and Communications Technology (ICT) is gradually being increasingly recognised as a catalyst and a facilitator of social and economic growth. Innovation, as a rule, causes companies to be more creative, experimenting with the development of new processes, services, and products, thus giving rise to new business models that allow companies to expand and improve overall competitiveness. ICTs have been pointed out as a key factor in developing innovation. 
  • 1.5K
  • 24 Jun 2022
Topic Review
Dostarlimab
Dostarlimab (JEMPERLI) is a PD-1 monoclonal antibody for the treatment of adult patients, with mismatch repair deficient (dMMR), recurrent or advanced endometrial cancer that has progressed on or following prior therapy with a platinum-containing regimen. As determined by an FDA-approved test this indication was granted rapid approval based on the rate of tumor response and the duration of the response. Continued approval for this indication is conditioned on further confirmatory trials demonstrating and documenting clinical benefit.
  • 1.5K
  • 11 Aug 2022
Topic Review
Biomarkers in Veterinary Medicine
New biomarkers promise to transform veterinary practice through rapid diagnosis of diseases, effective monitoring of animal health and improved welfare and production efficiency. However, the road from biomarker discovery to translation is not always straightforward. The use of biomarkers has been identified as an increasing trend in the animal health industry and has been applied to the evaluation of a variety of health parameters. In particular, it is useful in clinical applications such as diagnosing illness, predicting and/or tracking the response to treatment, and determining the toxicity or failure of an organ.
  • 1.5K
  • 02 Sep 2022
Topic Review
Abandonment (Emotional)
Emotional abandonment is a subjective emotional state in which people feel undesired, left behind, insecure, or discarded. People experiencing emotional abandonment may feel at loss, cut off from a crucial source of sustenance that has been withdrawn, either suddenly, or through a process of erosion. In a classic abandonment scenario, the severance of the emotional bond is unilateral, that is, the object of one’s attachment is the one who chose to break the connection. Feeling rejected, which is a significant component of emotional abandonment, has a biological impact in that it activates the physical pain centers in the brain and can leave an emotional imprint in the brain’s warning system. Abandonment has been a staple of poetry and literature since ancient times.
  • 1.5K
  • 30 Sep 2022
Topic Review
DSAdd
As the next version of Windows NT after Windows 2000, as well as the successor to Windows Me, Windows XP introduced many new features but it also removed some others.
  • 1.5K
  • 11 Oct 2022
Topic Review
Emotive Internet
Emotive Internet (also Emotive Web, Emotional Internet) is a conceptualization of the Internet as an emergent emotional public space, such as how it serves as a space for the social sharing of emotions. It can also denote the quality of the Internet that allows it to be used to communicate in an emotive fashion or with emotional intent. Since it is an expressive medium, it also enables users to construct and represent their identities online. This is evident in the way emotional responses have been integrated in online communication and interactions. The concept is also linked to emotional analytics and emotion-sensing applications, particularly those technologies that power the Internet of Things (IoTs) - the smart home devices that have the capability to store and process the user's emotional profile to deliver services.
  • 1.5K
  • 28 Nov 2022
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